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Mutation Information
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Mutation Site
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A1762T |
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Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
BCP |
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Combined Mutation
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bcp.G1764A+bcp.A1762T |
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Genotype/Subtype
|
E |
|
Country
|
Abidjan; Côte d'Ivoire |
Literature Information
|
PubMed PMID
|
29660214
|
|
Disease
|
HBV-HIV coinfection
|
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Published Year
|
2018 |
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Journal
|
Journal of viral hepatitis |
|
Title
|
Precore G1896A mutation is associated with reduced rates of HBsAg seroclearance in treated HIV hepatitis B virus co-infected patients from Western Africa. |
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Author
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Boyd A,Moh R,Maylin S,Abdou Chekaraou M,Mahjoub N,Gabillard D,Anglaret X,Eholié SP,Delaugerre C,Danel C,Zoulim F,Lacombe K,ANRS 12240 VarBVA study. |
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Evidence
|
At ARV-initiation, median HBV-DNA was 6.04 log10 copies/mL (IQR = 3.70-7.93) with 97.7% harbouring HBV genotype E. Baseline pcG1896A mutation was identified in 51 (59.3%) patients, who were more commonly HBeAg-negative (P < .001) and had basal core promotor A1762T/G1764A mutations (P < .001).
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HBV Mutation Detail Information