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Mutation Information
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Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
28902288
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2017 |
|
Journal
|
Memorias do Instituto Oswaldo Cruz |
|
Title
|
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases. |
|
Author
|
Chachá SGF,Gomes-Gouvêa MS,Malta FM,Ferreira SDC,Villanova MG,Souza FF,Teixeira AC,Passos ADDC,Pinho JRR,Martinelli ALC |
|
Evidence
|
The A1762T/G1764A variant was identified in 36.7% of the patients with grade 1 and 2 liver fibrosis (29/79) and in 81.8% of the patients with grade 3 and 4 liver fibrosis (9/11) (p < 0.01).
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HBV Mutation Detail Information