HBV Mutation Detail Information

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Mutation Information

Mutation Site	A1762T
Mutation Type	Nucleotide level
Gene/Protein/Region Type	BCP
Genotype/Subtype	C
Country	Japan

Literature Information

PubMed PMID	22523569
Disease	Chronic hepatitis B
Published Year	2012
Journal	PloS one
Title	Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.
Author	Nishijima N,Marusawa H,Ueda Y,Takahashi K,Nasu A,Osaki Y,Kou T,Yazumi S,Fujiwara T,Tsuchiya S,Shimizu K,Uemoto S,Chiba T
Evidence	For example, in chronic infection, G to A point mutation at nucleotide (nt) 1896 in the pre-core (pre-C) region as well as A1762T and G1764A mutations in the core-promoter region are highly associated with HBeAg seroconversion that in general results in the low levels of viremia and consequent clinical cure. In contrast, acute infection with the G1896A pre-C mutant represents a high risk for fulminant hepatic failure.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation