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Mutation Information
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Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
X |
|
Combined Mutation
|
x.V131I+x.K130M |
|
Nucleotide_Mutation
|
K130M |
|
Genotype/Subtype
|
C |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
18551606
|
|
Disease
|
Hepatocellular carcinoma;
Liver cirrhosis;
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Journal of medical virology |
|
Title
|
Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection. |
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Author
|
Kim HJ,Park JH,Jee Y,Lee SA,Kim H,Song BC,Yang S,Lee M,Yoon JH,Kim YJ,Lee HS,Hwang ES,Kook YH,Kim BJ |
|
Evidence
|
Mutation rates in the X region in patients with more severe liver disease, hepatocellular carcinoma (HCC) (3.6%) or liver cirrhosis (4%) were always significantly higher than in patients with corresponding less severe forms, chronic hepatitis (2.9%) or asymptomatic carriers (2.1%), but no significant difference in mutation rates was found in terms of HBeAg serostatus. All five mutation types (V5M/L, P38S, H94Y, I127T/N, and K130M and V131I) affecting the six codons were found to be related significantly to clinical severity.
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HBV Mutation Detail Information