|
Mutation Information
|
Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Genotype/Subtype
|
D |
Literature Information
|
PubMed PMID
|
18507754
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2008 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease. |
|
Author
|
Poustchi H,Mohamadkhani A,Bowden S,Montazeri G,Ayres A,Revill P,Farrell GC,Locarnini S,George J,Malekzadeh R |
|
Evidence
|
The results indicate that in genotype D CHB, the presence of the A1762T-G1764A mutation was associated with more aggressive liver disease while the G1757A substitution was associated with protection from advanced disease.
|
|
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HBV Mutation Detail Information