Mutation Information
Mutation Site
|
A1762T |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
C Promoter |
Combined Mutation
|
c promoter.G1764A+c promoter.A1762T;c promoter.C1766T+c promoter.G1764A+c promoter.A1762T+c promoter.T1753C |
Genotype/Subtype
|
A |
Literature Information
PubMed PMID
|
17627632
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2007 |
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
Title
|
Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus. |
Author
|
Tong S |
Evidence
|
We found that the hot spot mutations (A1762T/G1764A) only mildly reduced HBeAg expression and enhanced genome replication, while incorporation of additional core promoter mutations intensified both phenotypes.
|
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