HBV Mutation Detail Information

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Mutation Information
Mutation Site A1762T
Mutation Type Nucleotide level
Gene/Protein/Region Type C Promoter
Combined Mutation c promoter.G1764A+c promoter.A1762T;c promoter.C1766T+c promoter.G1764A+c promoter.A1762T+c promoter.T1753C
Genotype/Subtype A
Literature Information
PubMed PMID 17627632
Disease Chronic hepatitis B
Published Year 2007
Journal Hepatology research : the official journal of the Japan Society of Hepatology
Title Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus.
Author Tong S
Evidence We found that the hot spot mutations (A1762T/G1764A) only mildly reduced HBeAg expression and enhanced genome replication, while incorporation of additional core promoter mutations intensified both phenotypes.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation