|
Mutation Information
|
Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
Literature Information
|
PubMed PMID
|
16549970
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2006 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy. |
|
Author
|
Matthews GV,Bartholomeusz A,Locarnini S,Ayres A,Sasaduesz J,Seaberg E,Cooper DA,Lewin S,Dore GJ,Thio CL |
|
Evidence
|
The most common BCP mutation detected (11 patients) was the signature double mutation, A1762T/G1764A, which downregulates HBeAg expression secondary to reduced preC-mRNA transcription.
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HBV Mutation Detail Information