|
Mutation Information
|
Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
15048802
|
|
Disease
|
Liver cirrhosis
|
|
Published Year
|
2004 |
|
Journal
|
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society |
|
Title
|
Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin. |
|
Author
|
Lo CM,Cheung ST,Ng IO,Liu CL,Lai CL,Fan ST |
|
Evidence
|
Analysis of gene sequence variation by polymerase chain reaction (PCR) and direct sequencing showed that both had a core promoter variant A1762T/G1764A and 1 had a concomitant precore stop codon G1896A variant in prelamivudine and postrecurrence serum samples.
|
|
|
HBV Mutation Detail Information