Mutation Information
Mutation Site
|
A1727G |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
EnhII |
Country
|
China |
Literature Information
PubMed PMID
|
20959817
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis;
Hepatocellular carcinoma
|
Published Year
|
2011 |
Journal
|
The American journal of gastroenterology |
Title
|
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. |
Author
|
Yin J,Xie J,Liu S,Zhang H,Han L,Lu W,Shen Q,Xu G,Dong H,Shen J,Zhang J,Han J,Wang L,Liu Y,Wang F,Zhao J,Zhang Q,Ni W,Wang H,Cao G |
Evidence
|
As compared with ASCs and the patients with CHB,C1673T, T1674C, A1703G, A1726C, C1730G, C1799G, A1846T,and C1913A in genotype C and C1653T, G1719T, A1727G,T1753A / C, A1762T, G1764A, C1766T, T1768A, C1773T, and G1896A in both genotypes were signifi cantly associated with LC(see Supplementary Table 6 )
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