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Mutation Information
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Mutation Site
|
A1726C |
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Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
C Promoter |
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Country
|
China |
Literature Information
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PubMed PMID
|
23386590
|
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Disease
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Hepatocellular carcinoma
|
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Published Year
|
2013 |
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Journal
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Hepatology (Baltimore, Md.) |
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Title
|
Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma. |
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Author
|
Xie J,Zhang Y,Zhang Q,Han Y,Yin J,Pu R,Shen Q,Lu W,Du Y,Zhao J,Han X,Zhang H,Cao G |
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Evidence
|
In multivariate regression analyses, multiplicative interaction of rs1053004 with T1674C/G significantly increased HCC risk, whereas rs2293152 and A1726C interaction reduced it, adjusting for covariates including HBV mutations in the enhancer II/basal core promoter/precore region; the interaction of rs4796793 with preS2 start codon mutation significantly increased HCC risk, adjusting for covariates including HBV mutations in the preS region.
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HBV Mutation Detail Information