HIV Mutation Detail Information

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Mutation Information

Mutation Site	A146P
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag
Genotype/Subtype	B;C
Viral Reference	K03455.1
Immune Escape	Y
Country	South Africa

Literature Information

PubMed PMID	15067030
Disease	HIV infection/AIDS
Published Year	2004
Journal	The Journal of experimental medicine
Title	Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
Author	Draenert R,Le Gall S,Pfafferott KJ,Leslie AJ,Chetty P,Brander C,Holmes EC,Chang SC,Feeney ME,Addo MM,Ruiz L,Ramduth D,Jeena P,Altfeld M,Thomas S,Tang Y,Verrill CL,Dixon C,Prado JG,Kiepiela P,Martinez-Picado J,Walker BD,Goulder PJ
Evidence	The A146P mutation prevented NH2-terminal trimming of the optimal epitope by the endoplasmic reticulum aminopeptidase I.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation