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Mutation Information
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Mutation Site
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A1383C |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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X |
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Genotype/Subtype
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C |
Literature Information
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PubMed PMID
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25942596
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Published Year
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2015 |
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Journal
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PloS one |
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Title
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The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data. |
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Author
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Li W,Goto K,Matsubara Y,Ito S,Muroyama R,Li Q,Kato N |
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Evidence
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Logistic regression showed that mutations A1383C (OR: 2.32, 95% CI: 1.34-4.01), R1479C/T (OR: 1.96, 95% CI: 1.05-3.64; OR: 5.15, 95% CI: 2.53-10.48), C1485T (OR: 2.40, 95% CI: 1.41-4.08), C1631T (OR: 4.09, 95% CI: 1.41-11.85), C1653T (OR: 2.58, 95% CI: 1.59-4.19), G1719T (OR: 2.11, 95% CI: 1.19-3.73), and T1800C (OR: 23.59, 95% CI: 2.25-247.65) were independent risk factors for genotype C HBV-related HCC, presenting different trends among individual disease phases. 4) Several genotype C HCC risk mutations pre-existed, even as major types, in early disease phases with other genotypes.
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HBV Mutation Detail Information