|
Mutation Information
|
Mutation Site
|
A1287C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
EnhI |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
X01587
|
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
17697019
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2007 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis B virus polymerase. |
|
Author
|
Fukai K,Zhang KY,Imazeki F,Kurihara T,Mikata R,Yokosuka O |
|
Evidence
|
Sequence analysis of the HBV genome revealed that point mutations in the precore region (G1896A) and enhancer I (A1287G/C) were observed more frequently in the good responder group than in the poor responder group (P = 0.002 and 0.019 respectively)
|
|
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HBV Mutation Detail Information