HBV Mutation Detail Information

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Mutation Information

Mutation Site	A119F
Mutation Type	Amino acid level
Gene/Protein/Region Type	PreS1
Country	Taiwan(China)

Literature Information

PubMed PMID	16227269
Clinical information	Yes
Disease	Chronic hepatitis B
Published Year	2005
Journal	Journal of virology
Title	Reduced secretion of virions and hepatitis B virus (HBV) surface antigen of a naturally occurring HBV variant correlates with the accumulation of the small S envelope protein in the endoplasmic reticulum and Golgi apparatus.
Author	Chua PK,Wang RY,Lin MH,Masuda T,Suk FM,Shih C
Evidence	Although both pre-S1 mutant A119F and core mutant P5T have a low-level virion secretion phenotype and both are compensatory for the core mutant I97L (11, 27), a low-level virion secretion phenotype is neither necessary nor sufficient for the suppression of the immature secretion from core mutant I97L.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation