|
Mutation Information
|
Mutation Site
|
A115C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
S PromoterII |
|
Genotype/Subtype
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
30669266
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2019 |
|
Journal
|
Viruses |
|
Title
|
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients. |
|
Author
|
Hao R,Xiang K,Shi Y,Zhao D,Tian H,Xu B,Zhu Y,Dong H,Ding H,Zhuang H,Hu J,Li T |
|
Evidence
|
In vitro experiments in HepG2 cells showed that G82A, A115C and G120A mutants increased the hepatitis B surface antigen (HBsAg) levels, while C18T had an opposite effect.
|
|
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HBV Mutation Detail Information