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Mutation Information
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Mutation Site
|
A114V |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
Literature Information
|
PubMed PMID
|
30174310
|
|
Published Year
|
2018 |
|
Journal
|
Cell chemical biology |
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Title
|
The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase. |
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Author
|
Takamatsu Y,Das D,Kohgo S,Hayashi H,Delino NS,Sarafianos SG,Mitsuya H,Maeda K |
|
Evidence
|
A114V, Y115A, and D185A mutations, which reduced the activity of HIV-1 RT by >90%, also critically decreased viral replication (Figures 5A, B).
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HIV Mutation Detail Information