Mutation Information
Mutation Site
|
3014_3198 DEL |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreS1 |
Genotype/Subtype
|
C |
Viral Reference
|
Y18856
|
Country
|
China |
Literature Information
PubMed PMID
|
27182775
|
Disease
|
Occult HBV infection
|
Published Year
|
2016 |
Journal
|
PloS one |
Title
|
Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection. |
Author
|
Chen J,Liu Y,Zhao J,Xu Z,Chen R,Si L,Lu S,Li X,Wang S,Zhang K,Li J,Han J,Xu D |
Evidence
|
RESULTS: Twenty-one preS/S-gene mutants were cloned from four sequential serum samples, including 13 mutants that were not previously documented: (1) sI/T126V+sG145R; (2) preS1 nt 3014-3198 deletion; (3) preS1 nt 3046-3177 deletion; (4) preS1 nt 3046-3177 deletion+s115-116 "INGTST" insertion; (5) preS1 nt 3046-3177 deletion+s115-116 "INGTST" insertion+sG145R; (6) preS1 nt 3115-3123 deletion+sQ129N; (7) preS1 nt 3115-3123 deletion+s126-127 "RPCMNCTI" insertion; (8) s115-116 "INGTST" insertion; (9) s115-116 "INGTST" insertion+sG145R; (10) s126-127 "RPCMNCTI" insertion; (11) preS1 nt 2848-2862 deletion+preS2 initiation codon M-->I; (12) s122-123 "KSTGLCK" insertion+sQ129N; and (13) preS2 initiation codon M-->I+s131-133TSM-->NST.
|
|
|