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Mutation Information
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Mutation Site
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2848_2862 DELETION |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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S |
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Genotype/Subtype
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C |
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Viral Reference
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Y18856
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Country
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China |
Literature Information
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PubMed PMID
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27182775
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Disease
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Occult HBV infection
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Published Year
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2016 |
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Journal
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PloS one |
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Title
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Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection. |
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Author
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Chen J,Liu Y,Zhao J,Xu Z,Chen R,Si L,Lu S,Li X,Wang S,Zhang K,Li J,Han J,Xu D |
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Evidence
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RESULTS: Twenty-one preS/S-gene mutants were cloned from four sequential serum samples, including 13 mutants that were not previously documented: (1) sI/T126V+sG145R; (2) preS1 nt 3014-3198 deletion; (3) preS1 nt 3046-3177 deletion; (4) preS1 nt 3046-3177 deletion+s115-116 "INGTST" insertion; (5) preS1 nt 3046-3177 deletion+s115-116 "INGTST" insertion+sG145R; (6) preS1 nt 3115-3123 deletion+sQ129N; (7) preS1 nt 3115-3123 deletion+s126-127 "RPCMNCTI" insertion; (8) s115-116 "INGTST" insertion; (9) s115-116 "INGTST" insertion+sG145R; (10) s126-127 "RPCMNCTI" insertion; (11) preS1 nt 2848-2862 deletion+preS2 initiation codon M-->I; (12) s122-123 "KSTGLCK" insertion+sQ129N; and (13) preS2 initiation codon M-->I+s131-133TSM-->NST.
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HBV Mutation Detail Information