|
Mutation Information
|
Mutation Site
|
255 DELY |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
25320728
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2014 |
|
Journal
|
Clinical and molecular hepatology |
|
Title
|
Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers. |
|
Author
|
Kim KH,Chang HY,Park JY,Park ES,Park YK,Han KH,Ahn SH |
|
Evidence
|
Functional analysis via transfection experiments indicate that the C139R and D144E mutations drastically reduced HBsAg antigenicity, while the Y225del mutation found in one interferon-treated patient impaired HBsAg secretion.
|
|
|
HBV Mutation Detail Information