Primary Site >> Stomach Cancer

Gene >> ZHX2

Journal: Proc Natl Acad Sci U S A. 1985 Sep;82(17):5641-5.
Title: Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer.
Author: Shimizu, K|Nakatsu, Y|Sekiguchi, M|Hokamura, K|Tanaka, K|Terada, M|Sugimura, T
PMID: 3862088
Journal: Jpn J Cancer Res. 1989 Jan;80(1):10-4.
Title: A murine monoclonal antibody that recognizes an extracellular domain of the human c-erbB-2 protooncogene product.
Author: Masuko, T|Sugahara, K|Kozono, M|Otsuki, S|Akiyama, T|Yamamoto, T|Toyoshima, K|Hashimoto, Y
PMID: 2565325
Journal: J Biol Chem. 1997 Oct 24;272(43):27015-24.
Title: Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells.
Author: Hocker, M|Henihan, R J|Rosewicz, S|Riecken, E O|Zhang, Z|Koh, T J|Wang, T C
PMID: 9341140
Journal: J Biol Chem. 1998 Sep 4;273(36):23046-54.
Title: Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells.
Author: Hocker, M|Rosenberg, I|Xavier, R|Henihan, R J|Wiedenmann, B|Rosewicz, S|Podolsky, D K|Wang, T C
PMID: 9722530
Journal: Biochem J. 2002 Aug 1;365(Pt 3):873-9.
Title: Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression.
Author: Wroblewski, Lydia E|Pritchard, David M|Carter, Stuart|Varro, Andrea
PMID: 11971760
Journal: J Biol Chem. 2003 Mar 7;278(10):8190-8. Epub 2002 Dec 30.
Title: Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements.
Author: Schafer, Georgia|Cramer, Thorsten|Suske, Guntram|Kemmner, Wolfgang|Wiedenmann, Bertram|Hocker, Michael
PMID: 12509426
Journal: World J Gastroenterol. 2003 Jul;9(7):1431-4.
Title: Expression of NGF family and their receptors in gastric carcinoma: a cDNA microarray study.
Author: Du, Jian-Jun|Dou, Ke-Feng|Peng, Shu-You|Qian, Bing-Zhi|Xiao, Hua-Sheng|Liu, Feng|Wang, Wei-Zhong|Guan, Wen-Xian|Gao, Zhi-Qing|Liu, Ying-Bin|Han, Ze-Guang
PMID: 12854135
Journal: Gastroenterology. 2003 Aug;125(2):510-21.
Title: Transcriptional regulation of the human trefoil factor, TFF1, by gastrin.
Author: Khan, Zara E|Wang, Timothy C|Cui, Guanglin|Chi, Alfred L|Dimaline, Rod
PMID: 12891554
Journal: Oncogene. 2003 Oct 9;22(44):6942-5.
Title: BRAF and KRAS mutations in stomach cancer.
Author: Lee, Sug Hyung|Lee, Jong Woo|Soung, Young Hwa|Kim, Hong Sug|Park, Won Sang|Kim, Su Young|Lee, Jong Heun|Park, Jik Young|Cho, Yong Gu|Kim, Chang Jae|Nam, Suk Woo|Kim, Sang Ho|Lee, Jung Young|Yoo, Nam Jin
PMID: 14534542
Journal: Oncogene. 2003 Dec 11;22(57):9192-6.
Title: BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Author: Oliveira, Carla|Pinto, Mafalda|Duval, Alex|Brennetot, Caroline|Domingo, Enric|Espin, Eloi|Armengol, Manel|Yamamoto, Hiroyuki|Hamelin, Richard|Seruca, Raquel|Schwartz, Simo Jr
PMID: 14668801
Journal: Biochemistry. 2005 Mar 15;44(10):4074-82.
Title: A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad.
Author: Antignani, Antonella|Youle, Richard J
PMID: 15751984
Journal: Clin Colorectal Cancer. 2005 Sep;5(3):188-96.
Title: Results of a phase I trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer.
Author: Kupsch, Petra|Henning, Bernhard F|Passarge, Katrin|Richly, Heike|Wiesemann, Katrin|Hilger, Ralf A|Scheulen, Max E|Christensen, Olaf|Brendel, Erich|Schwartz, Brian|Hofstra, Elke|Voigtmann, Rudolf|Seeber, Siegfried|Strumberg, Dirk
PMID: 16197622
Journal: APMIS. 2005 Jan;113(1):54-7.
Title: Mutational analysis of the ARAF gene in human cancers.
Author: Lee, Jong Woo|Soung, Young Hwa|Kim, Su Young|Park, Won Sang|Nam, Suk Woo|Min, Woo Sung|Kim, Sang Ho|Lee, Jung Young|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 15676015
Journal: Cancer Biol Ther. 2005 Jan;4(1):113-7. Epub 2005 Jan 8.
Title: Inhibition of gastric cancer angiogenesis by vector-based RNA interference for Raf-1.
Author: Meng, Fanping|Ding, Jie|Liu, Na|Zhang, Jing|Shao, Xiaodong|Shen, Huiqin|Xue, Yan|Xie, Huahong|Fan, Daiming
PMID: 15662129
Journal: Int J Oncol. 2006 Jul;29(1):163-8.
Title: FGF signaling network in the gastrointestinal tract (review).
Author: Katoh, Masuko|Katoh, Masaru
PMID: 16773196
Journal: Oncol Rep. 2006 Jul;16(1):11-5.
Title: Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients.
Author: Sasao, Shogo|Hiyama, Toru|Tanaka, Shinji|Yoshihara, Masaharu|Yasui, Wataru|Chayama, Kazuaki
PMID: 16786117
Journal: Yi Chuan. 2007 May;29(5):537-40.
Title: [Effect of B-RAF-specific RNA interference on gastric cancer BGC823 cell line].
Author: Fu, Hao|Zhao, Dan-Yi|Sun, Xiu-Ju|Hua, Jun|Yan, Yang|Qiu, Guang-Rong|Shang, Chao|Fu, Wei-Neng|Sun, Kai-Lai
PMID: 17548320
Journal: Br J Nutr. 2008 Jun;99(6):1247-54. Epub 2007 Dec 17.
Title: Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
Author: Sun, Wenguang|Wang, Qi|Chen, Bingqing|Liu, Jiaren|Liu, Huikun|Xu, Weili
PMID: 18081943
Journal: Cancer Biol Ther. 2009 Jan;8(2):174-9. Epub 2009 Feb 17.
Title: RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
Author: Meng, Fanping|Dong, Baoxia|Li, Hanwei|Fan, Daiming|Ding, Jie
PMID: 19029826
Journal: Mol Cancer Ther. 2009 Sep;8(9):2537-45.
Title: AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer.
Author: Yang, Shu|Ngo, Van Chanh|Lew, Guo Bin|Chong, Lih Wen Valerie|Lee, Swee Shean|Ong, Wei Jie Richard|Lam, Wei Ling Irene|Thng, Choon Hua|Koong, Heng Nung|Ong, Hock Soo|Chung, Alexander|Chow, Pierce|Lee, Jonathan|Soo, Khee Chee|Huynh, Hung
PMID: 19723882
Journal: Nat Med. 2010 Jul;16(7):793-8.
Title: Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.
Author: Palanisamy, Nallasivam|Ateeq, Bushra|Kalyana-Sundaram, Shanker|Pflueger, Dorothee|Ramnarayanan, Kalpana|Shankar, Sunita|Han, Bo|Cao, Qi|Cao, Xuhong|Suleman, Khalid|Kumar-Sinha, Chandan|Dhanasekaran, Saravana M|Chen, Ying-bei|Esgueva, Raquel|Banerjee, Samp
PMID: 20526349
Journal: J Proteome Res. 2011 Nov 4;10(11):5084-94.
Title: Discovery of a novel B-Raf fusion protein related to c-Met drug resistance.
Author: Dillon, Roslyn|Nilsson, Carol L|Shi, Stone D-H|Lee, Nathan V|Krastins, Bryan|Greig, Michael J
PMID: 21936566
Journal: Clin Cancer Res. 2011 Apr 15;17(8):2130-9.
Title: Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis.
Author: Kang, Wei|Tong, Joanna H M|Chan, Anthony W H|Lee, Tin-Lap|Lung, Raymond W M|Leung, Patrick P S|So, Ken K Y|Wu, Kaichun|Fan, Daiming|Yu, Jun|Sung, Joseph J Y|To, Ka-Fai
PMID: 21346147
Journal: Expert Opin Investig Drugs. 2011 May;20(5):595-604.
Title: New targeted therapies for gastric cancer.
Author: Asaoka, Yoshinari|Ikenoue, Tsuneo|Koike, Kazuhiko
PMID: 21406037
Journal: Gut. 2012 Jan;61(1):43-52.
Title: Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells.
Author: Xing, Rui|Li, Wenmei|Cui, Jiantao|Zhang, Jun|Kang, Bin|Wang, Yuan|Wang, Zhaohui|Liu, Siqi|Lu, Youyong
PMID: 21676900
Journal: PLoS One. 2012;7(6):e39653.
Title: A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation.
Author: Lee, Nathan V|Lira, Maruja E|Pavlicek, Adam|Ye, Jingjing|Buckman, Dana|Bagrodia, Shubha|Srinivasa, Sreesha P|Zhao, Yongjun|Aparicio, Samuel|Rejto, Paul A|Christensen, James G|Ching, Keith A
PMID: 22745804
Journal: Dig Dis Sci. 2013 Feb;58(2):389-96.
Title: RKIP and 14-3-3epsilon exert an opposite effect on human gastric cancer cells SGC7901 by regulating the ERK/MAPK pathway differently.
Author: Yan, Lu|Gu, Huan|Li, Jia|Xu, Meihua|Liu, Ting|Shen, Yueming|Chen, Bolin|Zhang, Guiying
PMID: 22899242
Journal: PLoS One. 2013 Jul 29;8(7):e70191.
Title: Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer.
Author: Wang, Qinchuan|Liu, Xiyong|Zhou, Jichun|Huang, Yasheng|Zhang, Shengjie|Shen, Jianguo|Loera, Sofia|Yuan, Xiaoming|Chen, Wenjun|Jin, Mei|Shibata, Stephen|Liu, Yingbin|Chu, Peiguo|Wang, Linbo|Yen, Yun
PMID: 23922955
Journal: PLoS One. 2014 Jan 20;9(1):e85296.
Title: Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
Author: Lin, Zhaohu|Zhang, Chao|Zhang, Meifang|Xu, Danqing|Fang, Yanfen|Zhou, Zheng|Chen, Xiaolong|Qin, Ning|Zhang, Xiongwen
PMID: 24465527
Journal: BMC Res Notes. 2014 Apr 29;7:271.
Title: Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer.
Author: Takahashi, Naoki|Yamada, Yasuhide|Taniguchi, Hirokazu|Fukahori, Masaru|Sasaki, Yusuke|Shoji, Hirokazu|Honma, Yoshitaka|Iwasa, Satoru|Takashima, Atsuo|Kato, Ken|Hamaguchi, Tetsuya|Shimada, Yasuhiro
PMID: 24774510
Journal: Tumour Biol. 2014 Sep;35(9):9139-46.
Title: Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway.
Author: Liu, Hua|Qian, Changlin|Shen, Zhiyong
PMID: 24916572
Journal: Tumour Biol. 2014 Oct;35(10):10095-103.
Title: RKIP suppresses gastric cancer cell proliferation and invasion and enhances apoptosis regulated by microRNA-224.
Author: Liu, Hongyi|Li, Peng|Li, Bing|Sun, Peng|Zhang, Jiajin|Wang, Baishi|Jia, Baoqing
PMID: 25017365
Journal: Cancer Biomark. 2014;14(5):389-400.
Title: Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: a meta-analysis.
Author: Yu, Min|Wang, Qian|Ding, Jiang-Wu|Yang, Zhen|Xie, Chuan|Lu, Nong-Hua
PMID: 25171481
Journal: Asian Pac J Cancer Prev. 2015;16(3):1077-82.
Title: RASAL1 attenuates gastric carcinogenesis in nude mice by blocking RAS/ERK signaling.
Author: Chen, Hong|Zhao, Ji-Yi|Qian, Xu-Chen|Cheng, Zheng-Yuan|Liu, Yang|Wang, Zhi
PMID: 25735335
Journal: Cell Cycle. 2015 Aug 3;14(15):2473-83.
Title: Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer.
Author: Ji, Runbi|Zhang, Bin|Zhang, Xu|Xue, Jianguo|Yuan, Xiao|Yan, Yongmin|Wang, Mei|Zhu, Wei|Qian, Hui|Xu, Wenrong
PMID: 26091251
Journal: Oncotarget. 2015 Jan 1;6(1):221-33.
Title: Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.
Author: Petti, Consalvo|Picco, Gabriele|Martelli, Maria Luisa|Trisolini, Elena|Bucci, Enrico|Perera, Timothy|Isella, Claudio|Medico, Enzo
PMID: 25473895
Journal: Am J Transl Res. 2016 Feb 15;8(2):742-8. eCollection 2016.
Title: BRD7: a novel tumor suppressor gene in different cancers.
Author: Yu, Xin|Li, Zheng|Shen, Jianxiong
PMID: 27158366
Journal: Oncotarget. 2016 Aug 23;7(34):54445-54462.
Title: Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation.
Author: Saisana, Marina|Griffin, S Michael|May, Felicity E B
PMID: 27437872
Journal: Cancer Sci. 2016 Dec;107(12):1919-1928.
Title: Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells.
Author: Hirashita, Yuka|Tsukamoto, Yoshiyuki|Yanagihara, Kazuyoshi|Fumoto, Shoichi|Hijiya, Naoki|Nakada, Chisato|Uchida, Tomohisa|Matsuura, Keiko|Kodama, Masaaki|Okimoto, Tadayoshi|Daa, Tsutomu|Seike, Masataka|Iha, Hidekatsu|Shirao, Kuniaki|Murakami, Kazunari|Mor
PMID: 27699948
Journal: Oncol Res. 2017 Sep 21;25(8):1399-1407.
Title: Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPKalpha.
Author: Kun, Zhuang|Hanqing, Guo|Hailing, Tang|Yuan, Yan|Jun, Zhang|Lingxia, Zhang|Kun, Han|Xin, Zhang
PMID: 28059052
Journal: Cancer Sci. 2017 Mar;108(3):296-307.
Title: Hepatocyte growth factor/MET in cancer progression and biomarker discovery.
Author: Matsumoto, Kunio|Umitsu, Masataka|De Silva, Dinuka M|Roy, Arpita|Bottaro, Donald P
PMID: 28064454
Journal: Mol Cancer. 2017 Jan 23;16(1):18.
Title: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway.
Author: Zhang, Jia-Xing|Xu, Yi|Gao, Ying|Chen, Cui|Zheng, Zhou-San|Yun, Miao|Weng, Hui-Wen|Xie, Dan|Ye, Sheng
PMID: 28114937
Journal: BMC Cancer. 2017 Nov 15;17(1):766.
Title: Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.
Author: Ryu, Byung-Kyu|Lee, Min-Goo|Kim, Nam-Hoon|Lee, Kil Yeon|Oh, Shin-Ju|Moon, Jung-Rock|Kim, Hyo Jong|Chi, Sung-Gil
PMID: 29141593
Journal: NPJ Precis Oncol. 2017 May 1;1(1):9.
Title: Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival.
Author: Leong, Siew Hong|Lwin, Kyaw Myo|Lee, Sze Sing|Ng, Wai Har|Ng, Kia Min|Tan, Soo Yong|Ng, Bee Ling|Carter, Nigel P|Tang, Carol|Lian Kon, Oi
PMID: 29872697
Journal: Int J Mol Med. 2018 Apr;41(4):2389-2396.
Title: Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway.
Author: Su, Chin-Cheng
PMID: 29393362
Journal: Biomed Pharmacother. 2018 Mar;99:766-773.
Title: Resveratrol inhibits Interleukin-6 induced invasion of human gastric cancer cells.
Author: Yang, Tingting|Zhang, Jianmei|Zhou, Junting|Zhu, Meixiao|Wang, Li|Yan, Lianhe
PMID: 29710474
Journal: Mol Cancer Ther. 2018 Jul 25. pii: 1535-7163.MCT-17-1022.
Title: Acquired JHDM1D-BRAF fusion confers resistance to FGFR inhibition in FGFR2- amplified gastric cancer.
Author: Sase, Hitoshi|Nakanishi, Yoshito|Aida, Satoshi|Horiguchi-Takei, Kana|Akiyama, Nukinori|Fujii, Toshihiko|Sakata, Kiyoaki|Mio, Toshiyuki|Aoki, Masahiro|Ishii, Nobuya
PMID: 30045926