Literatures

Primary Site >> Colorectal Cancer

Gene >> XRCC6

1.
Journal:	Carcinogenesis. 2000 Nov;21(11):2005-10.
Title:	Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism.
Author:	Zhao, Y L\|Piao, C Q\|Wu, L J\|Suzuki, M\|Hei, T K
PMID:	11062161

2.
Journal:	Cancer Res. 2001 Dec 1;61(23):8381-4.
Title:	Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
Author:	Rigas, B\|Borgo, S\|Elhosseiny, A\|Balatsos, V\|Manika, Z\|Shinya, H\|Kurihara, N\|Go, M\|Lipkin, M
PMID:	11731412

3.
Journal:	Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):832-7.
Title:	Ku86 is essential in human somatic cells.
Author:	Li, Gang\|Nelsen, Caron\|Hendrickson, Eric A
PMID:	11792868

4.
Journal:	Cancer. 2002 Sep 15;95(6):1199-205.
Title:	The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma.
Author:	Komuro, Yasuhiro\|Watanabe, Toshiaki\|Hosoi, Yoshio\|Matsumoto, Yoshihisa\|Nakagawa, Keiichi\|Tsuno, Nelson\|Kazama, Shinsuke\|Kitayama, Joji\|Suzuki, Norio\|Nagawa, Hirokazu
PMID:	12216085

5.
Journal:	J Exp Clin Cancer Res. 2003 Jun;22(2):223-8.
Title:	Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression.
Author:	Komuro, Y\|Watanabe, T\|Hosoi, Y\|Matsumoto, Y\|Nakagawa, K\|Saito, S\|Ishihara, S\|Kazama, S\|Tsuno, N\|Kitayama, J\|Suzuki, N\|Tsurita, G\|Muto, T\|Nagawa, H
PMID:	12866572

6.
Journal:	Carcinogenesis. 2004 Oct;25(10):1867-77. Epub 2004 Jun 17.
Title:	Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it.
Author:	Rashmi, Ramachandran\|Kumar, Santhosh\|Karunagaran, Devarajan
PMID:	15205359

7.
Journal:	Eur J Histochem. 2004 Apr-Jun;48(2):103-10.
Title:	The expression and the nuclear activity of the caretaker gene ku86 are modulated by somatostatin.
Author:	Pucci, S\|Bonanno, E\|Pichiorri, F\|Mazzarelli, P\|Spagnoli, L G
PMID:	15208076

8.
Journal:	Int J Oncol. 2004 Aug;25(2):461-8.
Title:	Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Author:	Hosoi, Yoshio\|Watanabe, Toshiaki\|Nakagawa, Keiichi\|Matsumoto, Yoshihisa\|Enomoto, Atsushi\|Morita, Akinori\|Nagawa, Hirokazu\|Suzuki, Norio
PMID:	15254745

9.
Journal:	Hepatogastroenterology. 2005 May-Jun;52(63):666-71.
Title:	Evaluating the combination of molecular prognostic factors in tumor radiosensitivity in rectal cancer.
Author:	Komuro, Yasuhiro\|Watanabe, Toshiaki\|Tsurita, Giichiro\|Muto, Tetsuichiro\|Nagawa, Hirokazu
PMID:	15966178

10.
Journal:	World J Gastroenterol. 2005 Nov 14;11(42):6694-700.
Title:	DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor.
Author:	Mazzarelli, Paola\|Parrella, Paola\|Seripa, Davide\|Signori, Emanuela\|Perrone, Giuseppe\|Rabitti, Carla\|Borzomati, Domenico\|Gabbrielli, Armando\|Matera, Maria Giovanna\|Gravina, Carolina\|Caricato, Marco\|Poeta, Maria Luana\|Rinaldi, Monica\|Valeri, Sergio\|Coppola,
PMID:	16425368

11.
Journal:	Hepatogastroenterology. 2005 Jul-Aug;52(64):995-8.
Title:	Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer.
Author:	Komuro, Yasuhiro\|Watanabe, Toshiaki\|Hosoi, Yoshio\|Matsumoto, Yoshihisa\|Nakagawa, Keiichi\|Suzuki, Norio\|Nagawa, Hirokazu
PMID:	16001615

12.
Journal:	Carcinogenesis. 2005 Oct;26(10):1716-30. Epub 2005 May 19.
Title:	Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.
Author:	Lee, Jenq-Chang\|Lee, Chao-Hung\|Su, Chun-Li\|Huang, Chung-Wei\|Liu, Hsiao-Sheng\|Lin, Chun-Nan\|Won, Shen-Jeu
PMID:	15905197

13.
Journal:	Hum Pathol. 2005 Apr;36(4):364-71.
Title:	Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma.
Author:	Chang, Hee Jin\|Jung, Kyung Hae\|Kim, Dae Yong\|Jeong, Seung-Yong\|Choi, Hyo Seong\|Kim, Young Hoon\|Sohn, Dae Kyung\|Yoo, Byong Chul\|Lim, Seok-Byung\|Kim, Dae-Hyun\|Ahn, Joong-Bae\|Kim, Il-Jin\|Kim, Jin Man\|Yoon, Wan-Hee\|Park, Jae-Gahb
PMID:	15891997

14.
Journal:	Mol Cancer Ther. 2005 Apr;4(4):529-36.
Title:	Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.
Author:	Ayene, Iraimoudi S\|Ford, Lance P\|Koch, Cameron J
PMID:	15827325

15.
Journal:	Clin Cancer Res. 2006 Mar 1;12(5):1494-500.
Title:	Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer.
Author:	Grabsch, Heike\|Dattani, Mit\|Barker, Lisa\|Maughan, Nicola\|Maude, Karen\|Hansen, Olaf\|Gabbert, Helmut E\|Quirke, Phil\|Mueller, Wolfram
PMID:	16533773

16.
Journal:	Hum Pathol. 2006 Apr;37(4):448-52.
Title:	Loss of Ku70/Ku80 expression occurs more frequently in hereditary than in sporadic colorectal tumors. Tissue microarray study.
Author:	Korabiowska, Monika\|Cordon-Cardo, Carlos\|Schinagl, Michael\|Karaus, Michael\|Stachura, Jerzy\|Schulz, Harald\|Fischer, Gosta
PMID:	16564919

17.
Journal:	Carcinogenesis. 2007 Mar;28(3):749-59.
Title:	Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.
Author:	Kim, D S\|Franklyn, J A\|Smith, V E\|Stratford, A L\|Pemberton, H N\|Warfield, A\|Watkinson, J C\|Ishmail, T\|Wakelam, M J O\|McCabe, C J
PMID:	17071631

18.
Journal:	Cancer Res. 2007 Jan 15;67(2):634-42.
Title:	Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions.
Author:	He, Fuqiu\|Li, Ligeng\|Kim, Dooha\|Wen, Bixiu\|Deng, Xuelong\|Gutin, Philip H\|Ling, Clifton C\|Li, Gloria C
PMID:	17234773

19.
Journal:	Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42.
Title:	Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells.
Author:	Lee, Jenq-Chang\|Won, Shen-Jeu\|Chao, Chien-Lin\|Wu, Feng-Ling\|Liu, Hsiao-Sheng\|Ling, Pin\|Lin, Chun-Nan\|Su, Chun-Li
PMID:	18485277

20.
Journal:	Cell Cycle. 2009 Feb 1;8(3):473-81. Epub 2009 Feb 18.
Title:	Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.
Author:	Pucci, Sabina\|Mazzarelli, Paola\|Sesti, Fabiola\|Boothman, David A\|Spagnoli, Luigi G
PMID:	19177010

21.
Journal:	Adv Cancer Res. 2009;105:45-61.
Title:	CLU and colon cancer. The dual face of CLU: from normal to malignant phenotype.
Author:	Mazzarelli, P\|Pucci, Sabina\|Spagnoli, L G
PMID:	19879422

22.
Journal:	Apoptosis. 2010 Feb;15(2):162-72.
Title:	Cellular responses to etoposide: cell death despite cell cycle arrest and repair of DNA damage.
Author:	Schonn, Ilona\|Hennesen, Jana\|Dartsch, Dorothee C
PMID:	20041303

23.
Journal:	Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):877-85.
Title:	Response to multiple radiation doses of human colorectal carcinoma cells infected with recombinant adenovirus containing dominant-negative Ku70 fragment.
Author:	Urano, Muneyasu\|He, Fuqiu\|Minami, Akiko\|Ling, C Clifton\|Li, Gloria C
PMID:	20510198

24.
Journal:	Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):226-34.
Title:	Radiation-induced survivin nuclear accumulation is linked to DNA damage repair.
Author:	Capalbo, Gianni\|Dittmann, Klaus\|Weiss, Christian\|Reichert, Sebastian\|Hausmann, Eva\|Rodel, Claus\|Rodel, Franz
PMID:	20394854

25.
Journal:	Exp Oncol. 2011 Mar;33(1):28-32.
Title:	Is there any association between TACSTD2, KIAA1253, Ku70 and mutant KRAS gene expression and clinical-pathological features of colorectal cancer?
Author:	Ghezzi, T L\|Brum, I S\|Biolchi, V\|Garicochea, B\|Fillmann, L S\|Corleta, O C
PMID:	21423092

26.
Journal:	Cell Death Differ. 2012 Aug;19(8):1317-27.
Title:	Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.
Author:	Kerr, E\|Holohan, C\|McLaughlin, K M\|Majkut, J\|Dolan, S\|Redmond, K\|Riley, J\|McLaughlin, K\|Stasik, I\|Crudden, M\|Van Schaeybroeck, S\|Fenning, C\|O'Connor, R\|Kiely, P\|Sgobba, M\|Haigh, D\|Johnston, P G\|Longley, D B
PMID:	22322857

27.
Journal:	Int J Radiat Biol. 2012 Jul;88(7):515-22.
Title:	The effect of DN (dominant-negative) Ku70 and reoxygenation on hypoxia cell-kill: evidence of hypoxia-induced potentially lethal damage.
Author:	Urano, Muneyasu\|Li, Gloria C\|He, Fuqiu\|Minami, Akiko\|Burgman, Paul\|Ling, C Clifton
PMID:	22617044

28.
Journal:	PLoS One. 2012;7(6):e39379.
Title:	Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis.
Author:	Zou, Huafei\|Volonte, Daniela\|Galbiati, Ferruccio
PMID:	22745744

29.
Journal:	Oncotarget. 2012 Nov;3(11):1348-55.
Title:	Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.
Author:	Beggs, Andrew D\|Domingo, Enric\|McGregor, Megan\|Presz, Mikael\|Johnstone, Elaine\|Midgley, Rachel\|Kerr, David\|Oukrif, Dahmane\|Novelli, Marco\|Abulafi, Muti\|Hodgson, Shirley V\|Fadhil, Wakkas\|Ilyas, Mohammad\|Tomlinson, Ian P M
PMID:	23154512

30.
Journal:	Radiat Oncol. 2013 Aug 9;8:196.
Title:	The different biological effects of single, fractionated and continuous low dose rate irradiation on CL187 colorectal cancer cells.
Author:	Wang, Hao\|Li, Jinna\|Qu, Ang\|Liu, Jingjia\|Zhao, Yong\|Wang, Junjie
PMID:	23937791

31.
Journal:	Onco Targets Ther. 2014 Oct 24;7:1955-61.
Title:	Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
Author:	Lu, Yuanfang\|Gao, Jingyan\|Lu, Yuanming
PMID:	25368522

32.
Journal:	Dis Colon Rectum. 2014 May;57(5):592-601.
Title:	Can a biomarker-based scoring system predict pathologic complete response after preoperative chemoradiotherapy for rectal cancer?
Author:	Hur, Hyuk\|Kim, Nam Kyu\|Min, Byung Soh\|Baik, Seung Hyuk\|Lee, Kang Young\|Koom, Woong Sub\|Ahn, Joong Bae\|Kim, Hoguen
PMID:	24819099

33.
Journal:	J Gastrointest Surg. 2014 Jul;18(7):1306-18.
Title:	Gender-related differences in pathological and clinical tumor response based on immunohistochemical proteins expression in rectal cancer patients treated with short course of preoperative radiotherapy.
Author:	Gasinska, Anna\|Adamczyk, Agnieszka\|Niemiec, Joanna\|Biesaga, Beata\|Darasz, Zbigniew\|Skolyszewski, Jan
PMID:	24756926

34.
Journal:	Oncogene. 2014 May 22;33(21):2748-57.
Title:	A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining.
Author:	Puebla-Osorio, N\|Kim, J\|Ojeda, S\|Zhang, H\|Tavana, O\|Li, S\|Wang, Y\|Ma, Q\|Schluns, K S\|Zhu, C
PMID:	23752193

35.
Journal:	Mol Med Rep. 2015 Jul;12(1):581-6.
Title:	Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis.
Author:	Meng, Jin\|Zhang, Feng\|Zhang, Xu-Tao\|Zhang, Tao\|Li, Yu-Hua\|Fan, Lei\|Sun, Yang\|Zhang, He-Long\|Mei, Qi-Bing
PMID:	25695595

36.
Journal:	Med Oncol. 2015 Apr;32(4):98.
Title:	Down-expression pattern of Ku70 and p53 coexisted in colorectal cancer.
Author:	Lu, Yuanfang\|Gao, Jingyan\|Lu, Yuanming
PMID:	25731619

37.
Journal:	Mol Cancer Res. 2016 Apr;14(4):385-96.
Title:	KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
Author:	Ghaleb, Amr M\|Elkarim, Enas A\|Bialkowska, Agnieszka B\|Yang, Vincent W
PMID:	26839262

38.
Journal:	Cancer Lett. 2016 May 1;374(2):208-15.
Title:	Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.
Author:	Soret, Christine\|Martin, Elisabeth\|Duluc, Isabelle\|Dantzer, Francoise\|Vanier, Marie\|Gross, Isabelle\|Freund, Jean-Noel\|Domon-Dell, Claire
PMID:	26902420

39.
Journal:	APMIS. 2016 Sep;124(9):736-40.
Title:	Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients.
Author:	Dimberg, Jan\|Skarstedt, Marita\|Slind Olsen, Renate\|Andersson, Roland E\|Matussek, Andreas
PMID:	27328741

40.
Journal:	Int J Radiat Oncol Biol Phys. 2017 Feb 1;97(2):381-388.
Title:	Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer.
Author:	Pucci, Sabina\|Polidoro, Chiara\|Joubert, Alessandro\|Mastrangeli, Francesca\|Tolu, Barbara\|Benassi, Michaela\|Fiaschetti, Valeria\|Greco, Laura\|Miceli, Roberto\|Floris, Roberto\|Novelli, Giuseppe\|Orlandi, Augusto\|Santoni, Riccardo
PMID:	28068245

41.
Journal:	Rep Pract Oncol Radiother. 2017 Sep-Oct;22(5):368-377.
Title:	Gender-related prognostic significance of clinical and biological tumor features in rectal cancer patients receiving short-course preoperative radiotherapy.
Author:	Gasinska, Anna\|Darasz, Zbigniew\|Adamczyk, Agnieszka\|Biesaga, Beata\|Niemiec, Joanna\|Reinfuss, Marian
PMID:	28794690

42.
Journal:	Oncotarget. 2017 Sep 21;8(49):86296-86311.
Title:	Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.
Author:	Jongen, Jennifer M J\|van der Waals, Lizet M\|Trumpi, Kari\|Laoukili, Jamila\|Peters, Niek A\|Schenning-van Schelven, Susanne J\|Govaert, Klaas M\|Borel Rinkes, Inne H M\|Kranenburg, Onno
PMID:	29156796

43.
Journal:	Turk J Gastroenterol. 2018 Oct 5.
Title:	Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
Author:	Gasinska, Anna\|Biesaga, Beata\|Widla, Anna Janecka\|Darasz, Zbigniew
PMID:	30289394