Primary Site >> Colorectal Cancer
Gene >> XRCC6
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Ref: Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism. PMID: 11062161 |
Ref: Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis. PMID: 11731412 |
Ref: Ku86 is essential in human somatic cells. PMID: 11792868 Ref: The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. PMID: 12216085 |
Ref: Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression. PMID: 12866572 |
Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 Ref: The expression and the nuclear activity of the caretaker gene ku86 are modulated by somatostatin. PMID: 15208076 Ref: Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. PMID: 15254745 |
Ref: Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. PMID: 15827325 Ref: Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. PMID: 15891997 Ref: Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. PMID: 15905197 Ref: Evaluating the combination of molecular prognostic factors in tumor radiosensitivity in rectal cancer. PMID: 15966178 Ref: Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer. PMID: 16001615 Ref: DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor. PMID: 16425368 |
Ref: Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. PMID: 16533773 Ref: Loss of Ku70/Ku80 expression occurs more frequently in hereditary than in sporadic colorectal tumors. Tissue microarray study. PMID: 16564919 |
Ref: Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. PMID: 17071631 Ref: Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions. PMID: 17234773 |
Ref: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. PMID: 18485277 |
Ref: Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression. PMID: 19177010 Ref: CLU and colon cancer. The dual face of CLU: from normal to malignant phenotype. PMID: 19879422 |
Ref: Cellular responses to etoposide: cell death despite cell cycle arrest and repair of DNA damage. PMID: 20041303 Ref: Radiation-induced survivin nuclear accumulation is linked to DNA damage repair. PMID: 20394854 Ref: Response to multiple radiation doses of human colorectal carcinoma cells infected with recombinant adenovirus containing dominant-negative Ku70 fragment. PMID: 20510198 |
Ref: Is there any association between TACSTD2, KIAA1253, Ku70 and mutant KRAS gene expression and clinical-pathological features of colorectal cancer? PMID: 21423092 |
Ref: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. PMID: 22322857 Ref: The effect of DN (dominant-negative) Ku70 and reoxygenation on hypoxia cell-kill: evidence of hypoxia-induced potentially lethal damage. PMID: 22617044 Ref: Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. PMID: 22745744 Ref: Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. PMID: 23154512 |
Ref: The different biological effects of single, fractionated and continuous low dose rate irradiation on CL187 colorectal cancer cells. PMID: 23937791 |
Ref: A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. PMID: 23752193 Ref: Gender-related differences in pathological and clinical tumor response based on immunohistochemical proteins expression in rectal cancer patients treated with short course of preoperative radiotherapy. PMID: 24756926 Ref: Can a biomarker-based scoring system predict pathologic complete response after preoperative chemoradiotherapy for rectal cancer? PMID: 24819099 Ref: Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients. PMID: 25368522 |
Ref: Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. PMID: 25695595 Ref: Down-expression pattern of Ku70 and p53 coexisted in colorectal cancer. PMID: 25731619 |
Ref: KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. PMID: 26839262 Ref: Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. PMID: 26902420 Ref: Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients. PMID: 27328741 |
Ref: Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer. PMID: 28068245 Ref: Gender-related prognostic significance of clinical and biological tumor features in rectal cancer patients receiving short-course preoperative radiotherapy. PMID: 28794690 Ref: Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability. PMID: 29156796 |
Ref: Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy. PMID: 30289394 |