Primary Site >> Colorectal Cancer

Gene >> WEE1

Journal: Int J Cancer. 1999 Sep 9;82(6):868-74.
Title: Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array.
Author: Backert, S|Gelos, M|Kobalz, U|Hanski, M L|Bohm, C|Mann, B|Lovin, N|Gratchev, A|Mansmann, U|Moyer, M P|Riecken, E O|Hanski, C
PMID: 10446455
Journal: Scand J Gastroenterol. 2004 May;39(5):464-9.
Title: Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line.
Author: Fan, C W|Chan, C C|Chao, C C K|Fan, H A|Sheu, D L|Chan, E C
PMID: 15180185
Journal: Cancer Biol Ther. 2005 Nov;4(11):1211-5. Epub 2005 Nov 8.
Title: Aberrant splicing of cables gene, a CDK regulator, in human cancers.
Author: Zhang, Hui|Duan, Hai Ou|Kirley, Sandra D|Zukerberg, Lawrence R|Wu, Chin-Lee
PMID: 16177568
Journal: Cell Cycle. 2007 Dec 15;6(24):3114-31.
Title: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis.
Author: Whittaker, Steven R|Te Poele, Robert H|Chan, Florence|Linardopoulos, Spiros|Walton, Michael I|Garrett, Michelle D|Workman, Paul
PMID: 18075315
Journal: Oncogene. 2008 Sep 18;27(42):5567-77.
Title: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.
Author: Moran, D M|Gawlak, G|Jayaprakash, M S|Mayar, S|Maki, C G
PMID: 18504430
Journal: Mol Pharmacol. 2009 Jan;75(1):124-33.
Title: 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.
Author: Tse, Archie N|Sheikh, Tahir N|Alan, Ho|Chou, Ting-Chao|Schwartz, Gary K
PMID: 18820127
Journal: Food Chem Toxicol. 2009 Jan;47(1):171-9.
Title: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways.
Author: Yang, Jai-Sing|Chen, Guang-Wei|Hsia, Te-Chun|Ho, Heng-Chien|Ho, Chin-Chin|Lin, Meng-Wei|Lin, Song-Shei|Yeh, Ru-Duan|Ip, Siu-Wan|Lu, Hsu-Fung|Chung, Jing-Gung
PMID: 19038304
Journal: J Biochem. 2009 Mar;145(3):289-97.
Title: Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.
Author: Yang, Xiaoming|Wood, Patricia A|Ansell, Christine M|Ohmori, Masami|Oh, Eun-Yeong|Xiong, Yin|Berger, Franklin G|Pena, Maria Marjorette O|Hrushesky, William J M
PMID: 19106159
Journal: Bioorg Med Chem. 2009 Dec 1;17(23):8040-7.
Title: Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies.
Author: Ortin, Irene|Gonzalez, Juan Francisco|Cuesta, Elena de la|Manguan-Garcia, Cristina|Perona, Rosario|Avendano, Carmen
PMID: 19875300
Journal: Cancer Biol Ther. 2010 Apr 1;9(7):514-22. Epub 2010 Apr 1.
Title: MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.
Author: Hirai, Hiroshi|Arai, Tsuyoshi|Okada, Megumu|Nishibata, Toshihide|Kobayashi, Makiko|Sakai, Naoko|Imagaki, Kazuhide|Ohtani, Junko|Sakai, Takumi|Yoshizumi, Takashi|Mizuarai, Shinji|Iwasawa, Yoshikazu|Kotani, Hidehito
PMID: 20107315
Journal: J Biochem. 2010 Sep;148(3):319-26.
Title: Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity.
Author: Zeng, Zhao-Lei|Wu, Ming-Wei|Sun, Jian|Sun, Yue-Li|Cai, Yu-Chen|Huang, Yi-Jun|Xian, Li-Jian
PMID: 20576619
Journal: Oncol Rep. 2010 Oct;24(4):1029-34.
Title: Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer.
Author: Hiro, Junichiro|Inoue, Yasuhiro|Toiyama, Yuji|Yoshiyama, Shigeyuki|Tanaka, Koji|Mohri, Yasuhiko|Miki, Chikao|Kusunoki, Masato
PMID: 20811685
Journal:
Title: Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry
Author: Simanski, Scott|Madoux, Franck|Rahaim, Ronald J.|Chase, Peter|Schurer, Stephan|Cameron, Michael|Mercer, Becky A.|Hodder, Peter|Roush, William R.|Ayad, Nagi G.
PMID: 23762957
Journal: Int J Cancer. 2013 Mar 1;132(5):1032-41.
Title: An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors.
Author: Sotak, Matus|Polidarova, Lenka|Ergang, Peter|Sumova, Alena|Pacha, Jiri
PMID: 22865596
Journal: Leukemia. 2015 Jan;29(1):27-37.
Title: Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies.
Author: Weisberg, Ellen|Nonami, Atsushi|Chen, Zhao|Liu, Feiyang|Zhang, Jianming|Sattler, Martin|Nelson, Erik|Cowens, Kristen|Christie, Amanda L|Mitsiades, Constantine|Wong, Kwok-Kin|Liu, Qingsong|Gray, Nathanael|Griffin, James D
PMID: 24791855
Journal: Int J Cancer. 2015 Mar 1;136(5):1024-32.
Title: Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.
Author: Huisman, Sander A|Oklejewicz, Malgorzata|Ahmadi, Ali R|Tamanini, Filippo|Ijzermans, Jan N M|van der Horst, Gijsbertus T J|de Bruin, Ron W F
PMID: 25045881
Journal: Int J Clin Exp Pathol. 2015 Sep 1;8(9):10985-94. eCollection 2015.
Title: Circadian gene expression predicts patient response to neoadjuvant chemoradiation therapy for rectal cancer.
Author: Lu, Haijie|Chu, Qiqi|Xie, Guojiang|Han, Hao|Chen, Zheng|Xu, Benhua|Yue, Zhicao
PMID: 26617816
Journal: Tumour Biol. 2016 Sep;37(9):12133-12140.
Title: Expression and clinical significance of Wee1 in colorectal cancer.
Author: Egeland, Eivind Valen|Flatmark, Kjersti|Nesland, Jahn M|Florenes, Vivi Ann|Maelandsmo, Gunhild M|Boye, Kjetil
PMID: 27220319
Journal: Tumour Biol. 2016 Oct;37(10):13973-13981.
Title: Disruption of clock gene expression in human colorectal liver metastases.
Author: Huisman, Sander A|Ahmadi, Ali R|IJzermans, Jan N M|Verhoef, Cees|van der Horst, Gijsbertus T J|de Bruin, Ron W F
PMID: 27492458
Journal: Oncotarget. 2017 Jun 27;8(26):42288-42299.
Title: Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.
Author: Webster, Peter J|Littlejohns, Anna T|Gaunt, Hannah J|Young, Richard S|Rode, Baptiste|Ritchie, Judith E|Stead, Lucy F|Harrison, Sally|Droop, Alastair|Martin, Heather L|Tomlinson, Darren C|Hyman, Adam J|Appleby, Hollie L|Boxall, Sally|Bruns, Alexander F|Li,
PMID: 28178688
Journal: Cell Cycle. 2017;16(22):2176-2182.
Title: AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells.
Author: Webster, Peter John|Littlejohns, Anna Tiffany|Gaunt, Hannah Jane|Prasad, K Raj|Beech, David John|Burke, Dermot Anthony
PMID: 28296564
Journal: Oncol Lett. 2017 Jun;13(6):4341-4348.
Title: Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer.
Author: Ge, Xiao-Chuan|Wu, Fan|Li, Wei-Tao|Zhu, Xuan-Jin|Liu, Jian-Wei|Wang, Bai-Lin
PMID: 28599436
Journal: Cancer Lett. 2018 Jan 1;412:264-271.
Title: MicroRNA-195 desensitizes HCT116 human colon cancer cells to 5-fluorouracil.
Author: Kim, Chongtae|Hong, Youlim|Lee, Heejin|Kang, Hoin|Lee, Eun Kyung
PMID: 29080751
Journal: Mol Med Rep. 2018 Feb;17(2):3344-3349.
Title: Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan.
Author: Yin, Yunping|Shen, Qian|Tao, Ruikang|Chang, Weilong|Li, Ruidong|Xie, Gengchen|Liu, Weizhen|Zhang, Peng|Tao, Kaixiong
PMID: 29257266
Journal: Biochem Biophys Res Commun. 2018 Jun 2;500(2):196-203.
Title: CDCA3 promotes cell proliferation by activating the NF-kappaB/cyclin D1 signaling pathway in colorectal cancer.
Author: Zhang, Wei|Lu, Yanxia|Li, Xiaomin|Zhang, Jianming|Zheng, Lin|Zhang, Wenjuan|Lin, Chun|Lin, Weihao|Li, Xuenong
PMID: 29627567
Journal: Int J Oncol. 2018 Nov;53(5):2021-2033.
Title: CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancer.
Author: Qian, Wenwei|Zhang, Zhiyuan|Peng, Wen|Li, Jie|Gu, Qiou|Ji, Dongjian|Wang, Qingyuan|Zhang, Yue|Ji, Bing|Wang, Sen|Zhang, Dongsheng|Sun, Yueming
PMID: 30226575