Primary Site >> Colorectal Cancer
Gene >> WEE1
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Ref: Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array. PMID: 10446455 |
Ref: Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line. PMID: 15180185 |
Ref: Aberrant splicing of cables gene, a CDK regulator, in human cancers. PMID: 16177568 |
Ref: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. PMID: 18075315 |
Ref: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. PMID: 18504430 |
Ref: 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. PMID: 18820127 Ref: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. PMID: 19038304 Ref: Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. PMID: 19106159 Ref: Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies. PMID: 19875300 |
Ref: MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil. PMID: 20107315 Ref: Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. PMID: 20576619 Ref: Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer. PMID: 20811685 Ref: Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry PMID: 23762957 |
Ref: An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors. PMID: 22865596 |
Ref: Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. PMID: 24791855 Ref: Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney. PMID: 25045881 Ref: Circadian gene expression predicts patient response to neoadjuvant chemoradiation therapy for rectal cancer. PMID: 26617816 |
Ref: Expression and clinical significance of Wee1 in colorectal cancer. PMID: 27220319 Ref: Disruption of clock gene expression in human colorectal liver metastases. PMID: 27492458 |
Ref: Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases. PMID: 28178688 Ref: AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells. PMID: 28296564 Ref: Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer. PMID: 28599436 |
Ref: MicroRNA-195 desensitizes HCT116 human colon cancer cells to 5-fluorouracil. PMID: 29080751 Ref: Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan. PMID: 29257266 Ref: CDCA3 promotes cell proliferation by activating the NF-kappaB/cyclin D1 signaling pathway in colorectal cancer. PMID: 29627567 Ref: CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancer. PMID: 30226575 |