Primary Site >> Colorectal Cancer

Gene >> VHL

Journal: World J Urol. 1994;12(3):162-8.
Title: Genetic alterations in sporadic renal-cell carcinoma: molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p.
Author: Brauch, H|Pomer, S|Hieronymus, T|Schadt, T|Lohrke, H|Komitowski, D
PMID: 7951344
Journal: Am J Pathol. 1995 Mar;146(3):620-5.
Title: A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size.
Author: Zhuang, Z|Bertheau, P|Emmert-Buck, M R|Liotta, L A|Gnarra, J|Linehan, W M|Lubensky, I A
PMID: 7887444
Journal: Hum Pathol. 1996 Feb;27(2):165-71.
Title: Genetic analysis of synchronous mucinous tumors of the ovary and appendix.
Author: Chuaqui, R F|Zhuang, Z|Emmert-Buck, M R|Bryant, B R|Nogales, F|Tavassoli, F A|Merino, M J
PMID: 8617458
Journal: Chin Med Sci J. 1996 Mar;11(1):36-40.
Title: Analysis of the N-glycosylation of the serum glycoproteins defined by Con A, PHA-E, RCA1 and WGA in Chinese patients with gastrointestinal diseases.
Author: Zhang, J|Chen, Y|Dai, X|Wang, S
PMID: 9206117
Journal: Hum Pathol. 1996 Feb;27(2):152-6.
Title: von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens.
Author: Zhuang, Z|Emmert-Buck, M R|Roth, M J|Gnarra, J|Linehan, W M|Liotta, L A|Lubensky, I A
PMID: 8617456
Journal: Arch Ital Urol Androl. 1997 Sep;69(4):241-6.
Title: [Heredity in renal and prostatic neoplasia].
Author: Prayer Galetti, T|D'Arrigo, L|De Zorzi, L|Patarnello, T
PMID: 9417296
Journal: Oncogene. 2002 Mar 14;21(12):1909-21.
Title: An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue.
Author: Huang, Jianmin|Kirk, Brian|Favis, Reyna|Soussi, Thierry|Paty, Philip|Cao, Weiguo|Barany, Francis
PMID: 11896624
Journal: Mol Cancer Ther. 2003 Mar;2(3):235-43.
Title: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
Author: Welsh, Sarah J|Williams, Ryan R|Birmingham, Anne|Newman, David J|Kirkpatrick, D Lynn|Powis, Garth
PMID: 12657718
Journal:
Title: (125)I-Labeled mouse anti-human carbonic anhydrase IX monoclonal antibody
Author: Shan, Liang
PMID: 22675743
Journal: World J Gastroenterol. 2004 Dec 1;10(23):3441-54.
Title: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Author: Xu, Xiao-Li|Yu, Jian|Zhang, Hong-Yu|Sun, Meng-Hong|Gu, Jun|Du, Xiang|Shi, Da-Ren|Wang, Peng|Yang, Zhen-Hua|Zhu, Jing-De
PMID: 15526363
Journal: Hum Pathol. 2004 Sep;35(9):1105-11.
Title: Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13.
Author: Beckner, Marie E|Sasatomi, Eizaburo|Swalsky, Patricia A|Hamilton, Ronald L|Pollack, Ian F|Finkelstein, Sydney D
PMID: 15343513
Journal: Nihon Rinsho. 2004 May;62(5):851-63.
Title: [Familial tumor syndrome and ectopic hormone-producing tumors].
Author: Tamura, Kazuo|Utsunomiya, Joji|Yamamura, Takehira
PMID: 15148809
Journal: Cancer Sci. 2004 Feb;95(2):149-53.
Title: Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1alpha.
Author: Kuwai, Toshio|Kitadai, Yasuhiko|Tanaka, Shinji|Hiyama, Toru|Tanimoto, Keiji|Chayama, Kazuaki
PMID: 14965365
Journal: Mod Pathol. 2005 Feb;18(2):170-8.
Title: Progressive methylation during the serrated neoplasia pathway of the colorectum.
Author: Dong, Seung M|Lee, Eui J|Jeon, Eun S|Park, Cheol K|Kim, Kyoung-Mee
PMID: 15389252
Journal: World J Gastroenterol. 2005 May 7;11(17):2616-25.
Title: Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.
Author: Kivela, Antti-J|Parkkila, Seppo|Saarnio, Juha|Karttunen, Tuomo-J|Kivela, Jyrki|Parkkila, Anna-Kaisa|Bartosova, Maria|Mucha, Vojtech|Novak, Michal|Waheed, Abdul|Sly, William-S|Rajaniemi, Hannu|Pastorekova, Silvia|Pastorek, Jaromir
PMID: 15849821
Journal: Oncogene. 2006 May 18;25(21):3065-70.
Title: Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis.
Author: Giles, R H|Lolkema, M P|Snijckers, C M|Belderbos, M|van der Groep, P|Mans, D A|van Beest, M|van Noort, M|Goldschmeding, R|van Diest, P J|Clevers, H|Voest, E E
PMID: 16407833
Journal: Nat Med. 2006 Jul;12(7):809-16.
Title: E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis.
Author: Jung, Cho-Rok|Hwang, Kyung-Sun|Yoo, Jinsang|Cho, Won-Kyung|Kim, Jin-Man|Kim, Woo Ho|Im, Dong-Soo
PMID: 16819549
Journal: Mol Carcinog. 2006 Nov;45(11):833-40.
Title: Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients.
Author: Fransen, Karin|Fenech, Matthew|Fredrikson, Mats|Dabrosin, Charlotta|Soderkvist, Peter
PMID: 16865676
Journal: Mutat Res. 2008 Jan-Feb;658(1-2):42-54.
Title: Etiologic impact of known cancer susceptibility genes.
Author: Hemminki, Kari|Forsti, Asta|Lorenzo Bermejo, Justo
PMID: 17827054
Journal: Int J Cancer. 2008 Mar 15;122(6):1435-40.
Title: Extracellular matrix and HIF-1 signaling: the role of prolidase.
Author: Surazynski, Arkadiusz|Donald, Steven P|Cooper, Sandra K|Whiteside, Martin A|Salnikow, Konstantin|Liu, Yongmin|Phang, James M
PMID: 17999410
Journal: Z Gastroenterol. 2008 Oct;46(10):1202-6.
Title: [Epigenetic alterations in colorectal carcinomas and precancerous lesions].
Author: Tischoff, I|Tannapfel, A
PMID: 18937191
Journal: APMIS. 2009 Dec;117(12):880-5.
Title: Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
Author: Park, Sang Wook|Chung, Nak Gyun|Hur, Soo Young|Kim, Ho Shik|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 20078552
Journal: Eur J Surg Oncol. 2009 Dec;35(12):1286-94.
Title: Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases.
Author: Rajaganeshan, R|Prasad, R|Guillou, P J|Scott, N|Poston, G|Jayne, D G
PMID: 19540709
Journal: Biochem Biophys Res Commun. 2009 Feb 6;379(2):583-8.
Title: Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.
Author: Jeong, Jee-Yeong|Wang, Yuxun|Sytkowski, Arthur J
PMID: 19118533
Journal: Biochem Biophys Res Commun. 2010 Jul 23;398(2):205-11.
Title: Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1alpha synthesis in HT-29 colon cancer cells.
Author: Shin, Hyun-Woo|Cho, Chung-Hyun|Kim, Tae-You|Park, Jong-Wan
PMID: 20599738
Journal: Biochem Pharmacol. 2010 Oct 1;80(7):982-9.
Title: LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line.
Author: Lee, Kyeong|Kang, Jung Eun|Park, Song-Kyu|Jin, Yinglan|Chung, Kyung-Sook|Kim, Hwan-Mook|Lee, Kiho|Kang, Moo Rim|Lee, Myung Kyu|Song, Kyung Bin|Yang, Eun-Gyeong|Lee, Jung-Jun|Won, Misun
PMID: 20599784
Journal: Cell Death Dis. 2011 Dec 1;2:e235.
Title: Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
Author: Lee, S-H|Jung, Y-S|Chung, J-Y|Oh, A Y|Lee, S-J|Choi, D H|Jang, S M|Jang, K-S|Paik, S S|Ha, N-C|Park, B-J
PMID: 22130069
Journal: Mol Cell. 2012 Jan 27;45(2):233-43.
Title: Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis.
Author: Gamper, Armin M|Qiao, Xinxian|Kim, Jennifer|Zhang, Liyong|DeSimone, Michelle C|Rathmell, W Kimryn|Wan, Yong
PMID: 22284679
Journal: J Biol Chem. 2012 Apr 20;287(17):13584-97.
Title: Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis.
Author: Hu, Dong|Zhou, Zhuan|Davidson, Nancy E|Huang, Yi|Wan, Yong
PMID: 22389506
Journal: Cancer Res. 2012 May 1;72(9):2285-93.
Title: Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis.
Author: Xue, Xiang|Taylor, Matthew|Anderson, Erik|Hao, Cathy|Qu, Aijuan|Greenson, Joel K|Zimmermann, Ellen M|Gonzalez, Frank J|Shah, Yatrik M
PMID: 22419665
Journal: Int J Oncol. 2012 Sep;41(3):793-7.
Title: Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).
Author: Banno, Kouji|Kisu, Iori|Yanokura, Megumi|Tsuji, Kosuke|Masuda, Kenta|Ueki, Arisa|Kobayashi, Yusuke|Yamagami, Wataru|Nomura, Hiroyuki|Tominaga, Eiichiro|Susumu, Nobuyuki|Aoki, Daisuke
PMID: 22735547
Journal: BMC Cancer. 2012 Jul 17;12:293.
Title: Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
Author: Chintala, Sreenivasulu|Najrana, Tanbir|Toth, Karoly|Cao, Shousong|Durrani, Farukh A|Pili, Roberto|Rustum, Youcef M
PMID: 22804960
Journal: J Biomol Screen. 2013 Aug;18(7):782-96.
Title: A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-kappaB pathway.
Author: Pan, Jing|Zhang, Jing|Hill, Andrew|Lapan, Peter|Berasi, Steve|Bates, Brian|Miller, Christopher|Haney, Steven
PMID: 23591012
Journal: Pathology. 2013 Apr;45(3):316-30.
Title: Precursor lesions of endocrine system neoplasms.
Author: Mete, Ozgur|Asa, Sylvia L
PMID: 23478233
Journal: Carcinogenesis. 2013 Jan;34(1):163-9.
Title: Hypoxia-inducible factor-2alpha is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
Author: Xue, Xiang|Shah, Yatrik M
PMID: 23042097
Journal: Int J Cancer. 2014 Jun 1;134(11):2656-62.
Title: Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer.
Author: Melson, Joshua|Li, Yan|Cassinotti, Elisa|Melnikov, Anatoliy|Boni, Luigi|Ai, Junmei|Greenspan, Michael|Mobarhan, Sohrab|Levenson, Victor|Deng, Youping
PMID: 24288256
Journal: Int J Oncol. 2014 Dec;45(6):2455-67.
Title: Monoclonal antibody G250 targeting CA : Binding specificity, internalization and therapeutic effects in a non-renal cancer model.
Author: Zatovicova, Miriam|Jelenska, Lenka|Hulikova, Alzbeta|Ditte, Peter|Ditte, Zuzana|Csaderova, Lucia|Svastova, Eliska|Schmalix, Wolfgang|Boettger, Volker|Bevan, Paul|Pastorek, Jaromir|Pastorekova, Silvia
PMID: 25230982
Journal: Cancer Lett. 2015 Aug 10;364(2):156-64.
Title: The BH3-mimetic obatoclax reduces HIF-1alpha levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil.
Author: Gariboldi, Marzia B|Taiana, Elisa|Bonzi, Maria Chiara|Craparotta, Ilaria|Giovannardi, Stefano|Mancini, Monica|Monti, Elena
PMID: 25979228
Journal: Virchows Arch. 2016 Oct;469(4):395-404.
Title: HIF-1alpha expression and high microvessel density are characteristic features in serrated colorectal cancer.
Author: Tuomisto, Anne|Garcia-Solano, Jose|Sirnio, Paivi|Vayrynen, Juha|Perez-Guillermo, Miguel|Makinen, Markus J|Conesa-Zamora, Pablo
PMID: 27421843
Journal: Med Oncol. 2016 Oct;33(10):106.
Title: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Author: Jauhri, Mayank|Bhatnagar, Akanksha|Gupta, Satish|Shokeen, Yogender|Minhas, Sachin|Aggarwal, Shyam
PMID: 27568332
Journal: Mol Cancer. 2016 Oct 18;15(1):63.
Title: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Author: Kovaleva, Valentina|Geissler, Anna-Lena|Lutz, Lisa|Fritsch, Ralph|Makowiec, Frank|Wiesemann, Sebastian|Hopt, Ulrich T|Passlick, Bernward|Werner, Martin|Lassmann, Silke
PMID: 27756406
Journal: J Gen Virol. 2016 Dec;97(12):3174-3182.
Title: Newcastle disease virus degrades HIF-1alpha through proteasomal pathways independent of VHL and p53.
Author: Abd-Aziz, Noraini|Stanbridge, Eric J|Shafee, Norazizah
PMID: 27902314
Journal: Exp Mol Pathol. 2017 Apr;102(2):255-261.
Title: Detecting circulating tumor DNA in renal cancer: An open challenge.
Author: Corro, Claudia|Hejhal, Tomas|Poyet, Cedric|Sulser, Tullio|Hermanns, Thomas|Winder, Thomas|Prager, Gerald|Wild, Peter J|Frew, Ian|Moch, Holger|Rechsteiner, Markus
PMID: 28214514
Journal: Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1154-H1162.
Title: Increased hypoxia-inducible factor-1alpha in striated muscle of tumor-bearing mice.
Author: Devine, Raymond D|Bicer, Sabahattin|Reiser, Peter J|Wold, Loren E
PMID: 28341633
Journal: Clin Neurol Neurosurg. 2017 Jul;158:46-48.
Title: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer).
Author: Zhu, Viola W|Hinduja, Sanjay|Knezevich, Stevan R|Silveira, William R|DeLozier, Celia D
PMID: 28460341