Primary Site >> Colorectal Cancer

Gene >> VHL

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Ref: Genetic alterations in sporadic renal-cell carcinoma: molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p.
PMID: 7951344
 Ref: A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size.
PMID: 7887444
 Ref: von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens.
PMID: 8617456
Ref: Genetic analysis of synchronous mucinous tumors of the ovary and appendix.
PMID: 8617458
Ref: Analysis of the N-glycosylation of the serum glycoproteins defined by Con A, PHA-E, RCA1 and WGA in Chinese patients with gastrointestinal diseases.
PMID: 9206117
 Ref: [Heredity in renal and prostatic neoplasia].
PMID: 9417296
 Ref: An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue.
PMID: 11896624
 Ref: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
PMID: 12657718
 Ref: Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1alpha.
PMID: 14965365
Ref: [Familial tumor syndrome and ectopic hormone-producing tumors].
PMID: 15148809
Ref: Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13.
PMID: 15343513
Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
PMID: 15526363
Ref: (125)I-Labeled mouse anti-human carbonic anhydrase IX monoclonal antibody
PMID: 22675743
 Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum.
PMID: 15389252
Ref: Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.
PMID: 15849821
 Ref: Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis.
PMID: 16407833
Ref: E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis.
PMID: 16819549
Ref: Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients.
PMID: 16865676
 Ref: Etiologic impact of known cancer susceptibility genes.
PMID: 17827054
Ref: Extracellular matrix and HIF-1 signaling: the role of prolidase.
PMID: 17999410
Ref: [Epigenetic alterations in colorectal carcinomas and precancerous lesions].
PMID: 18937191
 Ref: Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.
PMID: 19118533
Ref: Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases.
PMID: 19540709
Ref: Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
PMID: 20078552
 Ref: Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1alpha synthesis in HT-29 colon cancer cells.
PMID: 20599738
Ref: LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line.
PMID: 20599784
 Ref: Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
PMID: 22130069
 Ref: Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis.
PMID: 22284679
Ref: Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis.
PMID: 22389506
Ref: Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis.
PMID: 22419665
Ref: Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).
PMID: 22735547
Ref: Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
PMID: 22804960
 Ref: Hypoxia-inducible factor-2alpha is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
PMID: 23042097
Ref: Precursor lesions of endocrine system neoplasms.
PMID: 23478233
Ref: A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-kappaB pathway.
PMID: 23591012
 Ref: Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer.
PMID: 24288256
Ref: Monoclonal antibody G250 targeting CA : Binding specificity, internalization and therapeutic effects in a non-renal cancer model.
PMID: 25230982
 Ref: The BH3-mimetic obatoclax reduces HIF-1alpha levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil.
PMID: 25979228
 Ref: HIF-1alpha expression and high microvessel density are characteristic features in serrated colorectal cancer.
PMID: 27421843
Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
PMID: 27568332
Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
PMID: 27756406
Ref: Newcastle disease virus degrades HIF-1alpha through proteasomal pathways independent of VHL and p53.
PMID: 27902314
 Ref: Detecting circulating tumor DNA in renal cancer: An open challenge.
PMID: 28214514
Ref: Increased hypoxia-inducible factor-1alpha in striated muscle of tumor-bearing mice.
PMID: 28341633
Ref: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer).
PMID: 28460341