Primary Site >> Stomach Cancer
Gene >> UMPS
| 1. | |||||||||||
| Journal: | Jpn J Cancer Res. 1996 Feb;87(2):212-20. | ||||||||||
| Title: | Reduced activity of anabolizing enzymes in 5-fluorouracil-resistant human stomach cancer cells. | ||||||||||
| Author: | Inaba, M|Mitsuhashi, J|Sawada, H|Miike, N|Naoe, Y|Daimon, A|Koizumi, K|Tsujimoto, H|Fukushima, M | ||||||||||
| PMID: | 8609072 | ||||||||||
| 2. | |||||||||||
| Journal: | Cancer Lett. 2000 Oct 16;159(1):95-101. | ||||||||||
| Title: | Establishment and characterization of 5-fluorouracil-resistant gastric cancer cells. | ||||||||||
| Author: | Chung, Y M|Park, S|Park, J K|Kim, Y|Kang, Y|Yoo, Y D | ||||||||||
| PMID: | 10974411 | ||||||||||
| 3. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2001 Mar;28(3):345-50. | ||||||||||
| Title: | [Expression and pathophysiologic features of orotate phosphoribosyl transferase activity (OPRT) in gastric carcinoma]. | ||||||||||
| Author: | Ochiai, T|Sugitani, M|Nishimura, K|Noguchi, H|Watanabe, T|Sengoku, H|Kihara, A|Okano, M | ||||||||||
| PMID: | 11265402 | ||||||||||
| 4. | |||||||||||
| Journal: | Cancer Lett. 2004 Oct 8;214(1):19-33. | ||||||||||
| Title: | Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. | ||||||||||
| Author: | Park, Ji-Seon|Young Yoon, Sun|Kim, Jeong-Min|Yeom, Young-Il|Kim, Yong Sung|Kim, Nam-Soon | ||||||||||
| PMID: | 15331170 | ||||||||||
| 5. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2005 Jul;32(7):1017-22. | ||||||||||
| Title: | [Establishment of enzyme-linked immunosorbent assay for quantification of orotate phosphoribosyltransferase in gastric carcinoma]. | ||||||||||
| Author: | Sakurai, Yoichi|Sakamoto, Kazuki|Sugimoto, Yoshikazu|Yoshida, Ikuo|Masui, Toshihiko|Tonomura, Shuhei|Inaba, Kazuki|Shoji, Mitsutaka|Nakamura, Yasuko|Uyama, Ichiro|Komori, Yoshiyuki|Ochiai, Masahiro|Matsuura, Shiro|Tanaka, Hideyuki|Oka, Toshinori|Fukushima | ||||||||||
| PMID: | 16044965 | ||||||||||
| 6. | |||||||||||
| Journal: | Oncol Rep. 2005 Oct;14(4):987-92. | ||||||||||
| Title: | Impact of orotate phosphoribosyl transferase activity as a predictor of lymph node metastasis in gastric cancer. | ||||||||||
| Author: | Ochiai, Takumi|Sugitani, Michiharu|Nishimura, Kazuhiko|Noguchi, Hajime|Okada, Tsuyoshi|Ouchi, Masakazu|Yamada, Masaki|Kitajima, Masayuki|Tsuruoka, Yuko|Takahashi, Yuka|Futagawa, Shunji | ||||||||||
| PMID: | 16142362 | ||||||||||
| 7. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 Aug;33(8):1111-8. | ||||||||||
| Title: | [Clinical and prognostic significance of protein and gene expression of orotate phosphoribosyltransferase in gastric carcinoma]. | ||||||||||
| Author: | Sakurai, Yoichi|Yoshida, Ikuo|Tonomura, Shuhei|Inaba, Kazuki|Shoji, Mitsutaka|Nakamura, Yasuko|Uyama, Ichiro|Komori, Yoshiyuki|Ochiai, Masahiro|Kamoshida, Shingo|Tsutsumi, Yutaka | ||||||||||
| PMID: | 16912530 | ||||||||||
| 8. | |||||||||||
| Journal: | Oncology. 2006;70(6):458-64. | ||||||||||
| Title: | Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines. | ||||||||||
| Author: | Taomoto, Jyunnya|Yoshida, Kazuhiro|Wada, Yoshiyuki|Tanabe, Kazuaki|Konishi, Kazuo|Tahara, Hidetoshi|Fukushima, Masakazu | ||||||||||
| PMID: | 17237621 | ||||||||||
| 9. | |||||||||||
| Journal: | Oncol Rep. 2006 Dec;16(6):1165-72. | ||||||||||
| Title: | The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance. | ||||||||||
| Author: | Oeda, Mamoru|Yoshida, Kazuhiro|Sanada, Yuichi|Wada, Yoshiyuki|Suzuki, Takahisa|Mizuiri, Hirozumi|Konishi, Kazuo|Shigematsu, Hideo|Tanabe, Kazuaki|Fukushima, Masakazu | ||||||||||
| PMID: | 17089033 | ||||||||||
| 10. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:83-6. | ||||||||||
| Title: | [Combination chemotherapy of S-1 and docetaxel on advanced and recurrent gastric cancer]. | ||||||||||
| Author: | Yoshida, Kazuhiro|Wada, Yoshiyuki|Tanabe, Kazuaki|Ukon, Kei|Hihara, Jyun | ||||||||||
| PMID: | 16897978 | ||||||||||
| 11. | |||||||||||
| Journal: | Int J Cancer. 2006 Oct 15;119(8):1927-33. | ||||||||||
| Title: | Simple combinations of 5-FU pathway genes predict the outcome of metastatic gastric cancer patients treated by S-1. | ||||||||||
| Author: | Ichikawa, Wataru|Takahashi, Takehiro|Suto, Kenichi|Shirota, Yoshinori|Nihei, Zenro|Shimizu, Michio|Sasaki, Yasutsuna|Hirayama, Renzo | ||||||||||
| PMID: | 16736497 | ||||||||||
| 12. | |||||||||||
| Journal: | Cancer Sci. 2006 Jun;97(6):492-8. | ||||||||||
| Title: | Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma. | ||||||||||
| Author: | Sakurai, Yoichi|Sakamoto, Kazuki|Sugimoto, Yoshikazu|Yoshida, Ikuo|Masui, Toshihiko|Tonomura, Shuhei|Inaba, Kazuki|Shoji, Mitsutaka|Nakamura, Yasuko|Uyama, Ichiro|Komori, Yoshiyuki|Ochiai, Masahiro|Matsuura, Shiro|Tanaka, Hideyuki|Oka, Toshinori|Fukushima | ||||||||||
| PMID: | 16734727 | ||||||||||
| 13. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 Apr;33(4):487-92. | ||||||||||
| Title: | [Clinicopathological significance of orotate phosphoribosyltransferase in gastric carcinoma]. | ||||||||||
| Author: | Sakurai, Yoichi|Yoshida, Ikuo|Tonomura, Shuhei|Inaba, Kazuki|Shoji, Mitsutaka|Nakamura, Yasuko|Uyama, Ichiro|Komori, Yoshiyuki|Ochiai, Masahiro|Kamoshida, Shingo|Tsutsumi, Yutaka | ||||||||||
| PMID: | 16612158 | ||||||||||
| 14. | |||||||||||
| Journal: | Int J Cancer. 2006 Aug 15;119(4):783-91. | ||||||||||
| Title: | Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines. | ||||||||||
| Author: | Wada, Yoshiyuki|Yoshida, Kazuhiro|Suzuki, Takahisa|Mizuiri, Hirozumi|Konishi, Kazuo|Ukon, Kei|Tanabe, Kazuaki|Sakata, Yu|Fukushima, Masakazu | ||||||||||
| PMID: | 16557585 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer Lett. 2007 Jul 18;252(2):307-13. Epub 2007 Feb 15. | ||||||||||
| Title: | Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil. | ||||||||||
| Author: | Kodera, Yasuhiro|Ito, Seiji|Fujiwara, Michitaka|Mochizuki, Yoshinari|Nakayama, Goro|Ohashi, Norifumi|Koike, Masahiko|Yamamura, Yoshitaka|Nakao, Akimasa | ||||||||||
| PMID: | 17303323 | ||||||||||
| 16. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2007 Oct;34(10):1581-7. | ||||||||||
| Title: | [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]. | ||||||||||
| Author: | Sakurai, Yoichi|Furuta, Shinpei|Sunagawa, Risaburo|Tonomura, Shuhei|Inaba, Kazuki|Shoji, Mitsutaka|Nakamura, Yasuko|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Kamoshida, Shingo|Tsutsumi, Yutaka | ||||||||||
| PMID: | 17940372 | ||||||||||
| 17. | |||||||||||
| Journal: | Gastric Cancer. 2007;10(4):234-40. | ||||||||||
| Title: | Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues. | ||||||||||
| Author: | Sakurai, Yoichi|Kamoshida, Shingo|Furuta, Shinpei|Sunagawa, Risaburo|Inaba, Kazuki|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Tsutsumi, Yutaka | ||||||||||
| PMID: | 18095079 | ||||||||||
| 18. | |||||||||||
| Journal: | Int J Mol Med. 2008 Dec;22(6):709-16. | ||||||||||
| Title: | Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. | ||||||||||
| Author: | Fukui, Yousuke|Oka, Toshinori|Nagayama, Sekio|Danenberg, Peter V|Danenberg, Kathleen D|Fukushima, Masakazu | ||||||||||
| PMID: | 19020767 | ||||||||||
| 19. | |||||||||||
| Journal: | Oncol Rep. 2008 Dec;20(6):1545-51. | ||||||||||
| Title: | Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line. | ||||||||||
| Author: | Tsutani, Yasuhiro|Yoshida, Kazuhiro|Sanada, Yuichi|Wada, Yoshiyuki|Konishi, Kazuo|Fukushima, Masakazu|Okada, Morihito | ||||||||||
| PMID: | 19020740 | ||||||||||
| 20. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2008 Jul;35(7):1147-55. | ||||||||||
| Title: | [Predictive value of orotate phosphoribosyltransferase in chemoresistant patients with gastric carcinoma who underwent S-1-based neoadjuvant/adjuvant chemotherapy]. | ||||||||||
| Author: | Sakurai, Yoichi|Kamoshida, Shingo|Furuta, Shinpei|Sunagawa, Risaburo|Inaba, Kazuki|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Tsutsumi, Yutaka | ||||||||||
| PMID: | 18633253 | ||||||||||
| 21. | |||||||||||
| Journal: | Ann Surg Oncol. 2008 Aug;15(8):2301-9. | ||||||||||
| Title: | Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts. | ||||||||||
| Author: | Sakurai, Yoichi|Yoshida, Ikuo|Kamoshida, Shingo|Inaba, Kazuki|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Tsutsumi, Yutaka | ||||||||||
| PMID: | 18506536 | ||||||||||
| 22. | |||||||||||
| Journal: | Int J Clin Oncol. 2008 Jun;13(3):212-9. | ||||||||||
| Title: | Challenge for a better combination with basic evidence. | ||||||||||
| Author: | Yoshida, Kazuhiro|Yamaguchi, Kazuya|Osada, Shinji|Kawaguchi, Yoshihiro|Takahashi, Takao|Sakashita, Fumio|Tanaka, Yoshihiro | ||||||||||
| PMID: | 18553230 | ||||||||||
| 23. | |||||||||||
| Journal: | Toxicology. 2009 Feb 4;256(1-2):135-40. | ||||||||||
| Title: | Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. | ||||||||||
| Author: | Wang, Jun|Liu, Wei|Zhao, Qing|Qi, Qi|Lu, Na|Yang, Yong|Nei, Fei-Fei|Rong, Jing-Jing|You, Qi-Dong|Guo, Qing-Long | ||||||||||
| PMID: | 19084572 | ||||||||||
| 24. | |||||||||||
| Journal: | J Clin Oncol. 2009 Jun 10;27(17):2863-73. | ||||||||||
| Title: | Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie. | ||||||||||
| Author: | Goekkurt, Eray|Al-Batran, Salah-Eddin|Hartmann, Jorg T|Mogck, Ulrike|Schuch, Gunter|Kramer, Michael|Jaeger, Elke|Bokemeyer, Carsten|Ehninger, Gerhard|Stoehlmacher, Jan | ||||||||||
| PMID: | 19332728 | ||||||||||
| 25. | |||||||||||
| Journal: | Int J Cancer. 2010 Jan 1;126(1):162-70. | ||||||||||
| Title: | Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer. | ||||||||||
| Author: | Koizumi, Wasaburo|Tanabe, Satoshi|Azuma, Mizutomo|Ishido, Kenji|Nishimura, Ken|Sasaki, Tohru|Nakatani, Kento|Higuchi, Katsuhiko|Nakayama, Norisuke|Katada, Chikatoshi | ||||||||||
| PMID: | 19588501 | ||||||||||
| 26. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2010 Mar;37(3):447-51. | ||||||||||
| Title: | [Therapeutic outcome and prognosis in S-1+CDDP chemotherapy for advanced gastric cancer--postoperative histopathological assessment]. | ||||||||||
| Author: | Tanemura, Hiromi|Oshita, Hiroo|Yamada, Makoto|Hatoh, Tsuneaki|Adachi, Takahito|Matsui, Koji|Tomita, Eiichi|Sugiyama, Akihiko|Yamada, Tetsuya | ||||||||||
| PMID: | 20332681 | ||||||||||
| 27. | |||||||||||
| Journal: | Int J Oncol. 2010 Aug;37(2):257-64. | ||||||||||
| Title: | A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer. | ||||||||||
| Author: | Hashiguchi, Kazuyoshi|Kitajima, Yoshihiko|Kai, Keita|Hiraki, Masatsugu|Nakamura, Jun|Tokunaga, Osamu|Noshiro, Hirokazu|Miyazaki, Kohji | ||||||||||
| PMID: | 20596652 | ||||||||||
| 28. | |||||||||||
| Journal: | World J Gastroenterol. 2010 Sep 28;16(36):4575-82. | ||||||||||
| Title: | A predictive factor for the response to S-1 plus cisplatin in gastric cancer. | ||||||||||
| Author: | Miyazaki, Ikuko|Kawai, Takashi|Harada, Youji|Moriyasu, Fuminori | ||||||||||
| PMID: | 20857529 | ||||||||||
| 29. | |||||||||||
| Journal: | Cancer Invest. 2011 Feb;29(2):130-6. | ||||||||||
| Title: | Relationship between gene expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in primary cancer cells isolated from malignant ascites. | ||||||||||
| Author: | Wang, Tingting|Wang, Lifeng|Qian, Xiaoping|Yu, Lixia|Ding, Yitao|Liu, Baorui | ||||||||||
| PMID: | 21210725 | ||||||||||
| 30. | |||||||||||
| Journal: | Exp Ther Med. 2011 Sep;2(5):985-990. | ||||||||||
| Title: | S-1 and the treatment of gastric cancer with peritoneal dissemination. | ||||||||||
| Author: | Izuishi, Kunihiko|Haba, Reiji|Kushida, Yoshio|Kadota, Kyuichi|Takebayashi, Ryusuke|Sano, Takanori|Usuki, Hisashi|Hossain, Mohammad Akram|Mori, Hirohito|Masaki, Tsutomu|Suzuki, Yasuyuki | ||||||||||
| PMID: | 22977609 | ||||||||||
| 31. | |||||||||||
| Journal: | Anticancer Drugs. 2011 Sep;22(8):801-10. | ||||||||||
| Title: | Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer. | ||||||||||
| Author: | Jeung, Hei-Cheul|Rha, Sun Young|Shin, Sang Joon|Lim, Seung Joon|Roh, Jae Kyung|Noh, Sung Hoon|Chung, Hyun Cheol | ||||||||||
| PMID: | 21572321 | ||||||||||
| 32. | |||||||||||
| Journal: | Med Oncol. 2011 Dec;28(4):991-8. | ||||||||||
| Title: | Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes. | ||||||||||
| Author: | Choi, In Sil|Lee, Hye Seung|Lee, Keun-Wook|Kim, Haeryoung|Kim, Ki Hwan|Kim, Yu Jung|Kim, Jee Hyun|Kim, Woo Ho|Lee, Jong Seok | ||||||||||
| PMID: | 20533001 | ||||||||||
| 33. | |||||||||||
| Journal: | Zhonghua Yi Xue Za Zhi. 2014 Jan 14;94(2):127-30. | ||||||||||
| Title: | [Correlated analysis of 5 fluorouracil metabolic enzymes with tumor response after SOX regimen neoadjuvant chemotherapy in advanced gastric cancer]. | ||||||||||
| Author: | Li, Tao|Liang, Meixia|Yuan, Jing|Guo, Xu|Feng, Daofu|Li, Ting|Teng, Da|Peng, Zheng|Wu, Xin|Li, Zexue|Wang, Hua|Chen, Lin | ||||||||||
| PMID: | 24721353 | ||||||||||
| 34. | |||||||||||
| Journal: | Gastric Cancer. 2015 Jul;18(3):538-48. | ||||||||||
| Title: | Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer. | ||||||||||
| Author: | Sasako, Mitsuru|Terashima, Masanori|Ichikawa, Wataru|Ochiai, Atsushi|Kitada, Koji|Kurahashi, Issei|Sakuramoto, Shinichi|Katai, Hitoshi|Sano, Takeshi|Imamura, Hiroshi | ||||||||||
| PMID: | 25112781 | ||||||||||
| 35. | |||||||||||
| Journal: | PLoS One. 2015 Mar 20;10(3):e0120324. | ||||||||||
| Title: | Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer. | ||||||||||
| Author: | Kim, Ji-Yeon|Shin, Eun|Kim, Jin Won|Lee, Hye Seung|Lee, Dae-Won|Kim, Se-Hyun|Lee, Jeong-Ok|Kim, Yu Jung|Kim, Jee Hyun|Bang, Soo-Mee|Ahn, Sang-Hoon|Park, Do Joong|Lee, Jong Seok|Lee, Ju-Seog|Kim, Hyung-Ho|Lee, Keun-Wook | ||||||||||
| PMID: | 25793299 | ||||||||||
| 36. | |||||||||||
| Journal: | Int J Biol Markers. 2016 May 28;31(2):e101-9. | ||||||||||
| Title: | High/positive expression of 5-fluorouracil metabolic enzymes predicts better response to S-1 in patients with gastric cancer: a meta-analysis. | ||||||||||
| Author: | Wang, Dan|Yu, Xuejun|Wang, Xiuwen | ||||||||||
| PMID: | 27012156 | ||||||||||
| 37. | |||||||||||
| Journal: | Oncotarget. 2016 Aug 23;7(34):55449-55457. | ||||||||||
| Title: | ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients. | ||||||||||
| Author: | Li, Ziyu|Xing, Xiaofang|Shan, Fei|Li, Shuangxi|Li, Zhongwu|Xiao, Aitang|Xing, Zhaodong|Xue, Kan|Li, Zhemin|Hu, Ying|Jia, Yongning|Miao, Rulin|Zhang, Lianhai|Bu, Zhaode|Wu, Aiwen|Ji, Jiafu | ||||||||||
| PMID: | 27487151 | ||||||||||
| 38. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2017 Jan;79(1):69-79. | ||||||||||
| Title: | Phase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathway. | ||||||||||
| Author: | He, Ming-Ming|Zhang, Dong-Sheng|Wang, Feng|Wang, Zi-Xian|Yuan, Shu-Qiang|Wang, Zhi-Qiang|Luo, Hui-Yan|Ren, Chao|Qiu, Miao-Zhen|Jin, Ying|Wang, De-Shen|Chen, Dong-Liang|Zeng, Zhao-Lei|Li, Yu-Hong|He, Yang-Yang|Hao, Yuan-Tao|Guo, Pi|Wang, Feng-Hua|Zeng, Yi- | ||||||||||
| PMID: | 27913881 | ||||||||||
| 39. | |||||||||||
| Journal: | Gastric Cancer. 2018 Oct 1. pii: 10.1007/s10120-018-0881-3. | ||||||||||
| Title: | The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells. | ||||||||||
| Author: | Mori, Ryutaro|Yoshida, Kazuhiro|Futamura, Manabu|Suetsugu, Tomonari|Shizu, Kaoru|Tanahashi, Toshiyuki|Tanaka, Yoshihiro|Matsuhashi, Nobuhisha|Yamaguchi, Kazuya | ||||||||||
| PMID: | 30276573 | ||||||||||