Primary Site >> Stomach Cancer
Gene >> UMPS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Reduced activity of anabolizing enzymes in 5-fluorouracil-resistant human stomach cancer cells. PMID: 8609072 |
Ref: Establishment and characterization of 5-fluorouracil-resistant gastric cancer cells. PMID: 10974411 |
Ref: [Expression and pathophysiologic features of orotate phosphoribosyl transferase activity (OPRT) in gastric carcinoma]. PMID: 11265402 |
Ref: Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. PMID: 15331170 |
Ref: [Establishment of enzyme-linked immunosorbent assay for quantification of orotate phosphoribosyltransferase in gastric carcinoma]. PMID: 16044965 Ref: Impact of orotate phosphoribosyl transferase activity as a predictor of lymph node metastasis in gastric cancer. PMID: 16142362 |
Ref: Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines. PMID: 16557585 Ref: [Clinicopathological significance of orotate phosphoribosyltransferase in gastric carcinoma]. PMID: 16612158 Ref: Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma. PMID: 16734727 Ref: Simple combinations of 5-FU pathway genes predict the outcome of metastatic gastric cancer patients treated by S-1. PMID: 16736497 Ref: [Combination chemotherapy of S-1 and docetaxel on advanced and recurrent gastric cancer]. PMID: 16897978 Ref: [Clinical and prognostic significance of protein and gene expression of orotate phosphoribosyltransferase in gastric carcinoma]. PMID: 16912530 Ref: The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance. PMID: 17089033 Ref: Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines. PMID: 17237621 |
Ref: Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil. PMID: 17303323 Ref: [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]. PMID: 17940372 Ref: Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues. PMID: 18095079 |
Ref: Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts. PMID: 18506536 Ref: Challenge for a better combination with basic evidence. PMID: 18553230 Ref: [Predictive value of orotate phosphoribosyltransferase in chemoresistant patients with gastric carcinoma who underwent S-1-based neoadjuvant/adjuvant chemotherapy]. PMID: 18633253 Ref: Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line. PMID: 19020740 Ref: Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. PMID: 19020767 |
Ref: Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. PMID: 19084572 Ref: Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie. PMID: 19332728 |
Ref: Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer. PMID: 19588501 Ref: [Therapeutic outcome and prognosis in S-1+CDDP chemotherapy for advanced gastric cancer--postoperative histopathological assessment]. PMID: 20332681 Ref: A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer. PMID: 20596652 Ref: A predictive factor for the response to S-1 plus cisplatin in gastric cancer. PMID: 20857529 |
Ref: Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes. PMID: 20533001 Ref: Relationship between gene expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in primary cancer cells isolated from malignant ascites. PMID: 21210725 Ref: Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer. PMID: 21572321 Ref: S-1 and the treatment of gastric cancer with peritoneal dissemination. PMID: 22977609 |
Ref: [Correlated analysis of 5 fluorouracil metabolic enzymes with tumor response after SOX regimen neoadjuvant chemotherapy in advanced gastric cancer]. PMID: 24721353 |
Ref: Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer. PMID: 25112781 Ref: Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer. PMID: 25793299 |
Ref: High/positive expression of 5-fluorouracil metabolic enzymes predicts better response to S-1 in patients with gastric cancer: a meta-analysis. PMID: 27012156 Ref: ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients. PMID: 27487151 |
Ref: Phase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathway. PMID: 27913881 |
Ref: The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells. PMID: 30276573 |