Primary Site >> Colorectal Cancer

Gene >> ULK1

Journal: Gastroenterology. 2012 Jun;142(7):1504-15.e3.
Title: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.
Author: Din, Farhat V N|Valanciute, Asta|Houde, Vanessa P|Zibrova, Daria|Green, Kevin A|Sakamoto, Kei|Alessi, Dario R|Dunlop, Malcolm G
PMID: 22406476
Journal: Mol Cell Biochem. 2013 Jun;378(1-2):171-81.
Title: AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells.
Author: Huo, Hai-zhong|Wang, Bing|Qin, Jian|Guo, Shan-yu|Liu, Wen-yong|Gu, Yan
PMID: 23508272
Journal: Cancer Chemother Pharmacol. 2014 Jul;74(1):167-76.
Title: Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
Author: Min, Han|Xu, Min|Chen, Zhi-Rong|Zhou, Jun-Dong|Huang, Min|Zheng, Kai|Zou, Xiao-Ping
PMID: 24842158
Journal: Autophagy. 2014 Sep;10(9):1495-508.
Title: Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.
Author: Xie, Chuan-Ming|Liu, Xiao-Yu|Sham, Kathy W Y|Lai, Josie M Y|Cheng, Christopher H K
PMID: 24955726
Journal: Exp Mol Med. 2014 Dec 5;46:e124.
Title: Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells.
Author: Hwang, Won Chan|Kim, Mi Kyoung|Song, Ju Hyun|Choi, Kang-Yell|Min, Do Sik
PMID: 25475140
Journal: Oncol Lett. 2015 Sep;10(3):1583-1588.
Title: High expression levels of unc-51-like kinase 1 as a predictor of poor prognosis in colorectal cancer.
Author: Zou, Yifeng|Chen, Zexian|He, Xiaowen|He, Xiaosheng|Wu, Xianrui|Chen, Yufeng|Wu, Xiaojian|Wang, Jianping|Lan, Ping
PMID: 26622714
Journal: Sci Rep. 2016 Jan 11;6:18949.
Title: BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
Author: Sueda, Toshinori|Sakai, Daisuke|Kawamoto, Koichi|Konno, Masamitsu|Nishida, Naohiro|Koseki, Jun|Colvin, Hugh|Takahashi, Hidekazu|Haraguchi, Naotsugu|Nishimura, Junichi|Hata, Taishi|Takemasa, Ichiro|Mizushima, Tsunekazu|Yamamoto, Hirofumi|Satoh, Taroh|Doki,
PMID: 26750638
Journal: World J Surg Oncol. 2016 Jul 22;14(1):189.
Title: Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status.
Author: Schmitz, Klaus Juergen|Ademi, Ceflije|Bertram, Stefanie|Schmid, Kurt Werner|Baba, Hideo Andreas
PMID: 27444698
Journal: Cell Death Dis. 2017 May 11;8(5):e2789.
Title: Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer.
Author: Chen, Guo-Qing|Gong, Rui-Hong|Yang, Da-Jian|Zhang, Ge|Lu, Ai-Ping|Yan, Siu-Cheong|Lin, Shu-Hai|Bian, Zhao-Xiang
PMID: 28492544
Journal: J Exp Clin Cancer Res. 2017 Dec 22;36(1):190.
Title: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice.
Author: Zhang, Pan|Lai, Ze-Lin|Chen, Hui-Fen|Zhang, Min|Wang, An|Jia, Tao|Sun, Wen-Qin|Zhu, Xi-Min|Chen, Xiao-Feng|Zhao, Zheng|Zhang, Jun
PMID: 29273065
Journal: Sci Rep. 2017 Oct 24;7(1):13912.
Title: Phosphoinositide-specific phospholipase Cgamma1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Author: Dai, Lianzhi|Chen, Xiaolei|Lu, Xiaohong|Wang, Fen|Zhan, Yanyan|Song, Gang|Hu, Tianhui|Xia, Chun|Zhang, Bing
PMID: 29066806
Journal: Oncol Rep. 2017 Oct;38(4):2369-2377.
Title: MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma.
Author: Wu, Jian|Zhang, Dawei|Li, Jun|Deng, Xin|Liang, Guannan|Long, Yang|He, Xuemei|Dai, Tianyang|Ren, Delian
PMID: 28791376
Journal: Med Oncol. 2017 Feb;34(2):16.
Title: The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer.
Author: Gil, Justyna|Ramsey, David|Szmida, Elzbieta|Leszczynski, Przemyslaw|Pawlowski, Pawel|Bebenek, Marek|Sasiadek, Maria M
PMID: 28035578
Journal: Pathol Oncol Res. 2018 Oct;24(4):827-832.
Title: Intratumoral Heterogeneity of Somatic Mutations for NRIP1, DOK1, ULK1, ULK2, DLGAP3, PARD3 and PRKCI in Colon Cancers.
Author: Choi, Eun Ji|Lee, Ju Hwa|Kim, Min Sung|Song, Sang Yong|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 28844109
Journal: Acta Pharmacol Sin. 2018 Jun 19. pii: 10.1038/s41401-018-0047-1.
Title: Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy.
Author: Li, Bin|Wu, Guo-Liang|Dai, Wei|Wang, Gang|Su, Hao-Yuan|Shen, Xue-Ping|Zhan, Rui|Xie, Jia-Ming|Wang, Zhong|Qin, Zheng-Hong|Gao, Quan-Gen|Shen, Gen-Hai
PMID: 29921885
Journal: Oncol Lett. 2018 Jun;15(6):9719-9724.
Title: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells.
Author: Xu, Chunyan|Zhang, Wenlu|Liu, Shiquan|Wu, Wenhong|Qin, Mengbin|Huang, Jiean
PMID: 29928348
Journal: J Biol Chem. 2018 Sep 21;293(38):14891-14904.
Title: Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation.
Author: Boyle, Kathleen A|Van Wickle, Jonathan|Hill, R Blake|Marchese, Adriano|Kalyanaraman, Balaraman|Dwinell, Michael B
PMID: 30087121
Journal: Nutrients. 2018 Oct 12;10(10). pii: nu10101490.
Title: Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells.
Author: Emanuele, Sonia|Notaro, Antonietta|Palumbo Piccionello, Antonio|Maggio, Antonella|Lauricella, Marianna|D'Anneo, Antonella|Cernigliaro, Cesare|Calvaruso, Giuseppe|Giuliano, Michela
PMID: 30322062