Primary Site >> Colorectal Cancer
Gene >> UGT1A
| 1. | |||||||||||
| Journal: | Adv Enzyme Regul. 1998;38:207-22. | ||||||||||
| Title: | AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. | ||||||||||
| Author: | Bock, K W|Gschaidmeier, H|Heel, H|Lehmkoster, T|Munzel, P A|Raschko, F|Bock-Hennig, B | ||||||||||
| PMID: | 9762354 | ||||||||||
| 2. | |||||||||||
| Journal: | Drug Metab Dispos. 1999 May;27(5):569-73. | ||||||||||
| Title: | Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. | ||||||||||
| Author: | Munzel, P A|Schmohl, S|Heel, H|Kalberer, K|Bock-Hennig, B S|Bock, K W | ||||||||||
| PMID: | 10220484 | ||||||||||
| 3. | |||||||||||
| Journal: | Carcinogenesis. 1999 Jun;20(6):1107-14. | ||||||||||
| Title: | Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. | ||||||||||
| Author: | Nowell, S A|Massengill, J S|Williams, S|Radominska-Pandya, A|Tephly, T R|Cheng, Z|Strassburg, C P|Tukey, R H|MacLeod, S L|Lang, N P|Kadlubar, F F | ||||||||||
| PMID: | 10357796 | ||||||||||
| 4. | |||||||||||
| Journal: | Cancer Res. 1999 Dec 1;59(23):5938-46. | ||||||||||
| Title: | Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. | ||||||||||
| Author: | Brangi, M|Litman, T|Ciotti, M|Nishiyama, K|Kohlhagen, G|Takimoto, C|Robey, R|Pommier, Y|Fojo, T|Bates, S E | ||||||||||
| PMID: | 10606239 | ||||||||||
| 5. | |||||||||||
| Journal: | Ther Drug Monit. 2000 Feb;22(1):10-3. | ||||||||||
| Title: | Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid. | ||||||||||
| Author: | Mackenzie, P I | ||||||||||
| PMID: | 10688250 | ||||||||||
| 6. | |||||||||||
| Journal: | Life Sci. 2000;67(2):185-96. | ||||||||||
| Title: | Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7. | ||||||||||
| Author: | Sabolovic, N|Magdalou, J|Netter, P|Abid, A | ||||||||||
| PMID: | 10901286 | ||||||||||
| 7. | |||||||||||
| Journal: | Drug Metab Dispos. 2003 Apr;31(4):452-61. | ||||||||||
| Title: | Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. | ||||||||||
| Author: | Lu, Hong|Meng, Xiaofeng|Li, Chuan|Sang, Shengmin|Patten, Christopher|Sheng, Shuqun|Hong, Jungil|Bai, Naisheng|Winnik, Bozena|Ho, Chi-Tang|Yang, Chung S | ||||||||||
| PMID: | 12642472 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Res. 2003 Dec 1;63(23):8443-50. | ||||||||||
| Title: | Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. | ||||||||||
| Author: | Cummings, Jeffrey|Ethell, Brian T|Jardine, Lesley|Boyd, Gary|Macpherson, Janet S|Burchell, Brian|Smyth, John F|Jodrell, Duncan I | ||||||||||
| PMID: | 14679008 | ||||||||||
| 9. | |||||||||||
| Journal: | Clin Cancer Res. 2004 Aug 1;10(15):5151-9. | ||||||||||
| Title: | Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. | ||||||||||
| Author: | Rouits, Elisabeth|Boisdron-Celle, Michele|Dumont, Agnes|Guerin, Olivier|Morel, Alain|Gamelin, Erick | ||||||||||
| PMID: | 15297419 | ||||||||||
| 10. | |||||||||||
| Journal: | Oncol Rep. 2005 Feb;13(2):185-91. | ||||||||||
| Title: | UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. | ||||||||||
| Author: | Giuliani, Laura|Ciotti, Marco|Stoppacciaro, Antonella|Pasquini, Anna|Silvestri, Ida|De Matteis, Anna|Frati, Luigi|Agliano, Anna-Maria | ||||||||||
| PMID: | 15643497 | ||||||||||
| 11. | |||||||||||
| Journal: | World J Gastroenterol. 2005 Feb 14;11(6):797-802. | ||||||||||
| Title: | Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. | ||||||||||
| Author: | Huang, May-Jen|Yang, Sien-Sing|Lin, Min-Shung|Huang, Ching-Shan | ||||||||||
| PMID: | 15682470 | ||||||||||
| 12. | |||||||||||
| Journal: | Biol Pharm Bull. 2005 Feb;28(2):271-4. | ||||||||||
| Title: | The effects of coffee on conjugation reactions in human colon carcinoma cells. | ||||||||||
| Author: | Okamura, Shigeaki|Suzuki, Keiko|Yanase, Masayo|Koizumi, Masumi|Tamura, Hiro-omi | ||||||||||
| PMID: | 15684482 | ||||||||||
| 13. | |||||||||||
| Journal: | World J Gastroenterol. 2005 Jun 7;11(21):3250-4. | ||||||||||
| Title: | Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. | ||||||||||
| Author: | Tang, Kung-Sheng|Chiu, Hui-Fen|Chen, Hong-Hwa|Eng, Hock-Liew|Tsai, Chia-Jung|Teng, Hsiu-Chen|Huang, Ching-Shan | ||||||||||
| PMID: | 15929176 | ||||||||||
| 14. | |||||||||||
| Journal: | Zhonghua Yi Xue Za Zhi. 2005 Mar 30;85(12):819-24. | ||||||||||
| Title: | [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells]. | ||||||||||
| Author: | Wang, Min|Li, Yan-Qing|Zhong, Ning|Chen, Jian|Xu, Xiao-Qun|Yuan, Meng-Biao | ||||||||||
| PMID: | 15949398 | ||||||||||
| 15. | |||||||||||
| Journal: | Methods Enzymol. 2005;400:618-27. | ||||||||||
| Title: | Cancer and molecular biomarkers of phase 2. | ||||||||||
| Author: | Dalhoff, Kim|Buus Jensen, Kaspar|Enghusen Poulsen, Henrik | ||||||||||
| PMID: | 16399374 | ||||||||||
| 16. | |||||||||||
| Journal: | Drug Metab Rev. 2006;38(3):393-409. | ||||||||||
| Title: | Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan. | ||||||||||
| Author: | Nagar, Swati|Blanchard, Rebecca L | ||||||||||
| PMID: | 16877259 | ||||||||||
| 17. | |||||||||||
| Journal: | Biol Pharm Bull. 2006 Jul;29(7):1476-9. | ||||||||||
| Title: | Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. | ||||||||||
| Author: | Naganuma, Megumi|Saruwatari, Ayako|Okamura, Shigeaki|Tamura, Hiroomi | ||||||||||
| PMID: | 16819192 | ||||||||||
| 18. | |||||||||||
| Journal: | Zhonghua Yi Xue Za Zhi. 2006 Jan 10;86(2):82-7. | ||||||||||
| Title: | [The role of NF-E2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1A and its isoforms by epigallocatechin gallate in colon cancer cells]. | ||||||||||
| Author: | Yang, Xiao-yun|Zhao, Wei-ping|Li, Yan-qing|Sun, Zi-yuan|Zhang, Yan|Guo, Yu-ting|Yuan, Jun-hua|Zhu, Qiang|Wang, Min | ||||||||||
| PMID: | 16620709 | ||||||||||
| 19. | |||||||||||
| Journal: | Carcinogenesis. 2007 Nov;28(11):2412-8. Epub 2007 Jul 17. | ||||||||||
| Title: | Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10. | ||||||||||
| Author: | Dellinger, Ryan W|Chen, Gang|Blevins-Primeau, Andrea S|Krzeminski, Jacek|Amin, Shantu|Lazarus, Philip | ||||||||||
| PMID: | 17638922 | ||||||||||
| 20. | |||||||||||
| Journal: | Pharmacology. 2007;80(4):269-78. Epub 2007 Jul 26. | ||||||||||
| Title: | Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice. | ||||||||||
| Author: | Yuan, Jun-Hua|Li, Yan-Qing|Yang, Xiao-Yun | ||||||||||
| PMID: | 17657175 | ||||||||||
| 21. | |||||||||||
| Journal: | Zhonghua Zhong Liu Za Zhi. 2007 Dec;29(12):913-6. | ||||||||||
| Title: | [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. | ||||||||||
| Author: | Wang, Yan|Xu, Jian-Ming|Shen, Lin|Xu, Nong|Wang, Jin-Wan|Jiao, Shun-Chang|Zhang, Jing-Sheng|Song, San-Tai|Li, Jian|Bao, Han-Ying|Yang, Lin|Li, Fang | ||||||||||
| PMID: | 18478930 | ||||||||||
| 22. | |||||||||||
| Journal: | Arch Toxicol. 2008 Jul;82(7):415-33. | ||||||||||
| Title: | Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability. | ||||||||||
| Author: | Strassburg, Christian P|Lankisch, Tim O|Manns, Michael P|Ehmer, Ursula | ||||||||||
| PMID: | 18491077 | ||||||||||
| 23. | |||||||||||
| Journal: | Drug Metab Dispos. 2008 Nov;36(11):2331-6. | ||||||||||
| Title: | The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells. | ||||||||||
| Author: | Siissalo, Sanna|Zhang, Hongbo|Stilgenbauer, Eric|Kaukonen, Ann Marie|Hirvonen, Jouni|Finel, Moshe | ||||||||||
| PMID: | 18694909 | ||||||||||
| 24. | |||||||||||
| Journal: | J Clin Oncol. 2009 May 20;27(15):2457-65. | ||||||||||
| Title: | Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. | ||||||||||
| Author: | Cecchin, Erika|Innocenti, Federico|D'Andrea, Mario|Corona, Giuseppe|De Mattia, Elena|Biason, Paola|Buonadonna, Angela|Toffoli, Giuseppe | ||||||||||
| PMID: | 19364970 | ||||||||||
| 25. | |||||||||||
| Journal: | J Mol Diagn. 2009 Sep;11(5):381-9. | ||||||||||
| Title: | Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology. | ||||||||||
| Author: | Snozek, Christine L H|O'Kane, Dennis J|Algeciras-Schimnich, Alicia | ||||||||||
| PMID: | 19644023 | ||||||||||
| 26. | |||||||||||
| Journal: | Chin Med J (Engl). 2009 Jul 20;122(14):1660-5. | ||||||||||
| Title: | Modulation of NRF2 and UGT1A expression by epigallocatechin-3-gallate in colon cancer cells and BALB/c mice. | ||||||||||
| Author: | Zhang, Zhi-mian|Yang, Xiao-yun|Yuan, Jun-hua|Sun, Zi-yuan|Li, Yan-qing | ||||||||||
| PMID: | 19719968 | ||||||||||
| 27. | |||||||||||
| Journal: | Genome Med. 2009 Sep 4;1(9):83. | ||||||||||
| Title: | Networking of differentially expressed genes in human cancer cells resistant to methotrexate. | ||||||||||
| Author: | Selga, Elisabet|Oleaga, Carlota|Ramirez, Sara|de Almagro, M Cristina|Noe, Veronique|Ciudad, Carlos J | ||||||||||
| PMID: | 19732436 | ||||||||||
| 28. | |||||||||||
| Journal: | Drug Metab Rev. 2010 Feb;42(1):6-13. | ||||||||||
| Title: | UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. | ||||||||||
| Author: | Bock, Karl W|Bock-Hennig, Barbara S | ||||||||||
| PMID: | 19831498 | ||||||||||
| 29. | |||||||||||
| Journal: | Pharmacogenomics J. 2010 Oct;10(5):431-41. | ||||||||||
| Title: | Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines. | ||||||||||
| Author: | Bellemare, J|Rouleau, M|Harvey, M|Tetu, B|Guillemette, C | ||||||||||
| PMID: | 19997083 | ||||||||||
| 30. | |||||||||||
| Journal: | Mol Cancer. 2010 Mar 2;9:46. | ||||||||||
| Title: | Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. | ||||||||||
| Author: | Raynal, Caroline|Pascussi, Jean-Marc|Leguelinel, Geraldine|Breuker, Cyril|Kantar, Jovana|Lallemant, Benjamin|Poujol, Sylvain|Bonnans, Caroline|Joubert, Dominique|Hollande, Frederic|Lumbroso, Serge|Brouillet, Jean-Paul|Evrard, Alexandre | ||||||||||
| PMID: | 20196838 | ||||||||||
| 31. | |||||||||||
| Journal: | Br J Cancer. 2010 Aug 10;103(4):581-9. | ||||||||||
| Title: | UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. | ||||||||||
| Author: | Martinez-Balibrea, E|Abad, A|Martinez-Cardus, A|Gines, A|Valladares, M|Navarro, M|Aranda, E|Marcuello, E|Benavides, M|Massuti, B|Carrato, A|Layos, L|Manzano, J L|Moreno, V | ||||||||||
| PMID: | 20628391 | ||||||||||
| 32. | |||||||||||
| Journal: | Mol Med Rep. 2011 Mar-Apr;4(2):203-8. | ||||||||||
| Title: | Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review). | ||||||||||
| Author: | Aiello, Marco|Vella, Nadia|Cannavo, Calogero|Scalisi, Aurora|Spandidos, Demetrios A|Toffoli, Giuseppe|Buonadonna, Angela|Libra, Massimo|Stivala, Franca | ||||||||||
| PMID: | 21468552 | ||||||||||
| 33. | |||||||||||
| Journal: | Cancer Biol Ther. 2011 Nov 1;12(9):780-7. | ||||||||||
| Title: | Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study. | ||||||||||
| Author: | Di Martino, Maria Teresa|Arbitrio, Mariamena|Leone, Emanuela|Guzzi, Pietro Hiram|Rotundo, Maria Saveria|Ciliberto, Domenico|Tomaino, Vera|Fabiani, Fernanda|Talarico, Danilo|Sperlongano, Pasquale|Doldo, Patrizia|Cannataro, Mario|Caraglia, Michele|Tassone, | ||||||||||
| PMID: | 21892003 | ||||||||||
| 34. | |||||||||||
| Journal: | Tumori. 2011 Mar-Apr;97(2):243-7. | ||||||||||
| Title: | Concurrence of UGT1A polymorphism and end-stage renal disease leads to severe toxicities of irinotecan in a patient with metastatic colon cancer. | ||||||||||
| Author: | Huang, Sung-Hao|Chao, Yee|Wu, Ying-Ying|Luo, Jiing-Chyuan|Kao, Chien-Hui|Yen, Sang-Hue|Li, Chung-Pin | ||||||||||
| PMID: | 21617725 | ||||||||||
| 35. | |||||||||||
| Journal: | J Pathol. 2011 Feb;223(3):425-35. | ||||||||||
| Title: | Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans. | ||||||||||
| Author: | Bellemare, Judith|Rouleau, Melanie|Harvey, Mario|Popa, Ion|Pelletier, Georges|Tetu, Bernard|Guillemette, Chantal | ||||||||||
| PMID: | 21171088 | ||||||||||
| 36. | |||||||||||
| Journal: | AAPS J. 2011 Mar;13(1):1-13. | ||||||||||
| Title: | Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. | ||||||||||
| Author: | Wu, Tien-Yuan|Khor, Tin Oo|Saw, Constance Lay Lay|Loh, Stephanie C|Chen, Alvin I|Lim, Soon Sung|Park, Jung Han Yoon|Cai, Li|Kong, Ah-Ng Tony | ||||||||||
| PMID: | 20967519 | ||||||||||
| 37. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2011 Aug;68(2):279-84. | ||||||||||
| Title: | UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer. | ||||||||||
| Author: | Sunakawa, Yu|Ichikawa, Wataru|Fujita, Ken-Ichi|Nagashima, Fumio|Ishida, Hiroo|Yamashita, Keishi|Mizuno, Keiko|Miwa, Keisuke|Kawara, Kaori|Akiyama, Yuko|Araki, Kazuhiro|Yamamoto, Wataru|Miya, Toshimichi|Narabayashi, Masaru|Ando, Yuichi|Hirose, Takashi|Saji | ||||||||||
| PMID: | 20957480 | ||||||||||
| 38. | |||||||||||
| Journal: | Toxicol Lett. 2011 Jun 24;203(3):258-64. | ||||||||||
| Title: | Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. | ||||||||||
| Author: | Bothe, Hanno|Gassmann, Kathrin|Gotz, Christine|Fritsche, Ellen|Abel, Josef|Haarmann-Stemmann, Thomas | ||||||||||
| PMID: | 21458546 | ||||||||||
| 39. | |||||||||||
| Journal: | Drug Metab Pharmacokinet. 2012;27(3):325-35. Epub 2011 Dec 27. | ||||||||||
| Title: | Association of ABCC2 genotype with efficacy of first-line FOLFIRI in Japanese patients with advanced colorectal cancer. | ||||||||||
| Author: | Akiyama, Yuko|Fujita, Ken-ichi|Ishida, Hiroo|Sunakawa, Yu|Yamashita, Keishi|Kawara, Kaori|Miwa, Keisuke|Saji, Shigehira|Sasaki, Yasutsuna | ||||||||||
| PMID: | 22201120 | ||||||||||
| 40. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2012 Apr;69(4):1107-11. | ||||||||||
| Title: | Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity. | ||||||||||
| Author: | Cao, Shousong|Durrani, Farukh A|Rustum, Youcef M|Yu, Y Eugene | ||||||||||
| PMID: | 22237959 | ||||||||||
| 41. | |||||||||||
| Journal: | Oncology. 2012;82(4):242-8. | ||||||||||
| Title: | A phase I study of infusional 5-fluorouracil, leucovorin, oxaliplatin and irinotecan in Japanese patients with advanced colorectal cancer who harbor UGT1A1*1/*1,*1/*6 or *1/*28. | ||||||||||
| Author: | Sunakawa, Yu|Fujita, Ken-ichi|Ichikawa, Wataru|Ishida, Hiroo|Yamashita, Keishi|Araki, Kazuhiro|Miwa, Keisuke|Kawara, Kaori|Akiyama, Yuko|Yamamoto, Wataru|Nagashima, Fumio|Saji, Shigehira|Sasaki, Yasutsuna | ||||||||||
| PMID: | 22508373 | ||||||||||
| 42. | |||||||||||
| Journal: | Carcinogenesis. 2012 Jul;33(7):1332-9. | ||||||||||
| Title: | Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. | ||||||||||
| Author: | Gilsing, Anne M J|Berndt, Sonja I|Ruder, Elizabeth H|Graubard, Barry I|Ferrucci, Leah M|Burdett, Laura|Weissfeld, Joel L|Cross, Amanda J|Sinha, Rashmi | ||||||||||
| PMID: | 22552404 | ||||||||||
| 43. | |||||||||||
| Journal: | Chin J Physiol. 2012 Apr 30;55(2):134-44. | ||||||||||
| Title: | Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. | ||||||||||
| Author: | Wang, Min|Chen, Shuo|Wang, Shuai|Sun, Defeng|Chen, Jian|Li, Yanqing|Han, Wei|Yang, Xiaoyun|Gao, Hai-Qing | ||||||||||
| PMID: | 22559738 | ||||||||||
| 44. | |||||||||||
| Journal: | Oncol Lett. 2012 Mar;3(3):694-698. | ||||||||||
| Title: | Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene. | ||||||||||
| Author: | Hirose, Koichi|Kozu, Chihiro|Yamashita, Koshiro|Maruo, Eiji|Kitamura, Mizuho|Hasegawa, Junichi|Omoda, Kei|Murakami, Teruo|Maeda, Yorinobu | ||||||||||
| PMID: | 22740978 | ||||||||||
| 45. | |||||||||||
| Journal: | Clin Transl Oncol. 2012 Sep;14(9):641-58. | ||||||||||
| Title: | Management of colorectal cancer patients after resection of liver metastases: can we offer a tailored treatment? | ||||||||||
| Author: | Lopez-Gomez, Miriam|Cejas, Paloma|Merino, Maria|Fernandez-Luengas, David|Casado, Enrique|Feliu, Jaime | ||||||||||
| PMID: | 22911546 | ||||||||||
| 46. | |||||||||||
| Journal: | Carcinogenesis. 2012 Dec;33(12):2311-9. | ||||||||||
| Title: | Splice isoforms as therapeutic targets for colorectal cancer. | ||||||||||
| Author: | Miura, Koh|Fujibuchi, Wataru|Unno, Michiaki | ||||||||||
| PMID: | 23118106 | ||||||||||
| 47. | |||||||||||
| Journal: | Acta Medica (Hradec Kralove). 2012;55(4):153-9. | ||||||||||
| Title: | Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer. | ||||||||||
| Author: | Paulik, Adam|Grim, Jiri|Filip, Stanislav | ||||||||||
| PMID: | 23631285 | ||||||||||
| 48. | |||||||||||
| Journal: | PLoS One. 2013 Nov 14;8(11):e79172. | ||||||||||
| Title: | UDP-glucuronosyltransferase 1A compromises intracellular accumulation and anti-cancer effect of tanshinone IIA in human colon cancer cells. | ||||||||||
| Author: | Liu, Miao|Wang, Qiong|Liu, Fang|Cheng, Xuefang|Wu, Xiaolan|Wang, Hong|Wu, Mengqiu|Ma, Ying|Wang, Guangji|Hao, Haiping | ||||||||||
| PMID: | 24244442 | ||||||||||
| 49. | |||||||||||
| Journal: | World J Gastroenterol. 2013 Sep 28;19(36):6020-5. | ||||||||||
| Title: | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas. | ||||||||||
| Author: | Hoensch, Harald P|Roelofs, Hennie M J|Edler, Lutz|Kirch, Wilhelm|Peters, Wilbert H M | ||||||||||
| PMID: | 24106402 | ||||||||||
| 50. | |||||||||||
| Journal: | Med Oncol. 2013;30(3):604. | ||||||||||
| Title: | UGT1A1 6/28 polymorphisms could predict irinotecan-induced severe neutropenia not diarrhea in Chinese colorectal cancer patients. | ||||||||||
| Author: | Gao, Jing|Zhou, Jun|Li, Yanyan|Lu, Ming|Jia, Ru|Shen, Lin | ||||||||||
| PMID: | 23686699 | ||||||||||
| 51. | |||||||||||
| Journal: | PLoS One. 2013;8(2):e57045. | ||||||||||
| Title: | Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer. | ||||||||||
| Author: | Wang, Min|Sun, De-Feng|Wang, Shuai|Qing, Ying|Chen, Shuo|Wu, Dong|Lin, Ying-Min|Luo, Ji-Zhuang|Li, Yan-Qing | ||||||||||
| PMID: | 23468910 | ||||||||||
| 52. | |||||||||||
| Journal: | J Pharmacol Exp Ther. 2013 Apr;345(1):95-101. | ||||||||||
| Title: | Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens. | ||||||||||
| Author: | Levesque, Eric|Belanger, Anne-Sophie|Harvey, Mario|Couture, Felix|Jonker, Derek|Innocenti, Federico|Cecchin, Erica|Toffoli, Giuseppe|Guillemette, Chantal | ||||||||||
| PMID: | 23386248 | ||||||||||
| 53. | |||||||||||
| Journal: | Tohoku J Exp Med. 2013;229(2):107-14. | ||||||||||
| Title: | Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. | ||||||||||
| Author: | Inoue, Kazuyuki|Sonobe, Momoyo|Kawamura, Yukinori|Etoh, Takashi|Takagi, Masakazu|Matsumura, Takashi|Kikuyama, Masataka|Kimura, Midori|Minami, Sato|Utsuki, Hiroaki|Yamazaki, Tomoaki|Suzuki, Takayo|Tsuji, Daiki|Hayashi, Hideki|Itoh, Kunihiko | ||||||||||
| PMID: | 23303296 | ||||||||||
| 54. | |||||||||||
| Journal: | Cancer. 2013 Jul 1;119(13):2477-85. | ||||||||||
| Title: | The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk. | ||||||||||
| Author: | Angstadt, Andrea Y|Berg, Arthur|Zhu, Junjia|Miller, Paige|Hartman, Terryl J|Lesko, Samuel M|Muscat, Joshua E|Lazarus, Philip|Gallagher, Carla J | ||||||||||
| PMID: | 23575887 | ||||||||||
| 55. | |||||||||||
| Journal: | Mol Pharmacol. 2014 Jan;85(1):29-36. | ||||||||||
| Title: | Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism. | ||||||||||
| Author: | Rouleau, Melanie|Roberge, Joannie|Bellemare, Judith|Guillemette, Chantal | ||||||||||
| PMID: | 24141015 | ||||||||||
| 56. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2014 Jun;53(6):454-66. | ||||||||||
| Title: | The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene-environment interactions. | ||||||||||
| Author: | Angstadt, Andrea Y|Hartman, Terryl J|Lesko, Samuel M|Muscat, Joshua E|Zhu, Junjia|Gallagher, Carla J|Lazarus, Philip | ||||||||||
| PMID: | 24822274 | ||||||||||
| 57. | |||||||||||
| Journal: | Oncol Lett. 2014 Dec;8(6):2407-2416. | ||||||||||
| Title: | Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. | ||||||||||
| Author: | Wang, Min|Zhu, Jing-Yu|Chen, Shuo|Qing, Ying|Wu, Dong|Lin, Ying-Min|Luo, Ji-Zhuang|Han, Wei|Li, Yan-Qing | ||||||||||
| PMID: | 25364403 | ||||||||||
| 58. | |||||||||||
| Journal: | Onco Targets Ther. 2014 Nov 21;7:2143-6. | ||||||||||
| Title: | FOLFIRI and regorafenib combination therapy with dose escalation of irinotecan as fourth-line treatment for patients with metastatic colon cancer according to UGT1A1 genotyping. | ||||||||||
| Author: | Lu, Chien-Yu|Yeh, Yung-Sung|Huang, Ching-Wen|Ma, Cheng-Jen|Yu, Fang-Jung|Wang, Jaw-Yuan | ||||||||||
| PMID: | 25473295 | ||||||||||
| 59. | |||||||||||
| Journal: | PLoS One. 2015 Feb 18;10(2):e0117051. | ||||||||||
| Title: | UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of beta-lapachone in human colon cancer cells. | ||||||||||
| Author: | Liu, Huiying|Li, Qingran|Cheng, Xuefang|Wang, Hong|Wang, Guangji|Hao, Haiping | ||||||||||
| PMID: | 25692465 | ||||||||||
| 60. | |||||||||||
| Journal: | Br J Cancer. 2015 May 12;112(10):1709-16. | ||||||||||
| Title: | An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients. | ||||||||||
| Author: | Ichikawa, W|Uehara, K|Minamimura, K|Tanaka, C|Takii, Y|Miyauchi, H|Sadahiro, S|Fujita, K|Moriwaki, T|Nakamura, M|Takahashi, T|Tsuji, A|Shinozaki, K|Morita, S|Ando, Y|Okutani, Y|Sugihara, M|Sugiyama, T|Ohashi, Y|Sakata, Y | ||||||||||
| PMID: | 25880011 | ||||||||||
| 61. | |||||||||||
| Journal: | Drug Resist Updat. 2015 May;20:39-70. | ||||||||||
| Title: | Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy. | ||||||||||
| Author: | De Mattia, Elena|Cecchin, Erika|Toffoli, Giuseppe | ||||||||||
| PMID: | 26027741 | ||||||||||
| 62. | |||||||||||
| Journal: | Int J Clin Oncol. 2016 Aug;21(4):696-703. | ||||||||||
| Title: | UDP-glucuronosyltransferase 1A1*6 and *28 polymorphisms as indicators of initial dose level of irinotecan to reduce risk of neutropenia in patients receiving FOLFIRI for colorectal cancer. | ||||||||||
| Author: | Miyata, Yoshinori|Touyama, Tetsuo|Kusumi, Takaya|Morita, Yoshitaka|Mizunuma, Nobuyuki|Taniguchi, Fumihiro|Manabe, Mitsuaki | ||||||||||
| PMID: | 26710796 | ||||||||||
| 63. | |||||||||||
| Journal: | World J Gastroenterol. 2016 Apr 28;22(16):4250-8. | ||||||||||
| Title: | Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy. | ||||||||||
| Author: | Yu, Qian-Qian|Qiu, Hong|Zhang, Ming-Sheng|Hu, Guang-Yuan|Liu, Bo|Huang, Liu|Liao, Xin|Li, Qian-Xia|Li, Zhi-Huan|Yuan, Xiang-Lin | ||||||||||
| PMID: | 27122675 | ||||||||||
| 64. | |||||||||||
| Journal: | Cell Mol Gastroenterol Hepatol. 2016 Jan;2(1):63-76.e5. | ||||||||||
| Title: | Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. | ||||||||||
| Author: | Liu, Miao|Chen, Shujuan|Yueh, Mei-Fei|Wang, Guangji|Hao, Haiping|Tukey, Robert H | ||||||||||
| PMID: | 26807433 | ||||||||||
| 65. | |||||||||||
| Journal: | Mol Pharmacol. 2017 Mar;91(3):167-177. | ||||||||||
| Title: | Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. | ||||||||||
| Author: | Audet-Delage, Yannick|Rouleau, Michele|Rouleau, Melanie|Roberge, Joannie|Miard, Stephanie|Picard, Frederic|Tetu, Bernard|Guillemette, Chantal | ||||||||||
| PMID: | 28049773 | ||||||||||
| 66. | |||||||||||
| Journal: | Zhonghua Zhong Liu Za Zhi. 2017 May 23;39(5):380-383. | ||||||||||
| Title: | [Safety and efficacy of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) in Chinese patients with advanced colorectal cancer]. | ||||||||||
| Author: | Song, Y|Li, W W|Huang, J | ||||||||||
| PMID: | 28535657 | ||||||||||
| 67. | |||||||||||
| Journal: | Mol Pharmacol. 2018 May;93(5):541-552. | ||||||||||
| Title: | Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4alpha Is Mediated by a Novel Composite Regulatory Element. | ||||||||||
| Author: | Mubarokah, Nurul|Hulin, Julie-Ann|Mackenzie, Peter I|McKinnon, Ross A|Haines, Alex Z|Hu, Dong Gui|Meech, Robyn | ||||||||||
| PMID: | 29519853 | ||||||||||
| 68. | |||||||||||
| Journal: | Pharmacol Rep. 2018 Jun;70(3):470-475. | ||||||||||
| Title: | Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems. | ||||||||||
| Author: | Bejrowska, Anna|Pawlowska, Monika|Mroz, Anna|Mazerska, Zofia | ||||||||||
| PMID: | 29649683 | ||||||||||
| 69. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2018 Jul;82(1):87-98. | ||||||||||
| Title: | UGT1A polymorphisms associated with worse outcome in colorectal cancer patients treated with irinotecan-based chemotherapy. | ||||||||||
| Author: | Yu, Qianqian|Zhang, Tao|Xie, Conghua|Qiu, Hong|Liu, Bo|Huang, Liu|Peng, Ping|Feng, Jueping|Chen, Jigui|Zang, Aihua|Yuan, Xianglin | ||||||||||
| PMID: | 29728798 | ||||||||||
| 70. | |||||||||||
| Journal: | Eur J Cancer. 2018 Aug;99:66-77. | ||||||||||
| Title: | Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial. | ||||||||||
| Author: | Tejpar, Sabine|Yan, Pu|Piessevaux, Hubert|Dietrich, Daniel|Brauchli, Peter|Klingbiel, Dirk|Fiocca, Roberto|Delorenzi, Mauro|Bosman, Fred|Roth, Arnaud D | ||||||||||
| PMID: | 29909091 | ||||||||||
| 71. | |||||||||||
| Journal: | Pharmacol Rep. 2018 Oct;70(5):972-980. | ||||||||||
| Title: | Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7. | ||||||||||
| Author: | Mroz, Anna|Ryska, Izabela|Sominko, Hanna|Bejrowska, Anna|Mazerska, Zofia | ||||||||||
| PMID: | 30107347 | ||||||||||
| 72. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2018 Oct 30. pii: 10.1007/s00280-018-3711-8. | ||||||||||
| Title: | Dose adjustment of irinotecan based on UGT1A1 polymorphisms in patients with colorectal cancer. | ||||||||||
| Author: | Fujii, Hironori|Yamada, Yunami|Watanabe, Daichi|Matsuhashi, Nobuhisa|Takahashi, Takao|Yoshida, Kazuhiro|Suzuki, Akio | ||||||||||
| PMID: | 30377777 | ||||||||||