Primary Site >> Colorectal Cancer
Gene >> UGT1A
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Ref: AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. PMID: 9762354 |
Ref: Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. PMID: 10220484 Ref: Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. PMID: 10357796 Ref: Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. PMID: 10606239 |
Ref: Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid. PMID: 10688250 Ref: Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7. PMID: 10901286 |
Ref: Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. PMID: 12642472 Ref: Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. PMID: 14679008 |
Ref: Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. PMID: 15297419 |
Ref: UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. PMID: 15643497 Ref: Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. PMID: 15682470 Ref: The effects of coffee on conjugation reactions in human colon carcinoma cells. PMID: 15684482 Ref: Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. PMID: 15929176 Ref: [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells]. PMID: 15949398 Ref: Cancer and molecular biomarkers of phase 2. PMID: 16399374 |
Ref: [The role of NF-E2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1A and its isoforms by epigallocatechin gallate in colon cancer cells]. PMID: 16620709 Ref: Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. PMID: 16819192 Ref: Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan. PMID: 16877259 |
Ref: Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10. PMID: 17638922 Ref: Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice. PMID: 17657175 Ref: [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. PMID: 18478930 |
Ref: Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability. PMID: 18491077 Ref: The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells. PMID: 18694909 |
Ref: Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. PMID: 19364970 Ref: Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology. PMID: 19644023 Ref: Modulation of NRF2 and UGT1A expression by epigallocatechin-3-gallate in colon cancer cells and BALB/c mice. PMID: 19719968 Ref: Networking of differentially expressed genes in human cancer cells resistant to methotrexate. PMID: 19732436 |
Ref: UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. PMID: 19831498 Ref: Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines. PMID: 19997083 Ref: Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. PMID: 20196838 Ref: UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. PMID: 20628391 |
Ref: UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer. PMID: 20957480 Ref: Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. PMID: 20967519 Ref: Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans. PMID: 21171088 Ref: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. PMID: 21458546 Ref: Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review). PMID: 21468552 Ref: Concurrence of UGT1A polymorphism and end-stage renal disease leads to severe toxicities of irinotecan in a patient with metastatic colon cancer. PMID: 21617725 Ref: Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study. PMID: 21892003 |
Ref: Association of ABCC2 genotype with efficacy of first-line FOLFIRI in Japanese patients with advanced colorectal cancer. PMID: 22201120 Ref: Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity. PMID: 22237959 Ref: A phase I study of infusional 5-fluorouracil, leucovorin, oxaliplatin and irinotecan in Japanese patients with advanced colorectal cancer who harbor UGT1A1*1/*1,*1/*6 or *1/*28. PMID: 22508373 Ref: Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. PMID: 22552404 Ref: Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. PMID: 22559738 Ref: Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene. PMID: 22740978 Ref: Management of colorectal cancer patients after resection of liver metastases: can we offer a tailored treatment? PMID: 22911546 Ref: Splice isoforms as therapeutic targets for colorectal cancer. PMID: 23118106 Ref: Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer. PMID: 23631285 |
Ref: Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. PMID: 23303296 Ref: Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens. PMID: 23386248 Ref: Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer. PMID: 23468910 Ref: The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk. PMID: 23575887 Ref: UGT1A1 6/28 polymorphisms could predict irinotecan-induced severe neutropenia not diarrhea in Chinese colorectal cancer patients. PMID: 23686699 Ref: Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas. PMID: 24106402 Ref: UDP-glucuronosyltransferase 1A compromises intracellular accumulation and anti-cancer effect of tanshinone IIA in human colon cancer cells. PMID: 24244442 |
Ref: Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism. PMID: 24141015 Ref: The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene-environment interactions. PMID: 24822274 Ref: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. PMID: 25364403 Ref: FOLFIRI and regorafenib combination therapy with dose escalation of irinotecan as fourth-line treatment for patients with metastatic colon cancer according to UGT1A1 genotyping. PMID: 25473295 |
Ref: UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of beta-lapachone in human colon cancer cells. PMID: 25692465 Ref: An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients. PMID: 25880011 Ref: Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy. PMID: 26027741 |
Ref: UDP-glucuronosyltransferase 1A1*6 and *28 polymorphisms as indicators of initial dose level of irinotecan to reduce risk of neutropenia in patients receiving FOLFIRI for colorectal cancer. PMID: 26710796 Ref: Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. PMID: 26807433 Ref: Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy. PMID: 27122675 |
Ref: Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. PMID: 28049773 Ref: [Safety and efficacy of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) in Chinese patients with advanced colorectal cancer]. PMID: 28535657 |
Ref: Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4alpha Is Mediated by a Novel Composite Regulatory Element. PMID: 29519853 Ref: Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems. PMID: 29649683 Ref: UGT1A polymorphisms associated with worse outcome in colorectal cancer patients treated with irinotecan-based chemotherapy. PMID: 29728798 Ref: Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial. PMID: 29909091 Ref: Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7. PMID: 30107347 Ref: Dose adjustment of irinotecan based on UGT1A1 polymorphisms in patients with colorectal cancer. PMID: 30377777 |