Literatures

Primary Site >> Colorectal Cancer

Gene >> TYMS

1.
Journal:	Adv Exp Med Biol. 1983;163:341-57.
Title:	Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.
Author:	Fernandes, D J\|Cardenas, R M\|Bertino, J R\|Hynes, J B
PMID:	6688493

2.
Journal:	Ann Genet. 1986;29(1):11-5.
Title:	Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma.
Author:	Dutrillaux, B\|Muleris, M
PMID:	2424358

3.
Journal:	Bull Tokyo Med Dent Univ. 1986 Dec;33(4):137-44.
Title:	Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.
Author:	Sakamoto, S\|Kasahara, N\|Kawasaki, T\|Kudo, H\|Okamoto, R\|Kawachi, Y\|Murakami, S\|Iwama, T\|Yaegashi, K\|Mishima, Y
PMID:	3105903

4.
Journal:	NCI Monogr. 1987;(5):199-202.
Title:	Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
Author:	Allegra, C J\|Chabner, B A\|Sholar, P W\|Bagley, C\|Drake, J C\|Lippman, M E
PMID:	3501543

5.
Journal:	Biochem Pharmacol. 1987 Apr 15;36(8):1285-9.
Title:	Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil.
Author:	Houghton, J A\|Radparvar, S\|Torrance, P M\|Williams, L G\|Houghton, P J
PMID:	3593415

6.
Journal:	Cancer Res. 1987 Nov 15;47(22):5975-81.
Title:	Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells.
Author:	McGuire, J J\|Sobrero, A F\|Hynes, J B\|Bertino, J R
PMID:	3664501

7.
Journal:	Cancer Treat Rep. 1987 Mar;71(3):261-5.
Title:	Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.
Author:	Clark, J L\|Berger, S H\|Mittelman, A\|Berger, F G
PMID:	3815393

8.
Journal:	Biochem Pharmacol. 1988 Mar 15;37(6):997-1001.
Title:	Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells.
Author:	Sobrero, A F\|McGuire, J J\|Bertino, J R
PMID:	2451526

9.
Journal:	Mol Pharmacol. 1988 Oct;34(4):474-9.
Title:	Thymidylate synthase as a determinant of 5-fluoro-2'-deoxyuridine response in human colonic tumor cell lines.
Author:	Berger, S H\|Berger, F G
PMID:	2971871

10.
Journal:	Mol Pharmacol. 1988 Oct;34(4):480-4.
Title:	A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.
Author:	Berger, S H\|Barbour, K W\|Berger, F G
PMID:	2971872

11.
Journal:	Cancer Invest. 1988;6(4):377-83.
Title:	Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Author:	Berne, M\|Gustavsson, B\|Almersjo, O\|Spears, P\|Sundstrom, E
PMID:	2972339

12.
Journal:	Adv Exp Med Biol. 1988;244:59-69.
Title:	The role of thymidylate synthase in the response to fluoropyrimidine-folinic acid combinations.
Author:	Berger, S H\|Davis, S T\|Barbour, K W\|Berger, F G
PMID:	2977716

13.
Journal:	J Clin Oncol. 1988 Oct;6(10):1653-64.
Title:	Fluorouracil: biochemistry and pharmacology.
Author:	Pinedo, H M\|Peters, G F
PMID:	3049954

14.
Journal:	J Clin Oncol. 1988 Jul;6(7):1184-91.
Title:	Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma.
Author:	Trave, F\|Rustum, Y M\|Petrelli, N J\|Herrera, L\|Mittelman, A\|Frank, C\|Creaven, P J
PMID:	3260621

15.
Journal:	Yale J Biol Med. 1988 Jan-Feb;61(1):23-34.
Title:	The effect of leucovorin on the therapeutic index of fluorouracil in cancer patients.
Author:	DeLap, R J
PMID:	3284210

16.
Journal:	Cancer Res. 1988 Jun 1;48(11):3062-9.
Title:	Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.
Author:	Houghton, J A\|Williams, L G\|Radparvar, S\|Houghton, P J
PMID:	3365696

17.
Journal:	Mol Pharmacol. 1989 Apr;35(4):422-7.
Title:	Modulation of 5-fluoro-2'-deoxyuridine response by folinic acid in human colonic tumor cell lines: the role of thymidylate synthase.
Author:	Davis, S T\|Berger, S H
PMID:	2523018

18.
Journal:	Adv Exp Med Biol. 1989;253A:439-45.
Title:	In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.
Author:	Peters, G J\|Laurensse, E J\|van Groeningen, C J\|Meijer, S\|Pinedo, H M
PMID:	2624224

19.
Journal:	Postgrad Med. 1989 Nov 1;86(6):81, 84.
Title:	Treatment of metastatic colorectal carcinoma. Recent advances in use of fluorouracil.
Author:	Treat, J\|Joseph, R R
PMID:	2813219

20.
Journal:	Cancer Res. 1990 Sep 15;50(18):5834-40.
Title:	Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
Author:	Chu, E\|Zinn, S\|Boarman, D\|Allegra, C J
PMID:	1697502

21.
Journal:	J Chemother. 1990 Feb;2 Suppl 1:12-6.
Title:	Resistance to 5-fluorouracil and 5-fluoro-2'-deoxyuridine mechanisms and clinical implications.
Author:	Sobrero, A\|Aschele, C\|Guglielmi, A\|Nobile, M T\|Rosso, R
PMID:	2142213

22.
Journal:	Pharmacol Ther. 1990;47(1):1-19.
Title:	Enhancement of the antitumor effects of 5-fluorouracil by folinic acid.
Author:	Mini, E\|Trave, F\|Rustum, Y M\|Bertino, J R
PMID:	2195551

23.
Journal:	Anticancer Res. 1990 May-Jun;10(3):759-64.
Title:	Comparison of in vitro drug sensitivity by inhibition of tritium release from [5-3H]-2'-deoxyuridine and a clonogenic assay.
Author:	Aschele, C\|Romanini, A\|Nicolin, A\|Rosso, R\|Sobrero, A
PMID:	2195987

24.
Journal:	Mol Pharmacol. 1991 Feb;39(2):136-43.
Title:	Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.
Author:	Chu, E\|Drake, J C\|Koeller, D M\|Zinn, S\|Jamis-Dow, C A\|Yeh, G C\|Allegra, C J
PMID:	1704999

25.
Journal:	Cancer Res. 1991 Dec 15;51(24):6668-76.
Title:	Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue.
Author:	Johnston, P G\|Liang, C M\|Henry, S\|Chabner, B A\|Allegra, C J
PMID:	1720706

26.
Journal:	Biochem Pharmacol. 1991 Nov 27;42(12):2369-75.
Title:	Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA.
Author:	Nord, L D\|Martin, D S
PMID:	1722409

27.
Journal:	Adv Exp Med Biol. 1991;309A:131-4.
Title:	Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer.
Author:	Peters, G J\|van Groeningen, C J\|van der Wilt, C L\|Smid, K\|Meijer, S\|Pinedo, H M
PMID:	1789191

28.
Journal:	Eur J Cancer. 1991;27(3):263-7.
Title:	Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.
Author:	Peters, G J\|van Groeningen, C J\|Laurensse, E J\|Pinedo, H M
PMID:	1827310

29.
Journal:	J Surg Oncol Suppl. 1991;2:116-23.
Title:	Modulation of fluoropyrimidines by leucovorin: rationale and status.
Author:	Rustum, Y M
PMID:	1832538

30.
Journal:	Int J Cancer. 1991 Nov 11;49(5):721-30.
Title:	Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation.
Author:	Lesuffleur, T\|Kornowski, A\|Luccioni, C\|Muleris, M\|Barbat, A\|Beaumatin, J\|Dussaulx, E\|Dutrillaux, B\|Zweibaum, A
PMID:	1937958

31.
Journal:	Int J Cancer. 1991 Mar 12;47(5):670-4.
Title:	Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns.
Author:	Bardot, V\|Luccioni, C\|Lefrancois, D\|Muleris, M\|Dutrillaux, B
PMID:	2004848

32.
Journal:	Cancer Res. 1992 Sep 15;52(18):4922-8.
Title:	Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
Author:	Van der Wilt, C L\|Pinedo, H M\|Smid, K\|Peters, G J
PMID:	1516048

33.
Journal:	Gan To Kagaku Ryoho. 1992 Sep;19(11):1837-42.
Title:	[Neo-adjuvant chemotherapy with tegafur suppository for rectal cancer--evaluation of the antitumor effects, tissue levels of 5-FU and inhibition of thymidylate synthase. Tochigi Colorectal Cancer Study Group].
Author:	Kotake, K\|Koyama, Y\|Konishi, F\|Kanazawa, K\|Namba, M\|Shida, S\|Umemoto, S\|Nara, K\|Kon, T\|Nozawa, K
PMID:	1519926

34.
Journal:	Cancer Res. 1992 Apr 1;52(7):1687-94.
Title:	Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.
Author:	Miller, E M\|Kinsella, T J
PMID:	1532343

35.
Journal:	Cancer Res. 1992 Apr 1;52(7):1729-36.
Title:	Enhancement of 5-fluoro-2'-deoxyuridine antineoplastic activity by 5-benzyloxybenzyloxybenzylacyclouridine in a human colon carcinoma cell line.
Author:	Chu, E\|Chu, M Y\|Darnowski, J W\|Chen, Z H\|Pan, B C\|Chu, S H
PMID:	1532344

36.
Journal:	Cancer Res. 1992 Apr 1;52(7):1855-64.
Title:	Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Author:	Aschele, C\|Sobrero, A\|Faderan, M A\|Bertino, J R
PMID:	1532346

37.
Journal:	Semin Oncol. 1992 Apr;19(2 Suppl 3):16-25.
Title:	Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Author:	van der Wilt, C L\|Pinedo, H M\|Smid, K\|Cloos, J\|Noordhuis, P\|Peters, G J
PMID:	1532671

38.
Journal:	Semin Oncol. 1992 Apr;19(2 Suppl 3):4-9.
Title:	Mechanisms of resistance to fluoropyrimidines.
Author:	Zhang, Z G\|Harstrick, A\|Rustum, Y M
PMID:	1532673

39.
Journal:	Semin Oncol. 1992 Apr;19(2 Suppl 3):26-35.
Title:	Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.
Author:	Peters, G J\|van Groeningen, C J\|van der Wilt, C L\|Meijer, S\|Smid, K\|Laurensse, E\|Pinedo, H M
PMID:	1557655

40.
Journal:	Semin Oncol. 1992 Apr;19(2 Suppl 3):36-44.
Title:	Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations.
Author:	Grem, J L\|Chu, E\|Boarman, D\|Balis, F M\|Murphy, R F\|McAtee, N\|Allegra, C J
PMID:	1557656

41.
Journal:	Gan To Kagaku Ryoho. 1992 Jul;19(7):1083-6.
Title:	[Potentiation of thymidylate synthetase (TS) inhibition by combined administration of HCFU and dipyridamole: preliminary report. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma].
Author:	Kikkawa, N\|Kato, T\|Iwanaga, T\|Utsunomiya, J\|Hioki, K\|Mori, T\|Yasutomi, M\|Fukuda, I\|Kameyama, M
PMID:	1626945

42.
Journal:	Gan To Kagaku Ryoho. 1992 Jul;19(7):954-62.
Title:	[High-dose leucovorin and 5-FU].
Author:	Sasaki, T
PMID:	1626951

43.
Journal:	Cancer Res. 1992 Aug 15;52(16):4306-12.
Title:	Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.
Author:	Johnston, P G\|Drake, J C\|Trepel, J\|Allegra, C J
PMID:	1643628

44.
Journal:	J Natl Cancer Inst. 1992 Mar 4;84(5):321-7.
Title:	Fluorouracil combined with the pure (6S)-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study.
Author:	Machover, D\|Grison, X\|Goldschmidt, E\|Zittoun, J\|Lotz, J P\|Metzger, G\|Richaud, J\|Hannoun, L\|Marquet, J\|Guillot, T
PMID:	1738182

45.
Journal:	J Natl Cancer Inst. 1993 Dec 1;85(23):1937-44.
Title:	Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells.
Author:	Sobrero, A F\|Aschele, C\|Guglielmi, A P\|Mori, A M\|Melioli, G G\|Rosso, R\|Bertino, J R
PMID:	8230285

46.
Journal:	Gan To Kagaku Ryoho. 1993 Nov;20(14):2195-9.
Title:	[Some problems of TS measurement after administration of fluoropyrimidines in colorectal cancer. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma].
Author:	Kameyama, M\|Nakamori, S\|Imaoka, S\|Utsunomiya, J\|Oshima, A\|Kikkawa, N\|Hioki, K\|Fukuda, I\|Mori, T\|Yasutomi, M
PMID:	8239685

47.
Journal:	Ann Oncol. 1993;4 Suppl 2:29-35.
Title:	5-Fluorouracil combined with the [6S]-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma. A phase I-II study of two consecutive regimens.
Author:	Machover, D\|Grison, X\|Goldschmidt, E\|Zittoun, J\|Metzger, G\|Richaud, J\|Lotz, J P\|Andre, T\|Hannoun, L\|Marquet, J
PMID:	8353102

48.
Journal:	Cancer Res. 1993 Sep 15;53(18):4243-50.
Title:	Locus of the interaction among 5-fluorouracil, leucovorin, and interferon-alpha 2a in colon carcinoma cells.
Author:	Houghton, J A\|Morton, C L\|Adkins, D A\|Rahman, A
PMID:	8364921

49.
Journal:	Gan To Kagaku Ryoho. 1993 Mar;20(4):485-91.
Title:	[Phase I study of 5-fluorouracil and l-leucovorin].
Author:	Sasaki, T\|Ota, K\|Wakui, A\|Akazawa, S\|Ogawa, M\|Ariyoshi, Y\|Yura, J\|Inagaki, J\|Hoshino, A\|Abe, T
PMID:	8452386

50.
Journal:	Mol Pharmacol. 1993 Apr;43(4):527-33.
Title:	Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
Author:	Chu, E\|Koeller, D M\|Johnston, P G\|Zinn, S\|Allegra, C J
PMID:	8474431

51.
Journal:	Cancer Chemother Pharmacol. 1993;32(3):215-20.
Title:	Phase I trial of a 5-day infusion of L-leucovorin plus daily bolus 5-fluorouracil in patients with advanced gastrointestinal malignancies.
Author:	Valone, F H\|Gandara, D R\|Luce, J A\|Wall, S\|Perez, E A\|Braham, N\|George, M\|Letvak, L
PMID:	8500227

52.
Journal:	Mol Pharmacol. 1993 May;43(5):702-8.
Title:	Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine.
Author:	Davis, S T\|Berger, S H
PMID:	8502227

53.
Journal:	Int J Oncol. 1993 Feb;2(2):275-8.
Title:	Immunoassay for thymidylate synthase in cytosols from human colorectal-carcinoma cell-lines.
Author:	Weitz, S\|Wildrick, D\|Boman, B
PMID:	21573550

54.
Journal:	Adv Exp Med Biol. 1994;370:109-14.
Title:	Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Author:	van der Wilt, C L\|van Laar, J A\|Smid, K\|Rustum, Y M\|Peters, G J
PMID:	7660870

55.
Journal:	Oncol Res. 1994;6(12):581-91.
Title:	Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Author:	Geoffroy, F J\|Allegra, C J\|Sinha, B\|Grem, J L
PMID:	7787251

56.
Journal:	Anticancer Res. 1994 Nov-Dec;14(6B):2677-80.
Title:	Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer.
Author:	Mulder, N H\|Timmer-Bosscha, H\|Meersma, G J\|Verschueren, R C
PMID:	7872700

57.
Journal:	J Clin Oncol. 1994 Oct;12(10):2035-42.
Title:	Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.
Author:	Peters, G J\|van der Wilt, C L\|van Groeningen, C J\|Smid, K\|Meijer, S\|Pinedo, H M
PMID:	7931471

58.
Journal:	J Clin Oncol. 1994 Dec;12(12):2640-7.
Title:	The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.
Author:	Johnston, P G\|Fisher, E R\|Rockette, H E\|Fisher, B\|Wolmark, N\|Drake, J C\|Chabner, B A\|Allegra, C J
PMID:	7989939

59.
Journal:	Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):519-23.
Title:	Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects.
Author:	Lawrence, T S\|Davis, M A\|Maybaum, J
PMID:	8005809

60.
Journal:	Cancer Res. 1994 Jul 15;54(14):3772-8.
Title:	ICI D1694 and idoxuridine: a synergistic antitumor combination.
Author:	Pressacco, J\|Hedley, D W\|Erlichman, C
PMID:	8033097

61.
Journal:	Cancer Res. 1994 Sep 15;54(18):4967-73.
Title:	Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.
Author:	Houghton, J A\|Harwood, F G\|Houghton, P J
PMID:	8069864

62.
Journal:	Gan To Kagaku Ryoho. 1994 May;21 Suppl 1:117-21.
Title:	[TS inhibition rate and flow cytometric analysis of DNA content in preoperative chemotherapy with biochemical modulator].
Author:	Sakuyama, T\|Takahashi, N
PMID:	8203923

63.
Journal:	Mol Cell Biol. 1994 Jan;14(1):207-13.
Title:	Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.
Author:	Chu, E\|Voeller, D M\|Jones, K L\|Takechi, T\|Maley, G F\|Maley, F\|Segal, S\|Allegra, C J
PMID:	8264588

64.
Journal:	Int J Oncol. 1994 Dec;5(6):1267-71.
Title:	Expression of thymidylate synthase gene in human colorectal carcinomas by northern blotting and reflectance in-situ hybridization (rish) - correlation with the number of chromosome-18.
Author:	Lasserre, C\|Sabatier, L\|Salmon, R\|Dutrillaux, B
PMID:	21559708

65.
Journal:	Biochem Pharmacol. 1995 Oct 26;50(9):1347-51.
Title:	Antitumour effects of pure diastereoisomers of 5-formyltetrahydrofolate in hepatic transplants of a rodent colon carcinoma model.
Author:	Carlsson, G\|Gustavsson, B\|Frosing, R\|Odin, E\|Hafstrom, L O\|Spears, C P\|Larsson, P A
PMID:	7503782

66.
Journal:	Biochem Pharmacol. 1995 Jun 29;50(1):55-60.
Title:	Biochemical modulation of iododeoxyuridine by N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2,6-diaminobenz[cd]indole glucuronate (AG-331) leading to enhanced cytotoxicity.
Author:	Pressacco, J\|Mitrovski, B\|Hedley, D W\|Tsang, R\|Erlichman, C
PMID:	7605345

67.
Journal:	Cancer Res. 1995 Sep 1;55(17):3897-901.
Title:	The number of 5-fluoro-2'-deoxyuridine-5'-monophosphate binding sites and reduced folate pool in human colorectal carcinoma tissues: changes after tegafur and uracil treatment.
Author:	Omura, K\|Kawakami, K\|Kanehira, E\|Nagasato, A\|Kawashima, S\|Tawaraya, K\|Watanabe, S\|Hirano, K\|Shirasaka, T\|Watanabe, Y
PMID:	7641209

68.
Journal:	Biochem Pharmacol. 1995 May 17;49(10):1419-26.
Title:	Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
Author:	Copur, S\|Aiba, K\|Drake, J C\|Allegra, C J\|Chu, E
PMID:	7763285

69.
Journal:	Br J Cancer. 1995 Jun;71(6):1145-50.
Title:	The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells.
Author:	Drake, J C\|Voeller, D M\|Allegra, C J\|Johnston, P G
PMID:	7779703

70.
Journal:	Br J Cancer. 1995 Jun;71(6):1151-7.
Title:	Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.
Author:	Pestalozzi, B C\|McGinn, C J\|Kinsella, T J\|Drake, J C\|Glennon, M C\|Allegra, C J\|Johnston, P G
PMID:	7779704

71.
Journal:	Mol Cell Biol. 1995 Jan;15(1):179-85.
Title:	Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro.
Author:	Chu, E\|Takechi, T\|Jones, K L\|Voeller, D M\|Copur, S M\|Maley, G F\|Maley, F\|Segal, S\|Allegra, C J
PMID:	7799924

72.
Journal:	Clin Cancer Res. 1995 Nov;1(11):1337-44.
Title:	In vitro synergism between 5-fluorouracil and natural beta interferon in human colon carcinoma cells.
Author:	Guglielmi, A\|Aschele, C\|Mori, A\|Baldo, C\|Russo, P\|Debernardis, D\|Valenti, M\|Bruno, S\|Taverna, M\|Rosso, R
PMID:	9815929

73.
Journal:	Oncol Rep. 1995 Sep;2(5):723-6.
Title:	Pathological and enzymatic features of 1,2-dimethylhydrazine induced colorectal carcinomas in rats.
Author:	Suzuki, S\|Okayasu, I\|Kuda, H\|Kuwa, K\|Yoshimura, S\|Mitamura, T\|Sakamoto, S
PMID:	21597804

74.
Journal:	Gan To Kagaku Ryoho. 1996 May;23(6):715-20.
Title:	[Comparative study of the combined effect of HCFU and dipyridamole (DP) in colorectal carcinoma--TS inhibition rate. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma].
Author:	Kanno, H\|Yoden, Y\|Ohashi, S\|Utsunomiya, J\|Oshima, A\|Kameyama, M\|Iwanaga, T\|Kikkawa, N\|Hioki, K\|Fukuda, I\|Mori, T\|Yasutomi, M
PMID:	8645023

75.
Journal:	Cancer Res. 1996 Jun 1;56(11):2602-6.
Title:	Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats.
Author:	Shirasaka, T\|Nakano, K\|Takechi, T\|Satake, H\|Uchida, J\|Fujioka, A\|Saito, H\|Okabe, H\|Oyama, K\|Takeda, S\|Unemi, N\|Fukushima, M
PMID:	8653704

76.
Journal:	Ann Oncol. 1996 Mar;7(3):283-9.
Title:	Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy.
Author:	Etienne, M C\|Guillot, T\|Milano, G
PMID:	8740793

77.
Journal:	Cancer Res. 1996 Jul 15;56(14):3203-6.
Title:	Fluoropyrimidine-mediated radiosensitization depends on cyclin E-dependent kinase activation.
Author:	Lawrence, T S\|Davis, M A\|Loney, T L
PMID:	8764107

78.
Journal:	Biochem Pharmacol. 1996 May 17;51(10):1349-55.
Title:	Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines.
Author:	Drake, J C\|Allegra, C J\|Moran, R G\|Johnston, P G
PMID:	8787551

79.
Journal:	Cancer Chemother Pharmacol. 1996;38(6):529-35.
Title:	Effect of interferon on 5-fluorouracil-induced perturbations in pools of deoxynucleotide triphosphates and DNA strand breaks.
Author:	Wadler, S\|Horowitz, R\|Mao, X\|Schwartz, E L
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81.
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84.
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PMID:	9155534

87.
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88.
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89.
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90.
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91.
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93.
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95.
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103.
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104.
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105.
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106.
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Title:	Comparison between short or long exposure to 5-fluorouracil in human gastric and colon cancer cell lines: biochemical mechanism of resistance.
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107.
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108.
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109.
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110.
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Title:	Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.
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111.
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Title:	Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex.
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112.
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113.
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114.
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Title:	Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
Author:	van Triest, B\|Pinedo, H M\|van Hensbergen, Y\|Smid, K\|Telleman, F\|Schoenmakers, P S\|van der Wilt, C L\|van Laar, J A\|Noordhuis, P\|Jansen, G\|Peters, G J
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115.
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Title:	Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: implications for chemotherapeutic options and survival.
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PMID:	10188059

116.
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Title:	The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells.
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PMID:	10213489

117.
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Title:	Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514.
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118.
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PMID:	10234293

119.
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Title:	Clinical implications of 5-FU modulation.
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120.
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Title:	Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil.
Author:	Cascinu, S\|Aschele, C\|Barni, S\|Debernardis, D\|Baldo, C\|Tunesi, G\|Catalano, V\|Staccioli, M P\|Brenna, A\|Muretto, P\|Catalano, G
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121.
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Title:	Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
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122.
Journal:	Cancer Chemother Pharmacol. 1999;44(5):372-80.
Title:	A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation.
Author:	Rinaldi, D A\|Kuhn, J G\|Burris, H A\|Dorr, F A\|Rodriguez, G\|Eckhardt, S G\|Jones, S\|Woodworth, J R\|Baker, S\|Langley, C\|Mascorro, D\|Abrahams, T\|Von Hoff, D D
PMID:	10501910

123.
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Title:	Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.
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PMID:	10531414

124.
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Title:	Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.
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PMID:	10533483

125.
Journal:	Biochem Pharmacol. 1999 Nov 15;58(10):1529-37.
Title:	Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line.
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126.
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Title:	Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer.
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127.
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Title:	Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Author:	Peters, G J\|Smitskamp-Wilms, E\|Smid, K\|Pinedo, H M\|Jansen, G
PMID:	10554030

128.
Journal:	Antisense Nucleic Acid Drug Dev. 1999 Oct;9(5):481-6.
Title:	Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
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PMID:	10555156

129.
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Title:	Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens.
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130.
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Title:	Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis.
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131.
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Title:	Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
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132.
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Title:	The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status.
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133.
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Title:	Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations.
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134.
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Title:	Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines.
Author:	Mans, D R\|Grivicich, I\|Peters, G J\|Schwartsmann, G
PMID:	10674003

135.
Journal:	Anticancer Res. 1999 Nov-Dec;19(6B):5139-42.
Title:	Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
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PMID:	10697523

136.
Journal:	Oncol Res. 1999;11(8):383-91.
Title:	Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
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PMID:	10803742

137.
Journal:	Oncol Res. 1999;11(9):437-45.
Title:	Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors.
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PMID:	10821538

138.
Journal:	Methods Mol Med. 1999;28:111-20.
Title:	5-Fluorouracil metabolizing enzymes.
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PMID:	21374032

139.
Journal:	Cancer Res. 2000 Jan 1;60(1):92-100.
Title:	Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization.
Author:	Hwang, H S\|Davis, T W\|Houghton, J A\|Kinsella, T J
PMID:	10646859

140.
Journal:	Clin Chim Acta. 2000 Jan 5;290(2):129-44.
Title:	A new quantitative RT-PCR assay for thymidylate synthase mRNA in blood leukocytes applied to cancer patients and healthy controls.
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PMID:	10660804

141.
Journal:	Nucleic Acids Res. 2000 Mar 15;28(6):1381-9.
Title:	Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.
Author:	Lin, X\|Parsels, L A\|Voeller, D M\|Allegra, C J\|Maley, G F\|Maley, F\|Chu, E
PMID:	10684933

142.
Journal:	Clin Cancer Res. 2000 Feb;6(2):488-92.
Title:	Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival.
Author:	Edler, D\|Kressner, U\|Ragnhammar, P\|Johnston, P G\|Magnusson, I\|Glimelius, B\|Pahlman, L\|Lindmark, G\|Blomgren, H
PMID:	10690528

143.
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Title:	Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport.
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PMID:	10732767

144.
Journal:	Clin Cancer Res. 2000 Mar;6(3):1063-72.
Title:	Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer.
Author:	van Triest, B\|Pinedo, H M\|Blaauwgeers, J L\|van Diest, P J\|Schoenmakers, P S\|Voorn, D A\|Smid, K\|Hoekman, K\|Hoitsma, H F\|Peters, G J
PMID:	10741735

145.
Journal:	Acta Oncol. 2000;39(1):53-7.
Title:	Changes in thymidylate synthase mRNA in blood leukocytes from patients with colorectal cancer after bolus administration of 5-fluorouracil.
Author:	Ehrnrooth, E\|Sorensen, B\|Poulsen, J H\|Sorensen, B S\|von der Maase, H
PMID:	10752654

146.
Journal:	Anticancer Res. 2000 Jan-Feb;20(1C):595-600.
Title:	Do the expression of CD44, apoptosis and thymidylate synthase inhibition rate correlate with the efficacy of chemotherapy in colorectal cancer?
Author:	Tachikawa, D\|Arima, S\|Futami, K\|Iwashita, A
PMID:	10769701

147.
Journal:	Clin Cancer Res. 2000 Apr;6(4):1322-7.
Title:	Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
Author:	Salonga, D\|Danenberg, K D\|Johnson, M\|Metzger, R\|Groshen, S\|Tsao-Wei, D D\|Lenz, H J\|Leichman, C G\|Leichman, L\|Diasio, R B\|Danenberg, P V
PMID:	10778957

148.
Journal:	Eur J Cancer. 2000 May;36(7):916-24.
Title:	Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
Author:	Peters, G J\|van Triest, B\|Backus, H H\|Kuiper, C M\|van der Wilt, C L\|Pinedo, H M
PMID:	10785598

149.
Journal:	Ann Surg Oncol. 2000 Apr;7(3):193-8.
Title:	Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method.
Author:	Takenoue, T\|Nagawa, H\|Matsuda, K\|Fujii, S\|Nita, M E\|Hatano, K\|Kitayama, J\|Tsuruo, T\|Muto, T
PMID:	10791849

150.
Journal:	Cancer Chemother Pharmacol. 2000;45(5):409-16.
Title:	Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Author:	Voeller, D M\|Grem, J L\|Pommier, Y\|Paull, K\|Allegra, C J
PMID:	10803925

151.
Journal:	Jpn J Cancer Res. 2000 Apr;91(4):424-32.
Title:	Schedule-dependent interactions between raltitrexed and cisplatin in human carcinoma cell lines in vitro.
Author:	Kano, Y\|Akutsu, M\|Suzuki, K\|Yazawa, Y\|Tsunoda, S
PMID:	10804291

152.
Journal:	Cancer Res. 2000 May 1;60(9):2365-7.
Title:	Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.
Author:	Banerjee, D\|Gorlick, R\|Liefshitz, A\|Danenberg, K\|Danenberg, P C\|Danenberg, P V\|Klimstra, D\|Jhanwar, S\|Cordon-Cardo, C\|Fong, Y\|Kemeny, N\|Bertino, J R
PMID:	10811110

153.
Journal:	J Histochem Cytochem. 2000 Jun;48(6):755-60.
Title:	Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody.
Author:	Van Triest, B\|Loftus, B M\|Pinedo, H M\|Backus, H H\|Schoenmakers, P\|Telleman, F\|Tadema, T\|Aherne, G W\|Van Groeningen, C J\|Zoetmulder, F A\|Taal, B G\|Johnston, P G\|Peters, G J
PMID:	10820149

154.
Journal:	Gan To Kagaku Ryoho. 2000 May;27(5):703-10.
Title:	[Thymidylate synthase activity after preoperative administration of 5-FU in patients with gastric or colorectal cancer].
Author:	Arima, S\|Tachikawa, D\|Kawahara, K\|Futami, K
PMID:	10832438

155.
Journal:	Stem Cells. 2000;18(3):166-75.
Title:	The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status.
Author:	Papamichael, D
PMID:	10840069

156.
Journal:	Exp Mol Pathol. 2000 Aug;69(1):37-45.
Title:	Postmitotic differentiation of colon carcinoma caco-2 cells does not prevent reentry in the cell cycle and tumorigenicity.
Author:	Pandrea, I V\|Carriere, V\|Barbat, A\|Cambier, D\|Dussaulx, E\|Lesuffleur, T\|Rousset, M\|Zweibaum, A
PMID:	10891291

157.
Journal:	Clin Cancer Res. 2000 Jul;6(7):2707-11.
Title:	Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer.
Author:	Kasahara, M\|Takahashi, Y\|Nagata, T\|Asai, S\|Eguchi, T\|Ishii, Y\|Fujii, M\|Ishikawa, K
PMID:	10914714

158.
Journal:	Eur J Cancer. 2000 Oct;36(15):1998-2006.
Title:	Differential growth inhibition by 5-fluorouracil in human colorectal carcinoma cell lines.
Author:	Tokunaga, E\|Oda, S\|Fukushima, M\|Maehara, Y\|Sugimachi, K
PMID:	11000583

159.
Journal:	Crit Rev Oncol Hematol. 2000 Nov-Dec;36(2-3):141-57.
Title:	The multilayered postconfluent cell culture as a model for drug screening.
Author:	Padron, J M\|van der Wilt, C L\|Smid, K\|Smitskamp-Wilms, E\|Backus, H H\|Pizao, P E\|Giaccone, G\|Peters, G J
PMID:	11033303

160.
Journal:	Ann Oncol. 2000 Aug;11(8):1053-6.
Title:	Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination.
Author:	Cascinu, S\|Catalano, V\|Aschele, C\|Barni, S\|Debernardis, D\|Gallo, L\|Bandelloni, R\|Staccioli, M P\|Baldelli, A M\|Brenna, A\|Valenti, A\|Muretto, P\|Catalano, G
PMID:	11038045

161.
Journal:	Cancer J. 2000 Jul-Aug;6(4):234-42.
Title:	Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines.
Author:	McGinn, C J\|Pestalozzi, B C\|Drake, J C\|Glennon, M C\|Kunugi, K\|Otterson, G\|Allegra, C J\|Johnston, P G\|Kinsella, T J
PMID:	11038143

162.
Journal:	Acta Med Okayama. 2000 Oct;54(5):217-25.
Title:	Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma.
Author:	Funaki, M\|Gouchi, A\|Iwagaki, H\|Morimoto, Y\|Shimamura, H\|Ariki, N\|Tanaka, N
PMID:	11061571

163.
Journal:	Cancer Lett. 2000 Dec 8;161(1):63-71.
Title:	Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system.
Author:	Nakayama, Y\|Sakamoto, H\|Satoh, K\|Yamamoto, T
PMID:	11078914

164.
Journal:	Gan To Kagaku Ryoho. 2000 Oct;27(12):1883-5.
Title:	[Thymidylate synthase and dihydropyrimidine dehydrogenase activity in a metastatic liver tumor from colorectal cancer].
Author:	Umekita, N\|Tanaka, S\|Abe, H\|Kitamura, M
PMID:	11086436

165.
Journal:	Oncology (Williston Park). 2000 Oct;14(10 Suppl 9):35-7.
Title:	Impact of UFT on tumoral TS and DPD levels in colorectal cancer.
Author:	Bastian, G\|Seitz, J F\|Moutardier, V\|Delperro, J R\|Fargeot, P\|Fraisse, J\|Formento, P\|Chazard, M\|Renee, N\|Milano, G
PMID:	11098489

166.
Journal:	Anticancer Res. 2000 Nov-Dec;20(6A):4103-7.
Title:	Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma.
Author:	Tachikawa, D\|Arima, S\|Futami, K
PMID:	11131679

167.
Journal:	Clin Cancer Res. 2000 Dec;6(12):4797-802.
Title:	Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil.
Author:	Aschele, C\|Debernardis, D\|Tunesi, G\|Maley, F\|Sobrero, A
PMID:	11156237

168.
Journal:	Anticancer Res. 2000 Nov-Dec;20(6B):4347-50.
Title:	Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study.
Author:	Sanguedolce, R\|Alessandro, R\|De Leo, G\|Gullotti, L\|Sanguedolce, F\|Vultaggio, G\|Diana, G\|Cirello, B\|Rausa, L
PMID:	11205269

169.
Journal:	Curr Opin Investig Drugs. 2000 Sep;1(1):141-9.
Title:	ZD-9331 AstraZeneca.
Author:	Niculescu-Duvaz, I
PMID:	11249590

170.
Journal:	Oncol Res. 2000;12(5):231-9.
Title:	Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.
Author:	Backus, H H\|Pinedo, H M\|Wouters, D\|Kuiper, C M\|Jansen, G\|van Groeningen, C J\|Peters, G J
PMID:	11417748

171.
Journal:	Zhonghua Wai Ke Za Zhi. 2000 Oct;38(10):781-3.
Title:	[Expression of thymidylate synthase gene and recurrence of colorectal carcinoma: their relation and clinical significance].
Author:	Li, S\|Yu, B\|An, P\|Liang, Z\|Yuan, S
PMID:	11832164

172.
Journal:	Nucleic Acids Res. 2001 Jan 15;29(2):415-22.
Title:	Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells.
Author:	Schmitz, J C\|Yu, D\|Agrawal, S\|Chu, E
PMID:	11139611

173.
Journal:	Biochem Pharmacol. 2001 Jan 15;61(2):179-89.
Title:	Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.
Author:	Lackey, D B\|Groziak, M P\|Sergeeva, M\|Beryt, M\|Boyer, C\|Stroud, R M\|Sayre, P\|Park, J W\|Johnston, P\|Slamon, D\|Shepard, H M\|Pegram, M
PMID:	11163332

174.
Journal:	Jpn J Cancer Res. 2001 Jan;92(1):74-82.
Title:	Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
Author:	Kano, Y\|Akutsu, M\|Tsunoda, S\|Suzuki, K\|Yazawa, Y\|Furukawa, Y
PMID:	11173547

175.
Journal:	Curr Oncol Rep. 2001 Mar;3(2):102-8.
Title:	Determinants of prognosis and response to therapy in colorectal cancer.
Author:	Iqbal, S\|Lenz, H J
PMID:	11177741

176.
Journal:	Mol Pharmacol. 2001 Mar;59(3):446-52.
Title:	A novel approach to thymidylate synthase as a target for cancer chemotherapy.
Author:	Li, Q\|Boyer, C\|Lee, J Y\|Shepard, H M
PMID:	11179438

177.
Journal:	Gastroenterology. 2001 Mar;120(4):874-88.
Title:	Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis.
Author:	Bras-Goncalves, R A\|Pocard, M\|Formento, J L\|Poirson-Bichat, F\|De Pinieux, G\|Pandrea, I\|Arvelo, F\|Ronco, G\|Villa, P\|Coquelle, A\|Milano, G\|Lesuffleur, T\|Dutrillaux, B\|Poupon, M F
PMID:	11231942

178.
Journal:	J Clin Oncol. 2001 Mar 15;19(6):1779-86.
Title:	Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer.
Author:	Villafranca, E\|Okruzhnov, Y\|Dominguez, M A\|Garcia-Foncillas, J\|Azinovic, I\|Martinez, E\|Illarramendi, J J\|Arias, F\|Martinez Monge, R\|Salgado, E\|Angeletti, S\|Brugarolas, A
PMID:	11251009

179.
Journal:	J Biol Chem. 2001 Apr 27;276(17):14170-7.
Title:	Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
Author:	Phan, J\|Steadman, D J\|Koli, S\|Ding, W C\|Minor, W\|Dunlap, R B\|Berger, S H\|Lebioda, L
PMID:	11278511

180.
Journal:	Cancer. 2001 Apr 1;91(7):1256-63.
Title:	Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma.
Author:	Meropol, N J\|Niedzwiecki, D\|Hollis, D\|Schilsky, R L\|Mayer, R J
PMID:	11283924

181.
Journal:	Oncol Rep. 2001 May-Jun;8(3):497-500.
Title:	Molecular markers and prediction of response to chemoradiation in rectal cancer.
Author:	Okonkwo, A\|Musunuri, S\|Talamonti, M\|Benson, A 3rd\|Small, W Jr\|Stryker, S J\|Rao, M S
PMID:	11295069

182.
Journal:	Oncology (Williston Park). 2001 Mar;15(3 Suppl 6):52-60.
Title:	Novel approaches in the treatment of non-small-cell lung cancer.
Author:	Rosell, R\|Sanchez, J M\|Taron, M\|O'Brate, A\|Gutierrez, J L\|Monzo, M\|Felip, E\|Sanchez, J J\|Alberola, V
PMID:	11301850

183.
Journal:	Eur J Cancer. 2001 May;37(7):826-34.
Title:	Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.
Author:	Cunningham, D\|James, R D
PMID:	11313169

184.
Journal:	Cancer Res. 2001 May 1;61(9):3675-81.
Title:	Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Author:	van der Wilt, C L\|Backus, H H\|Smid, K\|Comijn, L\|Veerman, G\|Wouters, D\|Voorn, D A\|Priest, D G\|Bunni, M A\|Mitchell, F\|Jackman, A L\|Jansen, G\|Peters, G J
PMID:	11325838

185.
Journal:	Biochemistry. 2001 Feb 20;40(7):1897-902.
Title:	Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Author:	Phan, J\|Koli, S\|Minor, W\|Dunlap, R B\|Berger, S H\|Lebioda, L
PMID:	11329255

186.
Journal:	Gan To Kagaku Ryoho. 2001 May;28(5):661-7.
Title:	[Correlation between 5-fluorouracil (5-FU) sensitivity as measured by collagen gel droplet embedded culture drug sensitivity test (CD-DST) and expression of orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), and dihydropyrimidine dehydr
Author:	Ochiai, T\|Sugitani, M\|Nishimura, K\|Noguchi, H\|Watanabe, T\|Sengoku, H\|Kihara, A\|Okano, M
PMID:	11383215

187.
Journal:	Int J Oncol. 2001 Aug;19(2):341-6.
Title:	Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion.
Author:	Uchida, K\|Hayashi, K\|Kuramochi, H\|Takasaki, K
PMID:	11445849

188.
Journal:	Int J Oncol. 2001 Aug;19(2):383-6.
Title:	Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer.
Author:	Marsh, S\|McKay, J A\|Cassidy, J\|McLeod, H L
PMID:	11445856

189.
Journal:	Ann Oncol. 2001 Jun;12(6):779-85.
Title:	Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.
Author:	Backus, H H\|van Riel, J M\|van Groeningen, C J\|Vos, W\|Dukers, D F\|Bloemena, E\|Wouters, D\|Pinedo, H M\|Peters, G J
PMID:	11484952

190.
Journal:	Br J Cancer. 2001 Sep 14;85(6):827-30.
Title:	A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil.
Author:	Iacopetta, B\|Grieu, F\|Joseph, D\|Elsaleh, H
PMID:	11556832

191.
Journal:	J Clin Oncol. 2001 Dec 1;19(23):4298-304.
Title:	ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy.
Author:	Shirota, Y\|Stoehlmacher, J\|Brabender, J\|Xiong, Y P\|Uetake, H\|Danenberg, K D\|Groshen, S\|Tsao-Wei, D D\|Danenberg, P V\|Lenz, H J
PMID:	11731512

192.
Journal:	Br J Cancer. 2001 Dec 14;85(12):1937-43.
Title:	Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma.
Author:	Wong, N A\|Brett, L\|Stewart, M\|Leitch, A\|Longley, D B\|Dunlop, M G\|Johnston, P G\|Lessells, A M\|Jodrell, D I
PMID:	11747337

193.
Journal:	Clin Cancer Res. 2001 Dec;7(12):4096-101.
Title:	Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression.
Author:	Kawakami, K\|Salonga, D\|Park, J M\|Danenberg, K D\|Uetake, H\|Brabender, J\|Omura, K\|Watanabe, G\|Danenberg, P V
PMID:	11751507

194.
Journal:	J Chemother. 2001 Oct;13(5):519-26.
Title:	In vitro generation of cytotoxic T lymphocytes against HLA-A2.1-restricted peptides derived from human thymidylate synthase.
Author:	Correale, P\|Sabatino, M\|Cusi, M G\|Micheli, L\|Nencini, C\|Pozzessere, D\|Petrioli, R\|Aquino, A\|De Vecchis, L\|Turriziani, M\|Prete, S P\|Sanguedolce, R\|Rausa, L\|Giorgi, G\|Francini, G
PMID:	11760216

195.
Journal:	Am J Clin Oncol. 2001 Dec;24(6):597-602.
Title:	Thymidylate synthase expression in stage II and III colon cancer: a retrospective review.
Author:	Tomiak, A\|Vincent, M\|Earle, C C\|Johnston, P G\|Kocha, W\|Taylor, M\|Maroun, J\|Eidus, L\|Whiston, F\|Stitt, L
PMID:	11801762

196.
Journal:	Lancet Oncol. 2001 May;2(5):298-306.
Title:	Pemetrexed disodium, a novel antifolate with multiple targets.
Author:	Curtin, N J\|Hughes, A N
PMID:	11905785

197.
Journal:	Pharmacogenomics J. 2001;1(1):65-70.
Title:	Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy.
Author:	Pullarkat, S T\|Stoehlmacher, J\|Ghaderi, V\|Xiong, Y P\|Ingles, S A\|Sherrod, A\|Warren, R\|Tsao-Wei, D\|Groshen, S\|Lenz, H J
PMID:	11913730

198.
Journal:	Clin Colorectal Cancer. 2001 Aug;1(2):121-7.
Title:	Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments.
Author:	Backus, H H\|Rustum, Y M\|van Groeningen, C J\|Peters, G J
PMID:	12445371

199.
Journal:	Clin Colorectal Cancer. 2001 Nov;1(3):175-8; discussion 179-81.
Title:	Thymidylate synthase pharmacogenetics in colorectal cancer.
Author:	Marsh, S\|McLeod, H L
PMID:	12450432

200.
Journal:	Clin Colorectal Cancer. 2001 Nov;1(3):179-180.
Title:	Thymidylate Synthase Pharmacogenetics in Colorectal Cancer.
Author:	Copur, M Sitki\|Chu, Edward
PMID:	12450433

201.
Journal:	Clin Cancer Res. 2002 Jan;8(1):233-9.
Title:	In Vitro schedule-dependent interactions between the multitargeted antifolate LY231514 and gemcitabine in human colon adenocarcinoma cell lines.
Author:	Tesei, Anna\|Ricotti, Luca\|De Paola, Franca\|Amadori, Dino\|Frassineti, Giovanni L\|Zoli, Wainer
PMID:	11801564

202.
Journal:	Oncol Rep. 2002 Mar-Apr;9(2):231-4.
Title:	Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis.
Author:	Marsh, Sharon\|McKay, Judith A\|Curran, Stephanie\|Murray, Graeme I\|Cassidy, James\|McLeod, Howard L
PMID:	11836585

203.
Journal:	Oncology. 2002;62(2):167-74.
Title:	Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Author:	Kralovanszky, Judit\|Koves, Istvan\|Orosz, Zolst\|Katona, Csilla\|Toth, Katalin\|Rahoty, Pal\|Czegledi, Ferenc\|Kovacs, Tibor\|Budai, Barna\|Hullan, Lehel\|Jeney, Andras
PMID:	11914603

204.
Journal:	Anticancer Drugs. 2002 Jan;13(1):29-36.
Title:	Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Author:	Boyer, Christopher R\|Karjian, Patricia L\|Wahl, Geoffrey M\|Pegram, Mark\|Neuteboom, Saskia T C
PMID:	11914638

205.
Journal:	J Clin Oncol. 2002 Apr 1;20(7):1721-8.
Title:	Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy.
Author:	Edler, David\|Glimelius, Bengt\|Hallstrom, Marja\|Jakobsen, Anders\|Johnston, Patrick G\|Magnusson, Inger\|Ragnhammar, Peter\|Blomgren, Henric
PMID:	11919227

206.
Journal:	J Clin Oncol. 2002 Apr 1;20(7):1735-43.
Title:	Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer.
Author:	Allegra, Carmen J\|Parr, Allyson L\|Wold, Lester E\|Mahoney, Michelle R\|Sargent, Daniel J\|Johnston, Patrick\|Klein, Pam\|Behan, Katie\|O'Connell, Michael J\|Levitt, Ralph\|Kugler, John W\|Tria Tirona, Maria\|Goldberg, Richard M
PMID:	11919229

207.
Journal:	Br J Cancer. 2002 Apr 22;86(8):1365; author reply 1366.
Title:	Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil.
Author:	Ulrich, C M\|Potter, J D
PMID:	11953901

208.
Journal:	Anticancer Res. 2002 Jan-Feb;22(1A):339-41.
Title:	Human colorectal malignancy and oral UFT.
Author:	Sakamoto, Shinobu\|Tsukada, Kunio\|Sagara, Tetsuro\|Kawachi, Yasuyuki\|Murakami, Saburo\|Iwama, Takeo
PMID:	12017314

209.
Journal:	Int J Colorectal Dis. 2002 Jan;17(1):46-9.
Title:	Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer.
Author:	Park, David J\|Stoehlmacher, Jan\|Zhang, Wu\|Tsao-Wei, Denice\|Groshen, Susan\|Lenz, Heinz-Josef
PMID:	12018454

210.
Journal:	Semin Oncol. 2002 Apr;29(2 Suppl 5):23-9.
Title:	Pemetrexed combination therapy in the treatment of non-small cell lung cancer.
Author:	Rosell, Rafael\|Crino, Lucio
PMID:	12023789

211.
Journal:	Cancer Treat Rev. 2002 Feb;28(1):27-47.
Title:	Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer.
Author:	Aschele, C\|Lonardi, S\|Monfardini, S
PMID:	12027413

212.
Journal:	Biochim Biophys Acta. 2002 Jul 18;1587(2-3):194-205.
Title:	Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Author:	Peters, G J\|Backus, H H J\|Freemantle, S\|van Triest, B\|Codacci-Pisanelli, G\|van der Wilt, C L\|Smid, K\|Lunec, J\|Calvert, A H\|Marsh, S\|McLeod, H L\|Bloemena, E\|Meijer, S\|Jansen, G\|van Groeningen, C J\|Pinedo, H M
PMID:	12084461

213.
Journal:	Gan To Kagaku Ryoho. 2002 Jun;29(6):889-93.
Title:	[Dihydropyrimidine dehydrogenase and thymidylate synthase in colon carcinoma].
Author:	Hamaji, Masayasu\|Nishida, Toshiroh\|Miyazaki, Satoru\|Nishida, Yukihiro
PMID:	12090040

214.
Journal:	Curr Drug Targets. 2002 Aug;3(4):297-309.
Title:	The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.
Author:	Berg, Randal W\|Ferguso, Peter J\|DeMoor, Janice M\|Vincen, Mark D\|Koropatnick, James
PMID:	12102601

215.
Journal:	Int J Oncol. 2002 Aug;21(2):361-7.
Title:	Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.
Author:	Raymond, Eric\|Louvet, Christophe\|Tournigand, Christophe\|Coudray, Anne Marie\|Faivre, Sandrine\|De Gramont, Aimery\|Gespach, Christian
PMID:	12118332

216.
Journal:	Br J Cancer. 2002 Oct 7;87(8):868-75.
Title:	Role of biological markers in the clinical outcome of colon cancer.
Author:	Nanni, O\|Volpi, A\|Frassineti, G L\|De Paola, F\|Granato, A M\|Dubini, A\|Zoli, W\|Scarpi, E\|Turci, D\|Oliverio, G\|Gambi, A\|Amadori, D
PMID:	12373601

217.
Journal:	Br J Surg. 2002 Nov;89(11):1409-15.
Title:	p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer.
Author:	Saw, R P M\|Koorey, D\|Painter, D\|Gallagher, P J\|Solomon, M J
PMID:	12390383

218.
Journal:	Semin Oncol. 2002 Oct;29(5 Suppl 15):34-9.
Title:	The role of oxaliplatin in the treatment of advanced metastatic colorectal cancer: prospects and future directions.
Author:	Schmoll, H J
PMID:	12422306

219.
Journal:	Expert Opin Investig Drugs. 2002 Dec;11(12):1775-87.
Title:	Future potential of thymidylate synthase inhibitors in cancer therapy.
Author:	Lehman, Norman L
PMID:	12457437

220.
Journal:	Jpn J Cancer Res. 2002 Nov;93(11):1221-9.
Title:	Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity.
Author:	Kawakami, Kazuyuki\|Ishida, Yoshinori\|Danenberg, Kathleen D\|Omura, Kenji\|Watanabe, Go\|Danenberg, Peter V
PMID:	12460463

221.
Journal:	Mol Cancer Ther. 2002 Apr;1(6):377-84.
Title:	Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
Author:	Neuteboom, Saskia T C\|Karjian, Patricia L\|Boyer, Christopher R\|Beryt, Malgorzhata\|Pegram, Mark\|Wahl, Geoffrey M\|Shepard, H Michael
PMID:	12477050

222.
Journal:	Clin Colorectal Cancer. 2002 Nov;2(3):182-8.
Title:	Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance.
Author:	Xu, Jian-Ming\|Azzariti, Amalia\|Tommasi, Stefania\|Lacalamita, Rosanna\|Colucci, Giuseppe\|Johnston, Patrick G\|Church, Stewart W\|Paradiso, Angelo
PMID:	12482336

223.
Journal:	J Histochem Cytochem. 2002 Dec;50(12):1633-40.
Title:	Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice.
Author:	Derenzini, Massimo\|Montanaro, Lorenzo\|Chilla, Alessandra\|Tosti, Elena\|Ceccarelli, Claudio\|Dall'Olio, Fabio\|Ofner, Dietmar\|Trere, Davide
PMID:	12486085

224.
Journal:	Anticancer Res. 2002 Sep-Oct;22(5):2805-9.
Title:	Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer.
Author:	Ishida, Yoshinori\|Kawakami, Kazuyuki\|Tanaka, Yoko\|Kanehira, Eiji\|Omura, Kenji\|Watanabe, Go
PMID:	12530000

225.
Journal:	Anticancer Res. 2002 Sep-Oct;22(5):3113-6.
Title:	Thymidylate synthase expression in rectal cancer and proliferation, assessed by cyclin A and Ki-67 expression.
Author:	Edler, David\|Hallstrom, Marja\|Ragnhammar, Peter\|Blomgren, Henric
PMID:	12530053

226.
Journal:	Anticancer Res. 2002 Nov-Dec;22(6B):3537-40.
Title:	Different pathways of 5-fluorouracil metabolism after continuous venous or bolus injection in patients with colon carcinoma: possible predictive value of thymidylate synthetase mRNA and ribonucleotide reductase for 5-fluorouracil sensitivity.
Author:	Kubota, Tetsuro\|Watanabe, Masahiko\|Otani, Yoshihide\|Kitajima, Masaki\|Fukushiuma, Masakazu
PMID:	12552952

227.
Journal:	Semin Oncol. 2002 Dec;29(6 Suppl 18):54-6.
Title:	The role of pemetrexed in the treatment of colorectal cancer.
Author:	Hochster, Howard
PMID:	12571812

228.
Journal:	Oncol Rep. 2003 Jan-Feb;10(1):109-13.
Title:	Differential effects of two fluorouracil administration regimens for colorectal cancer.
Author:	Matsusaka, Satoshi\|Yamasaki, Hajime\|Kitayama, Yoshihiro\|Okada, Toshihiro\|Maeda, Shigeto
PMID:	12469154

229.
Journal:	Clin Cancer Res. 2003 Feb;9(2):786-91.
Title:	Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.
Author:	Ichikawa, Wataru\|Uetake, Hiroyuki\|Shirota, Yoshinori\|Yamada, Hiroyuki\|Nishi, Naoto\|Nihei, Zenro\|Sugihara, Kenichi\|Hirayama, Renzo
PMID:	12576451

230.
Journal:	Clin Cancer Res. 2003 Feb;9(2):792-801.
Title:	Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
Author:	Farrugia, David C\|Ford, Hugo E R\|Cunningham, David\|Danenberg, Kathleen D\|Danenberg, Peter V\|Brabender, Jan\|McVicar, A David\|Aherne, G Wynne\|Hardcastle, Anthea\|McCarthy, Keith\|Jackman, Ann L
PMID:	12576452

231.
Journal:	Dis Colon Rectum. 2003 Feb;46(2):192-202.
Title:	p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy.
Author:	Saw, Robyn P M\|Morgan, Matthew\|Koorey, David\|Painter, Dorothy\|Findlay, Michael\|Stevens, Graham\|Clarke, Stephen\|Chapuis, Pierre\|Solomon, Michael J
PMID:	12576893

232.
Journal:	J Clin Oncol. 2003 Mar 1;21(5):815-9.
Title:	Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites.
Author:	Johnston, Patrick G\|Benson, Al B 3rd\|Catalano, Paul\|Rao, M Sambasiva\|O'Dwyer, Peter J\|Allegra, Carmen J
PMID:	12610179

233.
Journal:	Cancer Chemother Pharmacol. 2003 Feb;51(2):155-60.
Title:	Correlation between clinicopathologic factors and kinetics of metabolic enzymes for 5-fluorouracil given to patients with colon carcinoma by two different dosage regimens.
Author:	Katsumata, Kenji\|Tomioka, Hidenori\|Sumi, Tetsuo\|Yamashita, Shinya\|Takagi, Makoto\|Kato, Fumiaki\|Nakamura, Ryuji\|Koyanagi, Yasuhisa\|Aoki, Tatsuya\|Kato, Kohichiro
PMID:	12647017

234.
Journal:	Anticancer Res. 2003 Jan-Feb;23(1A):447-52.
Title:	Cytotoxic effects and mechanisms of an alteration in the dose and duration of 5-fluorouracil.
Author:	Patel, Manish\|Ardalan, Katherine\|Hochman, Ian\|Tian, Er-Ming\|Ardalan, Bach
PMID:	12680247

235.
Journal:	Hum Gene Ther. 2003 Mar 20;14(5):435-46.
Title:	Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil.
Author:	Capiaux, Gina M\|Budak-Alpdogan, Tulin\|Takebe, Naoko\|Mayer-Kuckuk, Philipp\|Banerjee, Debabrata\|Maley, Frank\|Bertino, Joseph R
PMID:	12691609

236.
Journal:	Int J Clin Oncol. 2003 Apr;8(2):72-8.
Title:	Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma.
Author:	Fujii, Ryuta\|Seshimo, Akiyoshi\|Kameoka, Shingo
PMID:	12720098

237.
Journal:	Expert Opin Investig Drugs. 2003 May;12(5):853-63.
Title:	Pemetrexed and its emerging role in the treatment of thoracic malignancies.
Author:	Scagliotti, Giorgio V\|Novello, Silvia
PMID:	12720495

238.
Journal:	Gan To Kagaku Ryoho. 2003 Apr;30(4):495-500.
Title:	[Thymidine phosphorylase is correlated with DPD in colon cancer].
Author:	Hamaji, Masayasu\|Nishida, Toshiroh\|Miyazaki, Satoru\|Nishida, Yukihiro
PMID:	12722680

239.
Journal:	Am J Pharmacogenomics. 2003;3(2):73-88.
Title:	Implications of genetic testing in the management of colorectal cancer.
Author:	Stoehlmacher, Jan\|Lenz, Heinz-Josef
PMID:	12749725

240.
Journal:	Eur J Cancer. 2003 Jun;39(9):1310-7.
Title:	Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
Author:	Backus, H H J\|Wouters, D\|Ferreira, C G\|van Houten, V M M\|Brakenhoff, R H\|Pinedo, H M\|Peters, G J
PMID:	12763222

241.
Journal:	Mol Cancer Ther. 2003 Jun;2(6):535-41.
Title:	mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Author:	Sowers, Rebecca\|Toguchida, Junya\|Qin, Jing\|Meyers, Paul A\|Healey, John H\|Huvos, Andrew\|Banerjee, Debabrata\|Bertino, Joseph R\|Gorlick, Richard
PMID:	12813132

242.
Journal:	Cancer Sci. 2003 Jul;94(7):633-8.
Title:	Gene expression in colorectal cancer and in vitro chemosensitivity to 5-fluorouracil: a study of 88 surgical specimens.
Author:	Yoshinare, Kentaro\|Kubota, Tetsuro\|Watanabe, Masahiko\|Wada, Norihito\|Nishibori, Hideki\|Hasegawa, Hirotoshi\|Kitajima, Masaki\|Takechi, Teiji\|Fukushima, Masakazu
PMID:	12841874

243.
Journal:	Ann Oncol. 2003 Jul;14(7):1026-38.
Title:	Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?
Author:	Graziano, F\|Cascinu, S
PMID:	12853343

244.
Journal:	J Int Med Res. 2003 May-Jun;31(3):181-7.
Title:	Intratumoural thymidylate synthase and dihydropyrimidine dehydrogenase activities are good predictors of 5-fluorouracil sensitivity in colorectal cancer.
Author:	Ishibiki, Y\|Kitajima, M\|Sakamoto, K\|Tomiki, Y\|Sakamoto, S\|Kamano, T
PMID:	12870370

245.
Journal:	Oncol Rep. 2003 Sep-Oct;10(5):1081-90.
Title:	Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial.
Author:	Sakamoto, Junichi\|Hamashima, Hiroshi\|Suzuki, Harumi\|Ito, Katsuki\|Mai, Masayoshi\|Saji, Shigetoyo\|Fukushima, Masakazu\|Matsushita, Yasuyuki\|Nakazato, Hiroaki
PMID:	12883662

246.
Journal:	Oncol Rep. 2003 Sep-Oct;10(5):1425-9.
Title:	Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival.
Author:	Tanaka-Nozaki, Motoko\|Tajiri, Takashi\|Tanaka, Noritake\|Furukawa, Kiyonori\|Takasaki, Hideaki\|Yoshimura, Kazuyasu\|Suzuki, Hideyuki\|Naito, Zenya\|Sugizaki, Yuuichi\|Merk, Hans F\|Blomeke, Brunhilde\|Kato, Shunji
PMID:	12883718

247.
Journal:	Clin Cancer Res. 2003 Sep 15;9(11):4116-24.
Title:	Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil.
Author:	Kornmann, Marko\|Schwabe, Wolfgang\|Sander, Silvia\|Kron, Martina\|Strater, Jorn\|Polat, Sucan\|Kettner, Erika\|Weiser, Hans F\|Baumann, Wolfram\|Schramm, Harald\|Hausler, Peter\|Ott, Kati\|Behnke, Detlev\|Staib, Ludger\|Beger, Hans G\|Link, Karl H
PMID:	14519634

248.
Journal:	Clin Cancer Res. 2003 Sep 15;9(11):4165-71.
Title:	Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer.
Author:	Hu, Ying Chuan\|Komorowski, Richard A\|Graewin, Shannon\|Hostetter, Galen\|Kallioniemi, Olli-P\|Pitt, Henry A\|Ahrendt, Steven A
PMID:	14519641

249.
Journal:	Cancer Res. 2003 Sep 15;63(18):6004-7.
Title:	Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene.
Author:	Kawakami, Kazuyuki\|Watanabe, Go
PMID:	14522928

250.
Journal:	Nihon Rinsho. 2003 Sep;61 Suppl 7:480-6.
Title:	[Significance of thymidylate synthase and dihydropyrimidine dehydrogenase activity in colon cancer].
Author:	Hasuo, Kimiatsu
PMID:	14574940

251.
Journal:	Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):958-62.
Title:	Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer.
Author:	Chen, Jia\|Hunter, David J\|Stampfer, Meir J\|Kyte, Charles\|Chan, Wendy\|Wetmur, James G\|Mosig, Rebecca\|Selhub, Jacob\|Ma, Jing
PMID:	14578129

252.
Journal:	Int J Mol Med. 2003 Dec;12(6):839-44.
Title:	Population study of expression of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with solid tumors.
Author:	Fukushima, Masakazu\|Morita, Masao\|Ikeda, Kazumasa\|Nagayama, Sekio
PMID:	14612954

253.
Journal:	Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5860-5.
Title:	The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase.
Author:	Kawakami, Kazuyuki\|Ruszkiewicz, Andrew\|Bennett, Graeme\|Moore, James\|Watanabe, Go\|Iacopetta, Barry
PMID:	14676107

254.
Journal:	Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):6012-9.
Title:	Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
Author:	Odin, Elisabeth\|Wettergren, Yvonne\|Nilsson, Staffan\|Willen, Roger\|Carlsson, Goran\|Spears, C Paul\|Larsson, Lars\|Gustavsson, Bengt
PMID:	14676127

255.
Journal:	Gan To Kagaku Ryoho. 2003 Dec;30(13):2077-81.
Title:	[Effect and mechanism of orally administered leucovorin/5-fluorouracil on colon cancer].
Author:	Iba, Toshiaki\|Kidokoro, Akio\|Fukunaga, Masaki\|Sugiyama, Kazuyoshi\|Fukunaga, Tetsu\|Aihara, Nobuyoshi
PMID:	14712768

256.
Journal:	Cancer Chemother Pharmacol. 2004 Mar;53(3):225-32.
Title:	Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.
Author:	Sakoff, Jennette A\|Howitt, Ian J\|Ackland, Stephen P\|McCluskey, Adam
PMID:	14648018

257.
Journal:	Ann Oncol. 2004 Jan;15(1):55-8.
Title:	Lack of correlation between immunohistochemical expression of E2F-1, thymidylate synthase expression and clinical response to 5-fluorouracil in advanced colorectal cancer.
Author:	Belvedere, O\|Puglisi, F\|Di Loreto, C\|Cataldi, P\|Guglielmi, A\|Aschele, C\|Sobrero, A
PMID:	14679120

258.
Journal:	Int J Cancer. 2004 Mar 1;108(6):852-6.
Title:	Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients.
Author:	Adleff, Vilmos\|Hitre, Erika\|Koves, Istvan\|Orosz, Zsolt\|Hajnal, Anna\|Kralovanszky, Judit
PMID:	14712487

259.
Journal:	Biochim Biophys Acta. 2004 Jan 14;1696(1):15-22.
Title:	Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase.
Author:	Berger, Sondra H\|Berger, Franklin G\|Lebioda, Lukasz
PMID:	14726200

260.
Journal:	Cancer Biol Ther. 2004 Apr;3(4):395-9. Epub 2004 Apr 29.
Title:	Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification.
Author:	Iwamoto, Marian\|Banerjee, Debabrata\|Menon, Lata G\|Jurkiewicz, Anna\|Rao, Pulivarthi H\|Kemeny, Nancy E\|Fong, Yuman\|Jhanwar, Suresh C\|Gorlick, Richard\|Bertino, Joseph R
PMID:	14726656

261.
Journal:	J Clin Oncol. 2004 Feb 1;22(3):529-36.
Title:	Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis.
Author:	Popat, Sanjay\|Matakidou, Athena\|Houlston, Richard S
PMID:	14752076

262.
Journal:	Clin Cancer Res. 2004 Jan 15;10(2):433-9.
Title:	Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene.
Author:	Uchida, Kazumi\|Hayashi, Kazuhiko\|Kawakami, Kazuyuki\|Schneider, Sylke\|Yochim, Ji Min\|Kuramochi, Hidekazu\|Takasaki, Ken\|Danenberg, Kathleen D\|Danenberg, Peter V
PMID:	14760062

263.
Journal:	Eur J Cancer. 2004 Mar;40(4):508-14.
Title:	Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer.
Author:	Veronese, M L\|Stevenson, J P\|Sun, W\|Redlinger, M\|Algazy, K\|Giantonio, B\|Hahn, S\|Vaughn, D\|Thorn, C\|Whitehead, A S\|Haller, D G\|O'Dwyer, P J
PMID:	14962716

264.
Journal:	Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3089-94. Epub 2004 Feb 17.
Title:	Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Author:	Wang, Tian-Li\|Diaz, Luis A Jr\|Romans, Katharine\|Bardelli, Alberto\|Saha, Saurabh\|Galizia, Gennaro\|Choti, Michael\|Donehower, Ross\|Parmigiani, Giovanni\|Shih, Ie-Ming\|Iacobuzio-Donahue, Christine\|Kinzler, Kenneth W\|Vogelstein, Bert\|Lengauer, Christoph\|Velcule
PMID:	14970324

265.
Journal:	Am J Epidemiol. 2004 Mar 1;159(5):423-43.
Title:	Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
Author:	Sharp, Linda\|Little, Julian
PMID:	14977639

266.
Journal:	Oncol Rep. 2004 Apr;11(4):839-43.
Title:	Associations between polymorphisms in the thymidylate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer.
Author:	Merkelbach-Bruse, Sabine\|Hans, Volkmar\|Mathiak, Micaela\|Sanguedolce, Rosario\|Alessandro, Riccardo\|Ruschoff, Josef\|Buttner, Reinhard\|Houshdaran, Farzad\|Gullotti, Lucia
PMID:	15010882

267.
Journal:	Clin Colorectal Cancer. 2004 Feb;3(4):225-34.
Title:	Dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms and their association with 5-fluorouracil/leucovorin chemotherapy in colorectal cancer.
Author:	Zhu, Andrew X\|Puchalski, Thomas A\|Stanton, Vincent P Jr\|Ryan, David P\|Clark, Jeffrey W\|Nesbitt, Steven\|Charlat, Olga\|Kelly, Patrick\|Kreconus, Elaine\|Chabner, Bruce A\|Supko, Jeffrey G
PMID:	15025795

268.
Journal:	BMC Cancer. 2004 Mar 25;4:11.
Title:	Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy.
Author:	Libra, Massimo\|Navolanic, Patrick M\|Talamini, Renato\|Cecchin, Erica\|Sartor, Franca\|Tumolo, Salvatore\|Masier, Sara\|Travali, Salvatore\|Boiocchi, Mauro\|Toffoli, Giuseppe
PMID:	15040806

269.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):401-10.
Title:	Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.
Author:	Gmeiner, William H\|Trump, Eric\|Wei, Cui
PMID:	15043163

270.
Journal:	Anticancer Drugs. 2004 Apr;15(4):371-6.
Title:	Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells.
Author:	Yeh, Kun-Huei\|Cheng, Ann-Lii\|Wan, Joeu-Pei\|Lin, Chien-Shing\|Liu, Chih-Chun
PMID:	15057142

271.
Journal:	Cancer Chemother Pharmacol. 2004 May;53(5):391-6.
Title:	Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis.
Author:	Inokuchi, Mikito\|Uetake, Hiroyuki\|Shirota, Yoshinori\|Yamada, Hiroyuki\|Tajima, Masayuki\|Sugihara, Kenichi
PMID:	15060742

272.
Journal:	Int J Oncol. 2004 May;24(5):1279-88.
Title:	Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil.
Author:	de Angelis, Paula M\|Fjell, Bjorg\|Kravik, Katherine L\|Haug, Terje\|Tunheim, Siv H\|Reichelt, Wenche\|Beigi, Marzieh\|Clausen, Ole Petter\|Galteland, Eivind\|Stokke, Trond
PMID:	15067352

273.
Journal:	Pharmacogenetics. 2004 May;14(5):319-27.
Title:	A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels.
Author:	Mandola, Michael V\|Stoehlmacher, Jan\|Zhang, Wu\|Groshen, Susan\|Yu, Mimi C\|Iqbal, Syma\|Lenz, Heinz-Josef\|Ladner, Robert D
PMID:	15115918

274.
Journal:	Clin Cancer Res. 2004 May 15;10(10):3562-71.
Title:	The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.
Author:	Longley, Daniel Broderick\|Allen, Wendy Louise\|McDermott, Ultan\|Wilson, Timothy Richard\|Latif, Tariq\|Boyer, John\|Lynch, Maria\|Johnston, Patrick Gerard
PMID:	15161716

275.
Journal:	Curr Opin Oncol. 2004 Jul;16(4):378-84.
Title:	Hepatic arterial chemotherapy for colorectal cancer liver metastases: a review of advances in 2003.
Author:	Chan, Ray\|Kerr, David
PMID:	15187894

276.
Journal:	Int J Cancer. 2004 Aug 20;111(2):252-8.
Title:	Topoisomerase-I, thymidylate synthase primary tumour expression and clinical efficacy of 5-FU/CPT-11 chemotherapy in advanced colorectal cancer patients.
Author:	Paradiso, Angelo\|Xu, JanMing\|Mangia, Anita\|Chiriatti, Annalisa\|Simone, Gianni\|Zito, Alfredo\|Montemurro, Severino\|Giuliani, Francesco\|Maiello, Evaristo\|Colucci, Giuseppe
PMID:	15197779

277.
Journal:	Br J Cancer. 2004 Jul 19;91(2):344-54.
Title:	A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer.
Author:	Stoehlmacher, J\|Park, D J\|Zhang, W\|Yang, D\|Groshen, S\|Zahedy, S\|Lenz, H-J
PMID:	15213713

278.
Journal:	Gan To Kagaku Ryoho. 2004 Jun;31(6):889-92.
Title:	[Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method].
Author:	Nagano, Hiroto\|Ichikawa, Wataru\|Simizu, Michio\|Shirota, Yoshinori\|Nihei, Zenro
PMID:	15222106

279.
Journal:	Int J Oncol. 2004 Sep;25(3):571-8.
Title:	A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Author:	Emura, Tomohiro\|Suzuki, Norihiko\|Yamaguchi, Masahiro\|Ohshimo, Hideyuki\|Fukushima, Masakazu
PMID:	15289858

280.
Journal:	Cancer Res. 2004 Sep 1;64(17):6296-303.
Title:	P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Author:	Geller, James I\|Szekely-Szucs, Kinga\|Petak, Istvan\|Doyle, Belinda\|Houghton, Janet A
PMID:	15342418

281.
Journal:	Int J Cancer. 2004 Nov 1;112(2):200-12.
Title:	Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling.
Author:	Schmidt, Wolfgang M\|Kalipciyan, Maria\|Dornstauder, Eva\|Rizovski, Blanka\|Steger, Guenther G\|Sedivy, Roland\|Mueller, Manfred W\|Mader, Robert M
PMID:	15352031

282.
Journal:	Front Biosci. 2004 Sep 1;9:2467-73.
Title:	Thymidylate synthase: a critical target in cancer therapy?
Author:	Rustum, Youcef M
PMID:	15353299

283.
Journal:	Clin Cancer Res. 2004 Sep 1;10(17):5828-36.
Title:	Two proliferation-related proteins, TYMS and PGK1, could be new cytotoxic T lymphocyte-directed tumor-associated antigens of HLA-A2+ colon cancer.
Author:	Shichijo, Shigeki\|Azuma, Kouichi\|Komatsu, Nobukazu\|Ito, Masaaki\|Maeda, Yoshiaki\|Ishihara, Yuki\|Itoh, Kyogo
PMID:	15355913

284.
Journal:	Clin Cancer Res. 2004 Sep 1;10(17):5880-8.
Title:	Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy.
Author:	Lecomte, Thierry\|Ferraz, Jean-Marc\|Zinzindohoue, Franck\|Loriot, Marie-Anne\|Tregouet, David-Alexandre\|Landi, Bruno\|Berger, Anne\|Cugnenc, Paul-Henri\|Jian, Raymond\|Beaune, Philippe\|Laurent-Puig, Pierre
PMID:	15355920

285.
Journal:	Int J Oncol. 2004 Oct;25(4):877-85.
Title:	Thymidylate synthase expression pattern is a prognostic factor in patients of colorectal cancer treated with 5-fluorouracil.
Author:	Fernandez-Contreras, Maria-Encarnacion\|Jimenez De Ayala, Beatriz\|Garcia De Paredes, Maria-Luisa\|Velasco, Amalia\|Majano, Pedro L\|Palacios, Jose\|Gamallo, Carlos
PMID:	15375535

286.
Journal:	Clin Colorectal Cancer. 2004 Sep;4(3):190-5.
Title:	The role of pemetrexed in the treatment of gastrointestinal malignancy.
Author:	Hochster, Howard S
PMID:	15377402

287.
Journal:	Int J Cancer. 2004 Dec 10;112(5):733-7.
Title:	Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.
Author:	Marcuello, Eugenio\|Altes, Albert\|del Rio, Elisabeth\|Cesar, Angeles\|Menoyo, Anna\|Baiget, Montserrat
PMID:	15386371

288.
Journal:	Clin Cancer Res. 2004 Oct 1;10(19):6669-76.
Title:	Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.
Author:	Eiseman, Julie L\|Brown-Proctor, Clive\|Kinahan, Paul E\|Collins, Jerry M\|Anderson, Lawrence W\|Joseph, Erin\|Hamburger, Deborah R\|Pan, Su-Shu\|Mathis, Chester A\|Egorin, Merrill J\|Klecker, Raymond W
PMID:	15475457

289.
Journal:	Zhonghua Yi Xue Za Zhi. 2004 Sep 2;84(17):1432-5.
Title:	[Relationship between expression of thymidylate synthase and colorectal carcinoma].
Author:	Yu, Zhi-Gang\|Sun, Jing-Zhong\|Zhang, Qiang\|Jia, Hong-Ying\|Wang, Jian-Xin
PMID:	15500737

290.
Journal:	Oncology. 2004;67(2):135-42.
Title:	Thymidylate synthase expression in normal colonic mucosa: a predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy.
Author:	Santini, Daniele\|Vincenzi, Bruno\|Perrone, Giuseppe\|Rabitti, Carla\|Borzomati, Domenico\|Caricato, Marco\|La Cesa, Annalisa\|Grilli, Claudia\|Verzi, Alfio\|Coppola, Roberto\|Tonini, Giuseppe
PMID:	15539918

291.
Journal:	Gut. 2004 Dec;53(12):1825-31.
Title:	Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.
Author:	Sohn, K-J\|Smirnakis, F\|Moskovitz, D N\|Novakovic, P\|Yates, Z\|Lucock, M\|Croxford, R\|Kim, Y-I
PMID:	15542523

292.
Journal:	Oncol Rep. 2004 Dec;12(6):1163-7.
Title:	Relationship between immunohistochemical evaluation of thymidylate synthase and proliferating cell nuclear antigen labeling index in gastrointestinal carcinoma.
Author:	Kunimoto, Yukihiro\|Nakamura, Takeshi\|Ohno, Masakazu\|Kuroda, Yoshikazu
PMID:	15547732

293.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1377-9.
Title:	Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer.
Author:	Calascibetta, A\|Rausa, L\|Gullotti, L\|Buettner, R\|Sanguedolce, R
PMID:	15571262

294.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1503-6.
Title:	Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Author:	Sigmond, J\|Comijn, E M\|Kamphuis, J A E\|Peters, G J
PMID:	15571286

295.
Journal:	Eur J Cancer. 2004 Dec;40(18):2845-50.
Title:	Clinical relevance of thymidylate synthase expression in the signet ring cell histotype component of colorectal carcinoma.
Author:	Cabibi, D\|Calascibetta, A\|Campione, M\|Barresi, E\|Rausa, L\|Dardanoni, G\|Aragona, F\|Sanguedolce, R
PMID:	15571969

296.
Journal:	Cancer Invest. 2004;22(5):762-73.
Title:	Tailored chemotherapy for colorectal cancer: a new approach to therapy.
Author:	Iqbal, Syma\|Stoehlmacher, Jan\|Lenz, Heinz-Josef
PMID:	15581057

297.
Journal:	Jpn J Clin Oncol. 2004 Oct;34(10):594-601.
Title:	Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy.
Author:	Kamoshida, Shingo\|Matsuoka, Hiroshi\|Ishikawa, Taro\|Maeda, Kotaro\|Shimomura, Ryoichi\|Inada, Ken-ichi\|Tsutsumi, Yutaka
PMID:	15591457

298.
Journal:	Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2247-50.
Title:	Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas.
Author:	Chen, Jia\|Kyte, Charles\|Chan, Wendy\|Wetmur, James G\|Fuchs, Charles S\|Giovannucci, Edward
PMID:	15598787

299.
Journal:	Tumour Biol. 2004 Sep-Dec;25(5-6):258-63.
Title:	Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival.
Author:	Rosati, Gerardo\|Chiacchio, Rosistella\|Reggiardo, Giorgio\|De Sanctis, Domenico\|Manzione, Luigi
PMID:	15627889

300.
Journal:	Anticancer Res. 2004 Nov-Dec;24(6):3875-80.
Title:	Thymidylate synthase gene promoter polymorphisms are associated with TSmRNA expressions but not with microsatellite instability in colorectal cancer.
Author:	Calascibetta, A\|Cabibi, D\|Martorana, A\|Sanguedolce, G\|Rausa, L\|Feo, S\|Dardanoni, G\|Sanguedolce, R
PMID:	15736425

301.
Journal:	Int J Colorectal Dis. 2005 Mar;20(2):94-102.
Title:	Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer.
Author:	Broll, R\|Busch, P\|Duchrow, M\|Oevermann, E\|Schwandner, O\|Farke, S\|Bruch, H P\|Windhovel, U
PMID:	15309465

302.
Journal:	Br J Cancer. 2005 Jan 31;92(2):259-64.
Title:	Unfavourable expression of pharmacologic markers in mucinous colorectal cancer.
Author:	Glasgow, S C\|Yu, J\|Carvalho, L P\|Shannon, W D\|Fleshman, J W\|McLeod, H L
PMID:	15655543

303.
Journal:	Oncol Rep. 2005 Mar;13(3):405-12.
Title:	Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma.
Author:	Yasuno, Masamichi\|Mori, Takeo\|Koike, Morio\|Takahashi, Keiichi\|Toi, Masakazu\|Takizawa, Toichiro\|Shimizu, Shinichiro\|Yamaguchi, Tatsuro\|Matsumoto, Hiroshi
PMID:	15706408

304.
Journal:	Clin Cancer Res. 2005 Feb 1;11(3):1226-36.
Title:	UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.
Author:	Carlini, Leslie E\|Meropol, Neal J\|Bever, John\|Andria, Michael L\|Hill, Todd\|Gold, Philip\|Rogatko, Andre\|Wang, Hao\|Blanchard, Rebecca L
PMID:	15709193

305.
Journal:	Anticancer Drugs. 2005 Mar;16(3):285-92.
Title:	Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells.
Author:	Temmink, Olaf H\|de Bruin, Michiel\|Comijn, Elizabeth M\|Fukushima, Masakazu\|Peters, Godefridus J
PMID:	15711180

306.
Journal:	J Gastrointest Surg. 2005 Mar;9(3):336-42.
Title:	Thymidylate synthase gene polymorphism as a prognostic factor for colon cancer.
Author:	Suh, Kwang Wook\|Kim, Joo Hyung\|Kim, Young Bae\|Kim, Jeongmi\|Jeong, Soohyun
PMID:	15749593

307.
Journal:	Gan To Kagaku Ryoho. 2005 Feb;32(2):183-7.
Title:	[Assessment of dihydropyrimidine dehydrogenase and thymidylate synthase expression in gastric carcinoma and colonic carcinoma].
Author:	Yoshida, Toru\|Shimooki, Osamu\|Baba, Yuko\|Abe, Tadashi\|Sugai, Tamotsu\|Nakamura, Shin-ichi
PMID:	15751630

308.
Journal:	J Gastroenterol. 2005 Feb;40(2):143-7.
Title:	Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer.
Author:	Inoue, Tamotsu\|Hibi, Kenji\|Nakayama, Goro\|Komatsu, Yoshinao\|Fukuoka, Tomoki\|Kodera, Yasuhiro\|Ito, Katsuki\|Akiyama, Seiji\|Nakao, Akimasa
PMID:	15770397

309.
Journal:	J Clin Oncol. 2005 Mar 20;23(9):2108; author reply 2108-9.
Title:	Thymidylate synthase expression in colorectal cancer: the never-ending story.
Author:	Vincenzi, Bruno\|Santini, Daniele\|Tonini, Giuseppe
PMID:	15774806

310.
Journal:	Int J Surg Pathol. 2005 Apr;13(2):127-33.
Title:	Relationship between thymidylate synthase (TS) genotype and TS expression: a tissue microarray analysis of colorectal cancers.
Author:	Popat, Sanjay\|Wort, Richard\|Houlston, Richard S
PMID:	15864374

311.
Journal:	Neoplasma. 2005;52(3):208-10.
Title:	Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue.
Author:	Zimovjanova, M\|Sykora, V\|Novotny, J\|Gatek, J\|Petruzelka, L\|Holubec, L\|Pecen, L
PMID:	15875081

312.
Journal:	Methods Mol Med. 2005;111:257-65.
Title:	Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil.
Author:	Kubota, Tetsuro
PMID:	15911984

313.
Journal:	Cancer Chemother Pharmacol. 2005 Nov;56(5):465-72.
Title:	Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.
Author:	Yawata, Ayako\|Kim, Su-Ryang\|Miyajima, Atsuko\|Kubo, Takashi\|Ishida, Seiichi\|Saito, Yoshiro\|Nakajima, Yukiko\|Katori, Noriko\|Matsumoto, Yoshiaki\|Fukuoka, Masamichi\|Ohno, Yasuo\|Ozawa, Shogo\|Sawada, Jun-Ichi
PMID:	15918040

314.
Journal:	Clin Colorectal Cancer. 2005 May;5(1):57-60.
Title:	The rTS signaling pathway as a target for drug development.
Author:	Dolnick, Bruce J
PMID:	15929807

315.
Journal:	Clin Cancer Res. 2005 Jun 1;11(11):4144-50.
Title:	A phase I pharmacologic and pharmacogenetic trial of sequential 24-hour infusion of irinotecan followed by leucovorin and a 48-hour infusion of fluorouracil in adult patients with solid tumors.
Author:	Wright, Maurice A\|Morrison, Geraldine\|Lin, Pengxin\|Leonard, Gregory D\|Nguyen, Dat\|Guo, Xaiodu\|Szabo, Eva\|Hopkins, Jon L\|Leguizamo, Jorge P\|Harold, Nancy\|Fioravanti, Suzanne\|Schuler, Barbara\|Monahan, Brian P\|Saif, M Wasif\|Quinn, Mary G\|Pang, Janet\|Grem, Je
PMID:	15930350

316.
Journal:	Clin Cancer Res. 2005 Jun 1;11(11):4234-40.
Title:	High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies.
Author:	Ricciardiello, Luigi\|Ceccarelli, Claudio\|Angiolini, Graziella\|Pariali, Milena\|Chieco, Pasquale\|Paterini, Paola\|Biasco, Guido\|Martinelli, Giuseppe N\|Roda, Enrico\|Bazzoli, Franco
PMID:	15930362

317.
Journal:	J Pathol. 2005 Sep;207(1):53-60.
Title:	ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.
Author:	Wong, Newton A C S\|Malcomson, Roger D G\|Jodrell, Duncan I\|Groome, Nigel P\|Harrison, David J\|Saunders, Philippa T K
PMID:	15954165

318.
Journal:	Cancer Res. 2005 Jul 1;65(13):5917-24.
Title:	Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells.
Author:	Dolnick, Ree\|Wu, Qi\|Angelino, Norman J\|Stephanie, Lawrence V\|Chow, Kuan-Chih\|Sufrin, Janice R\|Dolnick, Bruce J
PMID:	15994970

319.
Journal:	Zhonghua Zhong Liu Za Zhi. 2005 May;27(5):312-5.
Title:	[Prognostic value of thymidylate synthase, topoisomerase-1 and Ki-67 in advanced colorectal cancer patients on irinotecan and fluorouracil treatment].
Author:	Xu, Jian-ming\|Zhu, Bu-dong\|Mangia, Anita\|Simone, Gianni\|Montemurro, Severino\|Giuliani, Francesco\|Maiello, Evaristo\|Colucci, Giuseppe\|Paradiso, Angelo
PMID:	15996331

320.
Journal:	J Immunol. 2005 Jul 15;175(2):820-8.
Title:	Dendritic cell-mediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response
Author:	Correale, Pierpaolo\|Cusi, Maria Grazia\|Del Vecchio, Maria Teresa\|Aquino, Angelo\|Prete, Salvatore Pasquale\|Tsang, Kwong Y\|Micheli, Lucia\|Nencini, Cristina\|La Placa, Marco\|Montagnani, Francesco\|Terrosi, Chiara\|Caraglia, Michele\|Formica, Vincenzo\|Giorgi, Gio
PMID:	16002679

321.
Journal:	J Clin Oncol. 2005 Aug 20;23(24):5628-34.
Title:	Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information.
Author:	Ohrling, Katarina\|Edler, David\|Hallstrom, Marja\|Ragnhammar, Peter\|Blomgren, Henric
PMID:	16009948

322.
Journal:	Ann Oncol. 2005 Oct;16(10):1646-53.
Title:	Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients.
Author:	Westra, J L\|Hollema, H\|Schaapveld, M\|Platteel, I\|Oien, K A\|Keith, W N\|Mauritz, R\|Peters, G J\|Buys, C H C M\|Hofstra, R M W\|Plukker, J Th M
PMID:	16012177

323.
Journal:	Korean J Gastroenterol. 2005 Jul;46(1):32-8.
Title:	[Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer].
Author:	Lee, Jun\|Jeong, Cheol Kweon\|Hong, Sung Pyo\|Chong, So Young\|Oh, Doyeun\|Hwang, Seong Gyu\|Ahn, Dae Ho\|Kim, Sehyun\|Han, Jin Hee\|Kim, Nam Keun
PMID:	16030402

324.
Journal:	Carcinogenesis. 2005 Dec;26(12):2164-71.
Title:	One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.
Author:	Matsuo, Keitaro\|Ito, Hidemi\|Wakai, Kenji\|Hirose, Kaoru\|Saito, Toshiko\|Suzuki, Takeshi\|Kato, Tomoyuki\|Hirai, Takashi\|Kanemitsu, Yukihide\|Hamajima, Hiroshi\|Tajima, Kazuo
PMID:	16051637

325.
Journal:	Immunol Lett. 2005 Aug 15;100(1):88-93.
Title:	Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy.
Author:	Shebzukhov, Yuriy V\|Koroleva, Ekaterina P\|Khlgatian, Svetlana V\|Lagarkova, Maria A\|Meshcheryakov, Andrey A\|Lichinitser, Mikhail R\|Karbach, Julia\|Jager, Elke\|Kuprash, Dmitry V\|Nedospasov, Sergei A
PMID:	16055198

326.
Journal:	J Clin Oncol. 2005 Dec 10;23(35):8950-8. Epub 2005 Aug 1.
Title:	Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer
Author:	Correale, Pierpaolo\|Cusi, Maria Grazia\|Tsang, Kwong Yok\|Del Vecchio, Maria Teresa\|Marsili, Stefania\|Placa, Marco La\|Intrivici, Chiara\|Aquino, Angelo\|Micheli, Lucia\|Nencini, Cristina\|Ferrari, Francesco\|Giorgi, Giorgio\|Bonmassar, Enzo\|Francini, Guido
PMID:	16061910

327.
Journal:	Oncol Rep. 2005 Sep;14(3):657-62.
Title:	Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer.
Author:	Bendardaf, R\|Lamlum, H\|Elzagheid, A\|Ristamaki, R\|Pyrhonen, S
PMID:	16077970

328.
Journal:	Int J Gastrointest Cancer. 2005;35(3):197-203.
Title:	Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue.
Author:	Kawai, Ken\|Watabe, Suguru\|Matsuda, Mitsuhiro\|Sakamoto, Kazuhiro\|Kamano, Toshiki
PMID:	16110121

329.
Journal:	Am J Surg Pathol. 2005 Oct;29(10):1304-9.
Title:	Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemorad
Author:	Jakob, Christiane\|Liersch, Torsten\|Meyer, Wolfdietrich\|Baretton, Gustavo B\|Hausler, Peter\|Schwabe, Wolfgang\|Becker, Heinz\|Aust, Daniela E
PMID:	16160472

330.
Journal:	Eur J Cancer. 2005 Sep;41(14):2176-83.
Title:	Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers.
Author:	Morganti, Maria\|Ciantelli, Monica\|Giglioni, Beatrice\|Putignano, Anna L\|Nobili, Stefania\|Papi, Laura\|Landini, Ida\|Napoli, Cristina\|Valanzano, Rosa\|Cianchi, Fabio\|Boddi, Vieri\|Tonelli, Francesco\|Cortesini, Camillo\|Mazzei, Teresita\|Genuardi, Maurizio\|Mini, E
PMID:	16182121

331.
Journal:	Gan To Kagaku Ryoho. 2005 Sep;32(9):1295-9.
Title:	[Clinical significant of semiquantificating DNA topoisomerase- I mRNA in colorectal cancer].
Author:	Ishida, Hideyuki\|Shirakawa, Kazuo\|Ohsawa, Tomonori\|Hayashi, Yoichi\|Okada, Norimichi\|Nakada, Hiroshi\|Yokoyama, Masaru
PMID:	16184927

332.
Journal:	J Clin Oncol. 2005 Oct 1;23(28):7230-1; author reply 7231.
Title:	Studying the predictive/prognostic role of thymidylate synthase genotypes in patients with colorectal cancer: Is one polymorphism enough?
Author:	Graziano, Francesco\|Kawakami, Kazuyuki
PMID:	16192610

333.
Journal:	J Natl Cancer Inst. 2005 Oct 5;97(19):1437-45.
Title:	5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.
Author:	Correale, Pierpaolo\|Del Vecchio, Maria Teresa\|Di Genova, Giuseppa\|Savellini, Gianni Gori\|La Placa, Marco\|Terrosi, Chiara\|Vestri, Marzio\|Urso, Renato\|Lemonnier, Francois\|Aquino, Angelo\|Bonmassar, Enzo\|Giorgi, Giorgio\|Francini, Guido\|Cusi, Maria Grazia
PMID:	16204693

334.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2509-16.
Title:	Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
Author:	Ulrich, Cornelia M\|Curtin, Karen\|Potter, John D\|Bigler, Jeannette\|Caan, Bette\|Slattery, Martha L
PMID:	16284371

335.
Journal:	J Gastrointest Surg. 2005 Dec;9(9):1216-21; discussion 1221.
Title:	Molecular predictors of lymph node metastasis in colon cancer: increased risk with decreased thymidylate synthase expression.
Author:	Artinyan, Avo\|Essani, Rahila\|Lake, Jeffrey\|Kaiser, Andreas M\|Vukasin, Peter\|Danenberg, Peter\|Danenberg, Kathleen\|Haile, Robert\|Beart, Robert W Jr
PMID:	16332476

336.
Journal:	Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2999-3003.
Title:	Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes.
Author:	Lightfoot, Tracy J\|Skibola, Christine F\|Willett, Eleanor V\|Skibola, Danica R\|Allan, James M\|Coppede, Fabio\|Adamson, Peter J\|Morgan, Gareth J\|Roman, Eve\|Smith, Martyn T
PMID:	16365025

337.
Journal:	Oncol Res. 2005;16(3):143-56.
Title:	Molecular characterization of established human colon carcinoma cell lines (HCT-8) made resistant to 5-fluorouracil by different selection schedules.
Author:	Tempestini, Alessio\|Caciagli, Barbara\|Morganti, Maria\|Witort, Ewa\|Nobili, Stefania\|Papucci, Laura\|Schiavone, Nicola\|Donnini, Martino\|Landini, Ida\|Lapucci, Andrea\|Perna, Federico\|Lulli, Matteo\|Mazzei, Teresita\|Sobrero, Alberto\|Mini, Enrico\|Capaccioli, Serg
PMID:	16925115

338.
Journal:	Cancer Res Treat. 2005 Aug;37(4):216-22.
Title:	Thymidylate synthase, thymidine phosphorylase, VEGF and p53 protein expression in primary colorectal cancer for predicting response to 5-fluorouracil-based chemotherapy.
Author:	Ahn, Myung-Ju\|Choi, Jung-Hye\|Oh, Ho-Suk\|Lee, Young-Yeul\|Kim, In-Soon\|Choi, Il-Young\|Lee, Kang-Hong\|Song, Kang-Won\|Park, Chan-Kum
PMID:	19956517

339.
Journal:	J Histochem Cytochem. 2006 Jan;54(1):19-29. Epub 2005 Jun 13.
Title:	Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples.
Author:	Bissoon-Haqqani, Seema\|Moyana, Terence\|Jonker, Derek\|Maroun, Jean A\|Birnboim, H Chaim
PMID:	15956025

340.
Journal:	Cancer Chemother Pharmacol. 2006 Feb;57(3):343-8.
Title:	Imaging the pharmacokinetics of [F-18]FAU in patients with tumors: PET studies.
Author:	Sun, Haihao\|Collins, Jerry M\|Mangner, Thomas J\|Muzik, Otto\|Shields, Anthony F
PMID:	16001172

341.
Journal:	Ann Oncol. 2006 Jan;17(1):35-42. Epub 2005 Oct 26.
Title:	Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Author:	Smorenburg, C H\|Peters, G J\|van Groeningen, C J\|Noordhuis, P\|Smid, K\|van Riel, A M G H\|Dercksen, W\|Pinedo, H M\|Giaccone, G
PMID:	16251201

342.
Journal:	Cancer Lett. 2006 Oct 28;242(2):168-79.
Title:	Tumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype.
Author:	Barbado, Maud\|Preisser, Laurence\|Boisdron-Celle, Michele\|Verriele, Veronique\|Lorimier, Gerard\|Gamelin, Erick\|Morel, Alain
PMID:	16387426

343.
Journal:	Int J Oncol. 2006 Feb;28(2):527-33.
Title:	Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis.
Author:	Vallbohmer, D\|Kuramochi, H\|Shimizu, D\|Danenberg, K D\|Lindebjerg, J\|Nielsen, J N\|Jakobsen, A\|Danenberg, P V
PMID:	16391809

344.
Journal:	Int J Cancer. 2006 Jun 15;118(12):3084-8.
Title:	Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy.
Author:	Ochiai, Takumi\|Nishimura, Kazuhiko\|Noguchi, Hajime\|Kitajima, Masayuki\|Tsukada, Akira\|Watanabe, Emiko\|Nagaoka, Isao\|Futagawa, Shunji
PMID:	16425285

345.
Journal:	Anal Biochem. 2006 Mar 1;350(1):71-80.
Title:	Validation of real-time reverse-transcription-polymerase chain reaction for quantification of capecitabine-metabolizing enzymes.
Author:	Macpherson, Janet S\|Jodrell, Duncan I\|Guichard, Sylvie M
PMID:	16438929

346.
Journal:	Cancer. 2006 Mar 1;106(5):1007-16.
Title:	Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Author:	Massacesi, Cristian\|Terrazzino, Salvatore\|Marcucci, Fabiana\|Rocchi, Marco B\|Lippe, Paolo\|Bisonni, Renato\|Lombardo, Marco\|Pilone, Alberta\|Mattioli, Rodolfo\|Leon, Alberta
PMID:	16456808

347.
Journal:	Cancer Invest. 2006 Feb;24(1):98-105.
Title:	Target practice: figuring out which, when, and why to use systemic therapies for metastatic colon cancer.
Author:	Holen, Kyle D
PMID:	16466998

348.
Journal:	Int J Cancer. 2006 Jul 15;119(2):406-13.
Title:	Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response.
Author:	Matsuyama, Ryusei\|Togo, Shinji\|Shimizu, Daisuke\|Momiyama, Nobuyoshi\|Ishikawa, Takashi\|Ichikawa, Yasushi\|Endo, Itaru\|Kunisaki, Chikara\|Suzuki, Harukazu\|Hayasizaki, Yoshihide\|Shimada, Hiroshi
PMID:	16477629

349.
Journal:	Mol Cancer Ther. 2006 Feb;5(2):438-49.
Title:	The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Author:	Chattopadhyay, Shrikanta\|Zhao, Rongbao\|Krupenko, Sergey A\|Krupenko, Natalia\|Goldman, I David
PMID:	16505119

350.
Journal:	Clin Colorectal Cancer. 2006 Jan;5(5):321-3.
Title:	Polymorphisms in the thymidylate synthase gene predict response to 5-fluorouracil therapy in colorectal cancer.
Author:	Gibson, Tara Beers
PMID:	16512989

351.
Journal:	J Gastroenterol. 2006 Feb;41(2):140-50.
Title:	Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines.
Author:	Miyazaki, Kaori\|Shibahara, Takeshi\|Sato, Daisuke\|Uchida, Kazuhiko\|Suzuki, Hideo\|Matsui, Hirofumi\|Yanaka, Akinori\|Nakahara, Akira\|Matsuzaki, Yasushi
PMID:	16568373

352.
Journal:	Int J Cancer. 2006 Aug 1;119(3):522-6.
Title:	5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis.
Author:	Kuramochi, Hidekazu\|Hayashi, Kazuhiko\|Uchida, Kazumi\|Miyakura, Satoru\|Shimizu, Daisuke\|Vallbohmer, Daniel\|Park, Seongjin\|Danenberg, Kathleen D\|Takasaki, Ken\|Danenberg, Peter V
PMID:	16572420

353.
Journal:	BMC Genomics. 2006 Apr 3;7:68.
Title:	Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer.
Author:	Xi, Yaguang\|Nakajima, Go\|Schmitz, John C\|Chu, Edward\|Ju, Jingfang
PMID:	16584549

354.
Journal:	Int J Oncol. 2006 May;28(5):1303-10.
Title:	Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil.
Author:	Fernandez-Contreras, Maria-Encarnacion\|Sanchez-Prudencio, Sandra\|Sanchez-Hernandez, Jose-Javier\|Garcia de Paredes, Maria-Luisa\|Gisbert, Javier P\|Roda-Navarro, Pedro\|Gamallo, Carlos
PMID:	16596248

355.
Journal:	Anticancer Res. 2006 Mar-Apr;26(2B):1391-6.
Title:	Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer.
Author:	Ajiki, Tetsuo\|Hirata, Kenro\|Okazaki, Taro\|Horiuchi, Hideki\|Fujita, Tsunenori\|Habara, Kazuto\|Kamigaki, Takashi\|Suzuki, Yasuyuki\|Kuroda, Yoshikazu
PMID:	16619549

356.
Journal:	Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R89-93.
Title:	Pharmacogenomics: from bedside to clinical practice.
Author:	Marsh, Sharon\|McLeod, Howard L
PMID:	16651374

357.
Journal:	Clin Cancer Res. 2006 May 1;12(9):2738-44.
Title:	Thymidylate synthase expression in colon carcinomas with microsatellite instability.
Author:	Sinicrope, Frank A\|Rego, Rafaela L\|Halling, Kevin C\|Foster, Nathan R\|Sargent, Daniel J\|La Plant, Betsy\|French, Amy J\|Allegra, Carmen J\|Laurie, John A\|Goldberg, Richard M\|Witzig, Thomas E\|Thibodeau, Stephen N
PMID:	16675565

358.
Journal:	Pol J Pathol. 2006;57(1):29-33.
Title:	High thymidylate synthase expression is typical for sporadic MSI-H colorectal carcinoma.
Author:	Okon, Krzysztof\|Klimkowska, Agnieszka\|Wojcik, Piotr\|Osuch, Czeslaw\|Papla, Boleslaw\|Stachura, Jerzy
PMID:	16739880

359.
Journal:	BMC Cancer. 2006 Jun 5;6:150.
Title:	Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance.
Author:	Popat, Sanjay\|Wort, Richard\|Houlston, Richard S
PMID:	16753067

360.
Journal:	Clin Cancer Res. 2006 Jul 1;12(13):3928-34.
Title:	Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen.
Author:	Ichikawa, Wataru\|Takahashi, Takehiro\|Suto, Kenichi\|Sasaki, Yasutsuna\|Hirayama, Renzo
PMID:	16818689

361.
Journal:	Pharmacogenet Genomics. 2006 Aug;16(8):555-63.
Title:	Gene expression in tumor-adjacent normal tissue is associated with recurrence in patients with rectal cancer treated with adjuvant chemoradiation.
Author:	Schneider, Sylke\|Park, David J\|Yang, Dongyun\|El-Khoueiry, Anthony\|Sherrod, Andy\|Groshen, Susan\|Streeter, Oscar\|Iqbal, Syma\|Danenberg, Kathleen D\|Lenz, Heinz-Josef
PMID:	16847424

362.
Journal:	Oncol Rep. 2006 Sep;16(3):465-71.
Title:	S-1, an oral fluoropyrimidine, enhances radiation response of DLD-1/FU human colon cancer xenografts resistant to 5-FU.
Author:	Nakata, Eiko\|Fukushima, Masakazu\|Takai, Yoshihiro\|Nemoto, Kenji\|Ogawa, Yoshihiro\|Nomiya, Takuma\|Nakamura, Yasuhiro\|Milas, Luka\|Yamada, Shogo
PMID:	16865244

363.
Journal:	J Int Med Res. 2006 May-Jun;34(3):307-15.
Title:	Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.
Author:	Takeda, R\|Kamano, T\|Sakamoto, K\|Sugano, M\|Hosoda, S\|Watanabe, T\|Maeda, T\|Kojima, Y
PMID:	16866026

364.
Journal:	Pharmacogenomics J. 2006 Nov-Dec;6(6):421-4. Epub 2006 Jul 25.
Title:	A novel G/C single-nucleotide polymorphism in the double 28-bp repeat thymidylate synthase allele.
Author:	Gusella, M\|Bolzonella, C\|Crepaldi, G\|Ferrazzi, E\|Padrini, R
PMID:	16868573

365.
Journal:	Am J Surg Pathol. 2006 Sep;30(9):1169-74.
Title:	Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy.
Author:	Jakob, Christiane\|Liersch, Torsten\|Meyer, Wolfdietrich\|Baretton, Gustavo B\|Schwabe, Wolfgang\|Hausler, Peter\|Kulle, Bettina\|Becker, Heinz\|Aust, Daniela E
PMID:	16931962

366.
Journal:	Br J Cancer. 2006 Oct 9;95(7):928-33.
Title:	The impact of surgically induced ischaemia on protein levels in patients undergoing rectal cancer surgery.
Author:	Atkin, G K\|Daley, F M\|Bourne, S\|Glynne-Jones, R\|Northover, J M A\|Wilson, G D
PMID:	17016487

367.
Journal:	Oncol Rep. 2006 Nov;16(5):1111-5.
Title:	Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer.
Author:	Matsui, Takanori\|Omura, Kenji\|Kawakami, Kazuyuki\|Morita, Satoshi\|Sakamoto, Junichi
PMID:	17016601

368.
Journal:	Cancer Res. 2006 Oct 1;66(19):9369-73.
Title:	Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.
Author:	Brody, Jonathan R\|Hucl, Tomas\|Gallmeier, Eike\|Winter, Jordan M\|Kern, Scott E\|Murphy, Kathleen M
PMID:	17018589

369.
Journal:	Pharmacogenet Genomics. 2006 Nov;16(11):809-16.
Title:	Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients.
Author:	Amatori, Federica\|Di Paolo, Antonello\|Del Tacca, Mario\|Fontanini, Gabriella\|Vannozzi, Francesca\|Boldrini, Laura\|Bocci, Guido\|Lastella, Marianna\|Danesi, Romano
PMID:	17047489

370.
Journal:	Pharmacogenet Genomics. 2006 Nov;16(11):817-24.
Title:	A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
Author:	Terrazzino, Salvatore\|Agostini, Marco\|Pucciarelli, Salvatore\|Pasetto, Lara Maria\|Friso, Maria Luisa\|Ambrosi, Alessandro\|Lisi, Veronica\|Leon, Alberta\|Lise, Mario\|Nitti, Donato
PMID:	17047490

371.
Journal:	Crit Rev Oncog. 2006 Jul;12(1-2):115-26.
Title:	Methyl-group metabolism and the response of colorectal cancer to 5-fluorouracil.
Author:	Iacopetta, Barry
PMID:	17078208

372.
Journal:	Gan To Kagaku Ryoho. 2006 Nov;33(11):1603-9.
Title:	[Prediction of sensitivity to 5-fluorouracil (5-fu) by metabolic and target enzyme activities in colon cancer].
Author:	Yamada, Takeshi\|Tanaka, Noritake\|Yokoi, Kimiyoshi\|Ishikawa, Noriyuki\|Seya, Tomoko\|Horiba, Kouji\|Kanazawa, Yoshikazu\|Shirakawa, Takashi\|Ohkawa, Keiichi\|Kudoh, Hidenori\|Koizumi, Michihiro\|Yoshioka, Masato\|Shinji, Seiichi\|Yamashita, Kiyohiko\|Tajiri, Takashi
PMID:	17108726

373.
Journal:	Oncology. 2006;70(5):366-77.
Title:	Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil.
Author:	Ciaparrone, M\|Quirino, M\|Schinzari, G\|Zannoni, G\|Corsi, D C\|Vecchio, F M\|Cassano, A\|La Torre, G\|Barone, C
PMID:	17179731

374.
Journal:	Anticancer Res. 2006 Nov-Dec;26(6C):4653-8.
Title:	Expression of genes for 5-FU-metabolizing enzymes and response to irinotecan plus 5-FU-leucovorin in colorectal cancer.
Author:	Noda, Eiji\|Maeda, Kiyoshi\|Inoue, Toru\|Nishihara, Tamahiro\|Nishiguchi, Yukio\|Ohira, Masaichi\|Hirakawa, Kosei
PMID:	17214322

375.
Journal:	Magy Onkol. 2006;50(4):315-23.
Title:	[Chemotherapy agents, response rates and mechanisms of resistance in the therapy of the colorectal carcinoma].
Author:	Tegze, Balint\|Tulassay, Zsolt\|Gyorffy, Balazs
PMID:	17216005

376.
Journal:	Chemotherapy. 2007;53(1):36-41. Epub 2006 Dec 28.
Title:	Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Author:	Matsusaka, Satoshi\|Yamasaki, Hajime\|Fukushima, Masakazu\|Wakabayashi, Ichiro
PMID:	17192711

377.
Journal:	Oncol Rep. 2007 Feb;17(2):325-8.
Title:	Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.
Author:	Salgado, Josefa\|Zabalegui, Natalia\|Gil, Carmen\|Monreal, Ignacio\|Rodriguez, Javier\|Garcia-Foncillas, Jesus
PMID:	17203168

378.
Journal:	J Clin Oncol. 2007 Mar 1;25(7):767-72.
Title:	Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study.
Author:	Kim, George P\|Colangelo, Linda H\|Wieand, H Samuel\|Paik, Soonmyung\|Kirsch, Ilan R\|Wolmark, Norman\|Allegra, Carmen J
PMID:	17228023

379.
Journal:	Int J Cancer. 2007 May 15;120(10):2226-32.
Title:	Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival.
Author:	Curtin, Karen\|Ulrich, Cornelia M\|Samowitz, Wade S\|Bigler, Jeannette\|Caan, Bette\|Potter, John D\|Slattery, Martha L
PMID:	17290389

380.
Journal:	Oncogene. 2007 Jul 19;26(33):4817-24. Epub 2007 Feb 12.
Title:	Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas.
Author:	Chen, M\|Rahman, L\|Voeller, D\|Kastanos, E\|Yang, S X\|Feigenbaum, L\|Allegra, C\|Kaye, F J\|Steeg, P\|Zajac-Kaye, M
PMID:	17297449

381.
Journal:	Biochemistry. 2007 Mar 13;46(10):2823-30.
Title:	Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.
Author:	Lovelace, Leslie L\|Gibson, Lydia M\|Lebioda, Lukasz
PMID:	17297914

382.
Journal:	Br J Cancer. 2007 Mar 12;96(5):769-75.
Title:	Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
Author:	Giovannetti, E\|Backus, H H J\|Wouters, D\|Ferreira, C G\|van Houten, V M M\|Brakenhoff, R H\|Poupon, M-F\|Azzarello, A\|Pinedo, H M\|Peters, G J
PMID:	17339891

383.
Journal:	Ther Drug Monit. 2007 Apr;29(2):190-6.
Title:	Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity.
Author:	Cho, Hyun-Jung\|Park, Young Suk\|Kang, Won Ki\|Kim, Jong-Won\|Lee, Soo-Youn
PMID:	17417073

384.
Journal:	Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1455-61.
Title:	Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy.
Author:	Bertolini, Federica\|Bengala, Carmelo\|Losi, Luisa\|Pagano, Maria\|Iachetta, Francesco\|Dealis, Cristina\|Jovic, Gordana\|Depenni, Roberta\|Zironi, Sandra\|Falchi, Anna Maria\|Luppi, Gabriele\|Conte, Pier Franco
PMID:	17445998

385.
Journal:	Carcinogenesis. 2007 Aug;28(8):1672-9. Epub 2007 Apr 21.
Title:	Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.
Author:	Curtin, Karen\|Slattery, Martha L\|Ulrich, Cornelia M\|Bigler, Jeannette\|Levin, Theodore R\|Wolff, Roger K\|Albertsen, Hans\|Potter, John D\|Samowitz, Wade S
PMID:	17449906

386.
Journal:	Scand J Gastroenterol. 2007 Apr;42(4):471-6.
Title:	Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases.
Author:	Bendardaf, Riyad\|Elzagheid, Adam\|Lamlum, Hanan\|Algars, Annika\|Korkeila, Eija\|Ristamaki, Raija\|Collan, Yrjo\|Syrjanen, Kari\|Pyrhonen, Seppo
PMID:	17454857

387.
Journal:	Scand J Gastroenterol. 2007 Apr;42(4):477-84.
Title:	Modified Irinotecan/5FU/Leucovorin therapy in advanced colorectal cancer and predicting therapeutic efficacy by expression of tumor-related enzymes.
Author:	Yanagisawa, Yoko\|Maruta, Fukuto\|Iinuma, Nobuyoshi\|Ishizone, Satoshi\|Koide, Naohiko\|Nakayama, Jun\|Miyagawa, Shinichi
PMID:	17454858

388.
Journal:	Onkologie. 2007 Jun;30(6):295-300.
Title:	Measurement of DPD and TS transcripts aimed to predict clinical benefit from fluoropyrimidines: confirmation of the trend in Russian colorectal cancer series and caution regarding the gene referees.
Author:	Iyevleva, Aglaya G\|Buslov, Konstantin G\|Togo, Alexandr V\|Matsko, Dmitry E\|Filimonenko, Vasily P\|Moiseyenko, Vladimir M\|Imyanitov, Evgeny N
PMID:	17551252

389.
Journal:	Int J Oncol. 2007 Aug;31(2):413-8.
Title:	DPD is a molecular determinant of capecitabine efficacy in colorectal cancer.
Author:	Vallbohmer, Daniel\|Yang, Dong Yun\|Kuramochi, Hidekazu\|Shimizu, D\|Danenberg, Kathleen D\|Lindebjerg, Jan\|Nielsen, Jens Nederby\|Jakobsen, Anders\|Danenberg, Peter V
PMID:	17611699

390.
Journal:	Gan To Kagaku Ryoho. 2007 Jul;34(7):1073-7.
Title:	[Expression of mRNA levels of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in diffusely infiltrating colorectal cancer].
Author:	Ishibashi, Keiichiro\|Sobajima, Jun\|Ohsawa, Tomonori\|Yokoyama, Masaru\|Miyazaki, Tatsuya\|Nakada, Hiroshi\|Gonda, Tsuyoshi\|Ishida, Hideyuki
PMID:	17637543

391.
Journal:	Magy Onkol. 2007;51(2):113-25. Epub 2007 Jul 29.
Title:	[Pharmacogenetic studies on the prediction of efficacy and toxicity of fluoropyrimidine-based adjuvant therapy in colorectal cancer].
Author:	Kralovanszky, Judit\|Adleff, Vilmos\|Hitre, Erika\|Pap, Eva\|Reti, Andrea\|Komlosi, Viktor\|Budai, Barna
PMID:	17660867

392.
Journal:	Pharmacogenomics. 2007 Aug;8(8):985-96.
Title:	G>C SNP of thymidylate synthase with respect to colorectal cancer.
Author:	Gusella, Milena\|Padrini, Roberto
PMID:	17716232

393.
Journal:	Br J Cancer. 2007 Oct 8;97(7):919-26.
Title:	In vitro and in vivo reversal of resistance to 5-fluorouracil in colorectal cancer cells with a novel stealth double-liposomal formulation.
Author:	Fanciullino, R\|Giacometti, S\|Mercier, C\|Aubert, C\|Blanquicett, C\|Piccerelle, P\|Ciccolini, J
PMID:	17848948

394.
Journal:	Mol Cancer. 2007 Sep 21;6:58.
Title:	Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines.
Author:	Hamaguchi, Jun\|Nakagawa, Hiroaki\|Takahashi, Masato\|Kudo, Takeaki\|Kamiyama, Naoya\|Sun, Bailong\|Oshima, Takahiro\|Sato, Yuji\|Deguchi, Kisaburo\|Todo, Satoru\|Nishimura, Shin-Ichiro
PMID:	17883871

395.
Journal:	Clin Colorectal Cancer. 2007 Nov;6(10):720-7.
Title:	Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
Author:	Odin, Elisabeth\|Wettergren, Yvonne\|Nilsson, Staffan\|Carlsson, Goran\|Gustavsson, Bengt
PMID:	18039426

396.
Journal:	Gastroenterology. 2007 Dec;133(6):1831-9.
Title:	Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy.
Author:	Lassmann, Silke\|Tang, Laura\|Capanu, Marinela\|Brabletz, Thomas\|Schopflin, Anja\|Zur Hausen, Axel\|Gonen, Mithat\|Kemeny, Nancy\|Shia, Jinru\|Klimstra, David\|Werner, Martin
PMID:	18054556

397.
Journal:	Pak J Biol Sci. 2007 Oct 1;10(19):3350-5.
Title:	Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients.
Author:	Bidgoli, Sepideh Arbabi\|Azizi, Ebrahim\|Zavarhei, Mansour Djamali
PMID:	19090149

398.
Journal:	Cancer Chemother Pharmacol. 2008 Feb;61(2):189-201.
Title:	Cell death in response to antimetabolites directed at thymidylate synthase.
Author:	Barbour, Karen W\|Berger, Franklin G
PMID:	17396263

399.
Journal:	Cancer Chemother Pharmacol. 2008 Apr;61(4):587-94. Epub 2007 May 23.
Title:	Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer.
Author:	Okumura, Kenji\|Mekata, Eiji\|Shiomi, Hisanori\|Naitoh, Hiroyuki\|Abe, Hajime\|Endo, Yoshihiro\|Kurumi, Yoshimasa\|Tani, Tohru
PMID:	17520254

400.
Journal:	Cancer Chemother Pharmacol. 2008 Apr;61(4):579-85. Epub 2007 May 23.
Title:	A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer.
Author:	Clamp, A R\|Schoffski, P\|Valle, J W\|Wilson, R H\|Marreaud, S\|Govaerts, A-S\|Debois, M\|Lacombe, D\|Twelves, C\|Chick, J\|Jayson, G C
PMID:	17520255

401.
Journal:	Pharmacogenomics J. 2008 Aug;8(4):278-88.
Title:	Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy.
Author:	Ruzzo, A\|Graziano, F\|Loupakis, F\|Santini, D\|Catalano, V\|Bisonni, R\|Ficarelli, R\|Fontana, A\|Andreoni, F\|Falcone, A\|Canestrari, E\|Tonini, G\|Mari, D\|Lippe, P\|Pizzagalli, F\|Schiavon, G\|Alessandroni, P\|Giustini, L\|Maltese, P\|Testa, E\|Menichetti, E T\|Magnani, M
PMID:	17549067

402.
Journal:	Pharmacogenomics J. 2008 Oct;8(5):315-20. Epub 2007 Aug 7.
Title:	Transcription factor-binding sites in the thymidylate synthase gene: predictors of outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin?
Author:	Pare, L\|Marcuello, E\|Altes, A\|del Rio, E\|Sedano, L\|Barnadas, A\|Baiget, M
PMID:	17684476

403.
Journal:	Dig Dis Sci. 2008 May;53(5):1289-96.
Title:	Prognostic and predictive value of thymidylate synthase expression in colon cancer.
Author:	Tsourouflis, Gerasimos\|Theocharis, Stamatios E\|Sampani, Anastasia\|Giagini, Athina\|Kostakis, Alkiviadis\|Kouraklis, Gregory
PMID:	17934851

404.
Journal:	Eur J Cancer. 2008 Feb;44(3):400-7.
Title:	Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy.
Author:	Nakajima, Takako Eguchi\|Yamada, Yasuhide\|Shimoda, Tadakazu\|Matsubara, Junichi\|Kato, Ken\|Hamaguchi, Tetsuya\|Shimada, Yasuhiro\|Okayama, Yoshihiro\|Oka, Toshinori\|Shirao, Kuniaki
PMID:	18068349

405.
Journal:	Br J Cancer. 2008 Jan 15;98(1):143-7.
Title:	Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy.
Author:	Negri, F V\|Campanini, N\|Camisa, R\|Pucci, F\|Bui, S\|Ceccon, G\|Martinelli, R\|Fumagalli, M\|Losardo, P L\|Crafa, P\|Bordi, C\|Cascinu, S\|Ardizzoni, A
PMID:	18087284

406.
Journal:	Oncol Rep. 2008 Jan;19(1):257-62.
Title:	Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer.
Author:	Xi, Yaguang\|Formentini, Andrea\|Nakajima, Go\|Kornmann, Marko\|Ju, Jingfang
PMID:	18097604

407.
Journal:	Clin Cancer Res. 2008 Feb 1;14(3):817-25.
Title:	Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
Author:	Sharma, Rohini\|Hoskins, Janelle M\|Rivory, Laurent P\|Zucknick, Manuela\|London, Rosyln\|Liddle, Christopher\|Clarke, Stephen J
PMID:	18245544

408.
Journal:	Ann Oncol. 2008 May;19(5):915-9.
Title:	Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.
Author:	Soong, R\|Shah, N\|Salto-Tellez, M\|Tai, B C\|Soo, R A\|Han, H C\|Ng, S S\|Tan, W L\|Zeps, N\|Joseph, D\|Diasio, R B\|Iacopetta, B
PMID:	18245778

409.
Journal:	BMC Cancer. 2008 Feb 12;8:50.
Title:	ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study.
Author:	Huang, Ming-Yii\|Fang, Wei-Yu\|Lee, Su-Chen\|Cheng, Tian-Lu\|Wang, Jaw-Yuan\|Lin, Shiu-Ru
PMID:	18267032

410.
Journal:	Cancer Chemother Pharmacol. 2008 Dec;63(1):85-9.
Title:	High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1.
Author:	Kuramochi, Hidekazu\|Hayashi, Kazuhiko\|Uchida, Kazumi\|Nakajima, Go\|Hatori, Takashi\|Danenberg, Kathleen D\|Danenberg, Peter V\|Yamamoto, Masakazu
PMID:	18309485

411.
Journal:	J Nippon Med Sch. 2008 Feb;75(1):23-7.
Title:	Correlation between clinical pathologic factors and activity of 5-FU-metabolizing enzymes in colorectal cancer.
Author:	Yamada, Takeshi\|Tanaka, Noritake\|Yokoi, Kimiyoshi\|Seya, Tomoko\|Kanazawa, Yoshikazu\|Koizumi, Michihiro\|Ohaki, Yoshiharu\|Tajiri, Takashi
PMID:	18360075

412.
Journal:	Mol Med. 2008 Jul-Aug;14(7-8):412-21.
Title:	p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer.
Author:	Wettergren, Yvonne\|Odin, Elisabeth\|Nilsson, Staffan\|Carlsson, Goran\|Gustavsson, Bengt
PMID:	18418463

413.
Journal:	Mol Diagn Ther. 2008;12(2):87-98.
Title:	The role of molecular markers in predicting response to therapy in patients with colorectal cancer.
Author:	Shankaran, Veena\|Wisinski, Kari B\|Mulcahy, Mary F\|Benson, Al B 3rd
PMID:	18422373

414.
Journal:	Drugs Aging. 2008;25(6):531-9.
Title:	Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy.
Author:	Agostini, Marco\|Pasetto, Lara Maria\|Pucciarelli, Salvatore\|Terrazzino, Salvatore\|Ambrosi, Alessandro\|Bedin, Chiara\|Galdi, Francesca\|Friso, Maria Luisa\|Mescoli, Claudia\|Urso, Emanuele\|Leon, Alberta\|Lise, Mario\|Nitti, Donato
PMID:	18540691

415.
Journal:	Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):650-7.
Title:	Phase II study of weekly intravenous oxaliplatin combined with oral daily capecitabine and radiotherapy with biologic correlates in neoadjuvant treatment of rectal adenocarcinoma.
Author:	Fakih, Marwan G\|Bullarddunn, Kelli\|Yang, Gary Y\|Pendyala, Lakshmi\|Toth, Karoly\|Andrews, Chris\|Rustum, Youcef M\|Ross, Mary Ellen\|Levea, Charles\|Puthillath, Ajithkumar\|Park, Young-Mee\|Rajput, Ashwani
PMID:	18565686

416.
Journal:	Cancer Invest. 2008 Jul;26(6):583-9.
Title:	Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer.
Author:	Jensen, Lars Henrik\|Lindebjerg, Jan\|Cruger, Dorthe Gylling\|Brandslund, Ivan\|Jakobsen, Anders\|Kolvraa, Steen\|Nielsen, Jens Nederby
PMID:	18584349

417.
Journal:	Rev Invest Clin. 2008 Jan-Feb;60(1):21-30.
Title:	[Frequency of TS1494del6 polymorphism in colorectal patients from west of Mexico].
Author:	Gallegos-Arreola, Martha Patricia\|Peralta-Leal, Valeria\|Morgan-Villela, Gilberto\|Puebla-Perez, Ana Maria
PMID:	18589584

418.
Journal:	Cancer Res. 2008 Jul 1;68(13):4977-82.
Title:	Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors.
Author:	Pezo, Rossanna C\|Gandhi, Saumil J\|Shirley, L Andrew\|Pestell, Richard G\|Augenlicht, Leonard H\|Singer, Robert H
PMID:	18593893

419.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):733-9.
Title:	Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Author:	Codacci-Pisanelli, G\|Noordhuis, P\|van der Wilt, C L\|Peters, G J
PMID:	18600533

420.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):740-5.
Title:	Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
Author:	Giovannetti, E\|Backus, H H J\|Wouters, D\|Peters, G J
PMID:	18600534

421.
Journal:	Acta Oncol. 2008;47(6):1054-61.
Title:	Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer.
Author:	Jensen, Soren Astrup\|Vainer, Ben\|Witton, Caroline Janet\|Jorgensen, Jan Trost\|Sorensen, Jens Benn
PMID:	18607850

422.
Journal:	Hepatogastroenterology. 2008 Mar-Apr;55(82-83):403-6.
Title:	Importance of thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase expression at the invasive front of T3 rectal cancer as prognostic factors.
Author:	Hayashi, Takenori\|Kawahara, Hidejiro\|Kobayashi, Susumu\|Kashiwagi, Hideyuki\|Hirai, Katsuya\|Yanaga, Katsuhiko
PMID:	18613375

423.
Journal:	BMC Cancer. 2008 Jul 25;8:210.
Title:	Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
Author:	Makino, Hiroshi\|Uetake, Hiroyuki\|Danenberg, Kathleen\|Danenberg, Peter V\|Sugihara, Kenichi
PMID:	18652704

424.
Journal:	Int J Cancer. 2008 Oct 15;123(8):1941-9.
Title:	Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer.
Author:	Gosens, Marleen J\|Moerland, Elna\|Lemmens, Valery P\|Rutten, Harm T\|Tan-Go, Ivonne\|van den Brule, Adriaan J
PMID:	18661526

425.
Journal:	Clin Cancer Res. 2008 Aug 1;14(15):4830-5.
Title:	K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Author:	Etienne-Grimaldi, Marie-Christine\|Formento, Jean-Louis\|Francoual, Mireille\|Francois, Eric\|Formento, Patricia\|Renee, Nicole\|Laurent-Puig, Pierre\|Chazal, Maurice\|Benchimol, Daniel\|Delpero, Jean-Robert\|Letoublon, Christian\|Pezet, Denis\|Seitz, Jean-Francois\|M
PMID:	18676755

426.
Journal:	Hum Pathol. 2008 Dec;39(12):1737-43.
Title:	Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer.
Author:	Elzagheid, Adam\|Korkeila, Eija\|Bendardaf, Riyad\|Buhmeida, Abdelbaset\|Heikkila, Suvi\|Vaheri, Antti\|Syrjanen, Kari\|Pyrhonen, Seppo\|Carpen, Olli
PMID:	18701134

427.
Journal:	Cancer Lett. 2008 Dec 18;272(2):221-5.
Title:	Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.
Author:	Stoehlmacher, Jan\|Goekkurt, Eray\|Mogck, Ulrike\|Aust, Daniela E\|Kramer, Michael\|Baretton, Gustavo B\|Liersch, Torsten\|Ehninger, Gerhard\|Jakob, Christiane
PMID:	18722050

428.
Journal:	Anticancer Res. 2008 Jul-Aug;28(4B):2175-80.
Title:	Resistance of colorectal cancer cells to 5-FUdR and 5-FU caused by Mycoplasma infection.
Author:	Jette, Lucie\|Bissoon-Haqqani, Seema\|Le Francois, Brice\|Maroun, Jean A\|Birnboim, H Chaim
PMID:	18751392

429.
Journal:	Mol Cancer Ther. 2008 Sep;7(9):3029-37.
Title:	Novel opportunities for thymidylate metabolism as a therapeutic target.
Author:	Wilson, Peter M\|Fazzone, William\|LaBonte, Melissa J\|Deng, Jinxia\|Neamati, Nouri\|Ladner, Robert D
PMID:	18790783

430.
Journal:	Pharmacogenomics. 2008 Oct;9(10):1459-66.
Title:	Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers.
Author:	Yu, Jinsheng\|Miller, Ryan\|Zhang, Wanghai\|Sharma, Mala\|Holtschlag, Vicky\|Watson, Mark A\|McLeod, Howard L
PMID:	18855534

431.
Journal:	Arch Pathol Lab Med. 2008 Nov;132(11):1746-52.
Title:	AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Author:	Gustavson, Mark D\|Molinaro, Annette M\|Tedeschi, Greg\|Camp, Robert L\|Rimm, David L
PMID:	18976010

432.
Journal:	Int J Oncol. 2008 Dec;33(6):1257-62.
Title:	Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis.
Author:	Kobayashi, Hirotoshi\|Sugihara, Kenichi\|Uetake, Hiroyuki\|Higuchi, Tetsuro\|Yasuno, Masamichi\|Enomoto, Masayuki\|Iida, Satoru\|Azuma, Mizutomo\|Mori, Ryutaro\|Omori, Akiko\|Lenz, Heinz-Josef\|Danenberg, Kathleen D\|Danenberg, Peter V
PMID:	19020759

433.
Journal:	Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S38-41.
Title:	Individualization of therapy for colorectal cancer based on clinical and molecular parameters.
Author:	Pohl, Alexandra\|Lenz, Heinz-Josef
PMID:	19343148

434.
Journal:	Gastrointest Cancer Res. 2008 May;2(3 Suppl):S51-6.
Title:	Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Author:	Lenz, Heinz-Josef\|Johnston, Patrick
PMID:	19352470

435.
Journal:	Proteomics Clin Appl. 2008 Jun;2(6):908-14.
Title:	Cetuximab inhibits thymidylate synthase in colorectal cells expressing epidermal growth factor receptor.
Author:	Skvortsov, Sergej\|Sarg, Bettina\|Lindner, Herbert\|Lukas, Peter\|Hilbe, Wolfgang\|Zwierzina, Heinz\|Skvortsova, Ira
PMID:	21136888

436.
Journal:	Mol Med Rep. 2008 Sep-Oct;1(5):747-52.
Title:	5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorectal cancer independently of the intake of methyl group donors.
Author:	Carmona, Bruno\|Guerreiro, Catarina\|Cravo, Marilia\|Nobre-Leitao, Carlos\|Brito, Miguel
PMID:	21479480

437.
Journal:	Expert Rev Clin Pharmacol. 2008 Jan;1(1):73-80.
Title:	Integrating pharmacogenomics into oncology clinical practice.
Author:	Marsh, Sharon\|Phillips, Michael S
PMID:	24410511

438.
Journal:	Pathol Oncol Res. 2009 Sep;15(3):335-44.
Title:	Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
Author:	Reti, Andrea\|Barna, Gabor\|Pap, Eva\|Adleff, Vilmos\|L Komlosi, Viktor\|Jeney, Andras\|Kralovanszky, Judit\|Budai, Barna
PMID:	19048402

439.
Journal:	Int J Cancer. 2009 Mar 1;124(5):1220-6.
Title:	Molecular determinants of efficacy for 5-FU-based treatments in advanced colorectal cancer: mRNA expression for 18 chemotherapy-related genes.
Author:	Gustavsson, Bengt\|Kaiser, Christopher\|Carlsson, Goran\|Wettergren, Yvonne\|Odin, Elisabeth\|Lindskog, Elinor Bexe\|Niyikiza, Clet\|Ma, Doreen
PMID:	19051292

440.
Journal:	Int J Oncol. 2009 Jan;34(1):219-29.
Title:	Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients.
Author:	Fernandez-Contreras, Maria-Encarnacion\|Sanchez-Hernandez, Jose Javier\|Gonzalez, Enrique\|Herraez, Belen\|Dominguez, Irene\|Lozano, Maria\|Garcia De Paredes, Maria-Luisa\|Munoz, Alberto\|Gamallo, Carlos
PMID:	19082493

441.
Journal:	Cancer Res. 2009 Feb 1;69(3):984-91.
Title:	Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
Author:	Brody, Jonathan R\|Hucl, Tomas\|Costantino, Christina L\|Eshleman, James R\|Gallmeier, Eike\|Zhu, Heng\|van der Heijden, Michiel S\|Winter, Jordan M\|Wikiewicz, Agnieszka K\|Yeo, Charles J\|Kern, Scott E
PMID:	19155291

442.
Journal:	Mol Cancer Ther. 2009 May;8(5):1000-7.
Title:	Thymidylate synthase gene variations: predictive and prognostic markers.
Author:	Lurje, Georg\|Manegold, Philipp C\|Ning, Yan\|Pohl, Alexandra\|Zhang, Wu\|Lenz, Heinz-Josef
PMID:	19383851

443.
Journal:	Br J Cancer. 2009 May 19;100(10):1549-57.
Title:	Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer.
Author:	Gusella, M\|Frigo, A C\|Bolzonella, C\|Marinelli, R\|Barile, C\|Bononi, A\|Crepaldi, G\|Menon, D\|Stievano, L\|Toso, S\|Pasini, F\|Ferrazzi, E\|Padrini, R
PMID:	19384296

444.
Journal:	Int J Cancer. 2009 Jul 15;125(2):463-73.
Title:	Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.
Author:	Fazzone, William\|Wilson, Peter M\|Labonte, Melissa J\|Lenz, Heinz-Josef\|Ladner, Robert D
PMID:	19384949

445.
Journal:	Expert Opin Pharmacother. 2009 May;10(7):1095-108.
Title:	Genotype-based therapeutic approach for colorectal cancer: state of the art and future perspectives.
Author:	Fogli, Stefano\|Caraglia, Michele
PMID:	19405786

446.
Journal:	J Dig Dis. 2009 May;10(2):118-23.
Title:	Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancer.
Author:	Cui, Yue Hong\|Liu, Tian Shu\|Zhuang, Rong Yuan\|Gao, Hen Jun\|Li, Hong
PMID:	19426394

447.
Journal:	Virchows Arch. 2009 Jun;454(6):695-702.
Title:	Nuclear thymidylate synthase expression in sporadic colorectal cancer depends on the site of the tumor.
Author:	Sulzyc-Bielicka, Violetta\|Domagala, Pawel\|Majdanik, Ewa\|Chosia, Maria\|Bielicki, Dariusz\|Kladny, Jozef\|Kaczmarczyk, Mariusz\|Safranow, Krzysztof\|Domagala, Wenancjusz
PMID:	19444465

448.
Journal:	Eur J Cancer. 2009 Jul;45(11):1999-2006.
Title:	Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study.
Author:	Koopman, Miriam\|Venderbosch, Sabine\|van Tinteren, Harm\|Ligtenberg, Marjolijn J\|Nagtegaal, Iris\|Van Krieken, Johan H\|Punt, Cornelis J
PMID:	19457654

449.
Journal:	Eur J Cancer. 2009 Jul;45(11):1935-49.
Title:	A review on the use of molecular markers of cytotoxic therapy for colorectal cancer, what have we learned?
Author:	Koopman, Miriam\|Venderbosch, Sabine\|Nagtegaal, Iris D\|van Krieken, Johan H\|Punt, Cornelis J
PMID:	19473832

450.
Journal:	Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):673-88.
Title:	Biomarkers for response to neoadjuvant chemoradiation for rectal cancer.
Author:	Kuremsky, Jeffrey G\|Tepper, Joel E\|McLeod, Howard L
PMID:	19480968

451.
Journal:	Anticancer Res. 2009 Jun;29(6):2083-9.
Title:	Molecular mechanisms of sequence-dependent antitumor effects of SN-38 and 5-fluorouracil combination therapy against colon cancer cells.
Author:	Torigoe, Shoujiro\|Ogata, Yutaka\|Matono, Keiko\|Shirouzu, Kazuo
PMID:	19528468

452.
Journal:	Clin Colorectal Cancer. 2009 Jul;8(3):146-54.
Title:	Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.
Author:	Mauritz, Robert\|Giovannetti, Elisa\|Beumer, Ines J\|Smid, Kees\|Van Groeningen, Cees J\|Pinedo, Herbert M\|Peters, Godefridus J
PMID:	19632929

453.
Journal:	Clin Cancer Res. 2009 Sep 1;15(17):5528-33.
Title:	Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial.
Author:	Bosman, Fred T\|Yan, Pu\|Tejpar, Sabine\|Fiocca, Roberto\|Van Cutsem, Eric\|Kennedy, Richard D\|Dietrich, Daniel\|Roth, Arnaud
PMID:	19690194

454.
Journal:	Oncol Rep. 2009 Oct;22(4):901-6.
Title:	Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues.
Author:	Inoue, Yasuhiro\|Tanaka, Koji\|Yokoe, Takeshi\|Saigusa, Susumu\|Toiyama, Yuji\|Miki, Chikao\|Kusunoki, Masato
PMID:	19724871

455.
Journal:	BMC Cancer. 2009 Sep 24;9:339.
Title:	Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy.
Author:	Kostopoulos, Ioannis\|Karavasilis, Vasilios\|Karina, Maria\|Bobos, Mattheos\|Xiros, Nikolaos\|Pentheroudakis, George\|Kafiri, Georgia\|Papakostas, Pavlos\|Vrettou, Eleni\|Fountzilas, George
PMID:	19775480

456.
Journal:	Clin Colorectal Cancer. 2009 Oct;8(4):231-4.
Title:	Toxicity and efficacy of 5-fluorouracil and capecitabine in a patient with TYMS gene polymorphism: A challenge or a dilemma?
Author:	Shahrokni, Armin\|Rajebi, Mohammad Reza\|Saif, Muhammad Wasif
PMID:	19822515

457.
Journal:	J Clin Oncol. 2009 Nov 20;27(33):5519-28.
Title:	Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.
Author:	Braun, Michael S\|Richman, Susan D\|Thompson, Lindsay\|Daly, Catherine L\|Meade, Angela M\|Adlard, Julian W\|Allan, James M\|Parmar, Mahesh K B\|Quirke, Philip\|Seymour, Matthew T
PMID:	19858398

458.
Journal:	Mol Med Rep. 2009 May-Jun;2(3):393-8.
Title:	Oral fluoropyrimidine S-1 combined with leucovorin is a promising therapy for colorectal cancer: Evidence from a xenograft model of folate-depleted mice.
Author:	Tsukioka, Sayaka\|Uchida, Junji\|Tsujimoto, Hiroaki\|Nakagawa, Fumio\|Sugimoto, Yoshikazu\|Oka, Toshinori\|Kiniwa, Mamoru
PMID:	21475840

459.
Journal:	J Surg Oncol. 2010 Jan 1;101(1):22-7.
Title:	Relationship of polymorphism of the tandem repeat sequence in the thymidylate synthase gene and the survival of stage III colorectal cancer patients receiving adjuvant 5-flurouracil-based chemotherapy.
Author:	Park, Chi-Min\|Lee, Woo Yong\|Chun, Ho-Kyung\|Cho, Yong Beom\|Yun, Hae Ran\|Heo, Jin Seok\|Yun, Seong Hyeon\|Kim, Hee Cheol
PMID:	19798689

460.
Journal:	Int J Cancer. 2010 Aug 15;127(4):881-8.
Title:	Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma.
Author:	Schwarzenbach, Heidi\|Goekkurt, Eray\|Pantel, Klaus\|Aust, Daniela E\|Stoehlmacher, Jan
PMID:	19998340

461.
Journal:	Anticancer Drugs. 2010 Mar;21(3):313-9.
Title:	Thymidine phosphorylase expression in metastatic sites is predictive for response in patients with colorectal cancer treated with continuous oral capecitabine and biweekly oxaliplatin.
Author:	Petrioli, Roberto\|Bargagli, Gianluca\|Lazzi, Stefano\|Pascucci, Alessandra\|Francini, Edoardo\|Bellan, Cristiana\|Conca, Raffaele\|Martellucci, Ignazio\|Fiaschi, Anna Ida\|Lorenzi, Bruno\|Francini, Guido
PMID:	20016369

462.
Journal:	Br J Clin Pharmacol. 2010 Jan;69(1):58-66.
Title:	Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients.
Author:	Etienne-Grimaldi, Marie-Christine\|Milano, Gerard\|Maindrault-Goebel, Frederique\|Chibaudel, Benoist\|Formento, Jean-Louis\|Francoual, Mireille\|Lledo, Gerard\|Andre, Thierry\|Mabro, May\|Mineur, Laurent\|Flesch, Michel\|Carola, Elisabeth\|de Gramont, Aimery
PMID:	20078613

463.
Journal:	J Cancer Res Clin Oncol. 2010 Nov;136(11):1681-9.
Title:	Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil.
Author:	Paez, David\|Pare, Laia\|Altes, Albert\|Sancho-Poch, Francesc Josep\|Petriz, Lourdes\|Garriga, Jordi\|Monill, Josep Maria\|Salazar, Juliana\|del Rio, Elisabeth\|Barnadas, Agusti\|Marcuello, Eugenio\|Baiget, Montserrat
PMID:	20165956

464.
Journal:	Anticancer Res. 2010 Feb;30(2):645-51.
Title:	Prognostic and predictive value of thymidylate synthase expression in primary colorectal cancer.
Author:	Karlberg, M\|Ohrling, K\|Edler, D\|Hallstrom, M\|Ullen, H\|Ragnhammar, P
PMID:	20332484

465.
Journal:	Mol Cancer Ther. 2010 Apr;9(4):1047-57.
Title:	Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.
Author:	Temmink, Olaf H\|Bijnsdorp, Irene V\|Prins, Henk-Jan\|Losekoot, Nienke\|Adema, Auke D\|Smid, Kees\|Honeywell, Richard J\|Ylstra, Bauke\|Eijk, Paul P\|Fukushima, Masakazu\|Peters, Godefridus J
PMID:	20371715

466.
Journal:	Oncol Rep. 2010 May;23(5):1393-400.
Title:	Influence of thymidylate synthase DNA polymorphisms and gender on the clinical evolution of patients with advanced colorectal cancer.
Author:	Fernandez-Contreras, Maria-Encarnacion\|Sanchez-Hernandez, Jose Javier\|Guijarro, Mercedes\|Gisbert, Javier P\|Rivas, Noa\|Garcia de Paredes, Maria-Luisa\|Hinojar-Gutierrez, Adolfo\|Gamallo, Carlos
PMID:	20372856

467.
Journal:	Int J Oncol. 2010 Jun;36(6):1573-80.
Title:	Effects of potential calcium sensing receptor inducers on promoting chemosensitivity of human colon carcinoma cells.
Author:	Wang, Xize\|Chen, Wei\|Singh, Navneet\|Promkan, Multira\|Liu, Guangming
PMID:	20428782

468.
Journal:	Mol Cancer. 2010 Apr 30;9:96.
Title:	Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Author:	Song, Bo\|Wang, Yuan\|Titmus, Matthew A\|Botchkina, Galina\|Formentini, Andrea\|Kornmann, Marko\|Ju, Jingfang
PMID:	20433742

469.
Journal:	Clin Cancer Res. 2010 Jul 15;16(14):3786-94.
Title:	A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors.
Author:	Fakih, Marwan G\|Fetterly, Gerald\|Egorin, Merrill J\|Muindi, Josephia R\|Espinoza-Delgado, Igor\|Zwiebel, James A\|Litwin, Alan\|Holleran, Julianne L\|Wang, Kangsheng\|Diasio, Robert B
PMID:	20463088

470.
Journal:	Cancer Sci. 2010 Aug;101(8):1853-60.
Title:	Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/ LV.
Author:	Ito, Yuichi\|Nakanishi, Hayao\|Kodera, Yasuhiro\|Hirai, Takashi\|Nakao, Akimasa\|Kato, Tomoyuki
PMID:	20500514

471.
Journal:	Pharmacogenomics. 2010 Jun;11(6):747-61.
Title:	Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.
Author:	Balboa, Emilia\|Duran, Goretti\|Lamas, Maria Jesus\|Gomez-Caamano, Antonio\|Celeiro-Munoz, Catuxa\|Lopez, Rafael\|Carracedo, Angel\|Barros, Francisco
PMID:	20504250

472.
Journal:	Anticancer Res. 2010 Apr;30(4):1157-62.
Title:	Arsenic trioxide suppresses thymidylate synthase in 5-FU-resistant colorectal cancer cell line HT29 In Vitro re-sensitizing cells to 5-FU.
Author:	Subbarayan, Pochi Ramalingam\|Lee, Kelvin\|Ardalan, Bach
PMID:	20530422

473.
Journal:	J Inorg Biochem. 2010 Sep;104(9):950-66.
Title:	Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: synthesis, structure, biological efficacy and QSAR studies.
Author:	Basu Baul, Tushar S\|Paul, Anup\|Pellerito, Lorenzo\|Scopelliti, Michelangelo\|Pellerito, Claudia\|Singh, Palwinder\|Verma, Pooja\|Duthie, Andrew\|de Vos, Dick\|Verma, Rajeshwar P\|Englert, Ulli
PMID:	20553814

474.
Journal:	Br J Cancer. 2010 Aug 10;103(4):581-9.
Title:	UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.
Author:	Martinez-Balibrea, E\|Abad, A\|Martinez-Cardus, A\|Gines, A\|Valladares, M\|Navarro, M\|Aranda, E\|Marcuello, E\|Benavides, M\|Massuti, B\|Carrato, A\|Layos, L\|Manzano, J L\|Moreno, V
PMID:	20628391

475.
Journal:	Mol Cancer Ther. 2010 Aug;9(8):2265-75.
Title:	miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation.
Author:	Boni, Valentina\|Bitarte, Nerea\|Cristobal, Ion\|Zarate, Ruth\|Rodriguez, Javier\|Maiello, Evaristo\|Garcia-Foncillas, Jesus\|Bandres, Eva
PMID:	20647341

476.
Journal:	Cancer Chemother Pharmacol. 2010 Nov;66(6):1167-71.
Title:	Value of gene polymorphisms as markers of 5-FU therapy response in stage III colon carcinoma: a pilot study.
Author:	Farina-Sarasqueta, Arantza\|van Lijnschoten, Gesina\|Rutten, Harm J T\|van den Brule, Adriaan J C
PMID:	20665215

477.
Journal:	Cancer Inform. 2010 Jul 29;9:147-61.
Title:	Clinical omics analysis of colorectal cancer incorporating copy number aberrations and gene expression data.
Author:	Yoshida, Tsuyoshi\|Kobayashi, Takumi\|Itoda, Masaya\|Muto, Taika\|Miyaguchi, Ken\|Mogushi, Kaoru\|Shoji, Satoshi\|Shimokawa, Kazuro\|Iida, Satoru\|Uetake, Hiroyuki\|Ishikawa, Toshiaki\|Sugihara, Kenichi\|Mizushima, Hiroshi\|Tanaka, Hiroshi
PMID:	20706620

478.
Journal:	J Nucleic Acids. 2010 Jan 26;2010.
Title:	Analysis of the thymidylate synthase gene structure in colorectal cancer patients and its possible relation with the 5-Fluorouracil drug response.
Author:	Calascibetta, A\|Contino, Flavia\|Feo, S\|Gulotta, G\|Cajozzo, M\|Antona, A\|Sanguedolce, G\|Sanguedolce, R
PMID:	20725619

479.
Journal:	Eur J Cancer. 2010 Dec;46(18):3358-64.
Title:	Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy.
Author:	Watson, Roshawn G\|Muhale, Filipe\|Thorne, Leigh B\|Yu, Jinsheng\|O'Neil, Bert H\|Hoskins, Janelle M\|Meyers, Michael O\|Deal, Allison M\|Ibrahim, Joseph G\|Hudson, Michael L\|Walko, Christine M\|McLeod, Howard L\|Auman, James T
PMID:	20727737

480.
Journal:	J Int Med Res. 2010 May-Jun;38(3):870-83.
Title:	Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
Author:	Kristensen, M H\|Pedersen, P L\|Melsen, G V\|Ellehauge, J\|Mejer, J
PMID:	20819423

481.
Journal:	Br J Cancer. 2010 Nov 23;103(11):1680-91.
Title:	Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Author:	Di Gennaro, E\|Piro, G\|Chianese, M I\|Franco, R\|Di Cintio, A\|Moccia, T\|Luciano, A\|de Ruggiero, I\|Bruzzese, F\|Avallone, A\|Arra, C\|Budillon, A
PMID:	21045833

482.
Journal:	Pharmacogenomics. 2010 Dec;11(12):1751-6.
Title:	Detection of the G>C SNP and rare mutations in the 28-bp repeat of TYMS using gel-based capillary electrophoresis.
Author:	Thomas, Fabienne\|Hoskins, Janelle M\|Dvorak, Anne\|Tan, Benjamin R\|McLeod, Howard L
PMID:	21142919

483.
Journal:	Gan To Kagaku Ryoho. 2010 Nov;37(12):2532-5.
Title:	[The expression of thymidylate synthase (TS) and excision repair complementing-1 (ERCC-1) protein in patients with unresectable colorectal cancer treated with mFOLFOX6 therapy].
Author:	Ishibashi, Keiichiro\|Okada, Norimichi\|Ishiguro, Toru\|Kuwabara, Kouki\|Ohsawa, Tomonori\|Yokoyama, Masaru\|Kumamoto, Kensuke\|Haga, Norihiro\|Mori, Takashi\|Yamada, Hirofumi\|Miura, Ichiro\|Tamaru, Junichi\|Itoyama, Shinji\|Ishida, Hideyuki
PMID:	21224630

484.
Journal:	Cancer Manag Res. 2010 Nov 19;2:293-301.
Title:	Cancer chemotherapy: targeting folic acid synthesis.
Author:	Hagner, Nicole\|Joerger, Markus
PMID:	21301589

485.
Journal:	EPMA J. 2010 Sep;1(3):485-94.
Title:	Predictive diagnostics in colorectal cancer: impact of genetic polymorphisms on individual outcomes and treatment with fluoropyrimidine-based chemotherapy.
Author:	Schwarzenbach, Heidi
PMID:	23199090

486.
Journal:	Pharmacogenomics J. 2011 Feb;11(1):61-71.
Title:	Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer.
Author:	Glimelius, B\|Garmo, H\|Berglund, A\|Fredriksson, L A\|Berglund, M\|Kohnke, H\|Bystrom, P\|Sorbye, H\|Wadelius, M
PMID:	20177420

487.
Journal:	J Cancer Res Clin Oncol. 2011 Feb;137(2):201-10.
Title:	Thymidilate synthase expression predicts longer survival in patients with stage II colon cancer treated with 5-flurouracil independently of microsatellite instability.
Author:	Donada, Marisa\|Bonin, Serena\|Nardon, Ermanno\|De Pellegrin, Alessandro\|Decorti, Giuliana\|Stanta, Giorgio
PMID:	20387074

488.
Journal:	Med Oncol. 2011 Dec;28(4):1136-9.
Title:	Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin.
Author:	Schneiders, Famke L\|van den Berg, H Pieter\|Peters, Godefridus J\|Verheul, Henk M W\|van der Vliet, Hans J
PMID:	20567941

489.
Journal:	Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1377-82.
Title:	Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression.
Author:	Unger, Keith R\|Romney, Davis A\|Koc, Mehmet\|Moskaluk, Christopher A\|Friel, Charles M\|Foley, E F\|Rich, Tyvin A
PMID:	20656421

490.
Journal:	Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):669-76.
Title:	Thymidylate synthase gene polymorphism affects the response to preoperative 5-fluorouracil chemoradiation therapy in patients with rectal cancer.
Author:	Hur, Hyuk\|Kang, Jeonghyun\|Kim, Nam Kyu\|Min, Byung Soh\|Lee, Kang Young\|Shin, Sang Joon\|Keum, Ki Chang\|Choi, Junjeong\|Kim, Hoguen\|Choi, Sung Ho\|Lee, Mi-Young
PMID:	20932673

491.
Journal:	J Clin Oncol. 2011 Mar 1;29(7):875-83.
Title:	Thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma.
Author:	Tan, Benjamin R\|Thomas, Fabienne\|Myerson, Robert J\|Zehnbauer, Barbara\|Trinkaus, Kathryn\|Malyapa, Robert S\|Mutch, Matthew G\|Abbey, Elliot E\|Alyasiry, Amer\|Fleshman, James W\|McLeod, Howard L
PMID:	21205745

492.
Journal:	Silence. 2011 Jan 19;2(1):1.
Title:	Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors.
Author:	Schmitz, John C\|Chu, Edward
PMID:	21247442

493.
Journal:	Clin Cancer Res. 2011 Apr 1;17(7):2006-13.
Title:	A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome.
Author:	Caronia, Daniela\|Martin, Miguel\|Sastre, Javier\|de la Torre, Julio\|Garcia-Saenz, Jose Angel\|Alonso, Maria R\|Moreno, Leticia T\|Pita, Guillermo\|Diaz-Rubio, Eduardo\|Benitez, Javier\|Gonzalez-Neira, Anna
PMID:	21325291

494.
Journal:	Mol Carcinog. 2011 Dec;50(12):922-30.
Title:	Nifedipine synergizes with calcium in activating the calcium sensing receptor, suppressing the expression of thymidylate synthase and survivin and promoting sensitivity to fluorouracil in human colon carcinoma cells.
Author:	Liu, Guangming\|Hu, Xin\|Premkumar, Louis\|Chakrabarty, Subhas
PMID:	21374737

495.
Journal:	Cancer Res. 2011 Mar 15;71(6):2098-107.
Title:	Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.
Author:	Macfarlane, Amanda J\|Perry, Cheryll A\|McEntee, Michael F\|Lin, David M\|Stover, Patrick J
PMID:	21406397

496.
Journal:	Int J Colorectal Dis. 2011 Aug;26(8):1019-23.
Title:	High survivin expression as a predictor of poor response to preoperative chemoradiotherapy in locally advanced rectal cancer.
Author:	Kim, Kyubo\|Chie, Eui Kyu\|Wu, Hong-Gyun\|Kim, Sang Gyun\|Lee, Seung-Hee\|Kang, Gyeong Hoon\|Hyun, Chang Lim\|Ha, Sung W
PMID:	21424389

497.
Journal:	Clin Cancer Res. 2011 Jun 1;17(11):3822-9.
Title:	Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients.
Author:	Afzal, Shoaib\|Gusella, Milena\|Vainer, Ben\|Vogel, Ulla B\|Andersen, Jon T\|Broedbaek, Kasper\|Petersen, Morten\|Jimenez-Solem, Espen\|Bertolaso, Laura\|Barile, Carmen\|Padrini, Roberto\|Pasini, Felice\|Jensen, Soren A\|Poulsen, Henrik E
PMID:	21471424

498.
Journal:	Pharmacol Res. 2011 Sep;64(3):242-8.
Title:	Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.
Author:	Vignoli, Marina\|Nobili, Stefania\|Napoli, Cristina\|Putignano, Anna Laura\|Morganti, Maria\|Papi, Laura\|Valanzano, Rosa\|Cianchi, Fabio\|Tonelli, Francesco\|Mazzei, Teresita\|Mini, Enrico\|Genuardi, Maurizio
PMID:	21536130

499.
Journal:	Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1319-27.
Title:	Pharmacogenetic study in rectal cancer patients treated with preoperative chemoradiotherapy: polymorphisms in thymidylate synthase, epidermal growth factor receptor, GSTP1, and DNA repair genes.
Author:	Paez, David\|Salazar, Juliana\|Pare, Laia\|Pertriz, Lourdes\|Targarona, Eduardo\|del Rio, Elisabeth\|Barnadas, Agusti\|Marcuello, Eugenio\|Baiget, Montserrat
PMID:	21570215

500.
Journal:	Mod Pathol. 2011 Sep;24(9):1221-8.
Title:	Folate receptor-alpha expression in resectable hepatic colorectal cancer metastases: patterns and significance.
Author:	D'Angelica, Michael\|Ammori, John\|Gonen, Mithat\|Klimstra, David S\|Low, Philip S\|Murphy, Linda\|Weiser, Martin R\|Paty, Philip B\|Fong, Yuman\|Dematteo, Ronald P\|Allen, Peter\|Jarnagin, William R\|Shia, Jinru
PMID:	21572402

501.
Journal:	Tumour Biol. 2011 Oct;32(5):853-61.
Title:	Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Author:	Guimaraes, Jose Luiz Miranda\|Ayrizono, Maria de Lurdes\|Coy, Claudio Saddy Rodrigues\|Lima, Carmen Silvia Passos
PMID:	21603981

502.
Journal:	Cell Oncol (Dordr). 2011 Aug;34(4):327-35.
Title:	TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.
Author:	Farina-Sarasqueta, A\|Gosens, M J E M\|Moerland, E\|van Lijnschoten, I\|Lemmens, V E P P\|Slooter, G D\|Rutten, H J T\|van den Brule, Adriaan J C
PMID:	21630057

503.
Journal:	Dis Colon Rectum. 2011 Aug;54(8):1026-35.
Title:	Gene expression of vascular endothelial growth factor A, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients.
Author:	Watanabe, Toshiaki\|Kobunai, Takashi\|Yamamoto, Yoko\|Matsuda, Keiji\|Ishihara, Soichiro\|Nozawa, Keijiro\|Iinuma, Hisae\|Ikeuchi, Hiroki
PMID:	21730794

504.
Journal:	Clin Colorectal Cancer. 2011 Dec;10(4):340-7.
Title:	Prognostic significance of miR-215 in colon cancer.
Author:	Karaayvaz, Mihriban\|Pal, Timothy\|Song, Bo\|Zhang, Cecilia\|Georgakopoulos, Penelope\|Mehmood, Saira\|Burke, Stephanie\|Shroyer, Kenneth\|Ju, Jingfang
PMID:	21752725

505.
Journal:	Curr Drug Metab. 2011 Dec;12(10):956-65.
Title:	DNA copy number profiles correlate with outcome in colorectal cancer patients treated with fluoropyrimidine/antifolate-based regimens.
Author:	Leon, Leticia G\|Giovannetti, Elisa\|Smid, Kees\|van Houte, Bart P P\|Hanauske, Axel R\|Giaccone, Giuseppe\|Peters, Godefridus J
PMID:	21787269

506.
Journal:	J Hematol Oncol. 2011 Aug 9;4:33.
Title:	Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer.
Author:	Liu, Yanyan\|Xia, Qingxin\|Jia, Yanzhao\|Guo, Hongqiang\|Wei, Bing\|Hua, Yawei\|Yang, Shujun
PMID:	21824439

507.
Journal:	J Biol Chem. 2011 Sep 30;286(39):33872-8.
Title:	Novel positron emission tomography tracer distinguishes normal from cancerous cells.
Author:	Saeed, Muhammad\|Sheff, David\|Kohen, Amnon
PMID:	21832075

508.
Journal:	Pharmacogenomics. 2011 Sep;12(9):1257-67.
Title:	The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.
Author:	Afzal, Shoaib\|Gusella, Milena\|Jensen, Soren Astrup\|Vainer, Ben\|Vogel, Ulla\|Andersen, Jon Traerup\|Brodbaek, Kasper\|Petersen, Morten\|Jimenez-Solem, Espen\|Adleff, Vilmos\|Budai, Barna\|Hitre, Erika\|Lang, Istvan\|Orosz, Eniko\|Bertolaso, Laura\|Barile, Carmen\|Padr
PMID:	21919605

509.
Journal:	Br J Cancer. 2011 Nov 22;105(11):1654-62.
Title:	Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.
Author:	Thomas, F\|Motsinger-Reif, A A\|Hoskins, J M\|Dvorak, A\|Roy, S\|Alyasiri, A\|Myerson, R J\|Fleshman, J W\|Tan, B R\|McLeod, H L
PMID:	22045187

510.
Journal:	ISRN Oncol. 2011;2011:936893.
Title:	Novel strategy with gemcitabine for advanced pancreatic cancer.
Author:	Komori, Shuji\|Osada, Shinji\|Yoshida, Kazuhiro
PMID:	22091436

511.
Journal:	Anticancer Res. 2011 Nov;31(11):3843-9.
Title:	Relationship between TYMS and ERCC1 mRNA expression and in vitro chemosensitivity in colorectal cancer.
Author:	Cho, Yong Beom\|Chung, Hyuk Jun\|Lee, Woo Yong\|Choi, Sung Ho\|Kim, Hee Cheol\|Yun, Seong Hyeon\|Chun, Ho-Kyung
PMID:	22110208

512.
Journal:	Gan To Kagaku Ryoho. 2011 Nov;38(12):2220-3.
Title:	[Prediction of the efficacy of modified FOLFOX6 therapy according to the mRNA levels of thymidylate synthase (TS), excision repair cross-complementing-1 and -2( ERCC-1 and ERCC-2) and methylenetetrahydrofolate dehydrogenase( MTHFD) in the primary lesion o
Author:	Ishibashi, Keiichiro\|Okada, Norimichi\|Tajima, Yusuke\|Ishiguro, Toru\|Kuwabara, Kouki\|Ohsawa, Tomonori\|Kumamoto, Kensuke\|Tsuji, Yoshitaka\|Haga, Norihiro\|Iwama, Takeo\|Ishida, Hideyuki\|Onouchi, Tsuneko\|Yakabi, Koji
PMID:	22202336

513.
Journal:	Exp Ther Med. 2011 May;2(3):393-397.
Title:	Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.
Author:	Suzuki, Norihiko\|Nakagawa, Fumio\|Nukatsuka, Mamoru\|Fukushima, Masakazu
PMID:	22977515

514.
Journal:	Cancers (Basel). 2011 Apr 26;3(2):2176-94.
Title:	Predictive factors of the response of rectal cancer to neoadjuvant radiochemotherapy.
Author:	Spolverato, Gaya\|Pucciarelli, Salvatore\|Bertorelle, Roberta\|De Rossi, Anita\|Nitti, Donato
PMID:	24212803

515.
Journal:	Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):138-44.
Title:	X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients.
Author:	Lamas, Maria J\|Duran, Goretti\|Gomez, Antonio\|Balboa, Emilia\|Anido, Urbano\|Bernardez, Beatriz\|Rana-Diez, Pablo\|Lopez, Rafael\|Carracedo, Angel\|Barros, Francisco
PMID:	21167658

516.
Journal:	Eur J Cancer. 2012 Jul;48(10):1443-51.
Title:	Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: results of a randomised multicentre trial.
Author:	Kornmann, Marko\|Hebart, Holger\|Danenberg, Kathleen\|Goeb, Roland\|Staib, Ludger\|Kron, Martina\|Henne-Bruns, Doris\|Danenberg, Peter\|Link, Karl-Heinrich
PMID:	22133572

517.
Journal:	Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1058.
Title:	In regard to "Thymidylate synthase gene polymorphism affects the response to preoperative 5-fluorouracil chemoradiation therapy in patients with rectal cancer" (Int J Radiat Oncol Biol Phys 2011;81:669-676).
Author:	Schirmer, Markus Anton\|Wolff, Hendrik Andreas\|Conradi, Lena Christin\|Christiansen, Hans
PMID:	22284030

518.
Journal:	Int J Cancer. 2012 Nov 1;131(9):2103-16.
Title:	The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis.
Author:	Zhou, Jue-Yu\|Shi, Rong\|Yu, Hai-Lang\|Zeng, Ye\|Zheng, Wen-Ling\|Ma, Wen-Li
PMID:	22307944

519.
Journal:	Ann Surg Oncol. 2012 Jul;19 Suppl 3:S682-92.
Title:	Cell cycle proteins predict recurrence in stage II and III colon cancer.
Author:	Belt, Eric J Th\|Brosens, Rebecca P M\|Delis-van Diemen, Pien M\|Bril, Herman\|Tijssen, Marianne\|van Essen, Dirk F\|Heymans, Martijn W\|Belien, Jeroen A M\|Stockmann, Hein B A C\|Meijer, Sybren\|Meijer, Gerrit A
PMID:	22311118

520.
Journal:	Pharmacogenet Genomics. 2012 Apr;22(4):290-304.
Title:	Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis.
Author:	Jennings, Barbara Anne\|Kwok, Chun Shing\|Willis, Gavin\|Matthews, Victoria\|Wawruch, Pawel\|Loke, Yoon Kong
PMID:	22388795

521.
Journal:	Basic Clin Pharmacol Toxicol. 2012 Sep;111(3):189-97.
Title:	Data-driven assessment of the association of polymorphisms in 5-Fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.
Author:	Sarac, Sinan B\|Rasmussen, Christian H\|Afzal, Shoaib\|Thirstrup, Steffen\|Jensen, Soren A\|Colding-Jorgensen, Morten\|Poulsen, Henrik E\|Mosekilde, Erik
PMID:	22448752

522.
Journal:	Br J Clin Pharmacol. 2012 May;73(5):776-85.
Title:	Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy together with cetuximab-irinotecan.
Author:	Etienne-Grimaldi, Marie-Christine\|Bennouna, Jaafar\|Formento, Jean-Louis\|Douillard, Jean-Yves\|Francoual, Mireille\|Hennebelle, Isabelle\|Chatelut, Etienne\|Francois, Eric\|Faroux, Roger\|El Hannani, Chaza\|Jacob, Jacques-Henri\|Milano, Gerard
PMID:	22486600

523.
Journal:	Int J Clin Exp Med. 2012;5(2):186-94. Epub 2012 Apr 6.
Title:	ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese.
Author:	Chai, Haina\|Pan, Jie\|Zhang, Xuelin\|Zhang, Xiaoyan\|Shen, Xiaoying\|Li, Hang\|Zhang, Kehao\|Yang, Changqing\|Sheng, Haihui\|Gao, Hengjun
PMID:	22567180

524.
Journal:	Hepatogastroenterology. 2012 Jun;59(116):1059-62.
Title:	Thymidylate synthase (TS) protein expression as a prognostic factor in advanced colorectal cancer: a comparison with TS mRNA expression.
Author:	Nakagawa, Tateo\|Shimada, Mitsuo\|Kurita, Nobuhiro\|Iwata, Takashi\|Nishioka, Masanori\|Yoshikawa, Kozo\|Higashijima, Jun\|Utsunomiya, Tohru
PMID:	22580655

525.
Journal:	Anticancer Res. 2012 May;32(5):1757-62.
Title:	Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer.
Author:	Goto, Tetsuhiro\|Shinmura, Kazuki\|Yokomizo, Kazuaki\|Sakuraba, Kazuma\|Kitamura, Youhei\|Shirahata, Atsushi\|Saito, Mitsuo\|Kigawa, Gaku\|Nemoto, Hiroshi\|Sanada, Yutaka\|Hibi, Kenji
PMID:	22593457

526.
Journal:	Cancer Chemother Pharmacol. 2012 Jul;70(1):25-32.
Title:	Phase II and gene expression analysis trial of neoadjuvant capecitabine plus irinotecan followed by capecitabine-based chemoradiotherapy for locally advanced rectal cancer: Hoosier Oncology Group GI03-53.
Author:	Chiorean, E Gabriela\|Sanghani, Sonal\|Schiel, Marissa A\|Yu, Menggang\|Burns, Matthew\|Tong, Yan\|Hinkle, David T\|Coleman, Nicki\|Robb, Bruce\|LeBlanc, Julia\|Clark, Romnee\|Bufill, Jose\|Curie, Colleen\|Loehrer, Patrick J\|Cardenes, Higinia
PMID:	22610353

527.
Journal:	Anticancer Res. 2012 Jun;32(6):2277-82.
Title:	Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.
Author:	Akagi, Yoshito\|Kinugasa, Tetsushi\|Mizobe, Tomoaki\|Kawahara, Akihiko\|Kage, Masayoshi\|Shirouzu, Kazuo
PMID:	22641663

528.
Journal:	Oncol Lett. 2012 May;3(5):983-989.
Title:	Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis.
Author:	Kumamoto, Kensuke\|Kuwabara, Koki\|Tajima, Yusuke\|Amano, Kunihiko\|Hatano, Satoshi\|Ohsawa, Tomonori\|Okada, Norimichi\|Ishibashi, Keiichiro\|Haga, Norihiro\|Ishida, Hideyuki
PMID:	22783377

529.
Journal:	Hepatogastroenterology. 2012 Sep;59(118):1859-64.
Title:	Thymidylate synthase and cyclin D1 protein expression in lymph node negative colorectal cancer: role as prognostic factors?
Author:	Formentini, Andrea\|Henne-Bruns, Doris\|Kornmann, Marko
PMID:	22819905

530.
Journal:	Pharmacogenomics. 2012 Jul;13(10):1173-91.
Title:	Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients.
Author:	Cortejoso, Lucia\|Lopez-Fernandez, Luis A
PMID:	22909207

531.
Journal:	Asian Pac J Cancer Prev. 2012;13(6):2605-10.
Title:	3R variant of thymidylate synthase 5'-untranslated enhanced region contributes to colorectal cancer risk: a meta-analysis.
Author:	Lu, Min\|Sun, Luhaoran\|Yang, Jing\|Li, Yue-Yao
PMID:	22938428

532.
Journal:	Asian Pac J Cancer Prev. 2012;13(8):4087-91.
Title:	Polymorphisms in the thymidylate synthase gene and risk of colorectal cancer.
Author:	Gao, Chang-Ming\|Ding, Jian-Hua\|Li, Su-Ping\|Liu, Yan-Ting\|Cao, Hai-Xia\|Wu, Jian-Zhong\|Tajima, Kazuo
PMID:	23098521

533.
Journal:	Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Nov;15(11):1187-91.
Title:	[Effects of RNA interference and nolatrexed on thymidylate synthase expression and cell proliferation of human colorectal carcinoma LOVO cells].
Author:	Tian, Shu-bo\|Jing, Chang-qing\|Li, Le-ping
PMID:	23172536

534.
Journal:	World J Gastroenterol. 2012 Dec 7;18(45):6635-44.
Title:	UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil.
Author:	Wang, Yan\|Shen, Lin\|Xu, Nong\|Wang, Jin-Wan\|Jiao, Shun-Chang\|Liu, Ze-Yuan\|Xu, Jian-Ming
PMID:	23236239

535.
Journal:	Chin J Cancer Res. 2012 Jun;24(2):116-23.
Title:	Glycogen Synthase Kinase 3beta Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells.
Author:	Liu, Kun-Ping\|Luo, Feng\|Xie, Si-Ming\|Tang, Li-Juan\|Chen, Mei-Xiang\|Wu, Xue-Fang\|Zhong, Xue-Yun\|Zhao, Tong
PMID:	23359767

536.
Journal:	Hepatogastroenterology. 2013 Mar-Apr;60(122):291-5.
Title:	Analysis of the mRNA expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) in liver metastases from colorectal cancer.
Author:	Yamane, Takao\|Seshimo, Akiyoshi\|Kameoka, Shingo
PMID:	22945388

537.
Journal:	Colorectal Dis. 2013 Apr;15(4):428-35.
Title:	Prognostic significance of thymidylate synthase polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy.
Author:	Arrazubi, V\|Suarez, J\|Guerrero, D\|Gomez, M\|Viudez, A\|Arias, F\|Balen, E\|Vera, R
PMID:	22958523

538.
Journal:	Oncol Rep. 2013 Feb;29(2):437-44.
Title:	Factors predicting the response to oral fluoropyrimidine drugs: a phase II trial on the individualization of postoperative adjuvant chemotherapy using oral fluorinated pyrimidines in stage III colorectal cancer treated by curative resection (ACT-01 Study)
Author:	Mori, Takeo\|Ohue, Masayuki\|Takii, Yasumasa\|Hashizume, Tadashi\|Kato, Tomoyuki\|Kotake, Kenjiro\|Sato, Toshihiko\|Tango, Toshiro
PMID:	23232805

539.
Journal:	Clin Colorectal Cancer. 2013 Jun;12(2):128-35.
Title:	A combined analysis of mismatch repair status and thymidylate synthase expression in stage II and III colon cancer.
Author:	Ohrling, Katarina\|Karlberg, Mia\|Edler, David\|Hallstrom, Marja\|Ragnhammar, Peter
PMID:	23276521

540.
Journal:	PLoS One. 2013;8(1):e51810.
Title:	Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer.
Author:	Bujanda, Luis\|Sarasqueta, Cristina\|Cosme, Angel\|Hijona, Elizabeth\|Enriquez-Navascues, Jose M\|Placer, Carlos\|Villarreal, Eloisa\|Herreros-Villanueva, Marta\|Giraldez, Maria D\|Gironella, Meritxell\|Balaguer, Francesc\|Castells, Antoni
PMID:	23300952

541.
Journal:	Curr Oncol Rep. 2013 Apr;15(2):152-61.
Title:	Pathological complete response after neoadjuvant therapy for rectal cancer and the role of adjuvant therapy.
Author:	Nelson, Valerie M\|Benson, Al B 3rd
PMID:	23381584

542.
Journal:	Mol Nutr Food Res. 2013 Apr;57(4):607-27.
Title:	Folate-genetics and colorectal neoplasia: what we know and need to know next.
Author:	Figueiredo, Jane C\|Levine, A Joan\|Crott, Jimmy W\|Baurley, James\|Haile, Robert W
PMID:	23401104

543.
Journal:	Cancer Sci. 2013 Jun;104(6):687-93.
Title:	Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells.
Author:	Watanabe, Motoki\|Sowa, Yoshihiro\|Yogosawa, Mayumi\|Sakai, Toshiyuki
PMID:	23438367

544.
Journal:	BMC Gastroenterol. 2013 Feb 27;13:36.
Title:	Management of stage II colon cancer - the use of molecular biomarkers for adjuvant therapy decision.
Author:	Donada, Marisa\|Bonin, Serena\|Barbazza, Renzo\|Pettirosso, Daniel\|Stanta, Giorgio
PMID:	23446022

545.
Journal:	Pharmacol Res. 2013 Jun;72:61-8.
Title:	Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells.
Author:	Gonzalez-Vallinas, Margarita\|Molina, Susana\|Vicente, Gonzalo\|de la Cueva, Ana\|Vargas, Teodoro\|Santoyo, Susana\|Garcia-Risco, Monica R\|Fornari, Tiziana\|Reglero, Guillermo\|Ramirez de Molina, Ana
PMID:	23557932

546.
Journal:	Mol Biol Rep. 2013 Jul;40(7):4637-44.
Title:	An integrated analysis of the association between Ts gene polymorphisms and clinical outcome in gastric and colorectal cancer patients treated with 5-FU-based regimens.
Author:	Wang, Ying-Chao\|Xue, Hui-Ping\|Wang, Zhen-Hua\|Fang, Jing-Yuan
PMID:	23645036

547.
Journal:	Int J Cancer. 2013 Nov 15;133(10):2307-14.
Title:	Induction of CaSR expression circumvents the molecular features of malignant CaSR null colon cancer cells.
Author:	Singh, Navneet\|Chakrabarty, Subhas
PMID:	23674327

548.
Journal:	Cancer Chemother Pharmacol. 2013 Aug;72(2):483-8.
Title:	DMET (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Author:	Rumiato, Enrica\|Boldrin, Elisa\|Amadori, Alberto\|Saggioro, Daniela
PMID:	23760813

549.
Journal:	Cancer Discov. 2013 Sep;3(9):1072-81.
Title:	Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.
Author:	Witherspoon, Mavee\|Chen, Qiuying\|Kopelovich, Levy\|Gross, Steven S\|Lipkin, Steven M
PMID:	23771434

550.
Journal:	Clin Biochem. 2013 Oct;46(15):1478-83.
Title:	TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer.
Author:	Lu, Yuanfang\|Zhuo, Changhua\|Cui, Bota\|Liu, Zhengxia\|Zhou, Ping\|Lu, Yuanming\|Wang, Baolin
PMID:	23810585

551.
Journal:	Mol Cancer Ther. 2013 Oct;12(10):2248-60.
Title:	Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.
Author:	Weeks, Lachelle D\|Fu, Pingfu\|Gerson, Stanton L
PMID:	23873851

552.
Journal:	Genes Chromosomes Cancer. 2013 Oct;52(10):945-53.
Title:	Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study.
Author:	Ashmore, Joseph H\|Lesko, Samuel M\|Muscat, Joshua E\|Gallagher, Carla J\|Berg, Arthur S\|Miller, Paige E\|Hartman, Terryl J\|Lazarus, Philip
PMID:	23893618

553.
Journal:	Oncol Rep. 2013 Dec;30(6):2845-51.
Title:	Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Author:	Mekata, Eiji\|Murata, Satoshi\|Sonoda, Hiromichi\|Shimizu, Tomoharu\|Umeda, Tomoko\|Shiomi, Hisanori\|Naka, Shigeyuki\|Yamamoto, Hiroshi\|Abe, Hajime\|Edamatsu, Takeo\|Fujieda, Ayako\|Fujioka, Masaki\|Wada, Tsutomu\|Tani, Tohru
PMID:	24100378

554.
Journal:	Anticancer Res. 2013 Oct;33(10):4611-7.
Title:	Thymidylate synthase, topoisomerase-1 and microsatellite instability: relationship with outcome in mucinous colorectal cancer treated with fluorouracil.
Author:	Negri, Francesca V\|Azzoni, Cinzia\|Bottarelli, Lorena\|Campanini, Nicoletta\|Mandolesi, Alessandra\|Wotherspoon, Andrew\|Cunningham, David\|Scartozzi, Mario\|Cascinu, Stefano\|Tinelli, Carmine\|Silini, Enrico Maria\|Ardizzoni, Andrea
PMID:	24123038

555.
Journal:	Oncology (Williston Park). 2013 Aug;27(8):746-54.
Title:	Use of molecular biomarkers to inform adjuvant therapy for colon cancer.
Author:	Mettu, Niharika B\|Hurwitz, Herbert\|Hsu, David S
PMID:	24133820

556.
Journal:	Oncol Lett. 2013 Sep;6(3):648-654.
Title:	Polymorphisms of GSTP1, ERCC2 and TS-3'UTR are associated with the clinical outcome of mFOLFOX6 in colorectal cancer patients.
Author:	Kumamoto, Kensuke\|Ishibashi, Keiichiro\|Okada, Norimichi\|Tajima, Yusuke\|Kuwabara, Kouki\|Kumagai, Yoichi\|Baba, Hiroyuki\|Haga, Norihiro\|Ishida, Hideyuki
PMID:	24137384

557.
Journal:	World J Gastroenterol. 2013 Nov 14;19(42):7374-88.
Title:	1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.
Author:	Das, Dipon\|Preet, Ranjan\|Mohapatra, Purusottam\|Satapathy, Shakti Ranjan\|Kundu, Chanakya Nath
PMID:	24259968

558.
Journal:	Asian Pac J Cancer Prev. 2013;14(11):6249-56.
Title:	Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study.
Author:	Morita, Makiko\|Yin, Guang\|Yoshimitsu, Shin-ichiro\|Ohnaka, Keizo\|Toyomura, Kengo\|Kono, Suminori\|Ueki, Takashi\|Tanaka, Masao\|Kakeji, Yoshihiro\|Maehara, Yoshihiko\|Okamura, Takeshi\|Ikejiri, Koji\|Futami, Kitaroh\|Maekawa, Takafumi\|Yasunami, Yohichi\|Takenaka, Ke
PMID:	24377513

559.
Journal:	Mol Clin Oncol. 2013 May;1(3):453-460.
Title:	Predictive value of orotate phosphoribosyltransferase in colorectal cancer patients receiving 5-FU-based chemotherapy.
Author:	Komori, Shuji\|Osada, Shinji\|Tomita, Hiroyuki\|Nishio, Kimitoshi\|Kumazawa, Iwao\|Tachibana, Susumu\|Tsuchiya, Juji\|Yoshida, Kazuhiro
PMID:	24649191

560.
Journal:	Am J Clin Oncol. 2014 Apr;37(2):117-21.
Title:	A prospective pilot study of target-guided personalized chemotherapy with intensity-modulated radiotherapy in patients with early rectal cancer.
Author:	Cubillo, Antonio\|Hernando-Requejo, Ovidio\|Garcia-Garcia, Elena\|Rodriguez-Pascual, Jesus\|De Vicente, Emilio\|Morelli, Pia\|Rubio, Carmen\|Lopez-Rios, Fernando\|Muro, Avertano\|Lopez, Ulpiano\|Prados, Susana\|Quijano, Yolanda\|Hidalgo, Manuel
PMID:	23211222

561.
Journal:	Ann Surg. 2014 Mar;259(3):508-15.
Title:	Pretreatment expression of 13 molecular markers as a predictor of tumor responses after neoadjuvant chemoradiation in rectal cancer.
Author:	Huh, Jung Wook\|Lee, Jae Hyuk\|Kim, Hyeong Rok
PMID:	23787217

562.
Journal:	Gene. 2014 Jan 10;533(2):558-64.
Title:	Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean population.
Author:	Jang, Moon Ju\|Kim, Jong Woo\|Jeon, Young Joo\|Chong, So Young\|Hong, Sung Pyo\|Hwang, Seong Gyu\|Oh, Doyeun\|Cho, Yun Kyung\|Ji, Young Geon\|Kim, Nam Keun
PMID:	24100087

563.
Journal:	Mol Med Rep. 2014 Feb;9(2):669-76.
Title:	Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer.
Author:	Yu, Chen\|Liu, Shen-Lin\|Qi, Ming-Hao\|Zou, Xi
PMID:	24276478

564.
Journal:	Cell Oncol (Dordr). 2014 Feb;37(1):17-28.
Title:	Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy.
Author:	Sulzyc-Bielicka, Violetta\|Domagala, Pawel\|Bielicki, Dariusz\|Safranow, Krzysztof\|Domagala, Wenancjusz
PMID:	24277474

565.
Journal:	Cancer Chemother Pharmacol. 2014 Feb;73(2):325-33.
Title:	TS mRNA levels can predict pemetrexed and raltitrexed sensitivity in colorectal cancer.
Author:	Zhang, Qun\|Shen, Jie\|Wang, Hao\|Hu, Jing\|Yu, Lixia\|Xie, Li\|Wei, Jia\|Liu, Baorui\|Guan, Wenxian\|Qian, Xiaoping
PMID:	24281197

566.
Journal:	Med Oncol. 2014 Feb;31(2):825.
Title:	Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment.
Author:	Baroudi, Olfa\|Baroudi, Thouraya\|Omrane, Ines\|Moussa, Amel\|Mezlini, Amel\|Ayari, Hajer\|Guermazi, Sami\|Bahloul, Abdesslem\|Bouzaienne, Hassen\|Uhrhammer, Nancy\|Bignon, Yves Jean\|El-Gaaied, Amel Benammar\|Bougatef, Karim
PMID:	24415354

567.
Journal:	Epigenetics. 2014 Apr;9(4):621-33.
Title:	Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism.
Author:	Coppede, Fabio\|Migheli, Francesca\|Lopomo, Angela\|Failli, Alessandra\|Legitimo, Annalisa\|Consolini, Rita\|Fontanini, Gabriella\|Sensi, Elisa\|Servadio, Adele\|Seccia, Massimo\|Zocco, Giuseppe\|Chiarugi, Massimo\|Spisni, Roberto\|Migliore, Lucia
PMID:	24500500

568.
Journal:	J Clin Oncol. 2014 Apr 1;32(10):1031-9.
Title:	Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Author:	Rosmarin, Dan\|Palles, Claire\|Church, David\|Domingo, Enric\|Jones, Angela\|Johnstone, Elaine\|Wang, Haitao\|Love, Sharon\|Julier, Patrick\|Scudder, Claire\|Nicholson, George\|Gonzalez-Neira, Anna\|Martin, Miguel\|Sargent, Daniel\|Green, Erin\|McLeod, Howard\|Zanger, Ul
PMID:	24590654

569.
Journal:	Clin Med Insights Oncol. 2014 Feb 17;8:15-20.
Title:	Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer.
Author:	Taflin, Helena\|Wettergren, Yvonne\|Odin, Elisabeth\|Carlsson, Goran\|Derwinger, Kristoffer
PMID:	24596472

570.
Journal:	Clin Res Hepatol Gastroenterol. 2014 Sep;38(4):481-90.
Title:	Thymidylate synthase genetic polymorphisms and colorectal cancer risk: a meta-analysis.
Author:	Wang, Jun\|Shi, Dengping\|Guo, Xufeng\|Zhang, Jixiang\|Yu, Shijie\|Song, Jia\|Cao, Zhuo\|Wang, Jing\|Ji, Mengyao\|Dong, Weiguo
PMID:	24685603

571.
Journal:	BMC Res Notes. 2014 Apr 23;7:260.
Title:	FOLFIRI(R) and bevacizumab in first-line treatment for colorectal cancer patients: safety, efficacy and genetic polymorphisms.
Author:	Becouarn, Yves\|Cany, Laurent\|Pulido, Marina\|Beyssac, Richard\|Texereau, Patrick\|Le Morvan, Valerie\|Bechade, Dominique\|Brunet, Rene\|Aitouferoukh, Sofiane\|Lalet, Caroline\|Mathoulin-Pelissier, Simone\|Fonck, Marianne\|Robert, Jacques
PMID:	24758527

572.
Journal:	Br J Cancer. 2014 May 27;110(11):2728-37.
Title:	Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study.
Author:	Etienne-Grimaldi, M-C\|Mahamat, A\|Chazal, M\|Laurent-Puig, P\|Olschwang, S\|Gaub, M-P\|Formento, J-L\|Formento, P\|Sudaka, A\|Boige, V\|Abderrahim-Ferkoune, A\|Benchimol, D\|Andre, T\|Houry, S\|Faucheron, J-L\|Letoublon, C\|Gilly, F-N\|Delpero, J-R\|Lasser, P\|Pradere, B\|P
PMID:	24800948

573.
Journal:	Am J Surg. 2014 Aug;208(2):228-34.
Title:	p27 expression in post-treatment rectal cancer: a potential novel approach for predicting residual nodal disease.
Author:	Leibold, Tobias\|Hui, Vanessa W\|Shia, Jinru\|Ruby, Jeannine A\|Riedel, Elyn R\|Guillem, Jose G
PMID:	24814310

574.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):413-21.
Title:	Radiosensitization by thymidine phosphorylase inhibitor in thymidine phosphorylase negative and overexpressing bladder cancer cell lines.
Author:	El-Naggar, Maha\|Ebbing, Eva\|Bijnsdorp, Irene\|van den Berg, Jaap\|Peters, Godefridus J
PMID:	24940699

575.
Journal:	Br J Cancer. 2014 Oct 28;111(9):1726-33.
Title:	Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Author:	Meulendijks, D\|Dewit, L\|Tomasoa, N B\|van Tinteren, H\|Beijnen, J H\|Schellens, J H M\|Cats, A
PMID:	25167226

576.
Journal:	World J Surg. 2014 Dec;38(12):3248-56.
Title:	Evaluation of 5-fluorouracil metabolic enzymes as predictors of response to adjuvant chemotherapy outcomes in patients with stage II/III colorectal cancer: a decision-curve analysis.
Author:	Shigeta, Kohei\|Ishii, Yoshiyuki\|Hasegawa, Hirotoshi\|Okabayashi, Koji\|Kitagawa, Yuko
PMID:	25167895

577.
Journal:	Anticancer Res. 2014 Sep;34(9):4949-62.
Title:	Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression.
Author:	Koumarianou, Anna\|Tzeveleki, Ioanna\|Mekras, Dimosthenis\|Eleftheraki, Anastasia G\|Bobos, Mattheos\|Wirtz, Ralph\|Fountzilas, Elena\|Valavanis, Christos\|Xanthakis, Ioannis\|Kalogeras, Konstantine T\|Basdanis, George\|Pentheroudakis, George\|Kotoula, Vassiliki\|Foun
PMID:	25202077

578.
Journal:	Oncol Rep. 2014 Dec;32(6):2319-26.
Title:	Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.
Author:	Tanaka, Nozomu\|Sakamoto, Kazuki\|Okabe, Hiroyuki\|Fujioka, Akio\|Yamamura, Keisuke\|Nakagawa, Fumio\|Nagase, Hideki\|Yokogawa, Tatsushi\|Oguchi, Kei\|Ishida, Keiji\|Osada, Akiko\|Kazuno, Hiromi\|Yamada, Yukari\|Matsuo, Kenichi
PMID:	25230742

579.
Journal:	Oncotarget. 2014 Oct 30;5(20):9980-91.
Title:	HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.
Author:	Nagaraju, Ganji Purnachandra\|Alese, Olatunji B\|Landry, Jerome\|Diaz, Roberto\|El-Rayes, Bassel F
PMID:	25296971

580.
Journal:	BMC Cancer. 2014 Nov 24;14:875.
Title:	Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial).
Author:	Avallone, Antonio\|Piccirillo, Maria Carmela\|Delrio, Paolo\|Pecori, Biagio\|Di Gennaro, Elena\|Aloj, Luigi\|Tatangelo, Fabiana\|D'Angelo, Valentina\|Granata, Cinzia\|Cavalcanti, Ernesta\|Maurea, Nicola\|Maiolino, Piera\|Bianco, Franco\|Montano, Massimo\|Silvestro, Luc
PMID:	25421252

581.
Journal:	Am J Ther. 2015 Mar-Apr;22(2):e36-9.
Title:	Dihydropyrimidine dehydrogenase 85T>C mutation is associated with ocular toxicity of 5-fluorouracil: a case report.
Author:	Baskin, Yasemin\|Amirfallah, Arsalan\|Unal, Olcun Umit\|Calibasi, Gizem\|Oztop, Ilhan
PMID:	24434920

582.
Journal:	Gut. 2015 Jan;64(1):111-20.
Title:	A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
Author:	Rosmarin, Dan\|Palles, Claire\|Pagnamenta, Alistair\|Kaur, Kulvinder\|Pita, Guillermo\|Martin, Miguel\|Domingo, Enric\|Jones, Angela\|Howarth, Kimberley\|Freeman-Mills, Luke\|Johnstone, Elaine\|Wang, Haitao\|Love, Sharon\|Scudder, Claire\|Julier, Patrick\|Fernandez-Roza
PMID:	24647007

583.
Journal:	Pharmacogenomics J. 2015 Feb;15(1):77-83.
Title:	EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer.
Author:	Sebio, A\|Salazar, J\|Paez, D\|Berenguer-Llergo, A\|Del Rio, E\|Tobena, M\|Martin-Richard, M\|Sullivan, I\|Targarona, E\|Balart, J\|Baiget, M\|Barnadas, A
PMID:	25026457

584.
Journal:	Int J Oncol. 2015 Jan;46(1):37-46.
Title:	Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5fluorouracil on the HT29 colon cancer cell line.
Author:	Hedbrant, Alexander\|Erlandsson, Ann\|Delbro, Dick\|Wijkander, Jonny
PMID:	25310018

585.
Journal:	Int J Oncol. 2015 Jan;46(1):113-22.
Title:	Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Author:	Lam, Sze-Kwan\|Li, Yuan-Yuan\|Zheng, Chun-Yan\|Ho, James Chung-Man
PMID:	25335113

586.
Journal:	Exp Mol Pathol. 2015 Jun;98(3):375-81.
Title:	Tissue-specific selection of optimal reference genes for expression analysis of anti-cancer drug-related genes in tumor samples using quantitative real-time RT-PCR.
Author:	Wang, Huijuan\|Yang, Bobo\|Geng, Tingting\|Li, Bin\|Dai, Penggao\|Chen, Chao
PMID:	25445497

587.
Journal:	J Surg Res. 2015 Apr;194(2):343-50.
Title:	Prognostic value of biomarkers in metastatic colorectal cancer patients.
Author:	Kataoka, Kozo\|Kanazawa, Akiyoshi\|Nakajima, Akio\|Yamaguchi, Ayane\|Arimoto, Akira
PMID:	25456112

588.
Journal:	Oncol Rep. 2015 Feb;33(2):607-14.
Title:	miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Author:	Li, Tao\|Gao, Feng\|Zhang, Xi-Peng
PMID:	25482885

589.
Journal:	Pharmacogenomics J. 2015 Aug;15(4):354-62.
Title:	Distinct gene expression profiles of proximal and distal colorectal cancer: implications for cytotoxic and targeted therapy.
Author:	Maus, M K H\|Hanna, D L\|Stephens, C L\|Astrow, S H\|Yang, D\|Grimminger, P P\|Loupakis, F\|Hsiang, J H\|Zeger, G\|Wakatsuki, T\|Barzi, A\|Lenz, H-J
PMID:	25532759

590.
Journal:	Biochemistry. 2015 Feb 10;54(5):1287-93.
Title:	Targeting the de novo biosynthesis of thymidylate for the development of a PET probe for pancreatic cancer imaging.
Author:	Nilaweera, Thushani D\|Saeed, Muhammad\|Kohen, Amnon
PMID:	25581782

591.
Journal:	Cancer Chemother Pharmacol. 2015 Apr;75(4):763-72.
Title:	Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy.
Author:	Joerger, M\|Huitema, A D R\|Boot, H\|Cats, A\|Doodeman, V D\|Smits, P H M\|Vainchtein, L\|Rosing, H\|Meijerman, I\|Zueger, M\|Meulendijks, D\|Cerny, T D\|Beijnen, J H\|Schellens, J H M
PMID:	25677447

592.
Journal:	Oncotarget. 2015 Mar 20;6(8):6422-30.
Title:	Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer.
Author:	Garcia-Gonzalez, Xandra\|Cortejoso, Lucia\|Garcia, Maria I\|Garcia-Alfonso, Pilar\|Robles, Luis\|Gravalos, Cristina\|Gonzalez-Haba, Eva\|Marta, Pellicer\|Sanjurjo, Maria\|Lopez-Fernandez, Luis A
PMID:	25691056

593.
Journal:	Gene. 2015 Oct 1;570(1):36-43.
Title:	Transcriptional profiles underpin microsatellite status and associated features in colon cancer.
Author:	Hogan, John\|DeJulius, Kathryn\|Liu, Xiuli\|Coffey, John C\|Kalady, Matthew F
PMID:	25704535

594.
Journal:	Eur J Clin Pharmacol. 2015 May;71(5):529-39.
Title:	Germ line polymorphisms as predictive markers for pre-surgical radiochemotherapy in locally advanced rectal cancer: a 5-year literature update and critical review.
Author:	Pezzolo, Elisa\|Modena, Yasmina\|Corso, Barbara\|Giusti, Pietro\|Gusella, Milena
PMID:	25740678

595.
Journal:	Case Rep Gastroenterol. 2015 Feb 10;9(1):44-8.
Title:	A unique case of a patient with rectal cancer who developed benign esophageal stenosis after localized rectal radiation and systemic chemotherapy.
Author:	Chahla, Elie\|Cheesman, Antonio\|Hammami, Muhammad\|Taylor, Jason R\|Poddar, Nishant\|Garrett, Robert W\|Alkaade, Samer
PMID:	25802497

596.
Journal:	PLoS One. 2015 Apr 16;10(4):e0123076.
Title:	Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.
Author:	Wakasa, Kentaro\|Kawabata, Rumi\|Nakao, Seiki\|Hattori, Hiroyoshi\|Taguchi, Kenichi\|Uchida, Junji\|Yamanaka, Takeharu\|Maehara, Yoshihiko\|Fukushima, Masakazu\|Oda, Shinya
PMID:	25881233

597.
Journal:	Clin Transl Oncol. 2015 Nov;17(11):876-83.
Title:	MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancer.
Author:	Sun, Z\|Zhou, N\|Han, Q\|Zhao, L\|Bai, C\|Chen, Y\|Zhou, J\|Zhao, R C
PMID:	26055341

598.
Journal:	Cancer. 2015 Oct 15;121(20):3684-91.
Title:	Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.
Author:	Cheng, Ting-Yuan David\|Makar, Karen W\|Neuhouser, Marian L\|Miller, Joshua W\|Song, Xiaoling\|Brown, Elissa C\|Beresford, Shirley A A\|Zheng, Yingye\|Poole, Elizabeth M\|Galbraith, Rachel L\|Duggan, David J\|Habermann, Nina\|Bailey, Lynn B\|Maneval, David R\|Caudill,
PMID:	26108676

599.
Journal:	Anticancer Res. 2015 Jul;35(7):3761-6.
Title:	Systematic Review of Candidate Single-nucleotide Polymorphisms as Biomarkers for Responsiveness to Neoadjuvant Chemoradiation for Rectal Cancer.
Author:	Maring, Elizabeth D\|Tawadros, Patrick S\|Steer, Clifford J\|Lee, Janet T
PMID:	26124319

600.
Journal:	Mol Clin Oncol. 2015 May;3(3):639-648.
Title:	Association between folate metabolism-related polymorphisms and colorectal cancer risk.
Author:	Kim, Jong Woo\|Jeon, Young Joo\|Jang, Moon Ju\|Kim, Jung O\|Chong, So Young\|Ko, Kwang Hyun\|Hwang, Seong Gyu\|Oh, Doyeun\|Oh, Jisu\|Kim, Nam Keun
PMID:	26137281

601.
Journal:	Tumour Biol. 2015 Dec;36(12):9599-609.
Title:	Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer.
Author:	Ma, Junli\|Zhang, Yan\|Shen, Hong\|Kapesa, Linda\|Liu, Wenqiang\|Zeng, Mengsi\|Zeng, Shan
PMID:	26142736

602.
Journal:	Mayo Clin Proc. 2015 Sep;90(9):1298-303.
Title:	Long Survival and Severe Toxicity Under 5-Fluorouracil-Based Therapy in a Patient With Colorectal Cancer Who Harbors a Germline Codon-Stop Mutation in TYMS.
Author:	Balboa-Beltran, Emilia\|Duran, Goretti\|Lamas, Maria Jesus\|Carracedo, Angel\|Barros, Francisco
PMID:	26210704

603.
Journal:	Cancer. 2015 Nov 1;121(21):3862-8.
Title:	A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors.
Author:	Grem, Jean L\|Kos, Mary E\|Evande, Ruby E\|Meza, Jane L\|Schwarz, James K
PMID:	26242208

604.
Journal:	Oncotarget. 2015 Oct 20;6(32):32622-33.
Title:	Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer.
Author:	Ahn, Ji-Young\|Lee, Ji-Sun\|Min, Hye-Young\|Lee, Ho-Young
PMID:	26416450

605.
Journal:	Int J Clin Exp Pathol. 2015 Oct 1;8(10):12333-45. eCollection 2015.
Title:	Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer.
Author:	Bai, Wenqi\|Wu, Yueqin\|Zhang, Ping\|Xi, Yanfeng
PMID:	26722420

606.
Journal:	Arkh Patol. 2015 Sep-Oct;77(5):26-30.
Title:	[Prognostic values of the clinical, morphological and molecular biological characteristics of colon adenocarcinoma].
Author:	Raskin, G A\|Pozharissky, K M\|Orlova, R V\|Petrov, S V
PMID:	26978017

607.
Journal:	Am J Clin Oncol. 2016 Jun;39(3):236-42.
Title:	Phase II Trial of Target-guided Personalized Chemotherapy in First-line Metastatic Colorectal Cancer.
Author:	Cubillo, Antonio\|Rodriguez-Pascual, Jesus\|Lopez-Rios, Fernando\|Plaza, Carlos\|Garcia, Elena\|Alvarez, Rafael\|de Vicente, Emilio\|Quijano, Yolanda\|Hernando, Ovidio\|Rubio, Carmen\|Perea, Sofia\|Sanchez, Gema\|Hidalgo, Manuel
PMID:	24517959

608.
Journal:	Pharmacogenomics J. 2016 Jun;16(3):249-65.
Title:	Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis.
Author:	Salnikova, L E\|Kolobkov, D S
PMID:	26122021

609.
Journal:	Int J Mol Med. 2016 Feb;37(2):319-28.
Title:	Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Author:	Shimamoto, Yuji\|Nukatsuka, Mamoru\|Takechi, Teiji\|Fukushima, Masakazu
PMID:	26676887

610.
Journal:	Tumour Biol. 2016 Jul;37(7):9465-72.
Title:	B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.
Author:	Jiang, Bo\|Liu, Fen\|Liu, ZhiHui\|Zhang, Ting\|Hua, Dong
PMID:	26787540

611.
Journal:	Cancer Lett. 2016 Apr 10;373(2):227-33.
Title:	Inhibition of NF-kappaB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer.
Author:	Rajitha, Balney\|Belalcazar, Astrid\|Nagaraju, Ganji Purnachandra\|Shaib, Walid L\|Snyder, James P\|Shoji, Mamoru\|Pattnaik, Subasini\|Alam, Afroz\|El-Rayes, Bassel F
PMID:	26850372

612.
Journal:	Exp Ther Med. 2016 Jan;11(1):201-207.
Title:	Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature.
Author:	Lin, L I\|Xu, Chun-Wei\|Zhang, B O\|Liu, Rong-Rui\|Ge, Fei-Jiao\|Zhao, Chuan-Hua\|Jia, R U\|Qin, Quan-Hong\|Stojsic, Jelena\|Wang, Yan\|Xu, Jian-Ming
PMID:	26889240

613.
Journal:	Springerplus. 2016 Feb 24;5:146.
Title:	Non-covalent interactions involving halogenated derivatives of capecitabine and thymidylate synthase: a computational approach.
Author:	Rahman, Adhip\|Hoque, Mohammad Mazharol\|Khan, Mohammad A K\|Sarwar, Mohammed G\|Halim, Mohammad A
PMID:	27026843

614.
Journal:	Oncol Res. 2016;23(5):237-48.
Title:	Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest.
Author:	Zhao, Hongwei\|Zhang, Yubao\|Sun, Jianmin\|Zhan, Chao\|Zhao, Liang
PMID:	27098147

615.
Journal:	Clin Cancer Res. 2016 Jun 15;22(12):2835-9.
Title:	TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.
Author:	van der Velden, Daphne L\|Opdam, Frans L\|Voest, Emile E
PMID:	27126991

616.
Journal:	Oncoimmunology. 2015 Dec 21;5(4):e1101205.
Title:	Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients.
Author:	Correale, Pierpaolo\|Botta, Cirino\|Martino, Elodia Claudio\|Ulivieri, Cristina\|Battaglia, Giuseppe\|Carfagno, Tommaso\|Rossetti, Maria Grazia\|Fioravanti, Antonella\|Guidelli, Giacomo Maria\|Cheleschi, Sara\|Gandolfo, Claudia\|Carbone, Francesco\|Baldari, Tatiana C
PMID:	27141384

617.
Journal:	Surgery. 2016 Nov;160(5):1326-1332.
Title:	Genetic polymorphisms in 5-Fluorouracil-related enzymes predict pathologic response after neoadjuvant chemoradiation for rectal cancer.
Author:	Nelson, Bailey\|Carter, Jane V\|Eichenberger, Maurice R\|Netz, Uri\|Galandiuk, Susan
PMID:	27423551

618.
Journal:	Clin Colorectal Cancer. 2016 Dec;15(4):369-376.e3.
Title:	Pretreatment Serum Folate Levels and Toxicity/Efficacy in Colorectal Cancer Patients Treated With 5-Fluorouracil and Folinic Acid.
Author:	Yan, Michael\|Ho, Cheryl\|Winquist, Eric\|Jonker, Derek\|Rayson, Daniel\|Stitt, Larry\|Tokmakejian, Sonya\|Tomiak, Anna\|Vincent, Mark D
PMID:	27474080

619.
Journal:	PLoS One. 2016 Sep 29;11(9):e0163961.
Title:	Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines.
Author:	Tsukihara, Hiroshi\|Tsunekuni, Kenta\|Takechi, Teiji
PMID:	27685866

620.
Journal:	J BUON. 2016 Jul-Aug;21(4):935-940.
Title:	Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.
Author:	Patricia Rios-Ibarra, Clara\|Janeth Rodriguez-Silva, Claudia\|Alonso Lopez-Chuken, Yamil\|Ortiz-Lopez, Rocio\|Fernandez-Castillo, Elisa\|Beatriz Del Toro Runzer, Claudia\|Paul Armenta-Perez, Vicente\|Flores-Gutierrez, Juan Pablo\|Quintanilla-Guzman, Arturo\|Salina
PMID:	27685916

621.
Journal:	Cancer Transl Med. 2016 Jan-Feb;2(1):1-6.
Title:	Implications of Circadian Rhythm Regulation by microRNAs in Colorectal Cancer.
Author:	Wu, Song\|Fesler, Andrew\|Ju, Jingfang
PMID:	27747302

622.
Journal:	Cureus. 2016 Sep 14;8(9):e783.
Title:	The First Case of Severe Takotsubo Cardiomyopathy Associated with 5-Fluorouracil in a Patient with Abnormalities of Both Dihydropyrimidine Dehydrogenase (DPYD) and Thymidylate Synthase (TYMS) Genes.
Author:	Saif, Muhammad W\|Smith, Melissa\|Maloney, Antonio
PMID:	27752409

623.
Journal:	Curr Mol Med. 2016;16(9):829-839.
Title:	Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) and Microsatellite Instability in Patients with Colorectal Cancer and Its Clinical Features.
Author:	Lee, H S\|Park, K U\|Kim, D-W\|Lhn, M H\|Kim, W H\|Seo, A N\|Chang, H E\|Nam, S K\|Lee, S Y\|Oh, H-K\|Kang, S-B
PMID:	27889996

624.
Journal:	Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):595-603.
Title:	Role of genomic factors beyond thymidylate synthase in the prediction of response to 5-fluorouracil.
Author:	Peters, Godefridus J\|Smid, K\|Meijer, E\|van Groeningen, C J\|Leon, L G
PMID:	27906628

625.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(12):2160-2162.
Title:	[A Case Report of Clinical Complete Response with Chemotherapy for Descending Colon Cancer Complicated with Severe Pulmonary Dysfunction].
Author:	Uno, Hidehiko\|Shida, Takashi\|Ogasawara, Takeshi\|Nomura, Satoru\|Takahara, Yoshihiro\|Sato, Yoshiharu\|Komatu, Teisuke\|Takahashi, Makoto
PMID:	28133255

626.
Journal:	Pharmacogenomics J. 2017 Jun;17(3):265-273.
Title:	Association of thymidylate synthase polymorphisms with the tumor response to preoperative chemoradiotherapy in rectal cancer: a systematic review and meta-analysis.
Author:	Yang, Y C\|Wu, G C\|Jin, L\|Wang, K L\|Bai, Z G\|Wang, J\|Zhang, Z T
PMID:	27001118

627.
Journal:	Oncologist. 2017 Jan;22(1):107-114.
Title:	A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
Author:	Niedzwiecki, Donna\|Hasson, Rian M\|Lenz, Heinz-Josef\|Ye, Cynthia\|Redston, Mark\|Ogino, Shuji\|Fuchs, Charles S\|Compton, Carolyn C\|Mayer, Robert J\|Goldberg, Richard M\|Colacchio, Thomas A\|Saltz, Leonard B\|Warren, Robert S\|Bertagnolli, Monica M
PMID:	27821793

628.
Journal:	Oncol Res. 2017 Aug 7;25(7):1129-1140.
Title:	Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo.
Author:	Di Paolo, Antonello\|Orlandi, Paola\|Di Desidero, Teresa\|Danesi, Romano\|Bocci, Guido
PMID:	28109077

629.
Journal:	J Nutr Biochem. 2017 Apr;42:126-133.
Title:	Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial.
Author:	Nunez-Sanchez, Maria A\|Gonzalez-Sarrias, Antonio\|Garcia-Villalba, Rocio\|Monedero-Saiz, Tamara\|Garcia-Talavera, Noelia V\|Gomez-Sanchez, Maria B\|Sanchez-Alvarez, Carmen\|Garcia-Albert, Ana M\|Rodriguez-Gil, Francisco J\|Ruiz-Marin, Miguel\|Pastor-Quirante, Fran
PMID:	28183047

630.
Journal:	Gastroenterol Res Pract. 2017;2017:2808235.
Title:	Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.
Author:	Del Gobbo, Alessandro\|Ferrero, Stefano
PMID:	28326100

631.
Journal:	Pharmacol Res. 2017 Jun;120:133-137.
Title:	Identification of new SNPs associated with severe toxicity to capecitabine.
Author:	Pellicer, Marta\|Garcia-Gonzalez, Xandra\|Garcia, Maria I\|Robles, Luis\|Gravalos, Cristina\|Garcia-Alfonso, Pilar\|Pachon, Vanessa\|Longo, Federico\|Martinez, Virginia\|Blanco, Carolina\|Iglesias, Irene\|Sanjurjo, Maria\|Lopez-Fernandez, Luis A
PMID:	28347776

632.
Journal:	Exp Ther Med. 2017 Feb;13(2):662-668.
Title:	Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis.
Author:	Wei, Jianchang\|Yang, Ping\|Li, Wanglin\|He, Feng\|Zeng, Shanqi\|Zhang, Tong\|Zhong, Junbin\|Huang, Di\|Chen, Zhuanpeng\|Wang, Chengxing\|Chen, Huacui\|Hu, He\|Cao, Jie
PMID:	28352348

633.
Journal:	Cancer Chemother Pharmacol. 2017 Jun;79(6):1077-1085.
Title:	Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer.
Author:	Sadahiro, Sotaro\|Suzuki, T\|Tanaka, A\|Okada, K\|Saito, G\|Miyakita, H\|Ogimi, T\|Nagase, H
PMID:	28417167

634.
Journal:	Oncol Lett. 2017 May;13(5):3387-3394.
Title:	MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase.
Author:	Xu, Weidong\|Jiang, Huayong\|Zhang, Fuli\|Gao, Junmao\|Hou, Jun
PMID:	28521444

635.
Journal:	World J Gastroenterol. 2017 Aug 28;23(32):5913-5924.
Title:	Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer.
Author:	Ntavatzikos, Anastasios\|Spathis, Aris\|Patapis, Paul\|Machairas, Nikolaos\|Peros, George\|Konstantoudakis, Stefanos\|Leventakou, Danai\|Panayiotides, Ioannis G\|Karakitsos, Petros\|Koumarianou, Anna
PMID:	28932083

636.
Journal:	World J Gastroenterol. 2017 Oct 7;23(37):6854-6867.
Title:	Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features.
Author:	Marques, Diego\|Ferreira-Costa, Layse Raynara\|Ferreira-Costa, Lorenna Larissa\|Correa, Romualdo da Silva\|Borges, Aline Maciel Pinheiro\|Ito, Fernanda Ribeiro\|Ramos, Carlos Cesar de Oliveira\|Bortolin, Raul Hernandes\|Luchessi, Andre Ducati\|Ribeiro-Dos-Santos,
PMID:	29085228

637.
Journal:	Oncotarget. 2017 Jul 28;8(43):74312-74319.
Title:	Rs7911488 modified the efficacy of capecitabine-based therapy in colon cancer through altering miR-1307-3p and TYMS expression.
Author:	Chen, Qi\|Mao, Yong\|Meng, Fanyi\|Wang, Lei\|Zhang, Hongjian\|Wang, Weipeng\|Hua, Dong
PMID:	29088787

638.
Journal:	Drug Metab Pers Ther. 2017 Dec 20;32(4):209-218.
Title:	Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer.
Author:	Castro-Rojas, Carlos A\|Esparza-Mota, Antonio R\|Hernandez-Cabrera, Francisco\|Romero-Diaz, Viktor J\|Gonzalez-Guerrero, Juan F\|Maldonado-Garza, Hector\|Garcia-Gonzalez, Irma S\|Buenaventura-Cisneros, Sergio\|Sanchez-Lopez, Josefina Y\|Ortiz-Lopez, Rocio\|Camacho-
PMID:	29257755

639.
Journal:	World J Gastroenterol. 2017 Dec 28;23(48):8533-8543.
Title:	Analysis of 12 variants in the development of gastric and colorectal cancers.
Author:	Cavalcante, Giovanna C\|Amador, Marcos At\|Ribeiro Dos Santos, Andre M\|Carvalho, Darlen C\|Andrade, Roberta B\|Pereira, Esdras Eb\|Fernandes, Marianne R\|Costa, Danielle F\|Santos, Ney Pc\|Assumpcao, Paulo P\|Ribeiro Dos Santos, Andrea\|Santos, Sidney
PMID:	29358861

640.
Journal:	Ann Oncol. 2018 Feb 1;29(2):439-444.
Title:	Genotype-based selection of treatment of patients with advanced colorectal cancer (SETICC): a pharmacogenetic-based randomized phase II trial.
Author:	Abad, A\|Martinez-Balibrea, E\|Vieitez, J M\|Alonso-Orduna, V\|Garcia Alfonso, P\|Manzano, J L\|Massuti, B\|Benavides, M\|Carrato, A\|Zanui, M\|Gallego, J\|Gravalos, C\|Conde, V\|Provencio, M\|Valladares-Ayerbes, M\|Salazar, R\|Sastre, J\|Montagut, C\|Rivera, F\|Aranda, E
PMID:	29145602

641.
Journal:	Anticancer Res. 2018 Feb;38(2):737-743.
Title:	Effective Timing of Surgical Resection of Colorectal Cancer Liver Metastases During Chemotherapy.
Author:	Osada, Shinji\|Gotoh, Ayana\|Yokoi, Ryoma\|Tsuchiya, Hiroshi\|Sakuratani, Takuji\|Sasaki, Yoshiyuki\|Okumura, Naoki\|Hayashi, Hideki\|Mukai, Tsuyoshi
PMID:	29374697

642.
Journal:	PLoS One. 2018 Feb 2;13(2):e0192316.
Title:	XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer.
Author:	He, Yanjing\|Penney, Michelle E\|Negandhi, Amit A\|Parfrey, Patrick S\|Savas, Sevtap\|Yilmaz, Yildiz E
PMID:	29394274

643.
Journal:	Cell Commun Signal. 2018 Feb 20;16(1):7.
Title:	Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway.
Author:	Liu, Haizhou\|Liu, Hui\|Zhou, Zhiyi\|Parise, Robert A\|Chu, Edward\|Schmitz, John C
PMID:	29458395

644.
Journal:	Cell Physiol Biochem. 2018;47(2):680-693.
Title:	Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
Author:	Gong, Shu\|Xu, Dongsheng\|Zhu, Jialin\|Zou, Fangdong\|Peng, Rui
PMID:	29794421

645.
Journal:	Cancer Med. 2018 May 29.
Title:	Pathway analysis of genetic variants in folate-mediated one-carbon metabolism-related genes and survival in a prospectively followed cohort of colorectal cancer patients.
Author:	Ose, Jennifer\|Botma, Akke\|Balavarca, Yesilda\|Buck, Katharina\|Scherer, Dominique\|Habermann, Nina\|Beyerle, Jolantha\|Pfutze, Katrin\|Seibold, Petra\|Kap, Elisabeth J\|Benner, Axel\|Jansen, Lina\|Butterbach, Katja\|Hoffmeister, Michael\|Brenner, Hermann\|Ulrich, Alex
PMID:	29845757

646.
Journal:	Acta Biochim Pol. 2018;65(2):227-234.
Title:	TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A gene mutation in Mexican colorectal cancer patients.
Author:	Gallegos-Arreola, Martha Patricia\|Zuniga-Gonzalez, Guillermo Moises\|Sanchez-Lopez, Josefina Yoaly\|Cruz, Alondra Yeraldi Naranjo\|Peralta-Leal, Valeria\|Figuera, Luis Eduardo\|Puebla-Perez, Ana Maria\|Ronquillo-Carreon, Carlos Alberto\|Puebla-Mora, Ana Graciela
PMID:	29906295

647.
Journal:	Drug Metab Pers Ther. 2018 Sep 12.
Title:	Early disease relapse in a patient with colorectal cancer who harbors genetic variants of DPYD, TYMS, MTHFR and DHFR after treatment with 5-fluorouracil-based chemotherapy.
Author:	Zawiah, Mohammed\|Yousef, Al-Motassem\|Kadi, Taha\|Yousef, Mohammed\|Majdalawi, Khalil\|Al-Yacoub, Shorouq\|Al-Hiary, Rasha\|Tantawi, Dua'a\|Mukred, Ramzi\|Ajaj, Abdel Rahman
PMID:	30207288