Primary Site >> Colorectal Cancer
Gene >> TYMS
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Ref: Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase. PMID: 6688493 |
Ref: Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma. PMID: 2424358 Ref: Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT. PMID: 3105903 |
Ref: Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin. PMID: 3501543 Ref: Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil. PMID: 3593415 Ref: Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells. PMID: 3664501 Ref: Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. PMID: 3815393 |
Ref: Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells. PMID: 2451526 Ref: Thymidylate synthase as a determinant of 5-fluoro-2'-deoxyuridine response in human colonic tumor cell lines. PMID: 2971871 Ref: A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line. PMID: 2971872 Ref: Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. PMID: 2972339 Ref: The role of thymidylate synthase in the response to fluoropyrimidine-folinic acid combinations. PMID: 2977716 Ref: Fluorouracil: biochemistry and pharmacology. PMID: 3049954 Ref: Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma. PMID: 3260621 Ref: The effect of leucovorin on the therapeutic index of fluorouracil in cancer patients. PMID: 3284210 Ref: Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma. PMID: 3365696 |
Ref: Modulation of 5-fluoro-2'-deoxyuridine response by folinic acid in human colonic tumor cell lines: the role of thymidylate synthase. PMID: 2523018 Ref: In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil. PMID: 2624224 Ref: Treatment of metastatic colorectal carcinoma. Recent advances in use of fluorouracil. PMID: 2813219 |
Ref: Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. PMID: 1697502 Ref: Resistance to 5-fluorouracil and 5-fluoro-2'-deoxyuridine mechanisms and clinical implications. PMID: 2142213 Ref: Enhancement of the antitumor effects of 5-fluorouracil by folinic acid. PMID: 2195551 Ref: Comparison of in vitro drug sensitivity by inhibition of tritium release from [5-3H]-2'-deoxyuridine and a clonogenic assay. PMID: 2195987 |
Ref: Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines. PMID: 1704999 Ref: Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue. PMID: 1720706 Ref: Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA. PMID: 1722409 Ref: Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer. PMID: 1789191 Ref: Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate. PMID: 1827310 Ref: Modulation of fluoropyrimidines by leucovorin: rationale and status. PMID: 1832538 Ref: Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation. PMID: 1937958 Ref: Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns. PMID: 2004848 |
Ref: Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. PMID: 1516048 Ref: [Neo-adjuvant chemotherapy with tegafur suppository for rectal cancer--evaluation of the antitumor effects, tissue levels of 5-FU and inhibition of thymidylate synthase. Tochigi Colorectal Cancer Study Group]. PMID: 1519926 Ref: Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization. PMID: 1532343 Ref: Enhancement of 5-fluoro-2'-deoxyuridine antineoplastic activity by 5-benzyloxybenzyloxybenzylacyclouridine in a human colon carcinoma cell line. PMID: 1532344 Ref: Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. PMID: 1532346 Ref: Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase. PMID: 1532671 Ref: Mechanisms of resistance to fluoropyrimidines. PMID: 1532673 Ref: Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. PMID: 1557655 Ref: Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations. PMID: 1557656 Ref: [Potentiation of thymidylate synthetase (TS) inhibition by combined administration of HCFU and dipyridamole: preliminary report. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma]. PMID: 1626945 Ref: [High-dose leucovorin and 5-FU]. PMID: 1626951 Ref: Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. PMID: 1643628 Ref: Fluorouracil combined with the pure (6S)-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study. PMID: 1738182 |
Ref: Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells. PMID: 8230285 Ref: [Some problems of TS measurement after administration of fluoropyrimidines in colorectal cancer. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma]. PMID: 8239685 Ref: 5-Fluorouracil combined with the [6S]-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma. A phase I-II study of two consecutive regimens. PMID: 8353102 Ref: Locus of the interaction among 5-fluorouracil, leucovorin, and interferon-alpha 2a in colon carcinoma cells. PMID: 8364921 Ref: [Phase I study of 5-fluorouracil and l-leucovorin]. PMID: 8452386 Ref: Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. PMID: 8474431 Ref: Phase I trial of a 5-day infusion of L-leucovorin plus daily bolus 5-fluorouracil in patients with advanced gastrointestinal malignancies. PMID: 8500227 Ref: Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine. PMID: 8502227 Ref: Immunoassay for thymidylate synthase in cytosols from human colorectal-carcinoma cell-lines. PMID: 21573550 |
Ref: Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase. PMID: 7660870 Ref: Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells. PMID: 7787251 Ref: Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer. PMID: 7872700 Ref: Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. PMID: 7931471 Ref: The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. PMID: 7989939 Ref: Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects. PMID: 8005809 Ref: ICI D1694 and idoxuridine: a synergistic antitumor combination. PMID: 8033097 Ref: Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells. PMID: 8069864 Ref: [TS inhibition rate and flow cytometric analysis of DNA content in preoperative chemotherapy with biochemical modulator]. PMID: 8203923 Ref: Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. PMID: 8264588 Ref: Expression of thymidylate synthase gene in human colorectal carcinomas by northern blotting and reflectance in-situ hybridization (rish) - correlation with the number of chromosome-18. PMID: 21559708 |
Ref: Antitumour effects of pure diastereoisomers of 5-formyltetrahydrofolate in hepatic transplants of a rodent colon carcinoma model. PMID: 7503782 Ref: Biochemical modulation of iododeoxyuridine by N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2,6-diaminobenz[cd]indole glucuronate (AG-331) leading to enhanced cytotoxicity. PMID: 7605345 Ref: The number of 5-fluoro-2'-deoxyuridine-5'-monophosphate binding sites and reduced folate pool in human colorectal carcinoma tissues: changes after tegafur and uracil treatment. PMID: 7641209 Ref: Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. PMID: 7763285 Ref: The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells. PMID: 7779703 Ref: Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells. PMID: 7779704 Ref: Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro. PMID: 7799924 Ref: In vitro synergism between 5-fluorouracil and natural beta interferon in human colon carcinoma cells. PMID: 9815929 Ref: Pathological and enzymatic features of 1,2-dimethylhydrazine induced colorectal carcinomas in rats. PMID: 21597804 |
Ref: [Comparative study of the combined effect of HCFU and dipyridamole (DP) in colorectal carcinoma--TS inhibition rate. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma]. PMID: 8645023 Ref: Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats. PMID: 8653704 Ref: Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy. PMID: 8740793 Ref: Fluoropyrimidine-mediated radiosensitization depends on cyclin E-dependent kinase activation. PMID: 8764107 Ref: Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines. PMID: 8787551 Ref: Effect of interferon on 5-fluorouracil-induced perturbations in pools of deoxynucleotide triphosphates and DNA strand breaks. PMID: 8823494 Ref: Synergy between the non-classical thymidylate synthase inhibitor AG337 (Thymitaq) and cisplatin in human colon and ovarian cancer cells. PMID: 8949986 Ref: Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model. PMID: 9816304 Ref: New Concepts for the Development and Use of Antifolates. PMID: 10387999 |
Ref: [The correlation between thymidylate synthase expression and cytotoxicity of 5-fluorouracil in human cancer cell lines: study using polyclonal antibody against recombinant human thymidylate synthase]. PMID: 9126308 Ref: Folate-based thymidylate synthase inhibitors in cancer chemotherapy. PMID: 9147608 Ref: Inhibition of thymidylate synthase: biochemical pharmacology of drugs with activity in colorectal cancer. PMID: 9154072 Ref: Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells. PMID: 9155534 Ref: Thymineless death in colon carcinoma cells is mediated via fas signaling. PMID: 9223329 Ref: [Study of preoperative combination therapy with UFT + CDDP in patients with gastric and colorectal cancer--concomitant effects based on the thymidylate synthase inhibitory rat]. PMID: 9239165 Ref: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. PMID: 9336359 Ref: Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay. PMID: 9337081 Ref: 'Tomudex' (raltitrexed) development: preclinical, phase I and II studies. PMID: 9376637 Ref: The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQ in human leukaemia and colorectal carcinoma cell lines. PMID: 9413945 Ref: Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro. PMID: 9416974 Ref: Preparation of the antibodies against recombinant human thymidylate synthase for the detection of its intratumoral levels and the application to sensitivity-study of 5-fluorouracil. PMID: 21590122 |
Ref: A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance. PMID: 9428481 Ref: Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma. PMID: 9463483 Ref: Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity. PMID: 9516938 Ref: Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma. PMID: 9552053 Ref: Resistance to high concentrations of methotrexate and 5-fluorouracil of differentiated HT-29 colon-cancer cells is restricted to cells of enterocytic phenotype. PMID: 9579576 Ref: p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. PMID: 9607581 Ref: Clinically relevant drug-drug interactions in oncology. PMID: 9663808 Ref: [The intratumoral levels of thymidylate synthetase and folate in gastric and colon cancer]. PMID: 9679579 Ref: Thymidylate synthase as a predictor of response. PMID: 9726090 Ref: Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA. PMID: 9748143 Ref: Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity. PMID: 9771954 Ref: Comparison between short or long exposure to 5-fluorouracil in human gastric and colon cancer cell lines: biochemical mechanism of resistance. PMID: 9773807 Ref: Resistance to 5-fluorouracil. PMID: 9809460 Ref: Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells. PMID: 9829751 Ref: Single agent infusional 5-fluorouracil is not effective second-line therapy after raltitrexed (Tomudex) in advanced colorectal cancer. PMID: 9849444 Ref: Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer. PMID: 9951876 |
Ref: Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex. PMID: 9891091 Ref: Regulation of p53 expression by thymidylate synthase. PMID: 10097112 Ref: [Leucovorin and 5-FU for advanced gastrointestinal cancer]. PMID: 10097740 Ref: Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. PMID: 10100718 Ref: Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: implications for chemotherapeutic options and survival. PMID: 10188059 Ref: The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. PMID: 10213489 Ref: Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. PMID: 10226579 Ref: [Comparison between continuous intravenous and oral administration of 5-FU with LV]. PMID: 10234293 Ref: Clinical implications of 5-FU modulation. PMID: 10442354 Ref: Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil. PMID: 10473077 Ref: Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. PMID: 10478484 Ref: A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. PMID: 10501910 Ref: Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. PMID: 10531414 Ref: Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications. PMID: 10533483 Ref: Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line. PMID: 10535743 Ref: Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer. PMID: 10545786 Ref: Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions. PMID: 10554030 Ref: Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. PMID: 10555156 Ref: Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. PMID: 10567440 Ref: Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis. PMID: 10598554 Ref: Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs. PMID: 10598558 Ref: The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status. PMID: 10631692 Ref: Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations. PMID: 10645207 Ref: Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines. PMID: 10674003 Ref: Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats. PMID: 10697523 Ref: Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines. PMID: 10803742 Ref: Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors. PMID: 10821538 Ref: 5-Fluorouracil metabolizing enzymes. PMID: 21374032 |
Ref: Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization. PMID: 10646859 Ref: A new quantitative RT-PCR assay for thymidylate synthase mRNA in blood leukocytes applied to cancer patients and healthy controls. PMID: 10660804 Ref: Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA. PMID: 10684933 Ref: Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival. PMID: 10690528 Ref: Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport. PMID: 10732767 Ref: Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer. PMID: 10741735 Ref: Changes in thymidylate synthase mRNA in blood leukocytes from patients with colorectal cancer after bolus administration of 5-fluorouracil. PMID: 10752654 Ref: Do the expression of CD44, apoptosis and thymidylate synthase inhibition rate correlate with the efficacy of chemotherapy in colorectal cancer? PMID: 10769701 Ref: Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. PMID: 10778957 Ref: Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed. PMID: 10785598 Ref: Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method. PMID: 10791849 Ref: Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs. PMID: 10803925 Ref: Schedule-dependent interactions between raltitrexed and cisplatin in human carcinoma cell lines in vitro. PMID: 10804291 Ref: Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. PMID: 10811110 Ref: Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody. PMID: 10820149 Ref: [Thymidylate synthase activity after preoperative administration of 5-FU in patients with gastric or colorectal cancer]. PMID: 10832438 Ref: The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status. PMID: 10840069 Ref: Postmitotic differentiation of colon carcinoma caco-2 cells does not prevent reentry in the cell cycle and tumorigenicity. PMID: 10891291 Ref: Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer. PMID: 10914714 Ref: Differential growth inhibition by 5-fluorouracil in human colorectal carcinoma cell lines. PMID: 11000583 Ref: The multilayered postconfluent cell culture as a model for drug screening. PMID: 11033303 Ref: Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination. PMID: 11038045 Ref: Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines. PMID: 11038143 Ref: Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma. PMID: 11061571 Ref: Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system. PMID: 11078914 Ref: [Thymidylate synthase and dihydropyrimidine dehydrogenase activity in a metastatic liver tumor from colorectal cancer]. PMID: 11086436 Ref: Impact of UFT on tumoral TS and DPD levels in colorectal cancer. PMID: 11098489 Ref: Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma. PMID: 11131679 Ref: Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil. PMID: 11156237 Ref: Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study. PMID: 11205269 Ref: ZD-9331 AstraZeneca. PMID: 11249590 Ref: Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates. PMID: 11417748 Ref: [Expression of thymidylate synthase gene and recurrence of colorectal carcinoma: their relation and clinical significance]. PMID: 11832164 |
Ref: Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells. PMID: 11139611 Ref: Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase. PMID: 11163332 Ref: Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro. PMID: 11173547 Ref: Determinants of prognosis and response to therapy in colorectal cancer. PMID: 11177741 Ref: A novel approach to thymidylate synthase as a target for cancer chemotherapy. PMID: 11179438 Ref: Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis. PMID: 11231942 Ref: Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. PMID: 11251009 Ref: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. PMID: 11278511 Ref: Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. PMID: 11283924 Ref: Molecular markers and prediction of response to chemoradiation in rectal cancer. PMID: 11295069 Ref: Novel approaches in the treatment of non-small-cell lung cancer. PMID: 11301850 Ref: Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer. PMID: 11313169 Ref: Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. PMID: 11325838 Ref: Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug. PMID: 11329255 Ref: [Correlation between 5-fluorouracil (5-FU) sensitivity as measured by collagen gel droplet embedded culture drug sensitivity test (CD-DST) and expression of orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), and dihydropyrimidine dehydr PMID: 11383215 Ref: Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. PMID: 11445849 Ref: Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. PMID: 11445856 Ref: Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. PMID: 11484952 Ref: A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. PMID: 11556832 Ref: ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. PMID: 11731512 Ref: Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma. PMID: 11747337 Ref: Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. PMID: 11751507 Ref: In vitro generation of cytotoxic T lymphocytes against HLA-A2.1-restricted peptides derived from human thymidylate synthase. PMID: 11760216 Ref: Thymidylate synthase expression in stage II and III colon cancer: a retrospective review. PMID: 11801762 Ref: Pemetrexed disodium, a novel antifolate with multiple targets. PMID: 11905785 Ref: Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. PMID: 11913730 Ref: Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments. PMID: 12445371 Ref: Thymidylate synthase pharmacogenetics in colorectal cancer. PMID: 12450432 Ref: Thymidylate Synthase Pharmacogenetics in Colorectal Cancer. PMID: 12450433 |
Ref: In Vitro schedule-dependent interactions between the multitargeted antifolate LY231514 and gemcitabine in human colon adenocarcinoma cell lines. PMID: 11801564 Ref: Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. PMID: 11836585 Ref: Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors. PMID: 11914603 Ref: Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. PMID: 11914638 Ref: Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. PMID: 11919227 Ref: Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer. PMID: 11919229 Ref: Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil. PMID: 11953901 Ref: Human colorectal malignancy and oral UFT. PMID: 12017314 Ref: Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer. PMID: 12018454 Ref: Pemetrexed combination therapy in the treatment of non-small cell lung cancer. PMID: 12023789 Ref: Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer. PMID: 12027413 Ref: Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. PMID: 12084461 Ref: [Dihydropyrimidine dehydrogenase and thymidylate synthase in colon carcinoma]. PMID: 12090040 Ref: The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger. PMID: 12102601 Ref: Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells. PMID: 12118332 Ref: Role of biological markers in the clinical outcome of colon cancer. PMID: 12373601 Ref: p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer. PMID: 12390383 Ref: The role of oxaliplatin in the treatment of advanced metastatic colorectal cancer: prospects and future directions. PMID: 12422306 Ref: Future potential of thymidylate synthase inhibitors in cancer therapy. PMID: 12457437 Ref: Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity. PMID: 12460463 Ref: Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. PMID: 12477050 Ref: Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance. PMID: 12482336 Ref: Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice. PMID: 12486085 Ref: Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer. PMID: 12530000 Ref: Thymidylate synthase expression in rectal cancer and proliferation, assessed by cyclin A and Ki-67 expression. PMID: 12530053 Ref: Different pathways of 5-fluorouracil metabolism after continuous venous or bolus injection in patients with colon carcinoma: possible predictive value of thymidylate synthetase mRNA and ribonucleotide reductase for 5-fluorouracil sensitivity. PMID: 12552952 Ref: The role of pemetrexed in the treatment of colorectal cancer. PMID: 12571812 |
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