Primary Site >> Colorectal Cancer

Gene >> TXN

Journal: Biochim Biophys Acta. 1994 Aug 2;1218(3):292-6.
Title: The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors.
Author: Gasdaska, P Y|Oblong, J E|Cotgreave, I A|Powis, G
PMID: 8049254
Journal: Clin Cancer Res. 1996 Feb;2(2):427-32.
Title: Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines.
Author: Yamada, M|Tomida, A|Yoshikawa, H|Taketani, Y|Tsuruo, T
PMID: 9816187
Journal: Cancer Res. 1997 Nov 1;57(21):4965-70.
Title: Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.
Author: Gallegos, A|Berggren, M|Gasdaska, J R|Powis, G
PMID: 9354464
Journal: Cancer Chemother Pharmacol. 1997;40(1):31-7.
Title: Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines.
Author: Yamada, M|Tomida, A|Yoshikawa, H|Taketani, Y|Tsuruo, T
PMID: 9137526
Journal: Hum Pathol. 2000 Apr;31(4):475-81.
Title: Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival.
Author: Grogan, T M|Fenoglio-Prieser, C|Zeheb, R|Bellamy, W|Frutiger, Y|Vela, E|Stemmerman, G|Macdonald, J|Richter, L|Gallegos, A|Powis, G
PMID: 10821495
Journal: Oncol Rep. 2002 Jan-Feb;9(1):75-9.
Title: Up-regulation of vitamin D3 up-regulated protein 1 gene in response to 5-fluorouracil in colon carcinoma SW620.
Author: Takahashi, Yasuo|Nagata, Toshihito|Ishii, Yukimoto|Ikarashi, Masahito|Ishikawa, Koichi|Asai, Satoshi
PMID: 11748459
Journal: Cancer Res. 2002 Sep 1;62(17):5089-95.
Title: The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
Author: Welsh, Sarah J|Bellamy, William T|Briehl, Margaret M|Powis, Garth
PMID: 12208766
Journal: Am J Physiol Gastrointest Liver Physiol. 2002 Dec;283(6):G1352-9.
Title: Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells.
Author: Nkabyo, Yvonne S|Ziegler, Thomas R|Gu, Li H|Watson, Walter H|Jones, Dean P
PMID: 12433666
Journal: Lab Invest. 2003 Sep;83(9):1321-31.
Title: Thioredoxin reductase 1 expression in colon cancer: discrepancy between in vitro and in vivo findings.
Author: Lechner, Sandra|Muller-Ladner, Ulf|Neumann, Elena|Spottl, Tanja|Schlottmann, Klaus|Ruschoff, Josef|Scholmerich, Jurgen|Kullmann, Frank
PMID: 13679440
Journal: Anticancer Res. 2003 May-Jun;23(3B):2425-33.
Title: The thioredoxin-thioredoxin reductase system: over-expression in human cancer.
Author: Lincoln, David T|Ali Emadi, Eman M|Tonissen, Kathryn F|Clarke, Frank M
PMID: 12894524
Journal: Mol Cancer Ther. 2003 Mar;2(3):235-43.
Title: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
Author: Welsh, Sarah J|Williams, Ryan R|Birmingham, Anne|Newman, David J|Kirkpatrick, D Lynn|Powis, Garth
PMID: 12657718
Journal: Di Yi Jun Yi Da Xue Xue Bao. 2005 Oct;25(10):1221-4.
Title: [PCR amplification, cloning and protein expression of interferon-inducible transmembrane protein-1 gene].
Author: Liu, Yu-hu|Zhong, Dong|Liu, Juan|Zhang, Zhen-shu|Chen, Cun-long|Wu, Jin-bao|Xiao, Bing|Guo, Wen-ying
PMID: 16234093
Journal: Anticancer Drugs. 2006 Jun;17(5):539-44.
Title: Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds.
Author: Engman, Lars|McNaughton, Michael|Gajewska, Malgorzata|Kumar, Sangit|Birmingham, Anne|Powis, Garth
PMID: 16702810
Journal: Br J Pharmacol. 2007 Aug;151(8):1167-75.
Title: A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines.
Author: Mukherjee, A|Huber, K|Evans, H|Lakhani, N|Martin, S
PMID: 17572693
Journal: Hum Pathol. 2008 Feb;39(2):201-8.
Title: Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.
Author: Noike, Terumasa|Miwa, Shiro|Soeda, Junpei|Kobayashi, Akira|Miyagawa, Shin-ichi
PMID: 17949784
Journal: Bioorg Med Chem Lett. 2008 Jun 15;18(12):3526-31.
Title: Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation.
Author: Fortin, Jessica S|Cote, Marie-France|Lacroix, Jacques|Patenaude, Alexandre|Petitclerc, Eric|C-Gaudreault, Rene
PMID: 18502639
Journal: Cancer Res. 2008 Oct 15;68(20):8269-77.
Title: The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents.
Author: Sun, Yu|Rigas, Basil
PMID: 18922898
Journal: Cancer Epidemiol. 2009 Oct;33(3-4):281-7.
Title: Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma.
Author: Cha, Mee-Kyung|Kim, Il-Han
PMID: 19797004
Journal: Dis Colon Rectum. 2010 Dec;53(12):1624-31.
Title: Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option?
Author: Kundel, Yulia|Brenner, Ronen|Purim, Ofer|Peled, Nir|Idelevich, Efraim|Fenig, Eyal|Sulkes, Aaron|Brenner, Baruch
PMID: 21178856
Journal: Rev Prat. 2010 Oct 20;60(8):1089-93.
Title: [Operable colon cancer: initial strategy].
Author: Andre, Thierry|Tuvignon, Noshine|Taieb, Julien|Vaillant, Jean-Christophe|Hannoun, Laurent|de Gramont, Aimery
PMID: 21197740
Journal: Invest New Drugs. 2012 Aug;30(4):1591-6.
Title: A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy.
Author: Ramanathan, Ramesh K|Stephenson, Joe J|Weiss, Glen J|Pestano, Linda A|Lowe, Ann|Hiscox, Alton|Leos, Rafael A|Martin, Julie C|Kirkpatrick, Lynn|Richards, Donald A
PMID: 21863237
Journal: Biochem Cell Biol. 2012 Apr;90(2):173-8.
Title: Changes in the levels of thioredoxin and indoleamine-2,3-dioxygenase activity in plasma of patients with colorectal cancer treated with chemotherapy.
Author: Cavia-Saiz, Monica|Muniz, Pilar|De Santiago, Reyes|Herreros-Villanueva, Marta|Garcia-Giron, Carlos|Lopez, Ana Sofia|Coma-Del Corral, Maria Jesus
PMID: 22257103
Journal: Biomed Chromatogr. 2013 Apr;27(4):440-50.
Title: Comprehensive fluorogenic derivatization-liquid chromatography/tandem mass spectrometry proteomic analysis of colorectal cancer cell to identify biomarker candidate.
Author: Koshiyama, Akiyo|Ichibangase, Tomoko|Imai, Kazuhiro
PMID: 22991145
Journal: Antioxid Redox Signal. 2013 Sep 20;19(9):899-911.
Title: Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran.
Author: Lu, Yuanyuan|Zhao, Xiaodi|Li, Kai|Luo, Guanhong|Nie, Yongzhan|Shi, Yongquan|Zhou, Yi|Ren, Gui|Feng, Bin|Liu, Zhenxiong|Pan, Yan|Li, Ting|Guo, Xuegang|Wu, Kaichun|Miranda-Vizuete, Antonio|Wang, Xin|Fan, Daiming
PMID: 23311631
Journal: Expert Opin Ther Targets. 2013 Nov;17(11):1369-79.
Title: Type 3 deiodinase and solid tumors: an intriguing pair.
Author: Dentice, Monica|Antonini, Dario|Salvatore, Domenico
PMID: 23991650
Journal: Int J Immunopathol Pharmacol. 2014 Apr-Jun;27(2):169-83.
Title: Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome.
Author: Mollbrink, A|Jawad, R|Vlamis-Gardikas, A|Edenvik, P|Isaksson, B|Danielsson, O|Stal, P|Fernandes, A P
PMID: 25004829
Journal: J Agric Food Chem. 2014 Mar 19;62(11):2353-63.
Title: Secretome profiling reveals the signaling molecules of apoptotic HCT116 cells induced by the dietary polyacetylene gymnasterkoreayne B.
Author: Kang, Kyungsu|Song, Dae-Geun|Lee, Eun Ha|Lee, Kyung-Mi|Park, Young Gyun|Jung, Sang Hoon|Pan, Cheol-Ho|Nho, Chu Won
PMID: 24571669
Journal: Biochim Biophys Acta. 2014 Mar;1840(3):1135-44.
Title: Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: involvement of PI3K/Akt pathway and thioredoxin system.
Author: Cotugno, Roberta|Gallotta, Dario|Piaz, Fabrizio Dal|Apicella, Ivana|De Falco, Sandro|Rosselli, Sergio|Bruno, Maurizio|Belisario, Maria Antonietta
PMID: 24321480
Journal: Oncol Rep. 2015 Feb;33(2):967-73.
Title: Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines.
Author: Wang, Fule|Lin, Feiyan|Zhang, Peili|Ni, Wuhua|Bi, Laixi|Wu, Jianbo|Jiang, Lei
PMID: 25483731
Journal: Cancer Lett. 2015 Jul 28;363(2):119-26.
Title: Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-kappaB pathway.
Author: Lu, Yuanyuan|Zhao, Xiaodi|Luo, Guanhong|Shen, Gaofei|Li, Kai|Ren, Gui|Pan, Yan|Wang, Xin|Fan, Daiming
PMID: 25555669
Journal: Redox Biol. 2015 Aug;5:319-27.
Title: Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor beta-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.
Author: Hrabe, Jennifer E|O'Leary, Brianne R|Fath, Melissa A|Rodman, Samuel N|Button, Anna M|Domann, Frederick E|Spitz, Douglas R|Mezhir, James J
PMID: 26114584
Journal: Oncotarget. 2016 Mar 1;7(9):10578-93.
Title: Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells.
Author: Chang, Elizabeth T|Parekh, Palak R|Yang, Qingyuan|Nguyen, Duc M|Carrier, France
PMID: 26824423
Journal: Oncotarget. 2016 Sep 20;7(38):62559-62571.
Title: Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation.
Author: Jung, Sung-Hoon|Kim, Su-Min|Lee, Choong-Eun
PMID: 27613835
Journal: J Biol Chem. 2017 Jun 2;292(22):9136-9149.
Title: Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy.
Author: Lou, Meng|Liu, Qian|Ren, Guoping|Zeng, Jiling|Xiang, Xueping|Ding, Yongfeng|Lin, Qinghui|Zhong, Tingting|Liu, Xia|Zhu, Lijun|Qi, Hongyan|Shen, Jing|Li, Haoran|Shao, Jimin
PMID: 28411237
Journal: J Cell Mol Med. 2018 Apr;22(4):2430-2441.
Title: Interplay between Trx-1 and S100P promotes colorectal cancer cell epithelial-mesenchymal transition by up-regulating S100A4 through AKT activation.
Author: Zuo, Zhigui|Zhang, Peili|Lin, Feiyan|Shang, Wenjing|Bi, Ruichun|Lu, Fengying|Wu, Jianbo|Jiang, Lei
PMID: 29383839
Journal: Oncol Lett. 2018 Feb;15(2):2364-2372.
Title: Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry.
Author: Horie, Kayo|Mikami, Tetuo|Yoshida, Tsutomu|Sato, Yuichi|Okayasu, Isao
PMID: 29434945