Primary Site >> Colorectal Cancer
Gene >> TXN
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Ref: The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors. PMID: 8049254 |
Ref: Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. PMID: 9816187 |
Ref: Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines. PMID: 9137526 Ref: Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium. PMID: 9354464 |
Ref: Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival. PMID: 10821495 |
Ref: Up-regulation of vitamin D3 up-regulated protein 1 gene in response to 5-fluorouracil in colon carcinoma SW620. PMID: 11748459 Ref: The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. PMID: 12208766 Ref: Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells. PMID: 12433666 |
Ref: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. PMID: 12657718 Ref: The thioredoxin-thioredoxin reductase system: over-expression in human cancer. PMID: 12894524 Ref: Thioredoxin reductase 1 expression in colon cancer: discrepancy between in vitro and in vivo findings. PMID: 13679440 |
Ref: [PCR amplification, cloning and protein expression of interferon-inducible transmembrane protein-1 gene]. PMID: 16234093 |
Ref: Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds. PMID: 16702810 |
Ref: A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. PMID: 17572693 |
Ref: Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer. PMID: 17949784 Ref: Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation. PMID: 18502639 Ref: The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. PMID: 18922898 |
Ref: Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma. PMID: 19797004 |
Ref: Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? PMID: 21178856 Ref: [Operable colon cancer: initial strategy]. PMID: 21197740 |
Ref: A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy. PMID: 21863237 Ref: Changes in the levels of thioredoxin and indoleamine-2,3-dioxygenase activity in plasma of patients with colorectal cancer treated with chemotherapy. PMID: 22257103 |
Ref: Comprehensive fluorogenic derivatization-liquid chromatography/tandem mass spectrometry proteomic analysis of colorectal cancer cell to identify biomarker candidate. PMID: 22991145 Ref: Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran. PMID: 23311631 Ref: Type 3 deiodinase and solid tumors: an intriguing pair. PMID: 23991650 |
Ref: Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: involvement of PI3K/Akt pathway and thioredoxin system. PMID: 24321480 Ref: Secretome profiling reveals the signaling molecules of apoptotic HCT116 cells induced by the dietary polyacetylene gymnasterkoreayne B. PMID: 24571669 Ref: Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome. PMID: 25004829 |
Ref: Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines. PMID: 25483731 Ref: Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-kappaB pathway. PMID: 25555669 Ref: Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor beta-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. PMID: 26114584 |
Ref: Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells. PMID: 26824423 Ref: Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation. PMID: 27613835 |
Ref: Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. PMID: 28411237 |
Ref: Interplay between Trx-1 and S100P promotes colorectal cancer cell epithelial-mesenchymal transition by up-regulating S100A4 through AKT activation. PMID: 29383839 Ref: Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry. PMID: 29434945 |