Primary Site >> Colorectal Cancer

Gene >> TTK

Journal: J Biol Chem. 2006 Mar 31;281(13):8675-85. Epub 2006 Jan 30.
Title: DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis.
Author: Bhonde, Mandar R|Hanski, Marie-Luise|Budczies, Jan|Cao, Minh|Gillissen, Bernd|Moorthy, Dhatchana|Simonetta, Federico|Scherubl, Hans|Truss, Matthias|Hagemeier, Christian|Mewes, Hans-Werner|Daniel, Peter T|Zeitz, Martin|Hanski, Christoph
PMID: 16446370
Journal: PLoS One. 2010 Dec 31;5(12):e16012.
Title: Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability.
Author: Williams, David S|Bird, Matthew J|Jorissen, Robert N|Yu, Yen Lin|Walker, Francesca|Zhang, Hui Hua|Nice, Edouard C|Burgess, Antony W
PMID: 21209843
Journal: Carcinogenesis. 2011 Mar;32(3):305-11.
Title: High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.
Author: Niittymaki, Iina|Gylfe, Alexandra|Laine, Leena|Laakso, Marko|Lehtonen, Heli J|Kondelin, Johanna|Tolvanen, Jaana|Nousiainen, Kari|Pouwels, Jeroen|Jarvinen, Heikki|Nuorva, Kyosti|Mecklin, Jukka-Pekka|Makinen, Markus|Ristimaki, Ari|Orntoft, Torben F|Hautanie
PMID: 21163887
Journal: EMBO Mol Med. 2012 Jun;4(6):500-14.
Title: Selective killing of p53-deficient cancer cells by SP600125.
Author: Jemaa, Mohamed|Vitale, Ilio|Kepp, Oliver|Berardinelli, Francesco|Galluzzi, Lorenzo|Senovilla, Laura|Marino, Guillermo|Malik, Shoaib Ahmad|Rello-Varona, Santiago|Lissa, Delphine|Antoccia, Antonio|Tailler, Maximilien|Schlemmer, Frederic|Harper, Francis|Pier
PMID: 22438244
Journal: Cell Cycle. 2012 Jun 1;11(11):2149-58.
Title: Preferential killing of p53-deficient cancer cells by reversine.
Author: Jemaa, Mohamed|Galluzzi, Lorenzo|Kepp, Oliver|Boileve, Alice|Lissa, Delphine|Senovilla, Laura|Harper, Francis|Pierron, Gerard|Berardinelli, Francesco|Antoccia, Antonio|Castedo, Maria|Vitale, Ilio|Kroemer, Guido
PMID: 22592527
Journal: Biochem Biophys Res Commun. 2014 Aug 8;450(4):1690-5.
Title: Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy.
Author: Ling, Youguo|Zhang, Xiaojuan|Bai, Yuanyuan|Li, Ping|Wei, Congwen|Song, Ting|Zheng, Zirui|Guan, Kai|Zhang, Yanhong|Zhang, Buchang|Liu, Xuedong|Ma, Runlin Z|Cao, Cheng|Zhong, Hui|Xu, Quanbin
PMID: 25063032
Journal: Oncotarget. 2015 Jul 10;6(19):17342-53.
Title: Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.
Author: Pierantoni, Giovanna Maria|Conte, Andrea|Rinaldo, Cinzia|Tornincasa, Mara|Gerlini, Raffaele|Federico, Antonella|Valente, Davide|Medico, Enzo|Fusco, Alfredo
PMID: 26009897
Journal: Cell Cycle. 2016;15(6):812-8.
Title: Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities.
Author: Pierantoni, Giovanna Maria|Conte, Andrea|Rinaldo, Cinzia|Tornincasa, Mara|Gerlini, Raffaele|Valente, Davide|Izzo, Antonella|Fusco, Alfredo
PMID: 26889953
Journal: Clin Immunol. 2016 May;166-167:48-58.
Title: Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors.
Author: Murahashi, Mutsunori|Hijikata, Yasuki|Yamada, Kazunari|Tanaka, Yoshihiro|Kishimoto, Junji|Inoue, Hiroyuki|Marumoto, Tomotoshi|Takahashi, Atsushi|Okazaki, Toshihiko|Takeda, Kazuyoshi|Hirakawa, Masakazu|Fujii, Hiroshi|Okano, Shinji|Morita, Masaru|Baba, Eish
PMID: 27072896
Journal: Cell Death Dis. 2016 Jul 7;7(7):e2292.
Title: Mps1 kinase regulates tumor cell viability via its novel role in mitochondria.
Author: Zhang, X|Ling, Y|Guo, Y|Bai, Y|Shi, X|Gong, F|Tan, P|Zhang, Y|Wei, C|He, X|Ramirez, A|Liu, X|Cao, C|Zhong, H|Xu, Q|Ma, R Z
PMID: 27383047
Journal: Dis Markers. 2016;2016:1987505.
Title: Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications.
Author: Tarnowski, Maciej|Czerewaty, Michal|Deskur, Anna|Safranow, Krzysztof|Marlicz, Wojciech|Urasinska, Elzbieta|Ratajczak, Mariusz Z|Starzynska, Teresa
PMID: 27635108
Journal: Zhonghua Zhong Liu Za Zhi. 2017 Mar 23;39(3):172-177.
Title: [Expression of tyrosine and threonine protein kinase in carcinogenic process of colorectal cancer and its relationship with prognosis].
Author: Zhang, X L|Han, W X|Ma, Y M|Baohan, H W Y|Zhao, X H|Wang, H Y
PMID: 28316214
Journal: Oncotarget. 2017 Jun 13;8(24):38309-38325.
Title: Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines.
Author: Libouban, Marion A A|de Roos, Jeroen A D M|Uitdehaag, Joost C M|Willemsen-Seegers, Nicole|Mainardi, Sara|Dylus, Jelle|de Man, Jos|Tops, Bastiaan|Meijerink, Jules P P|Storchova, Zuzana|Buijsman, Rogier C|Medema, Rene H|Zaman, Guido J R
PMID: 28415765
Journal: Oncotarget. 2016 Jul 18;9(28):19525-19542.
Title: Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
Author: Gurden, Mark D|Anderhub, Simon J|Faisal, Amir|Linardopoulos, Spiros
PMID: 29731963
Journal: Molecules. 2018 Jun 20;23(6). pii: molecules23061488.
Title: Insights into Resistance Mechanisms of Inhibitors to Mps1 C604Y Mutation via a Comprehensive Molecular Modeling Study.
Author: Chen, Yuan|Yu, Wenquan|Jiang, Cui-Cui|Zheng, Jin-Gui
PMID: 29925769