Primary Site >> Colorectal Cancer
Gene >> TTK
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Ref: DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis. PMID: 16446370 |
Ref: Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PMID: 21209843 |
Ref: High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint. PMID: 21163887 |
Ref: Selective killing of p53-deficient cancer cells by SP600125. PMID: 22438244 Ref: Preferential killing of p53-deficient cancer cells by reversine. PMID: 22592527 |
Ref: Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy. PMID: 25063032 |
Ref: Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. PMID: 26009897 |
Ref: Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. PMID: 26889953 Ref: Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors. PMID: 27072896 Ref: Mps1 kinase regulates tumor cell viability via its novel role in mitochondria. PMID: 27383047 Ref: Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications. PMID: 27635108 |
Ref: [Expression of tyrosine and threonine protein kinase in carcinogenic process of colorectal cancer and its relationship with prognosis]. PMID: 28316214 Ref: Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines. PMID: 28415765 |
Ref: Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. PMID: 29731963 Ref: Insights into Resistance Mechanisms of Inhibitors to Mps1 C604Y Mutation via a Comprehensive Molecular Modeling Study. PMID: 29925769 |