Primary Site >> Colorectal Cancer

Gene >> TNIK

Journal: EMBO J. 2009 Nov 4;28(21):3329-40.
Title: The kinase TNIK is an essential activator of Wnt target genes.
Author: Mahmoudi, Tokameh|Li, Vivian S W|Ng, Ser Sue|Taouatas, Nadia|Vries, Robert G J|Mohammed, Shabaz|Heck, Albert J|Clevers, Hans
PMID: 19816403
Journal: Cancer Res. 2010 Jun 15;70(12):5024-33.
Title: Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth.
Author: Shitashige, Miki|Satow, Reiko|Jigami, Takafumi|Aoki, Kazunori|Honda, Kazufumi|Shibata, Tatsuhiro|Ono, Masaya|Hirohashi, Setsuo|Yamada, Tesshi
PMID: 20530691
Journal: J Biol Chem. 2010 Aug 20;285(34):26289-94.
Title: Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation.
Author: Satow, Reiko|Shitashige, Miki|Jigami, Takafumi|Honda, Kazufumi|Ono, Masaya|Hirohashi, Setsuo|Yamada, Tesshi
PMID: 20566648
Journal: Hum Cell. 2011 Sep;24(3):121-6.
Title: Enormous influence of TNIK knockdown on intracellular signals and cell survival.
Author: Gui, Jinghua|Yang, Baotian|Wu, Jinyun|Zhou, Xiumei
PMID: 21710359
Journal: Methods. 2012 Feb;56(2):293-304.
Title: Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.
Author: Tauro, Bow J|Greening, David W|Mathias, Rommel A|Ji, Hong|Mathivanan, Suresh|Scott, Andrew M|Simpson, Richard J
PMID: 22285593
Journal: Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73.
Title: Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Author: Ho, Koc-Kan|Parnell, K Mark|Yuan, Yi|Xu, Yong|Kultgen, Steven G|Hamblin, Steven|Hendrickson, Thomas F|Luo, Bai|Foulks, Jason M|McCullar, Michael V|Kanner, Steven B
PMID: 23232060
Journal: Proteomics. 2013 May;13(10-11):1672-86.
Title: Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components.
Author: Ji, Hong|Greening, David W|Barnes, Thomas W|Lim, Justin W|Tauro, Bow J|Rai, Alin|Xu, Rong|Adda, Christopher|Mathivanan, Suresh|Zhao, Wei|Xue, Yanhong|Xu, Tao|Zhu, Hong-Jian|Simpson, Richard J
PMID: 23585443
Journal: Oncogenesis. 2014 Feb 24;2:e89.
Title: The essential role of TNIK gene amplification in gastric cancer growth.
Author: Yu, D-H|Zhang, X|Wang, H|Zhang, L|Chen, H|Hu, M|Dong, Z|Zhu, G|Qian, Z|Fan, J|Su, X|Xu, Y|Zheng, L|Dong, H|Yin, X|Ji, Q|Ji, J
PMID: 24566388
Journal: BMC Cancer. 2015 Oct 24;15:794.
Title: Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer.
Author: Takahashi, Hidenori|Ishikawa, Toshiaki|Ishiguro, Megumi|Okazaki, Satoshi|Mogushi, Kaoru|Kobayashi, Hirotoshi|Iida, Satoru|Mizushima, Hiroshi|Tanaka, Hiroshi|Uetake, Hiroyuki|Sugihara, Kenichi
PMID: 26499327
Journal: Pharmacol Ther. 2015 Dec;156:1-9.
Title: Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer.
Author: Masuda, Mari|Sawa, Masaaki|Yamada, Tesshi
PMID: 26542362
Journal: Expert Opin Ther Targets. 2016;20(4):419-29.
Title: Targeting the Wnt signaling pathway in colorectal cancer.
Author: Sawa, Masaaki|Masuda, Mari|Yamada, Tesshi
PMID: 26439805
Journal: Nat Commun. 2016 Aug 26;7:12586.
Title: TNIK inhibition abrogates colorectal cancer stemness.
Author: Masuda, Mari|Uno, Yuko|Ohbayashi, Naomi|Ohata, Hirokazu|Mimata, Ayako|Kukimoto-Niino, Mutsuko|Moriyama, Hideki|Kashimoto, Shigeki|Inoue, Tomoko|Goto, Naoko|Okamoto, Koji|Shirouzu, Mikako|Sawa, Masaaki|Yamada, Tesshi
PMID: 27562646
Journal: Sci Rep. 2016 Sep 21;6:33534.
Title: Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor.
Author: Tan, Zhi|Chen, Lu|Zhang, Shuxing
PMID: 27650168
Journal: Cancer Sci. 2017 May;108(5):818-823.
Title: Emergence of TNIK inhibitors in cancer therapeutics.
Author: Yamada, Tesshi|Masuda, Mari
PMID: 28208209
Journal: Expert Opin Ther Targets. 2017 Apr;21(4):353-355.
Title: The emergence of TNIK as a therapeutic target for colorectal cancer.
Author: Masuda, Mari|Yamada, Tesshi
PMID: 28281900