Primary Site >> Colorectal Cancer
Gene >> TLR9
| 1. | |||||||||||
| Journal: | Clin Cancer Res. 2006 Jan 15;12(2):577-83. | ||||||||||
| Title: | Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. | ||||||||||
| Author: | Damiano, Vincenzo|Caputo, Rosa|Bianco, Roberto|D'Armiento, Francesco P|Leonardi, Antonio|De Placido, Sabino|Bianco, A Raffaele|Agrawal, Sudhir|Ciardiello, Fortunato|Tortora, Giampaolo | ||||||||||
| PMID: | 16428503 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Oncol. 2007 Jun;30(6):1511-9. | ||||||||||
| Title: | Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. | ||||||||||
| Author: | Rayburn, Elizabeth R|Wang, Wei|Zhang, Ruiwen|Wang, Hui | ||||||||||
| PMID: | 17487373 | ||||||||||
| 3. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12468-73. Epub 2007 Jul 16. | ||||||||||
| Title: | TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts. | ||||||||||
| Author: | Damiano, Vincenzo|Caputo, Rosa|Garofalo, Sonia|Bianco, Roberto|Rosa, Roberta|Merola, Gerardina|Gelardi, Teresa|Racioppi, Luigi|Fontanini, Gabriella|De Placido, Sabino|Kandimalla, Ekambar R|Agrawal, Sudhir|Ciardiello, Fortunato|Tortora, Giampaolo | ||||||||||
| PMID: | 17636117 | ||||||||||
| 4. | |||||||||||
| Journal: | Mol Cell Proteomics. 2008 Dec;7(12):2311-22. | ||||||||||
| Title: | Comparative proteomics study reveals that bacterial CpG motifs induce tumor cell autophagy in vitro and in vivo. | ||||||||||
| Author: | Bertin, Samuel|Samson, Michel|Pons, Catherine|Guigonis, Jean-Marie|Gavelli, Adolfo|Baque, Patrick|Brossette, Nicole|Pagnotta, Sophie|Ricci, Jean-Ehrland|Pierrefite-Carle, Valerie | ||||||||||
| PMID: | 18632594 | ||||||||||
| 5. | |||||||||||
| Journal: | J Clin Invest. 2008 Nov;118(11):3751-61. | ||||||||||
| Title: | CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer. | ||||||||||
| Author: | Roux, Stephan|Apetoh, Lionel|Chalmin, Fanny|Ladoire, Sylvain|Mignot, Gregoire|Puig, Pierre-Emmanuel|Lauvau, Gregoire|Zitvogel, Laurence|Martin, Francois|Chauffert, Bruno|Yagita, Hideo|Solary, Eric|Ghiringhelli, Francois | ||||||||||
| PMID: | 18830416 | ||||||||||
| 6. | |||||||||||
| Journal: | J Immunol. 2009 Oct 1;183(7):4371-7. | ||||||||||
| Title: | Phosphorothioate-modified TLR9 ligands protect cancer cells against TRAIL-induced apoptosis. | ||||||||||
| Author: | Chiron, David|Pellat-Deceunynck, Catherine|Maillasson, Mike|Bataille, Regis|Jego, Gaetan | ||||||||||
| PMID: | 19734228 | ||||||||||
| 7. | |||||||||||
| Journal: | Mol Cancer Ther. 2010 Jun;9(6):1788-97. | ||||||||||
| Title: | Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8. | ||||||||||
| Author: | Wang, Daqing|Precopio, Melissa|Lan, Tao|Yu, Dong|Tang, Jimmy X|Kandimalla, Ekambar R|Agrawal, Sudhir | ||||||||||
| PMID: | 20515950 | ||||||||||
| 8. | |||||||||||
| Journal: | EMBO J. 2010 Jul 7;29(13):2242-52. | ||||||||||
| Title: | TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. | ||||||||||
| Author: | Mittal, Deepak|Saccheri, Fabiana|Venereau, Emilie|Pusterla, Tobias|Bianchi, Marco E|Rescigno, Maria | ||||||||||
| PMID: | 20526283 | ||||||||||
| 9. | |||||||||||
| Journal: | Cancer Gene Ther. 2011 Dec;18(12):850-8. | ||||||||||
| Title: | Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists. | ||||||||||
| Author: | Triozzi, P L|Aldrich, W|Ponnazhagan, S | ||||||||||
| PMID: | 21869824 | ||||||||||
| 10. | |||||||||||
| Journal: | Cancer Res. 2011 Oct 15;71(20):6382-90. | ||||||||||
| Title: | TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects. | ||||||||||
| Author: | Sommariva, Michele|De Cecco, Loris|De Cesare, Michelandrea|Sfondrini, Lucia|Menard, Sylvie|Melani, Cecilia|Delia, Domenico|Zaffaroni, Nadia|Pratesi, Graziella|Uva, Valentina|Tagliabue, Elda|Balsari, Andrea | ||||||||||
| PMID: | 21878529 | ||||||||||
| 11. | |||||||||||
| Journal: | Clin Cancer Res. 2011 Oct 15;17(20):6531-41. | ||||||||||
| Title: | Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers. | ||||||||||
| Author: | Rosa, Roberta|Melisi, Davide|Damiano, Vincenzo|Bianco, Roberto|Garofalo, Sonia|Gelardi, Teresa|Agrawal, Sudhir|Di Nicolantonio, Federica|Scarpa, Aldo|Bardelli, Alberto|Tortora, Giampaolo | ||||||||||
| PMID: | 21890455 | ||||||||||
| 12. | |||||||||||
| Journal: | PLoS One. 2012;7(1):e29357. | ||||||||||
| Title: | TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome. | ||||||||||
| Author: | Saha, Subhrajit|Bhanja, Payel|Liu, Laibin|Alfieri, Alan A|Yu, Dong|Kandimalla, Ekambar R|Agrawal, Sudhir|Guha, Chandan | ||||||||||
| PMID: | 22238604 | ||||||||||
| 13. | |||||||||||
| Journal: | J Clin Immunol. 2012 Aug;32(4):848-54. | ||||||||||
| Title: | Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer. | ||||||||||
| Author: | Eiro, Noemi|Gonzalez, Lucia|Gonzalez, Luis O|Andicoechea, Alejandro|Fernandez-Diaz, Maria|Altadill, Antonio|Vizoso, Francisco J | ||||||||||
| PMID: | 22371291 | ||||||||||
| 14. | |||||||||||
| Journal: | Cancer Res. 2013 Dec 15;73(24):7211-21. | ||||||||||
| Title: | TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. | ||||||||||
| Author: | Gao, Chan|Kozlowska, Anna|Nechaev, Sergey|Li, Haiqing|Zhang, Qifang|Hossain, Dewan M S|Kowolik, Claudia M|Chu, Peiguo|Swiderski, Piotr|Diamond, Don J|Pal, Sumanta K|Raubitschek, Andrew|Kortylewski, Marcin | ||||||||||
| PMID: | 24154870 | ||||||||||
| 15. | |||||||||||
| Journal: | World J Gastroenterol. 2013 Jul 14;19(26):4119-26. | ||||||||||
| Title: | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: clinico-pathogenic aspects. | ||||||||||
| Author: | Furi, Istvan|Sipos, Ferenc|Germann, Tiana M|Kalmar, Alexandra|Tulassay, Zsolt|Molnar, Bela|Muzes, Gyorgyi | ||||||||||
| PMID: | 23864774 | ||||||||||
| 16. | |||||||||||
| Journal: | Oncol Rep. 2013 May;29(5):1737-43. | ||||||||||
| Title: | The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma. | ||||||||||
| Author: | Nojiri, Keiichiro|Sugimoto, Kazushi|Shiraki, Katsuya|Tameda, Masahiko|Inagaki, Yuuji|Kusagawa, Satoko|Ogura, Suguru|Tanaka, Junichiro|Yoneda, Misao|Yamamoto, Norihiko|Okano, Hiroshi|Takei, Yoshiyuki|Ito, Masaaki|Kasai, Chika|Inoue, Hidekazu|Takase, Koujir | ||||||||||
| PMID: | 23467704 | ||||||||||
| 17. | |||||||||||
| Journal: | J Immunother. 2013 Jul-Aug;36(6):342-9. | ||||||||||
| Title: | Toll-like receptor-4 expression by stromal fibroblasts is associated with poor prognosis in colorectal cancer. | ||||||||||
| Author: | Eiro, Noemi|Gonzalez, Lucia|Gonzalez, Luis O|Fernandez-Garcia, Belen|Andicoechea, Alejandro|Barbon, Esther|Garcia-Muniz, Jose L|Vizoso, Francisco J | ||||||||||
| PMID: | 23799413 | ||||||||||
| 18. | |||||||||||
| Journal: | PLoS One. 2014 May 2;9(5):e95847. | ||||||||||
| Title: | Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice. | ||||||||||
| Author: | Westwood, Jennifer A|Potdevin Hunnam, Titaina C U|Pegram, Hollie J|Hicks, Rodney J|Darcy, Phillip K|Kershaw, Michael H | ||||||||||
| PMID: | 24788789 | ||||||||||
| 19. | |||||||||||
| Journal: | J Cancer Res Clin Oncol. 2014 Sep;140(9):1615-24. | ||||||||||
| Title: | Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. | ||||||||||
| Author: | Schmoll, Hans-Joachim|Wittig, Burghardt|Arnold, Dirk|Riera-Knorrenschild, Jorge|Nitsche, Dieter|Kroening, Hendrik|Mayer, Frank|Andel, Johannes|Ziebermayr, Reinhard|Scheithauer, Werner | ||||||||||
| PMID: | 24816725 | ||||||||||
| 20. | |||||||||||
| Journal: | World J Gastroenterol. 2014 May 21;20(19):5808-17. | ||||||||||
| Title: | Intervention on toll-like receptors in pancreatic cancer. | ||||||||||
| Author: | Vaz, Juan|Andersson, Roland | ||||||||||
| PMID: | 24914341 | ||||||||||
| 21. | |||||||||||
| Journal: | Medicine (Baltimore). 2014 Dec;93(29):e349. | ||||||||||
| Title: | IFNAR1 is a predictor for overall survival in colorectal cancer and its mRNA expression correlated with IRF7 but not TLR9. | ||||||||||
| Author: | Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chein, Hui-Ping|Hsieh, Tsan-Yu|Chen, Jim-Ray|Hwang, Cheng-Cheng|Hua, Chung-Ching | ||||||||||
| PMID: | 25546690 | ||||||||||
| 22. | |||||||||||
| Journal: | PLoS One. 2015 Jul 2;10(7):e0131699. | ||||||||||
| Title: | Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line. | ||||||||||
| Author: | Furi, Istvan|Kalmar, Alexandra|Wichmann, Barnabas|Spisak, Sandor|Scholler, Andrea|Bartak, Barbara|Tulassay, Zsolt|Molnar, Bela | ||||||||||
| PMID: | 26133168 | ||||||||||
| 23. | |||||||||||
| Journal: | Mol Cancer. 2015 May 15;14:104. | ||||||||||
| Title: | X-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes. | ||||||||||
| Author: | Koo, Jung Eun|Shin, Seung Won|Um, Soong Ho|Lee, Joo Young | ||||||||||
| PMID: | 25971982 | ||||||||||
| 24. | |||||||||||
| Journal: | Exp Ther Med. 2015 Apr;9(4):1455-1459. | ||||||||||
| Title: | Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis. | ||||||||||
| Author: | Fan, Yujing|Liu, Bingrong | ||||||||||
| PMID: | 25780451 | ||||||||||
| 25. | |||||||||||
| Journal: | Eur J Cancer. 2015 Jan;51(2):146-56. | ||||||||||
| Title: | Phase I clinical study of the toll-like receptor 9 agonist MGN1703 in patients with metastatic solid tumours. | ||||||||||
| Author: | Weihrauch, Martin R|Richly, Heike|von Bergwelt-Baildon, Michael S|Becker, Hans Jiro|Schmidt, Manuel|Hacker, Ulrich T|Shimabukuro-Vornhagen, Alexander|Holtick, Udo|Nokay, Bahar|Schroff, Matthias|Wittig, Burghardt|Scheulen, Max E | ||||||||||
| PMID: | 25480557 | ||||||||||
| 26. | |||||||||||
| Journal: | Biochem J. 2016 Jan 1;473(1):7-19. | ||||||||||
| Title: | Co-operation of alpha-galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model. | ||||||||||
| Author: | Dong, Tiangeng|Yi, Tuo|Yang, Mengxuan|Lin, Shengli|Li, Wenxiang|Xu, Xingyuan|Hu, Jianwei|Jia, Lijun|Hong, Xinqiang|Niu, Weixin | ||||||||||
| PMID: | 26450924 | ||||||||||
| 27. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7240-E7249. | ||||||||||
| Title: | Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells. | ||||||||||
| Author: | Wang, Shu|Campos, Jose|Gallotta, Marilena|Gong, Mei|Crain, Chad|Naik, Edwina|Coffman, Robert L|Guiducci, Cristiana | ||||||||||
| PMID: | 27799536 | ||||||||||
| 28. | |||||||||||
| Journal: | Immun Inflamm Dis. 2016 Oct 18;4(4):446-462. | ||||||||||
| Title: | Distinct immunological activation profiles of dSLIM(R) and ProMune(R) depend on their different structural context. | ||||||||||
| Author: | Kapp, Kerstin|Schneider, Jacqueline|Schneider, Lisa|Gollinge, Nadine|Jansch, Stefanie|Schroff, Matthias|Wittig, Burghardt|Kleuss, Christiane | ||||||||||
| PMID: | 27980779 | ||||||||||
| 29. | |||||||||||
| Journal: | Cancer Biomark. 2017;18(4):375-380. | ||||||||||
| Title: | Cell membrane and intracellular expression of toll-like receptor 9 (TLR9) in colorectal cancer and breast cancer cell-lines. | ||||||||||
| Author: | Shahriari, Shadab|Rezaeifard, Somayeh|Moghimi, Hamid Reza|Khorramizadeh, Mohammad Reza|Faghih, Zahra | ||||||||||
| PMID: | 28106541 | ||||||||||
| 30. | |||||||||||
| Journal: | PLoS One. 2018 Jun 8;13(6):e0197327. | ||||||||||
| Title: | Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer. | ||||||||||
| Author: | Messaritakis, Ippokratis|Stogiannitsi, Maria|Koulouridi, Asimina|Sfakianaki, Maria|Voutsina, Alexandra|Sotiriou, Afroditi|Athanasakis, Elias|Xynos, Evangelos|Mavroudis, Dimitris|Tzardi, Maria|Souglakos, John | ||||||||||
| PMID: | 29883450 | ||||||||||
| 31. | |||||||||||
| Journal: | Nanoscale Res Lett. 2018 Aug 17;13(1):240. | ||||||||||
| Title: | Modified Fe3O4 Magnetic Nanoparticle Delivery of CpG Inhibits Tumor Growth and Spontaneous Pulmonary Metastases to Enhance Immunotherapy. | ||||||||||
| Author: | Zhang, Xueyan|Wu, Fengbo|Men, Ke|Huang, Rong|Zhou, Bailin|Zhang, Rui|Zou, Rui|Yang, Li | ||||||||||
| PMID: | 30120629 | ||||||||||
| 32. | |||||||||||
| Journal: | Acta Biochim Biophys Sin (Shanghai). 2018 Sep 15. pii: 5098366. | ||||||||||
| Title: | Cell-free DNA derived from cancer cells facilitates tumor malignancy through Toll-like receptor 9 signaling-triggered interleukin-8 secretion in colorectal cancer. | ||||||||||
| Author: | Niu, Zhengchuan|Tang, Wentao|Liu, Tianyu|Xu, Pingping|Zhu, Dexiang|Ji, Meiling|Huang, Wenbai|Ren, Li|Wei, Ye|Xu, Jianmin | ||||||||||
| PMID: | 30239551 | ||||||||||
| 33. | |||||||||||
| Journal: | Onco Targets Ther. 2018 Sep 18;11:5963-5971. | ||||||||||
| Title: | TLR9 signaling activation at different stages in colorectal cancer and NF-kappaB expression. | ||||||||||
| Author: | Gao, Caixia|Qiao, Tiankui|Zhang, Bin|Yuan, Sujuan|Zhuang, Xibing|Luo, Youjun | ||||||||||
| PMID: | 30271180 | ||||||||||