Primary Site >> Colorectal Cancer
Gene >> TLR9
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Ref: Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. PMID: 16428503 |
Ref: Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. PMID: 17487373 Ref: TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts. PMID: 17636117 |
Ref: Comparative proteomics study reveals that bacterial CpG motifs induce tumor cell autophagy in vitro and in vivo. PMID: 18632594 Ref: CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer. PMID: 18830416 |
Ref: Phosphorothioate-modified TLR9 ligands protect cancer cells against TRAIL-induced apoptosis. PMID: 19734228 |
Ref: Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8. PMID: 20515950 Ref: TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. PMID: 20526283 |
Ref: Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists. PMID: 21869824 Ref: TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects. PMID: 21878529 Ref: Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers. PMID: 21890455 |
Ref: TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome. PMID: 22238604 Ref: Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer. PMID: 22371291 |
Ref: The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma. PMID: 23467704 Ref: Toll-like receptor-4 expression by stromal fibroblasts is associated with poor prognosis in colorectal cancer. PMID: 23799413 Ref: Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: clinico-pathogenic aspects. PMID: 23864774 Ref: TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. PMID: 24154870 |
Ref: Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice. PMID: 24788789 Ref: Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. PMID: 24816725 Ref: Intervention on toll-like receptors in pancreatic cancer. PMID: 24914341 Ref: IFNAR1 is a predictor for overall survival in colorectal cancer and its mRNA expression correlated with IRF7 but not TLR9. PMID: 25546690 |
Ref: Phase I clinical study of the toll-like receptor 9 agonist MGN1703 in patients with metastatic solid tumours. PMID: 25480557 Ref: Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis. PMID: 25780451 Ref: X-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes. PMID: 25971982 Ref: Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line. PMID: 26133168 |
Ref: Co-operation of alpha-galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model. PMID: 26450924 Ref: Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells. PMID: 27799536 Ref: Distinct immunological activation profiles of dSLIM(R) and ProMune(R) depend on their different structural context. PMID: 27980779 |
Ref: Cell membrane and intracellular expression of toll-like receptor 9 (TLR9) in colorectal cancer and breast cancer cell-lines. PMID: 28106541 |
Ref: Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer. PMID: 29883450 Ref: Modified Fe3O4 Magnetic Nanoparticle Delivery of CpG Inhibits Tumor Growth and Spontaneous Pulmonary Metastases to Enhance Immunotherapy. PMID: 30120629 Ref: Cell-free DNA derived from cancer cells facilitates tumor malignancy through Toll-like receptor 9 signaling-triggered interleukin-8 secretion in colorectal cancer. PMID: 30239551 Ref: TLR9 signaling activation at different stages in colorectal cancer and NF-kappaB expression. PMID: 30271180 |