Literatures

Primary Site >> Liver Cancer

Gene >> TLR4

1.
Journal:	J Natl Cancer Inst. 1975 Jan;54(1):61-4.
Title:	Unexpected high incidence of primary liver cancer in Geneva, Switzerland.
Author:	Tuyns, A J\|Obradovic, M
PMID:	163325

2.
Journal:	BMJ. 1999 Jun 5;318(7197):1510.
Title:	Liver cancer toll high in Japan.
Author:	Easton, A
PMID:	10356000

3.
Journal:	Clin Invest Med. 2008;31(3):E123-30.
Title:	The significance of Toll-like receptor 4 (TLR4) expression in patients with chronic hepatitis B.
Author:	Wei, Xiu-Qing\|Guo, Yun-Wei\|Liu, Jia-Jun\|Wen, Zhuo-Fu\|Yang, Shao-Ji\|Yao, Ji-Lu
PMID:	18544275

4.
Journal:	Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1548-53.
Title:	Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog.
Author:	Machida, Keigo\|Tsukamoto, Hidekazu\|Mkrtchyan, Hasmik\|Duan, Lewei\|Dynnyk, Alla\|Liu, Helene Minyi\|Asahina, Kinji\|Govindarajan, Sugantha\|Ray, Ratna\|Ou, Jing-Hsiung James\|Seki, Ekihiro\|Deshaies, Raymond\|Miyake, Kensuke\|Lai, Michael M-C
PMID:	19171902

5.
Journal:	J Hepatol. 2010 Mar;52(3):370-9.
Title:	Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients.
Author:	Chew, Valerie\|Tow, Charlene\|Teo, Marissa\|Wong, Hing Lok\|Chan, Jasmine\|Gehring, Adam\|Loh, Marie\|Bolze, Alexandre\|Quek, Richard\|Lee, Victor K M\|Lee, Kang Hoe\|Abastado, Jean-Pierre\|Toh, Han Chong\|Nardin, Alessandra
PMID:	19720422

6.
Journal:	Hepatology. 2010 Oct;52(4):1322-33.
Title:	Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents.
Author:	Yu, Le-Xing\|Yan, He-Xin\|Liu, Qiong\|Yang, Wen\|Wu, Hong-Ping\|Dong, Wei\|Tang, Liang\|Lin, Yan\|He, Ya-Qin\|Zou, Shan-Shan\|Wang, Chao\|Zhang, Hui-Lu\|Cao, Guang-Wen\|Wu, Meng-Chao\|Wang, Hong-Yang
PMID:	20803560

7.
Journal:	Gastroenterol Res Pract. 2010;2010.
Title:	Toll-like receptors in the pathogenesis of alcoholic liver disease.
Author:	Petrasek, Jan\|Mandrekar, Pranoti\|Szabo, Gyongyi
PMID:	20827314

8.
Journal:	Cancer Res. 2011 Mar 1;71(5):1989-98.
Title:	LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis.
Author:	Hsu, Rich Y C\|Chan, Carlos H F\|Spicer, Jonathan D\|Rousseau, Mathieu C\|Giannias, Betty\|Rousseau, Simon\|Ferri, Lorenzo E
PMID:	21363926

9.
Journal:	J Pathol. 2011 Nov;225(3):438-47.
Title:	Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop.
Author:	Wu, Yan\|Zhao, Qiyi\|Peng, Chen\|Sun, Lin\|Li, Xue-Feng\|Kuang, Dong-Ming
PMID:	21826665

10.
Journal:	Hepatology. 2011 Aug;54(2):745; author reply 745-6.
Title:	Mechanisms by which TLR4 and endotoxin promote hepatocellular carcinoma require further investigation.
Author:	Mencin, Ali\|Gwak, Geum-Youn\|Schwabe, Robert F
PMID:	21563198

11.
Journal:	PLoS One. 2011 Apr 29;6(4):e19466.
Title:	Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma.
Author:	Minmin, Shi\|Xiaoqian, Xu\|Hao, Chen\|Baiyong, Shen\|Xiaxing, Deng\|Junjie, Xie\|Xi, Zhan\|Jianquan, Zhao\|Songyao, Jiang
PMID:	21559380

12.
Journal:	Cancer Res. 2011 Apr 1;71(7):2529-40.
Title:	Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response.
Author:	Garcia, Alexis\|Zeng, Yu\|Muthupalani, Sureshkumar\|Ge, Zhongming\|Potter, Amanda\|Mobley, Melissa W\|Boussahmain, Chakib\|Feng, Yan\|Wishnok, John S\|Fox, James G
PMID:	21335546

13.
Journal:	Alcohol Clin Exp Res. 2011 May;35(5):787-93.
Title:	Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines.
Author:	Miller, Andrew M\|Horiguchi, Norio\|Jeong, Won-Il\|Radaeva, Svetlana\|Gao, Bin
PMID:	21284667

14.
Journal:	Exp Mol Pathol. 2011 Jun;90(3):239-43.
Title:	S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats.
Author:	Oliva, Joan\|Bardag-Gorce, Fawzia\|Li, Jun\|French, Barbara A\|French, Samuel W
PMID:	21276439

15.
Journal:	Dig Dis Sci. 2011 Apr;56(4):1131-7.
Title:	Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese.
Author:	Hishida, Asahi\|Matsuo, Keitaro\|Goto, Yasuyuki\|Naito, Mariko\|Wakai, Kenji\|Tajima, Kazuo\|Hamajima, Nobuyuki
PMID:	20721625

16.
Journal:	Hepatology. 2012 Mar;55(3):709-19.
Title:	Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.
Author:	Doi, Hiroyoshi\|Iyer, Tara K\|Carpenter, Erica\|Li, Hong\|Chang, Kyong-Mi\|Vonderheide, Robert H\|Kaplan, David E
PMID:	21932384

17.
Journal:	Virol J. 2012 Jun 22;9:126.
Title:	Interaction of Hepatitis C virus proteins with pattern recognition receptors.
Author:	Imran, Muhammad\|Waheed, Yasir\|Manzoor, Sobia\|Bilal, Muhammad\|Ashraf, Waseem\|Ali, Muhammad\|Ashraf, Muhammad
PMID:	22726246

18.
Journal:	Cancer Prev Res (Phila). 2012 Sep;5(9):1090-102.
Title:	Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4.
Author:	Lin, Yan\|Yu, Le-Xing\|Yan, He-Xin\|Yang, Wen\|Tang, Liang\|Zhang, Hui-Lu\|Liu, Qiong\|Zou, Shan-Shan\|He, Ya-Qin\|Wang, Chao\|Wu, Meng-Chao\|Wang, Hong-Yang
PMID:	22617167

19.
Journal:	Nat Rev Cancer. 2012 May 17;12(6):379.
Title:	Inflammation: the gut takes a toll on liver cancer.
Author:	Alderton, Gemma K
PMID:	22592299

20.
Journal:	Cancer Cell. 2012 Apr 17;21(4):504-16.
Title:	Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.
Author:	Dapito, Dianne H\|Mencin, Ali\|Gwak, Geum-Youn\|Pradere, Jean-Philippe\|Jang, Myoung-Kuk\|Mederacke, Ingmar\|Caviglia, Jorge M\|Khiabanian, Hossein\|Adeyemi, Adebowale\|Bataller, Ramon\|Lefkowitch, Jay H\|Bower, Maureen\|Friedman, Richard\|Sartor, R Balfour\|Rabadan, R
PMID:	22516259

21.
Journal:	Innate Immun. 2012 Oct;18(5):700-8.
Title:	Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence.
Author:	Soares, Joao-Bruno\|Pimentel-Nunes, Pedro\|Afonso, Luis\|Rolanda, Carla\|Lopes, Paula\|Roncon-Albuquerque, Roberto Jr\|Goncalves, Nadia\|Boal-Carvalho, Ines\|Pardal, Fernando\|Lopes, Susana\|Macedo, Guilherme\|Lara-Santos, Lucio\|Henrique, Rui\|Moreira-Dias, Luis\|Gonc
PMID:	22330637

22.
Journal:	J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:19-22.
Title:	Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus.
Author:	Machida, Keigo\|Chen, Chia-Lin\|Liu, Jian-Chang\|Kashiwabara, Claudine\|Feldman, Douglas\|French, Samuel W\|Sher, Linda\|Hyeongnam, Jeong Joseph\|Tsukamoto, Hidekazu
PMID:	22320911

23.
Journal:	Nature. 2012 Feb 1;482(7384):179-85.
Title:	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Author:	Henao-Mejia, Jorge\|Elinav, Eran\|Jin, Chengcheng\|Hao, Liming\|Mehal, Wajahat Z\|Strowig, Till\|Thaiss, Christoph A\|Kau, Andrew L\|Eisenbarth, Stephanie C\|Jurczak, Michael J\|Camporez, Joao-Paulo\|Shulman, Gerald I\|Gordon, Jeffrey I\|Hoffman, Hal M\|Flavell, Richar
PMID:	22297845

24.
Journal:	Oncology. 2012;82(1):35-40.
Title:	Polymorphism of the TLR4 gene reduces the risk of hepatitis C virus-induced hepatocellular carcinoma.
Author:	Agundez, Jose A\|Garcia-Martin, Elena\|Devesa, Maria J\|Carballo, Miguel\|Martinez, Carmen\|Lee-Brunner, Anna\|Fernandez, Cristina\|Diaz-Rubio, Manuel\|Ladero, Jose M
PMID:	22286521

25.
Journal:	PLoS One. 2013 Dec 11;8(12):e81312.
Title:	No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV.
Author:	Nakamura, Masato\|Kanda, Tatsuo\|Nakamoto, Shingo\|Miyamura, Tatsuo\|Jiang, Xia\|Wu, Shuang\|Yokosuka, Osamu
PMID:	24349054

26.
Journal:	Hepatology. 2013 Feb;57(2):763-74.
Title:	Beta-catenin-NF-kappaB interactions in murine hepatocytes: a complex to die for.
Author:	Nejak-Bowen, Kari\|Kikuchi, Alexander\|Monga, Satdarshan P S
PMID:	22941935

27.
Journal:	J Immunol. 2013 Dec 15;191(12):6178-90.
Title:	TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro.
Author:	Liu, Jia\|Jiang, Min\|Ma, Zhiyong\|Dietze, Kirsten K\|Zelinskyy, Gennadiy\|Yang, Dongliang\|Dittmer, Ulf\|Schlaak, Joerg F\|Roggendorf, Michael\|Lu, Mengji
PMID:	24227786

28.
Journal:	J Clin Invest. 2013 Jul;123(7):2832-49.
Title:	Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
Author:	Chen, Chia-Lin\|Tsukamoto, Hidekazu\|Liu, Jian-Chang\|Kashiwabara, Claudine\|Feldman, Douglas\|Sher, Linda\|Dooley, Steven\|French, Samuel W\|Mishra, Lopa\|Petrovic, Lydia\|Jeong, Joseph H\|Machida, Keigo
PMID:	23921128

29.
Journal:	J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:38-42.
Title:	Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
Author:	Roh, Yoon Seok\|Seki, Ekihiro
PMID:	23855294

30.
Journal:	Exp Mol Pathol. 2013 Aug;95(1):117-20.
Title:	Balloon liver cells forming Mallory-Denk-bodies are progenitor cells.
Author:	French, S W\|Vitocruz, E\|French, B A
PMID:	23773849

31.
Journal:	J Pharmacol Exp Ther. 2013 Mar;344(3):646-54.
Title:	Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression.
Author:	Peng, Jing-Hua\|Cui, Tuan\|Huang, Fu\|Chen, Liang\|Zhao, Yu\|Xu, Lin\|Xu, Li-Li\|Feng, Qin\|Hu, Yi-Yang
PMID:	23277536

32.
Journal:	J Hepatol. 2013 Feb;58(2):385-7.
Title:	Targeting gut flora to prevent progression of hepatocellular carcinoma.
Author:	Darnaud, Marion\|Faivre, Jamila\|Moniaux, Nicolas
PMID:	22940407

33.
Journal:	Surgery. 2013 Jul;154(1):69-77.
Title:	Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory ability of human esophageal cancer cells in a selectin-dependent manner.
Author:	Rousseau, Mathieu C\|Hsu, Rich Y C\|Spicer, Jonathan D\|McDonald, Braedon\|Chan, Carlos H F\|Perera, Rushika M\|Giannias, Betty\|Chow, Simon C\|Rousseau, Simon\|Law, Simon\|Ferri, Lorenzo E
PMID:	23809486

34.
Journal:	Tumour Biol. 2014 Dec;35(12):12345-52.
Title:	A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population.
Author:	Jiang, Zi-Cheng\|Tang, Xian-Mei\|Zhao, Ying-Ren\|Zheng, Lei
PMID:	25179842

35.
Journal:	Hepatol Int. 2014 Jul;8(3):330-8.
Title:	Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.
Author:	Chen, Chia-Lin\|Tsukamoto, Hidekazu\|Machida, Keigo
PMID:	26202636

36.
Journal:	Hepatol Int. 2014 Sep;8 Suppl 2:408-12.
Title:	Alcohol, TLR4-TGF-beta antagonism, and liver cancer.
Author:	Tsukamoto, Hidekazu\|Mishra, Lopa\|Machida, Keigo
PMID:	26201318

37.
Journal:	Int J Clin Exp Pathol. 2014 Aug 15;7(9):6048-55. eCollection 2014.
Title:	Relationship between expression of toll-like receptors 2/4 in dendritic cells and chronic hepatitis B virus infection.
Author:	Lu, Xiaobo\|Xu, Qi\|Bu, Xianyu\|Ma, Xiuming\|Zhang, Fengbo\|Deng, Qiang\|Zhang, Yuexin\|Ding, Jianbing
PMID:	25337250

38.
Journal:	J Clin Invest. 2014 Oct;124(10):4657-67.
Title:	B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Author:	Kuang, Dong-Ming\|Xiao, Xiao\|Zhao, Qiyi\|Chen, Min-Min\|Li, Xue-Feng\|Liu, Rui-Xian\|Wei, Yuan\|Ouyang, Fang-Zhu\|Chen, Dong-Ping\|Wu, Yan\|Lao, Xiang-Ming\|Deng, Hong\|Zheng, Limin
PMID:	25244097

39.
Journal:	Biomed Res Int. 2014;2014:357062.
Title:	The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabian patients.
Author:	Al-Qahtani, Ahmed A\|Al-Anazi, Mashael R\|Al-Zoghaibi, Fahad\|Abdo, Ayman A\|Sanai, Faisal M\|Khan, Mohammed Q\|Albenmousa, Ali\|Al-Ashgar, Hamad I\|Al-Ahdal, Mohammed N
PMID:	25177689

40.
Journal:	Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11455-60.
Title:	Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice.
Author:	Hartwell, Hadley J\|Petrosky, Keiko Y\|Fox, James G\|Horseman, Nelson D\|Rogers, Arlin B
PMID:	25049387

41.
Journal:	Tumour Biol. 2014 Oct;35(10):10267-73.
Title:	Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma.
Author:	Xu, Donghua\|Wang, Xiaochen\|Yan, Shushan\|Yin, Yin\|Hou, Jiajie\|Wang, Xuehao\|Sun, Beicheng
PMID:	25034527

42.
Journal:	Viral Immunol. 2014 Sep;27(7):321-6.
Title:	Toll-like receptor 4 and hepatitis B infection: molecular mechanisms and pathogenesis.
Author:	Zare-Bidaki, Mohammad\|Tsukiyama-Kohara, Kyoko\|Arababadi, Mohammad Kazemi
PMID:	25014492

43.
Journal:	Hepatol Res. 2014 Jul;44(7):769-78.
Title:	Toll-like receptors 3, 4 and 9 in hepatocellular carcinoma: Relationship with clinicopathological characteristics and prognosis.
Author:	Eiro, Noemi\|Altadill, Antonio\|Juarez, Luis M\|Rodriguez, Manuel\|Gonzalez, Luis O\|Atienza, Sara\|Bermudez, Sandra\|Fernandez-Garcia, Belen\|Fresno-Forcelledo, Manuel F\|Rodrigo, Luis\|Vizoso, Francisco J
PMID:	23742263

44.
Journal:	J Hepatocell Carcinoma. 2015 Feb 16;2:11-7.
Title:	Emerging role of Toll-like receptor 4 in hepatocellular carcinoma.
Author:	Yang, Jing\|Li, Min\|Zheng, Qi Chang
PMID:	27508190

45.
Journal:
Title:	Liver Cancer
Author:	Gelband, Hellen\|Chen, Chien-Jen\|Chen, Wendong\|Franceschi, Silvia\|Hall, Sir Andrew\|London, W Thomas\|McGlynn, Katherine A\|Wild, Christopher P
PMID:	26913346

46.
Journal:	Mol Immunol. 2015 Dec;68(2 Pt C):671-83.
Title:	Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through MKK4/JNK pathway.
Author:	Dong, Yu-Qing\|Lu, Chuan-Wei\|Zhang, Lu\|Yang, Jia\|Hameed, Waqaar\|Chen, Wei
PMID:	26589455

47.
Journal:	Oncogenesis. 2015 Oct 26;4:e173.
Title:	TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer.
Author:	Shen, W\|Chang, A\|Wang, J\|Zhou, W\|Gao, R\|Li, J\|Xu, Y\|Luo, X\|Xiang, R\|Luo, N\|Stupack, D G
PMID:	26501855

48.
Journal:	Cell Physiol Biochem. 2015;37(1):214-24.
Title:	Aggravated Liver Injury but Attenuated Inflammation in PTPRO-Deficient Mice Following LPS/D-GaIN Induced Fulminant Hepatitis.
Author:	Wang, Xiaochen\|Yan, Shushan\|Xu, Donghua\|Li, Jun\|Xie, Yu\|Hou, Jiajie\|Jiang, Runqiu\|Zhang, Chuanyong\|Sun, Beicheng
PMID:	26303994

49.
Journal:	Hepatology. 2015 Oct;62(4):1160-73.
Title:	Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.
Author:	Won, Cheolhee\|Kim, Byung-Hak\|Yi, Eun Hee\|Choi, Kyung-Ju\|Kim, Eun-Kyung\|Jeong, Jong-Min\|Lee, Jae-Ho\|Jang, Ja-June\|Yoon, Jung-Hwan\|Jeong, Won-Il\|Park, In-Chul\|Kim, Tae Woo\|Bae, Sun Sik\|Factor, Valentina M\|Ma, Stephanie\|Thorgeirsson, Snorri S\|Lee, Yun-Han\|Ye
PMID:	26154152

50.
Journal:	Oncotarget. 2015 Apr 20;6(11):8822-38.
Title:	The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells.
Author:	Wan, Xin\|Cheng, Ci\|Lin, Zhe\|Jiang, Runqiu\|Zhao, Wei\|Yan, Xin\|Tang, Junwei\|Yao, Kun\|Sun, Beicheng\|Chen, Yun
PMID:	25826093

51.
Journal:	Biochem Biophys Res Commun. 2015 Jan 2;456(1):373-9.
Title:	CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-kappaB and MAPK pathway.
Author:	Wang, Yiting\|Tu, Qunfei\|Yan, Wei\|Xiao, Dan\|Zeng, Zhimin\|Ouyang, Yuming\|Huang, Long\|Cai, Jing\|Zeng, Xiaoli\|Chen, Ya-Jie\|Liu, Anwen
PMID:	25475726

52.
Journal:	Adv Exp Med Biol. 2015;815:131-44.
Title:	TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis.
Author:	Machida, Keigo\|Feldman, Douglas E\|Tsukamoto, Hidekazu
PMID:	25427905

53.
Journal:	J Clin Invest. 2015 Nov 2;125(11):4239-54.
Title:	STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Author:	Li, Weiyun\|Xiao, Jun\|Zhou, Xin\|Xu, Ming\|Hu, Chaobo\|Xu, Xiaoyan\|Lu, Yao\|Liu, Chang\|Xue, Shengjie\|Nie, Lei\|Zhang, Haibin\|Li, Zhiqi\|Zhang, Yanbo\|Ji, Fu\|Hui, Lijian\|Tao, Wufan\|Wei, Bin\|Wang, Hongyan
PMID:	26457732

54.
Journal:	Oncoimmunology. 2016 Nov 29;5(12):e1254313.
Title:	CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients.
Author:	D'Alterio, Crescenzo\|Nasti, Guglielmo\|Polimeno, Marianeve\|Ottaiano, Alessandro\|Conson, Manuel\|Circelli, Luisa\|Botti, Giovanni\|Scognamiglio, Giosue\|Santagata, Sara\|De Divitiis, Chiara\|Nappi, Anna\|Napolitano, Maria\|Tatangelo, Fabiana\|Pacelli, Roberto\|Izzo,
PMID:	28123896

55.
Journal:	J Transplant. 2016;2016:4369574.
Title:	Everolimus and Malignancy after Solid Organ Transplantation: A Clinical Update.
Author:	Holdaas, Hallvard\|De Simone, Paolo\|Zuckermann, Andreas
PMID:	27807479

56.
Journal:	Oncotarget. 2016 Sep 20;7(38):61728-61740.
Title:	Novel chemokine-like activities of histones in tumor metastasis.
Author:	Chen, Ruochan\|Xie, Yangchun\|Zhong, Xiao\|Fu, Yongmin\|Huang, Yan\|Zhen, Yixiang\|Pan, Pinhua\|Wang, Haichao\|Bartlett, David L\|Billiar, Timothy R\|Lotze, Michael T\|Zeh, Herbert J 3rd\|Fan, Xue-Gong\|Tang, Daolin\|Kang, Rui
PMID:	27623211

57.
Journal:	Tumour Biol. 2016 Oct;37(10):13951-13959.
Title:	Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway.
Author:	Zhe, Yi\|Li, Yan\|Liu, Dan\|Su, Dong-Ming\|Liu, Jin-Gang\|Li, Hang-Yu
PMID:	27492456

58.
Journal:	Genet Mol Res. 2016 Jul 14;15(2). pii: gmr7419.
Title:	Expression of toll-like receptors in hepatic cirrhosis and hepatocellular carcinoma.
Author:	Sun, L\|Dai, J J\|Hu, W F\|Wang, J
PMID:	27420991

59.
Journal:	Genet Test Mol Biomarkers. 2016 Sep;20(9):535-43.
Title:	Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B.
Author:	Zhang, Yuan-Qing\|Peng, Li-Jun\|Cao, Yi-Rong\|Zeng, Zhi-Ping\|Wu, Yu-Jing\|Shi, Hong\|Cheng, Shi-Yao\|Wang, Ji-Yao\|Friedman, Scott L\|Sninsky, John J\|Guo, Jin-Sheng
PMID:	27391584

60.
Journal:	PLoS One. 2016 Jul 8;11(7):e0158819.
Title:	TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
Author:	Weber, Susanne Nicole\|Bohner, Annika\|Dapito, Dianne H\|Schwabe, Robert F\|Lammert, Frank
PMID:	27391331

61.
Journal:	J Hepatol. 2016 Nov;65(5):944-952.
Title:	CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation.
Author:	Li, Chang Xian\|Ling, Chang Chun\|Shao, Yan\|Xu, Aimin\|Li, Xiang Cheng\|Ng, Kevin Tak-Pan\|Liu, Xiao Bing\|Ma, Yuen Yuen\|Qi, Xiang\|Liu, Hui\|Liu, Jiang\|Yeung, Oscar Wai Ho\|Yang, Xin Xiang\|Liu, Qing Sheng\|Lam, Yin Fan\|Zhai, Yuan\|Lo, Chung Mau\|Man, Kwan
PMID:	27245433

62.
Journal:	Oncol Lett. 2016 May;11(5):3054-3060.
Title:	Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells.
Author:	Liu, Yating\|Li, Tao\|Xu, Yuanhong\|Xu, Enjun\|Zhou, Min\|Wang, Baolong\|Shen, Jilong
PMID:	27123062

63.
Journal:	J Virol. 2016 Jun 24;90(14):6187-6199.
Title:	Hepatitis B Virus Surface Antigen Activates Myeloid Dendritic Cells via a Soluble CD14-Dependent Mechanism.
Author:	van Montfoort, Nadine\|van der Aa, Evelyn\|van den Bosch, Aniek\|Brouwers, Hilde\|Vanwolleghem, Thomas\|Janssen, Harry L A\|Javanbakht, Hassan\|Buschow, Sonja I\|Woltman, Andrea M
PMID:	27099316

64.
Journal:	Oncoimmunology. 2015 Aug 12;5(2):e1074376.
Title:	TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells.
Author:	Lin, Ang\|Wang, Guan\|Zhao, Huajun\|Zhang, Yuyi\|Han, Qiuju\|Zhang, Cai\|Tian, Zhigang\|Zhang, Jian
PMID:	27057441

65.
Journal:	J Biol Chem. 2016 May 27;291(22):11504-17.
Title:	Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice.
Author:	Miura, Kouichi\|Ishioka, Mitsuaki\|Minami, Shinichiro\|Horie, Yasuo\|Ohshima, Shigetoshi\|Goto, Takashi\|Ohnishi, Hirohide
PMID:	27022031

66.
Journal:	Cancer Discov. 2016 May;6(5):546-59.
Title:	PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression.
Author:	Xiao, Xiao\|Lao, Xiang-Ming\|Chen, Min-Min\|Liu, Rui-Xian\|Wei, Yuan\|Ouyang, Fang-Zhu\|Chen, Dong-Ping\|Zhao, Xiao-Yu\|Zhao, Qiyi\|Li, Xue-Feng\|Liu, Chuan-Lu\|Zheng, Limin\|Kuang, Dong-Ming
PMID:	26928313

67.
Journal:	World J Hepatol. 2016 Jan 28;8(3):162-82.
Title:	Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis?
Author:	Lopes, Jorge Andre Gomes\|Borges-Canha, Marta\|Pimentel-Nunes, Pedro
PMID:	26839640

68.
Journal:	Hepatology. 2016 Sep;64(3):955-65.
Title:	Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Author:	Tilg, Herbert\|Moschen, Alexander R\|Szabo, Gyongyi
PMID:	26773297

69.
Journal:	Am J Pathol. 2016 Jan;186(1):145-58.
Title:	Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling.
Author:	Benbow, Jennifer H\|Thompson, Kyle J\|Cope, Heidi L\|Brandon-Warner, Elizabeth\|Culberson, Catherine R\|Bossi, Krista L\|Li, Ting\|Russo, Mark W\|Gersin, Keith S\|McKillop, Iain H\|deLemos, Andrew S\|Schrum, Laura W
PMID:	26603137

70.
Journal:	Gastroenterology. 2016 Mar;150(3):707-19.
Title:	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.
Author:	Uthaya Kumar, Dinesh Babu\|Chen, Chia-Lin\|Liu, Jian-Chang\|Feldman, Douglas E\|Sher, Linda S\|French, Samuel\|DiNorcia, Joseph\|French, Samuel W\|Naini, Bita V\|Junrungsee, Sunhawit\|Agopian, Vatche Garen\|Zarrinpar, Ali\|Machida, Keigo
PMID:	26582088

71.
Journal:	Oncol Rep. 2016 Jan;35(1):307-17.
Title:	Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-kappaB activity.
Author:	Kuang, Haoyu\|Hua, Xiaoli\|Zhou, Jianhui\|Yang, Rui
PMID:	26531230

72.
Journal:	Oncol Lett. 2016 May;11(5):2965-2970.
Title:	TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-kappaB-IL6 signaling pathway.
Author:	Ren, Xingbin\|Wang, Fei\|Ji, Baoju\|Gao, Chunhai
PMID:	27123047

73.
Journal:	Int J Mol Med. 2017 Aug;40(2):263-270.
Title:	Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
Author:	Kawaratani, Hideto\|Moriya, Kei\|Namisaki, Tadashi\|Uejima, Masakazu\|Kitade, Mitsuteru\|Takeda, Kousuke\|Okura, Yasushi\|Kaji, Kousuke\|Takaya, Hiroaki\|Nishimura, Norihisa\|Sato, Shinya\|Sawada, Yasuhiko\|Seki, Kenichiro\|Kubo, Takuya\|Mitoro, Akira\|Yamao, Junichi\|Yo
PMID:	28627645

74.
Journal:	Arch Med Res. 2017 Aug;48(6):553-560.
Title:	Donor Polymorphisms of Toll-like Receptor 4 rs1927914 Associated with the Risk of Hepatocellular Carcinoma Recurrence Following Liver Transplantation.
Author:	Shi, Guangjun\|Wang, Chuanxu\|Zhang, Ping\|Ji, Lisha\|Xu, Shifeng\|Tan, Xueying\|Li, Hao
PMID:	29221801

75.
Journal:	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Sep;33(9):1182-1186.
Title:	[Expression of Toll-like receptors in human hepatocellular carcinoma and its correlation with inflammasome-associated cytokines].
Author:	Xu, Cong\|Qiao, Yali\|Zhang, Daolai
PMID:	29089073

76.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2017 Nov 1;49(11):1029-1034.
Title:	Lipopolysaccharide promotes angiogenesis in mice model of HCC by stimulating hepatic stellate cell activation via TLR4 pathway.
Author:	Lu, Yi\|Xu, Jianliang\|Chen, Shuxian\|Zhou, Zheng\|Lin, Nan
PMID:	29036356

77.
Journal:	DNA Cell Biol. 2017 Nov;36(11):1029-1038.
Title:	A896G and C1196T Polymorphisms Within the TLR4 Gene Abate Toll-Like Receptor 4-Mediated Signaling in HepG2 Cells.
Author:	Huang, Cuiyuan\|Zhang, Hong\|Bai, Ruidan\|Wang, Li\|Lv, Jian
PMID:	28945461

78.
Journal:	Sci Rep. 2017 Sep 22;7(1):12200.
Title:	Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD.
Author:	Pierantonelli, Irene\|Rychlicki, Chiara\|Agostinelli, Laura\|Giordano, Debora Maria\|Gaggini, Melania\|Fraumene, Cristina\|Saponaro, Chiara\|Manghina, Valeria\|Sartini, Loris\|Mingarelli, Eleonora\|Pinto, Claudio\|Buzzigoli, Emma\|Trozzi, Luciano\|Giordano, Antonio\|Ma
PMID:	28939830

79.
Journal:	Nat Med. 2017 Jun;23(6):742-752.
Title:	Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.
Author:	Zhao, Guang-Nian\|Zhang, Peng\|Gong, Jun\|Zhang, Xiao-Jing\|Wang, Pi-Xiao\|Yin, Miao\|Jiang, Zhou\|Shen, Li-Jun\|Ji, Yan-Xiao\|Tong, Jingjing\|Wang, Yutao\|Wei, Qiao-Fang\|Wang, Yong\|Zhu, Xue-Yong\|Zhang, Xin\|Fang, Jing\|Xie, Qingguo\|She, Zhi-Gang\|Wang, Zhihua\|Huang, Z
PMID:	28481357

80.
Journal:	Oncol Lett. 2017 Mar;13(3):1847-1855.
Title:	A polysaccharide component from Strongylocentrotus nudus eggs inhibited hepatocellular carcinoma in mice by activating T lymphocytes.
Author:	Zhang, Min\|Liu, Yang\|Li, Jingwen\|Ke, Mengyun\|Yu, Jie\|Dou, Jie\|Wang, Hui\|Zhou, Changlin
PMID:	28454333

81.
Journal:	Int Immunopharmacol. 2017 Mar;44:174-182.
Title:	Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-kappaB translocation.
Author:	Afrin, Rejina\|Arumugam, Somasundaram\|Rahman, Azizur\|Wahed, Mir Imam Ibne\|Karuppagounder, Vengadeshprabhu\|Harima, Meilei\|Suzuki, Hiroshi\|Miyashita, Shizuka\|Suzuki, Kenji\|Yoneyama, Hiroyuki\|Ueno, Kazuyuki\|Watanabe, Kenichi
PMID:	28110063

82.
Journal:	Oncol Rep. 2017 Feb;37(2):684-694.
Title:	Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-gamma.
Author:	Okuyama, Hiromi\|Tominaga, Akira\|Fukuoka, Satoshi\|Taguchi, Takahiro\|Kusumoto, Yutaka\|Ono, Shiro
PMID:	28075473

83.
Journal:	Metabolism. 2017 Jan;66:32-44.
Title:	Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice.
Author:	Bae, Jin-Sik\|Park, Jong-Min\|Lee, Junghoon\|Oh, Byung-Chul\|Jang, Sang-Ho\|Lee, Yun Bin\|Han, Young-Min\|Ock, Chan-Young\|Cha, Ji-Young\|Hahm, Ki-Baik
PMID:	27923447

84.
Journal:	Nat Med. 2017 Jul;23(7):829-838.
Title:	Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Author:	Giles, Daniel A\|Moreno-Fernandez, Maria E\|Stankiewicz, Traci E\|Graspeuntner, Simon\|Cappelletti, Monica\|Wu, David\|Mukherjee, Rajib\|Chan, Calvin C\|Lawson, Matthew J\|Klarquist, Jared\|Sunderhauf, Annika\|Softic, Samir\|Kahn, C Ronald\|Stemmer, Kerstin\|Iwakura, Y
PMID:	28604704

85.
Journal:	Adv Exp Med Biol. 2018;1032:105-113.
Title:	NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells.
Author:	Machida, Keigo
PMID:	30362094

86.
Journal:	Cell Mol Life Sci. 2018 Oct 20. pii: 10.1007/s00018-018-2947-0.
Title:	Molecular pathways of nonalcoholic fatty liver disease development and progression.
Author:	Bessone, Fernando\|Razori, Maria Valeria\|Roma, Marcelo G
PMID:	30343320

87.
Journal:	Cancer Biol Ther. 2018 Oct 2:1-8.
Title:	Sorafenib inhibits caspase-1 expression through suppressing TLR4/stat3/SUMO1 pathway in hepatocellular carcinoma.
Author:	Li, Jun\|Zhou, Yuan\|Liu, Yang\|Dai, Bo\|Zhang, Yu-Hen\|Zhang, Peng-Fei\|Shi, Xiao-Lei
PMID:	30277836

88.
Journal:	Hepatol Commun. 2018 Sep 7;2(9):1005-1020.
Title:	High-Mobility Group Box-1 and Liver Disease.
Author:	Gaskell, Harriet\|Ge, Xiaodong\|Nieto, Natalia
PMID:	30202816

89.
Journal:	Oncotarget. 2018 Jun 29;9(50):29495-29507.
Title:	Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis.
Author:	Nguyen, Jennifer\|Jiao, Jingjing\|Smoot, Kristin\|Watt, Gordon P\|Zhao, Chen\|Song, Xingzhi\|Stevenson, Heather L\|McCormick, Joseph B\|Fisher-Hoch, Susan P\|Zhang, Jianhua\|Futreal, P Andrew\|Beretta, Laura
PMID:	30034633

90.
Journal:	Int J Mol Sci. 2018 Jun 5;19(6). pii: ijms19061678.
Title:	Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function.
Author:	Wang, Yuan-Hsi\|Twu, Yuh-Ching\|Wang, Chung-Kwe\|Lin, Fu-Zhen\|Lee, Chun-Ya\|Liao, Yi-Jen
PMID:	29874879

91.
Journal:	Mol Immunol. 2018 Jul;99:171-181.
Title:	TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression.
Author:	Chi, Gang\|Feng, Xin-Xia\|Ru, Ying-Xia\|Xiong, Ting\|Gao, Yuan\|Wang, Han\|Luo, Zhen-Long\|Mo, Ran\|Guo, Fang\|He, Yong-Pei\|Zhang, Gui-Mei\|Tian, De-An\|Feng, Zuo-Hua
PMID:	29793131

92.
Journal:	J Cancer. 2018 Jan 5;9(3):614-628.
Title:	The role of cancer-associated fibroblast MRC-5 in pancreatic cancer.
Author:	Ding, Song-Ming\|Lu, Ai-Li\|Zhang, Wu\|Zhou, Lin\|Xie, Hai-Yang\|Zheng, Shu-Sen\|Li, Qi-Yong
PMID:	29483967

93.
Journal:	Hepatology. 2018 May;67(5):1872-1889.
Title:	Hypoxia-inducible factor-1alpha/interleukin-1beta signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment.
Author:	Zhang, Jingying\|Zhang, Qi\|Lou, Yu\|Fu, Qihan\|Chen, Qi\|Wei, Tao\|Yang, Jiaqi\|Tang, Jinlong\|Wang, Jianxin\|Chen, Yiwen\|Zhang, Xiaoyu\|Zhang, Jian\|Bai, Xueli\|Liang, Tingbo
PMID:	29171040

94.
Journal:	Mol Med Rep. 2018 Jan;17(1):1907-1912.
Title:	Protective effects of oxymatrine against lipopolysaccharide/Dgalactosamineinduced acute liver failure through oxidative damage, via activation of Nrf2/HO1 and modulation of inflammatory TLR4signaling pathways.
Author:	Xu, Jian\|Li, Chengmin\|Li, Ziwei\|Yang, Chan\|Lei, Lan\|Ren, Wei\|Su, Yan\|Chen, Chunping
PMID:	29138821

95.
Journal:	Int J Cancer. 2018 Jan 1;142(1):81-91.
Title:	The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice.
Author:	Song, Isabelle Jingyi\|Yang, Yoon Mee\|Inokuchi-Shimizu, Sayaka\|Roh, Yoon Seok\|Yang, Ling\|Seki, Ekihiro
PMID:	28875549