Primary Site >> Liver Cancer
Gene >> TLR4
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Ref: Unexpected high incidence of primary liver cancer in Geneva, Switzerland. PMID: 163325 |
Ref: Liver cancer toll high in Japan. PMID: 10356000 |
Ref: The significance of Toll-like receptor 4 (TLR4) expression in patients with chronic hepatitis B. PMID: 18544275 |
Ref: Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. PMID: 19171902 |
Ref: Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. PMID: 19720422 Ref: Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. PMID: 20803560 Ref: Toll-like receptors in the pathogenesis of alcoholic liver disease. PMID: 20827314 |
Ref: Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. PMID: 20721625 Ref: S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. PMID: 21276439 Ref: Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. PMID: 21284667 Ref: Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response. PMID: 21335546 Ref: LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. PMID: 21363926 Ref: Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma. PMID: 21559380 Ref: Mechanisms by which TLR4 and endotoxin promote hepatocellular carcinoma require further investigation. PMID: 21563198 Ref: Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. PMID: 21826665 |
Ref: Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population. PMID: 21932384 Ref: Polymorphism of the TLR4 gene reduces the risk of hepatitis C virus-induced hepatocellular carcinoma. PMID: 22286521 Ref: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. PMID: 22297845 Ref: Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. PMID: 22320911 Ref: Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence. PMID: 22330637 Ref: Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. PMID: 22516259 Ref: Inflammation: the gut takes a toll on liver cancer. PMID: 22592299 Ref: Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4. PMID: 22617167 Ref: Interaction of Hepatitis C virus proteins with pattern recognition receptors. PMID: 22726246 |
Ref: Targeting gut flora to prevent progression of hepatocellular carcinoma. PMID: 22940407 Ref: Beta-catenin-NF-kappaB interactions in murine hepatocytes: a complex to die for. PMID: 22941935 Ref: Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. PMID: 23277536 Ref: Balloon liver cells forming Mallory-Denk-bodies are progenitor cells. PMID: 23773849 Ref: Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory ability of human esophageal cancer cells in a selectin-dependent manner. PMID: 23809486 Ref: Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. PMID: 23855294 Ref: Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells. PMID: 23921128 Ref: TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro. PMID: 24227786 Ref: No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV. PMID: 24349054 |
Ref: Toll-like receptors 3, 4 and 9 in hepatocellular carcinoma: Relationship with clinicopathological characteristics and prognosis. PMID: 23742263 Ref: Toll-like receptor 4 and hepatitis B infection: molecular mechanisms and pathogenesis. PMID: 25014492 Ref: Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma. PMID: 25034527 Ref: Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice. PMID: 25049387 Ref: The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabian patients. PMID: 25177689 Ref: A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population. PMID: 25179842 Ref: B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. PMID: 25244097 Ref: Relationship between expression of toll-like receptors 2/4 in dendritic cells and chronic hepatitis B virus infection. PMID: 25337250 Ref: Alcohol, TLR4-TGF-beta antagonism, and liver cancer. PMID: 26201318 Ref: Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. PMID: 26202636 |
Ref: TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. PMID: 25427905 Ref: CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-kappaB and MAPK pathway. PMID: 25475726 Ref: The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells. PMID: 25826093 Ref: Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma. PMID: 26154152 Ref: Aggravated Liver Injury but Attenuated Inflammation in PTPRO-Deficient Mice Following LPS/D-GaIN Induced Fulminant Hepatitis. PMID: 26303994 Ref: STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma. PMID: 26457732 Ref: TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. PMID: 26501855 Ref: Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through MKK4/JNK pathway. PMID: 26589455 Ref: Liver Cancer PMID: 26913346 Ref: Emerging role of Toll-like receptor 4 in hepatocellular carcinoma. PMID: 27508190 |
Ref: Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-kappaB activity. PMID: 26531230 Ref: TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. PMID: 26582088 Ref: Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling. PMID: 26603137 Ref: Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. PMID: 26773297 Ref: Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis? PMID: 26839640 Ref: PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression. PMID: 26928313 Ref: Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. PMID: 27022031 Ref: TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. PMID: 27057441 Ref: Hepatitis B Virus Surface Antigen Activates Myeloid Dendritic Cells via a Soluble CD14-Dependent Mechanism. PMID: 27099316 Ref: TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-kappaB-IL6 signaling pathway. PMID: 27123047 Ref: Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells. PMID: 27123062 Ref: CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation. PMID: 27245433 Ref: TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. PMID: 27391331 Ref: Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B. PMID: 27391584 Ref: Expression of toll-like receptors in hepatic cirrhosis and hepatocellular carcinoma. PMID: 27420991 Ref: Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway. PMID: 27492456 Ref: Novel chemokine-like activities of histones in tumor metastasis. PMID: 27623211 Ref: Everolimus and Malignancy after Solid Organ Transplantation: A Clinical Update. PMID: 27807479 Ref: CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients. PMID: 28123896 |
Ref: Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice. PMID: 27923447 Ref: Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-gamma. PMID: 28075473 Ref: Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-kappaB translocation. PMID: 28110063 Ref: A polysaccharide component from Strongylocentrotus nudus eggs inhibited hepatocellular carcinoma in mice by activating T lymphocytes. PMID: 28454333 Ref: Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. PMID: 28481357 Ref: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. PMID: 28604704 Ref: Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review). PMID: 28627645 Ref: Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD. PMID: 28939830 Ref: A896G and C1196T Polymorphisms Within the TLR4 Gene Abate Toll-Like Receptor 4-Mediated Signaling in HepG2 Cells. PMID: 28945461 Ref: Lipopolysaccharide promotes angiogenesis in mice model of HCC by stimulating hepatic stellate cell activation via TLR4 pathway. PMID: 29036356 Ref: [Expression of Toll-like receptors in human hepatocellular carcinoma and its correlation with inflammasome-associated cytokines]. PMID: 29089073 Ref: Donor Polymorphisms of Toll-like Receptor 4 rs1927914 Associated with the Risk of Hepatocellular Carcinoma Recurrence Following Liver Transplantation. PMID: 29221801 |
Ref: The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. PMID: 28875549 Ref: Protective effects of oxymatrine against lipopolysaccharide/Dgalactosamineinduced acute liver failure through oxidative damage, via activation of Nrf2/HO1 and modulation of inflammatory TLR4signaling pathways. PMID: 29138821 Ref: Hypoxia-inducible factor-1alpha/interleukin-1beta signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment. PMID: 29171040 Ref: The role of cancer-associated fibroblast MRC-5 in pancreatic cancer. PMID: 29483967 Ref: TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression. PMID: 29793131 Ref: Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function. PMID: 29874879 Ref: Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis. PMID: 30034633 Ref: High-Mobility Group Box-1 and Liver Disease. PMID: 30202816 Ref: Sorafenib inhibits caspase-1 expression through suppressing TLR4/stat3/SUMO1 pathway in hepatocellular carcinoma. PMID: 30277836 Ref: Molecular pathways of nonalcoholic fatty liver disease development and progression. PMID: 30343320 Ref: NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells. PMID: 30362094 |