Primary Site >> Colorectal Cancer

Gene >> TIMP3

Journal: Carcinogenesis. 1996 Sep;17(9):1805-11.
Title: Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3.
Author: Bian, J|Wang, Y|Smith, M R|Kim, H|Jacobs, C|Jackman, J|Kung, H F|Colburn, N H|Sun, Y
PMID: 8824499
Journal: Br J Cancer. 1997;75(11):1678-83.
Title: TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma.
Author: Powe, D G|Brough, J L|Carter, G I|Bailey, E M|Stetler-Stevenson, W G|Turner, D R|Hewitt, R E
PMID: 9184186
Journal: Cytokine. 1997 Oct;9(10):770-80.
Title: TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells.
Author: Smith, M R|Kung, H|Durum, S K|Colburn, N H|Sun, Y
PMID: 9344510
Journal: Biochim Biophys Acta. 1998 Sep 30;1407(3):200-4.
Title: Identification of novel genes that are differentially expressed in human colorectal carcinoma.
Author: Chan, E C|Lue, M Y|Hsu, K C|Fan, H A
PMID: 9748578
Journal: J Pathol. 2000 Dec;192(4):455-9.
Title: Increased expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) in a more tumourigenic colon cancer cell line.
Author: Hewitt, R E|Brown, K E|Corcoran, M|Stetler-Stevenson, W G
PMID: 11113862
Journal: Zhonghua Wai Ke Za Zhi. 2000 Jul;38(7):510-3.
Title: [Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal neoplasm].
Author: Wan, Y|Wei, Q|Pan, Y|Liu, Y
PMID: 11832095
Journal: Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5860-5.
Title: The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase.
Author: Kawakami, Kazuyuki|Ruszkiewicz, Andrew|Bennett, Graeme|Moore, James|Watanabe, Go|Iacopetta, Barry
PMID: 14676107
Journal: Clin Cancer Res. 2004 Dec 15;10(24):8229-34.
Title: Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Author: Curran, Stephanie|Dundas, Sinclair R|Buxton, Jenny|Leeman, Matthew F|Ramsay, Robin|Murray, Graeme I
PMID: 15623598
Journal: World J Gastroenterol. 2004 Dec 1;10(23):3441-54.
Title: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Author: Xu, Xiao-Li|Yu, Jian|Zhang, Hong-Yu|Sun, Meng-Hong|Gu, Jun|Du, Xiang|Shi, Da-Ren|Wang, Peng|Yang, Zhen-Hua|Zhu, Jing-De
PMID: 15526363
Journal: Int J Cancer. 2004 Dec 10;112(5):846-53.
Title: Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
Author: Bai, Alfa H C|Tong, Joanna H M|To, Ka-Fai|Chan, Michael W Y|Man, Ellen P S|Lo, Kwok-Wai|Lee, Janet F Y|Sung, Joseph J Y|Leung, Wai K
PMID: 15386372
Journal: Anticancer Res. 2004 Mar-Apr;24(2B):649-54.
Title: The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
Author: Oyama, Kaeko|Kawakami, Kazuyuki|Maeda, Kazuya|Ishiguro, Kaname|Watanabe, Go
PMID: 15161007
Journal: Lab Invest. 2004 Jul;84(7):884-93.
Title: Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Author: Lee, Sun|Hwang, Kyu Sang|Lee, Hyeon Joo|Kim, Jung-Sun|Kang, Gyeong Hoon
PMID: 15122305
Journal: Mod Pathol. 2005 Feb;18(2):170-8.
Title: Progressive methylation during the serrated neoplasia pathway of the colorectum.
Author: Dong, Seung M|Lee, Eui J|Jeon, Eun S|Park, Cheol K|Kim, Kyoung-Mee
PMID: 15389252
Journal: Cancer Lett. 2005 Jun 1;223(1):137-42. Epub 2004 Nov 2.
Title: Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI).
Author: Brueckl, Wolfgang M|Grombach, Jens|Wein, Axel|Ruckert, Stefan|Porzner, Marc|Dietmaier, Wolfgang|Rummele, Petra|Croner, Roland S|Boxberger, Frank|Kirchner, Thomas|Hohenberger, Werner|Hahn, Eckhart G|Jung, Andreas
PMID: 15890246
Journal: J Cancer Res Clin Oncol. 2005 Nov;131(11):733-40. Epub 2005 Nov 1.
Title: Aberrant CpG island methylation in early-onset sporadic gastric carcinoma.
Author: Kim, Hee Cheol|Kim, Jin Cheon|Roh, Sun Ae|Yu, Chang Sik|Yook, Jeong Hwan|Oh, Sung Tae|Kim, Byung Sik|Park, Kun Choon|Chang, Rin
PMID: 16075282
Journal: Neoplasia. 2005 Aug;7(8):771-8.
Title: Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers.
Author: Ebert, Matthias P A|Mooney, Suzanne H|Tonnes-Priddy, Lori|Lograsso, Joe|Hoffmann, Juliane|Chen, Jie|Rocken, Christoph|Schulz, Hans-Ulrich|Malfertheiner, Peter|Lofton-Day, Catherine
PMID: 16207479
Journal: Genome Res. 2006 Feb;16(2):282-9.
Title: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay.
Author: Cheng, Yu-Wei|Shawber, Carrie|Notterman, Dan|Paty, Philip|Barany, Francis
PMID: 16369045
Journal: Br J Cancer. 2006 Feb 27;94(4):593-8.
Title: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer.
Author: Kawakami, K|Ruszkiewicz, A|Bennett, G|Moore, J|Grieu, F|Watanabe, G|Iacopetta, B
PMID: 16421593
Journal: Genes Chromosomes Cancer. 2006 Aug;45(8):781-9.
Title: CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.
Author: Kim, Young-Ho|Petko, Zsolt|Dzieciatkowski, Slavomir|Lin, Li|Ghiassi, Mahan|Stain, Steve|Chapman, William C|Washington, Mary Kay|Willis, Joseph|Markowitz, Sanford D|Grady, William M
PMID: 16708352
Journal: Int J Cancer. 2006 Nov 15;119(10):2272-8.
Title: APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer.
Author: Iacopetta, Barry|Grieu, Fabienne|Li, Wei|Ruszkiewicz, Andrew|Caruso, Maria|Moore, James|Watanabe, Goh|Kawakami, Kazuyuki
PMID: 16981189
Journal: Cancer Sci. 2007 Sep;98(9):1454-60.
Title: Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa.
Author: Iacopetta, Barry|Grieu, Fabienne|Phillips, Michael|Ruszkiewicz, Andrew|Moore, James|Minamoto, Toshinari|Kawakami, Kazuyuki
PMID: 17640302
Journal: World J Gastroenterol. 2007 Jul 28;13(28):3883-5.
Title: Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma.
Author: Bai, Yu-Xian|Yi, Ji-Lin|Li, Jian-Feng|Sui, Hong
PMID: 17657847
Journal: Genome Biol. 2007;8(7):R131.
Title: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.
Author: Kaiser, Sergio|Park, Young-Kyu|Franklin, Jeffrey L|Halberg, Richard B|Yu, Ming|Jessen, Walter J|Freudenberg, Johannes|Chen, Xiaodi|Haigis, Kevin|Jegga, Anil G|Kong, Sue|Sakthivel, Bhuvaneswari|Xu, Huan|Reichling, Timothy|Azhar, Mohammad|Boivin, Gregory P|
PMID: 17615082
Journal: Surg Today. 2007;37(3):220-5. Epub 2007 Mar 9.
Title: TIMP-3 and Phosphatidylinositol 3-kinase genes were found to be related to the progression of colon cancer in a comparison of pneumoperitoneum and laparotomy in a murine model.
Author: Tanaka, Fumiaki|Sonoda, Hideto|Okamoto, Masahiro|Mimori, Koshi|Utsunomiya, Tohru|Inoue, Hiroshi|Hanai, Taizo|Mori, Masaki
PMID: 17342361
Journal: Gastroenterology. 2007 Jan;132(1):127-38.
Title: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
Author: Goel, Ajay|Nagasaka, Takeshi|Arnold, Christian N|Inoue, Toru|Hamilton, Cody|Niedzwiecki, Donna|Compton, Carolyn|Mayer, Robert J|Goldberg, Richard|Bertagnolli, Monica M|Boland, C Richard
PMID: 17087942
Journal: Int J Cancer. 2007 Aug 15;121(4):714-23.
Title: Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer.
Author: Hilska, Marja|Roberts, Peter J|Collan, Yrjo U|Laine, Veli Jukka O|Kossi, Jyrki|Hirsimaki, Pirkko|Rahkonen, Otto|Laato, Matti
PMID: 17455256
Journal: J Korean Med Sci. 2008 Apr;23(2):270-7.
Title: CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteria.
Author: Kim, Hee Cheol|Lee, Hyeon Jung|Roh, Seon Ae|Kim, Jung-Sun|Yu, Chang Sik|Kim, Jin Cheon
PMID: 18437011
Journal: Cancer Res. 2008 Jun 15;68(12):4597-605.
Title: Epigenetic signatures of familial cancer are characteristic of tumor type and family category.
Author: Joensuu, Emmi I|Abdel-Rahman, Wael M|Ollikainen, Miina|Ruosaari, Salla|Knuutila, Sakari|Peltomaki, Paivi
PMID: 18559504
Journal: Dis Markers. 2008;25(1):1-16.
Title: Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature.
Author: Galamb, Orsolya|Gyorffy, Balazs|Sipos, Ferenc|Spisak, Sandor|Nemeth, Anna Maria|Miheller, Pal|Tulassay, Zsolt|Dinya, Elek|Molnar, Bela
PMID: 18776587
Journal: Cancer. 2010 Oct 1;116(19):4495-501.
Title: Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas.
Author: Paun, Bogdan C|Kukuruga, Debra|Jin, Zhe|Mori, Yuriko|Cheng, Yulan|Duncan, Mark|Stass, Sanford A|Montgomery, Elizabeth|Hutcheon, David|Meltzer, Stephen J
PMID: 20572039
Journal: Folia Med (Plovdiv). 2010 Apr-Jun;52(2):22-30.
Title: DNA methylation in patients with colorectal cancer--correlation with some clinical and morphological features and with local tumour invasion.
Author: Mirchev, Milko B|Kahl, Philip|Friedrichs, Nicolaus|Kotzev, Iskren A|Buettner, Reinhard
PMID: 20836393
Journal: Tohoku J Exp Med. 2011 Jan;223(1):67-73.
Title: Matrix metalloproteinase-9 is a prognostic marker to predict survival of patients who underwent surgery due to rectal carcinoma.
Author: Svagzdys, Saulius|Lesauskaite, Vaiva|Pangonyte, Dalia|Saladzinskas, Zilvinas|Tamelis, Algimantas|Pavalkis, Dainius
PMID: 21212604
Journal: Br J Surg. 2011 May;98(5):724-34.
Title: Methylation profiling of rectal cancer identifies novel markers of early-stage disease.
Author: Leong, K J|Wei, W|Tannahill, L A|Caldwell, G M|Jones, C E|Morton, D G|Matthews, G M|Bach, S P
PMID: 21360524
Journal: Am J Pathol. 2011 Apr;178(4):1835-46.
Title: Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis.
Author: Ju, Hai-Xing|An, Byonggu|Okamoto, Yasuyuki|Shinjo, Keiko|Kanemitsu, Yukihide|Komori, Koji|Hirai, Takashi|Shimizu, Yasuhiro|Sano, Tsuyoshi|Sawaki, Akira|Tajika, Masahiro|Yamao, Kenji|Fujii, Makiko|Murakami, Hideki|Osada, Hirotaka|Ito, Hidemi|Takeuchi, Ichi
PMID: 21406167
Journal: PLoS One. 2011;6(11):e27889.
Title: DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis.
Author: Konishi, Kazuo|Watanabe, Yoshiyuki|Shen, Lanlan|Guo, Yi|Castoro, Ryan J|Kondo, Kimie|Chung, Woonbok|Ahmed, Saira|Jelinek, Jaroslav|Boumber, Yanis A|Estecio, Marcos R|Maegawa, Shinji|Kondo, Yutaka|Itoh, Fumio|Imawari, Michio|Hamilton, Stanley R|Issa, Jean-
PMID: 22132162
Journal: Mol Cell Biochem. 2012 Apr;363(1-2):1-10.
Title: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA.
Author: Wang, Jingchun|Ding, Weifeng|Sun, Baolan|Jing, Rongrong|Huang, Hua|Shi, Gongsheng|Wang, Huimin
PMID: 22170570
Journal: Cancer Gene Ther. 2012 Dec;19(12):845-51.
Title: Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells.
Author: Lin, H|Zhang, Y|Wang, H|Xu, D|Meng, X|Shao, Y|Lin, C|Ye, Y|Qian, H|Wang, S
PMID: 23037807
Journal: J Prev Med Public Health. 2012 Jul;45(4):251-8.
Title: Quantitative analysis of cancer-associated gene methylation connected to risk factors in Korean colorectal cancer patients.
Author: Kang, Ho-Jin|Kim, Eun-Jeong|Kim, Byoung-Gwon|You, Chang-Hun|Lee, Sang-Yong|Kim, Dong-Il|Hong, Young-Seoub
PMID: 22880157
Journal: Dig Dis Sci. 2012 Aug;57(8):2063-71.
Title: Effect of the expression of matrix metalloproteases and their tissue inhibitors on survival of patients with resectable colorectal cancer.
Author: Gonzalez, Lucia|Eiro, Noemi|Gonzalez, Luis O|Andicoechea, Alejandro|Barbon, Esther|Garcia-Muniz, Jose L|Vizoso, Francisco J
PMID: 22488635
Journal: J Cell Physiol. 2013 Dec;228(12):2343-9.
Title: Gene methylation in rectal cancer: predictive marker of response to chemoradiotherapy?
Author: Molinari, Chiara|Casadio, Valentina|Foca, Flavia|Zingaretti, Chiara|Giannini, Massimo|Avanzolini, Andrea|Lucci, Enrico|Saragoni, Luca|Passardi, Alessandro|Amadori, Dino|Calistri, Daniele|Zoli, Wainer
PMID: 23702823
Journal: Neoplasma. 2013 Sep 20.
Title: MicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3.
Author: Qin, S|Zhu, Y|Ai, F|Li, Y|Bai, B|Yao, W|Dong, L
PMID: 24050546
Journal: J Exp Med. 2013 Nov 18;210(12):2675-92.
Title: Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation.
Author: Leung, Wai-Hang|Vong, Queenie P|Lin, Wenwei|Janke, Laura|Chen, Taosheng|Leung, Wing
PMID: 24190430
Journal: Neoplasma. 2014;61(1):27-34.
Title: MicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3.
Author: Qin, S|Zhu, Y|Ai, F|Li, Y|Bai, B|Yao, W|Dong, L
PMID: 24195505
Journal: Otolaryngol Pol. 2016 Jun 30;70(3):32-43.
Title: Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study.
Author: Pietruszewska, Wioletta|Bojanowska-Pozniak, Katarzyna|Kobos, Jozef
PMID: 27386931
Journal: Mol Ther Nucleic Acids. 2017 Sep 15;8:469-481.
Title: Long Noncoding RNA BC032913 as a Novel Therapeutic Target for Colorectal Cancer that Suppresses Metastasis by Upregulating TIMP3.
Author: Lin, Jiaxin|Tan, Xin|Qiu, Lin|Huang, Long|Zhou, Yi|Pan, Zhizhong|Liu, Ranyi|Chen, Shuai|Geng, Rong|Wu, Jiangxue|Huang, Wenlin
PMID: 28918047
Journal: J Biomed Nanotechnol. 2018 May 1;14(5):946-958.
Title: Fluorescent Nanodiamonds are Efficient, Easy-to-Use Cyto-Compatible Vehicles for Monitored Delivery of Non-Coding Regulatory RNAs.
Author: Lukowski, Sonja|Neuhoferova, Eva|Kinderman, Marek|Krivohlava, Romana|Mineva, Andrea|Petrakova, Vladimira|Benson, Veronika
PMID: 29883564
Journal: PLoS One. 2018 Jul 2;13(7):e0194160.
Title: The stress response gene ATF3 is a direct target of the Wnt/beta-catenin pathway and inhibits the invasion and migration of HCT116 human colorectal cancer cells.
Author: Inoue, Makoto|Uchida, Yohei|Edagawa, Makoto|Hirata, Manabu|Mitamura, Jun|Miyamoto, Daiki|Taketani, Kenji|Sekine, Shigeki|Kawauchi, Junya|Kitajima, Shigetaka
PMID: 29966001
Journal: Cancer Res. 2018 Sep 5. pii: 0008-5472.CAN-18-1583.
Title: CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases.
Author: Liang, Jiaxin|Chen, Mengqian|Hughes, Daniel|Chumanevich, Alexander A|Altilia, Serena|Kaza, Vimala|Lim, Chang-Uk|Kiaris, Hippokratis|Mythreye, Karthikeyan|Pena, Maria Marjorette|Broude, Eugenia V|Roninson, Igor B
PMID: 30185549