Primary Site >> Colorectal Cancer
Gene >> TGFBR2
| 1. | |||||||||||
| Journal: | Cancer Res. 1987 Sep 1;47(17):4590-4. | ||||||||||
| Title: | Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. | ||||||||||
| Author: | Coffey, R J Jr|Goustin, A S|Soderquist, A M|Shipley, G D|Wolfshohl, J|Carpenter, G|Moses, H L | ||||||||||
| PMID: | 2887281 | ||||||||||
| 2. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 1995 Nov 13;216(2):452-7. | ||||||||||
| Title: | Mutations of the transforming growth factor-beta type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. | ||||||||||
| Author: | Lu, S L|Akiyama, Y|Nagasaki, H|Saitoh, K|Yuasa, Y | ||||||||||
| PMID: | 7488133 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Res. 1995 Dec 1;55(23):5548-50. | ||||||||||
| Title: | Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. | ||||||||||
| Author: | Parsons, R|Myeroff, L L|Liu, B|Willson, J K|Markowitz, S D|Kinzler, K W|Vogelstein, B | ||||||||||
| PMID: | 7585632 | ||||||||||
| 4. | |||||||||||
| Journal: | J Biol Chem. 1995 Sep 15;270(37):22044-9. | ||||||||||
| Title: | Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. | ||||||||||
| Author: | Wang, J|Sun, L|Myeroff, L|Wang, X|Gentry, L E|Yang, J|Liang, J|Zborowska, E|Markowitz, S|Willson, J K | ||||||||||
| PMID: | 7665626 | ||||||||||
| 5. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 1996 Oct 14;227(2):553-7. | ||||||||||
| Title: | Mutations of E2F-4 trinucleotide repeats in colorectal cancer with microsatellite instability. | ||||||||||
| Author: | Yoshitaka, T|Matsubara, N|Ikeda, M|Tanino, M|Hanafusa, H|Tanaka, N|Shimizu, K | ||||||||||
| PMID: | 8878551 | ||||||||||
| 6. | |||||||||||
| Journal: | Nihon Rinsho. 1996 Apr;54(4):1014-8. | ||||||||||
| Title: | [Mutations of hMSH2 gene and hMLH1 gene in human colovectal carcinomas]. | ||||||||||
| Author: | Yokozaki, H|Yamamoto, S|Tahara, E | ||||||||||
| PMID: | 8920666 | ||||||||||
| 7. | |||||||||||
| Journal: | Am J Pathol. 1997 Jul;151(1):33-5. | ||||||||||
| Title: | Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas. | ||||||||||
| Author: | Samowitz, W S|Slattery, M L | ||||||||||
| PMID: | 9212728 | ||||||||||
| 8. | |||||||||||
| Journal: | Nat Genet. 1998 Mar;18(3):276-9. | ||||||||||
| Title: | Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. | ||||||||||
| Author: | Prolla, T A|Baker, S M|Harris, A C|Tsao, J L|Yao, X|Bronner, C E|Zheng, B|Gordon, M|Reneker, J|Arnheim, N|Shibata, D|Bradley, A|Liskay, R M | ||||||||||
| PMID: | 9500552 | ||||||||||
| 9. | |||||||||||
| Journal: | Cancer Lett. 1998 Mar 13;125(1-2):89-96. | ||||||||||
| Title: | Genetic alterations are frequent in APC but rare in the TGF-beta type II receptor gene in cancer in adenomas of the colon. | ||||||||||
| Author: | Akiyama, Y|Yagi, O K|Ishikawa, T|Nagasaki, H|Saitoh, K|Yuasa, Y | ||||||||||
| PMID: | 9566701 | ||||||||||
| 10. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 1998 Jun;22(2):138-44. | ||||||||||
| Title: | Novel mutations in the polyadenine tract of the transforming growth factor beta type II receptor gene are found in a subpopulation of human pancreatic adenocarcinomas. | ||||||||||
| Author: | Venkatasubbarao, K|Ahmed, M M|Swiderski, C|Harp, C|Lee, E Y|McGrath, P|Mohiuddin, M|Strodel, W|Freeman, J W | ||||||||||
| PMID: | 9598801 | ||||||||||
| 11. | |||||||||||
| Journal: | Blood. 1998 Jul 1;92(1):230-3. | ||||||||||
| Title: | Microsatellite instability and frameshift mutations in BAX and transforming growth factor-beta RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines. | ||||||||||
| Author: | Molenaar, J J|Gerard, B|Chambon-Pautas, C|Cave, H|Duval, M|Vilmer, E|Grandchamp, B | ||||||||||
| PMID: | 9639521 | ||||||||||
| 12. | |||||||||||
| Journal: | Mutat Res. 1998 May;382(3-4):115-20. | ||||||||||
| Title: | A novel missense mutation and frameshift mutations in the type II receptor of transforming growth factor-beta gene in sporadic colon cancer with microsatellite instability. | ||||||||||
| Author: | Orimo, H|Ikejima, M|Nakajima, E|Emi, M|Shimada, T | ||||||||||
| PMID: | 9691992 | ||||||||||
| 13. | |||||||||||
| Journal: | Vopr Onkol. 1998;44(6):667-71. | ||||||||||
| Title: | [Damage to the transforming growth factor TGF-beta type II receptor gene and microsatellite instability in carcinoma cells of the gastrointestinal tract]. | ||||||||||
| Author: | Vostriukhina, O A|Nikiforova, I F|Shtam, T A|Kantorov, S L|Kovalev, V K|Vasil'ev, S V|Pozharisskii, K M|Lantsov, V A | ||||||||||
| PMID: | 10087960 | ||||||||||
| 14. | |||||||||||
| Journal: | Int J Cancer. 1999 Feb 9;80(4):506-10. | ||||||||||
| Title: | Frequent aberration of the transforming growth factor-beta receptor II gene in cell lines but no apparent mutation in pre-invasive and invasive carcinomas of the uterine cervix. | ||||||||||
| Author: | Chu, T Y|Lai, J S|Shen, C Y|Liu, H S|Chao, C F | ||||||||||
| PMID: | 9935148 | ||||||||||
| 15. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3087-91. | ||||||||||
| Title: | Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression. | ||||||||||
| Author: | Ilyas, M|Efstathiou, J A|Straub, J|Kim, H C|Bodmer, W F | ||||||||||
| PMID: | 10077641 | ||||||||||
| 16. | |||||||||||
| Journal: | Am J Pathol. 1999 Jun;154(6):1867-76. | ||||||||||
| Title: | Evidence for control of nitric oxide synthesis by intracellular transforming growth factor-beta1 in tumor cells. Implications for tumor development. | ||||||||||
| Author: | Lagadec, P|Raynal, S|Lieubeau, B|Onier, N|Arnould, L|Saint-Giorgio, V|Lawrence, D A|Jeannin, J F | ||||||||||
| PMID: | 10362813 | ||||||||||
| 17. | |||||||||||
| Journal: | J Biol Chem. 1999 Jul 9;274(28):20002-10. | ||||||||||
| Title: | The mannose 6-phosphate/insulin-like growth factor-II receptor is a substrate of type V transforming growth factor-beta receptor. | ||||||||||
| Author: | Liu, Q|Grubb, J H|Huang, S S|Sly, W S|Huang, J S | ||||||||||
| PMID: | 10391950 | ||||||||||
| 18. | |||||||||||
| Journal: | J Biol Chem. 1999 Nov 19;274(47):33637-43. | ||||||||||
| Title: | Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. | ||||||||||
| Author: | Calonge, M J|Massague, J | ||||||||||
| PMID: | 10559252 | ||||||||||
| 19. | |||||||||||
| Journal: | Int J Oncol. 2000 Mar;16(3):617-22. | ||||||||||
| Title: | Mechanical deformation induces proliferation of human colorectal carcinoma cells. | ||||||||||
| Author: | Johnson, F E|Zhou, M|Collins, B T|Huang, J S | ||||||||||
| PMID: | 10675497 | ||||||||||
| 20. | |||||||||||
| Journal: | Br J Cancer. 2000 May;82(9):1557-60. | ||||||||||
| Title: | A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. | ||||||||||
| Author: | Tanaka, S|Mori, M|Mafune, K|Ohno, S|Sugimachi, K | ||||||||||
| PMID: | 10789724 | ||||||||||
| 21. | |||||||||||
| Journal: | Int J Colorectal Dis. 2000 Apr;15(2):83-6. | ||||||||||
| Title: | Genetic analysis of multiple sporadic colon carcinomas from a single patient. | ||||||||||
| Author: | Barnetson, R A|Symons, P|Robinson, B G|Schnitzler, M | ||||||||||
| PMID: | 10855548 | ||||||||||
| 22. | |||||||||||
| Journal: | Int J Oncol. 2000 Sep;17(3):551-8. | ||||||||||
| Title: | Expression of transforming growth factor beta1 and its type II receptor in mouse colon tumors induced by azoxymethane. | ||||||||||
| Author: | Wang, Q S|Guda, K|Papanikolaou, A|Dong, M|Rosenberg, D W | ||||||||||
| PMID: | 10938397 | ||||||||||
| 23. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2000 Jul;27(8):1253-9. | ||||||||||
| Title: | [Mechanism of resistance to growth inhibition by transforming growth factor-beta 1 (TGF-beta 1) in primary lung cancer and new molecular targets in therapy]. | ||||||||||
| Author: | Gemma, A|Uematsu, K|Hagiwara, K|Takenoshita, S|Kudoh, S | ||||||||||
| PMID: | 10945024 | ||||||||||
| 24. | |||||||||||
| Journal: | J Med Genet. 2001 Feb;38(2):E7. | ||||||||||
| Title: | Germline mutation analysis of the transforming growth factor beta receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer. | ||||||||||
| Author: | Verma, L|Porter, T R|Richards, F M|Rajpar, M H|Evans, D G|Macdonald, F|Maher, E R | ||||||||||
| PMID: | 11158177 | ||||||||||
| 25. | |||||||||||
| Journal: | Am J Pathol. 2001 Feb;158(2):537-42. | ||||||||||
| Title: | Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects. | ||||||||||
| Author: | Montgomery, E|Goggins, M|Zhou, S|Argani, P|Wilentz, R|Kaushal, M|Booker, S|Romans, K|Bhargava, P|Hruban, R|Kern, S | ||||||||||
| PMID: | 11159190 | ||||||||||
| 26. | |||||||||||
| Journal: | Cancer Res. 2001 Jan 15;61(2):482-5. | ||||||||||
| Title: | Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer. | ||||||||||
| Author: | Lucke, C D|Philpott, A|Metcalfe, J C|Thompson, A M|Hughes-Davies, L|Kemp, P R|Hesketh, R | ||||||||||
| PMID: | 11212236 | ||||||||||
| 27. | |||||||||||
| Journal: | J Cell Physiol. 2001 Jun;187(3):356-64. | ||||||||||
| Title: | Growth inhibition due to complementation of transforming growth factor-beta receptor type II-defect by human chromosome 3 transfer in human colorectal carcinoma cells. | ||||||||||
| Author: | Miyafuji, Y|Zhong, X|Uchida, I|Koi, M|Hemmi, H | ||||||||||
| PMID: | 11319759 | ||||||||||
| 28. | |||||||||||
| Journal: | Cancer Res. 2001 Aug 15;61(16):6046-9. | ||||||||||
| Title: | Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability. | ||||||||||
| Author: | Mori, Y|Yin, J|Rashid, A|Leggett, B A|Young, J|Simms, L|Kuehl, P M|Langenberg, P|Meltzer, S J|Stine, O C | ||||||||||
| PMID: | 11507051 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Carcinog. 2001 Aug;31(4):204-13. | ||||||||||
| Title: | Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. | ||||||||||
| Author: | Guda, K|Giardina, C|Nambiar, P|Cui, H|Rosenberg, D W | ||||||||||
| PMID: | 11536370 | ||||||||||
| 30. | |||||||||||
| Journal: | Cancer Immunol Immunother. 2001 Nov;50(9):469-76. | ||||||||||
| Title: | A TGF betaRII frameshift-mutation-derived CTL epitope recognised by HLA-A2-restricted CD8+ T cells. | ||||||||||
| Author: | Saeterdal, I|Gjertsen, M K|Straten, P|Eriksen, J A|Gaudernack, G | ||||||||||
| PMID: | 11761441 | ||||||||||
| 31. | |||||||||||
| Journal: | Aliment Pharmacol Ther. 2002 Apr;16 Suppl 2:115-27. | ||||||||||
| Title: | Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. | ||||||||||
| Author: | Hahm, K-B|Lee, K M|Kim, Y B|Hong, W S|Lee, W H|Han, S U|Kim, M W|Ahn, B O|Oh, T Y|Lee, M H|Green, J|Kim, S J | ||||||||||
| PMID: | 11966532 | ||||||||||
| 32. | |||||||||||
| Journal: | Annu Rev Genomics Hum Genet. 2002;3:101-28. | ||||||||||
| Title: | Genetic and epigenetic alterations in colon cancer. | ||||||||||
| Author: | Grady, William M|Markowitz, Sanford D | ||||||||||
| PMID: | 12142355 | ||||||||||
| 33. | |||||||||||
| Journal: | Clin Chem. 2003 Apr;49(4):552-61. | ||||||||||
| Title: | Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells. | ||||||||||
| Author: | Bonk, Thomas|Humeny, Andreas|Gebert, Johannes|Sutter, Christian|von Knebel Doeberitz, Magnus|Becker, Cord-Michael | ||||||||||
| PMID: | 12651806 | ||||||||||
| 34. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2003 May;37(1):29-35. | ||||||||||
| Title: | Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. | ||||||||||
| Author: | Seitz, Susanne|Wassmuth, Peter|Plaschke, Jens|Schackert, Hans K|Karsten, Uwe|Santibanez-Koref, Mauro-F|Schlag, Peter M|Scherneck, Siegfried | ||||||||||
| PMID: | 12661003 | ||||||||||
| 35. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2003 Jun;22(2):315-20. | ||||||||||
| Title: | Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. | ||||||||||
| Author: | Fukushima, T|Mashiko, M|Takita, K|Otake, T|Endo, Y|Sekikawa, K|Takenoshita, S | ||||||||||
| PMID: | 12866583 | ||||||||||
| 36. | |||||||||||
| Journal: | Dig Dis Sci. 2003 Dec;48(12):2284-9. | ||||||||||
| Title: | Prognostic significance and correlation with survival of bcl-2 and TGF-beta RII in colon cancer. | ||||||||||
| Author: | Kouraklis, Gregory|Kakisis, John|Theoharis, Stamatios|Tzonou, Antonia|Glinavou, Andromachi|Raftopoulos, John|Karatzas, Gabriel | ||||||||||
| PMID: | 14714614 | ||||||||||
| 37. | |||||||||||
| Journal: | Gastroenterology. 2004 Mar;126(3):654-9. | ||||||||||
| Title: | Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. | ||||||||||
| Author: | Jung, Barbara|Doctolero, Ryan T|Tajima, Akihiro|Nguyen, Alexie K|Keku, Temitope|Sandler, Robert S|Carethers, John M | ||||||||||
| PMID: | 14988818 | ||||||||||
| 38. | |||||||||||
| Journal: | Zhonghua Bing Li Xue Za Zhi. 2004 Feb;33(1):6-10. | ||||||||||
| Title: | [Transforming growth factor beta receptor II mutations in RER positive colorectal cancers]. | ||||||||||
| Author: | Lai, Mao-de|Huang, Zhi-da|Huang, Qiong|Chen, Jian | ||||||||||
| PMID: | 14989920 | ||||||||||
| 39. | |||||||||||
| Journal: | Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):11-27. | ||||||||||
| Title: | Genomic instability and colon cancer. | ||||||||||
| Author: | Grady, William M | ||||||||||
| PMID: | 15000146 | ||||||||||
| 40. | |||||||||||
| Journal: | Cancer Res. 2004 Jul 15;64(14):4687-92. | ||||||||||
| Title: | Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. | ||||||||||
| Author: | Biswas, Swati|Chytil, Anna|Washington, Kay|Romero-Gallo, Judith|Gorska, Agnieszka E|Wirth, Pamela S|Gautam, Shiva|Moses, Harold L|Grady, William M | ||||||||||
| PMID: | 15256431 | ||||||||||
| 41. | |||||||||||
| Journal: | Cancer Genet Cytogenet. 2004 Sep;153(2):108-14. | ||||||||||
| Title: | Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. | ||||||||||
| Author: | Huang, Rui-Len|Chao, Chung-Faye|Ding, Dah-Ching|Yu, Cheng-Ping|Chang, Cheng-Chang|Lai, Hung-Chen|Yu, Mu-Hsien|Liu, Hang-Seng|Chu, Tang-Yuan | ||||||||||
| PMID: | 15350299 | ||||||||||
| 42. | |||||||||||
| Journal: | Cancer Res. 2004 Nov 1;64(21):7690-6. | ||||||||||
| Title: | Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes. | ||||||||||
| Author: | Deacu, Elena|Mori, Yuriko|Sato, Fumiaki|Yin, Jing|Olaru, Andreea|Sterian, Anca|Xu, Yan|Wang, Suna|Schulmann, Karsten|Berki, Agnes|Kan, Takatsugu|Abraham, John M|Meltzer, Stephen J | ||||||||||
| PMID: | 15520171 | ||||||||||
| 43. | |||||||||||
| Journal: | Cell Cycle. 2005 Feb;4(2):217-20. Epub 2005 Feb 3. | ||||||||||
| Title: | IL-6 signaling promotes tumor growth in colorectal cancer. | ||||||||||
| Author: | Becker, C|Fantini, M C|Wirtz, S|Nikolaev, A|Lehr, H A|Galle, P R|Rose-John, S|Neurath, M F | ||||||||||
| PMID: | 15655344 | ||||||||||
| 44. | |||||||||||
| Journal: | Cancer Genet Cytogenet. 2005 Feb;157(1):18-24. | ||||||||||
| Title: | Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability. | ||||||||||
| Author: | Fernandez-Peralta, Antonia M|Nejda, Nargisse|Oliart, Soledad|Medina, Vicente|Azcoita, Mariano Moreno|Gonzalez-Aguilera, Juan J | ||||||||||
| PMID: | 15676142 | ||||||||||
| 45. | |||||||||||
| Journal: | Oncogene. 2005 Apr 7;24(15):2525-35. | ||||||||||
| Title: | Microsatellite instability of selective target genes in HNPCC-associated colon adenomas. | ||||||||||
| Author: | Woerner, Stefan M|Kloor, Matthias|Mueller, Annegret|Rueschoff, Josef|Friedrichs, Nicolaus|Buettner, Reinhard|Buzello, Moriz|Kienle, Peter|Knaebel, Hanns-Peter|Kunstmann, Erdmute|Pagenstecher, Constanze|Schackert, Hans K|Moslein, Gabriela|Vogelsang, Holger | ||||||||||
| PMID: | 15735733 | ||||||||||
| 46. | |||||||||||
| Journal: | Cell. 2005 Jun 17;121(6):837-48. | ||||||||||
| Title: | A genetic screen for candidate tumor suppressors identifies REST. | ||||||||||
| Author: | Westbrook, Thomas F|Martin, Eric S|Schlabach, Michael R|Leng, Yumei|Liang, Anthony C|Feng, Bin|Zhao, Jean J|Roberts, Thomas M|Mandel, Gail|Hannon, Gregory J|Depinho, Ronald A|Chin, Lynda|Elledge, Stephen J | ||||||||||
| PMID: | 15960972 | ||||||||||
| 47. | |||||||||||
| Journal: | Int J Cancer. 2006 Feb 1;118(3):600-8. | ||||||||||
| Title: | Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. | ||||||||||
| Author: | Grady, William M|Willis, Joseph E|Trobridge, Patty|Romero-Gallo, Judith|Munoz, Nina|Olechnowicz, Joseph|Ferguson, Kelly|Gautam, Shiva|Markowitz, Sanford D | ||||||||||
| PMID: | 16108056 | ||||||||||
| 48. | |||||||||||
| Journal: | Virchows Arch. 2006 Feb;448(2):127-34. Epub 2005 Sep 22. | ||||||||||
| Title: | Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers. | ||||||||||
| Author: | Minhajat, Rahmawati|Mori, Daisuke|Yamasaki, Fumio|Sugita, Yasuo|Satoh, Toshimi|Tokunaga, Osamu | ||||||||||
| PMID: | 16177881 | ||||||||||
| 49. | |||||||||||
| Journal: | Int J Cancer. 2006 May 15;118(10):2509-13. | ||||||||||
| Title: | Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. | ||||||||||
| Author: | Jung, Barbara|Smith, E Julieta|Doctolero, Ryan T|Gervaz, Pascal|Alonso, Julio C|Miyai, Katsumi|Keku, Temitope|Sandler, Robert S|Carethers, John M | ||||||||||
| PMID: | 16380996 | ||||||||||
| 50. | |||||||||||
| Journal: | Br J Surg. 2006 Apr;93(4):395-406. | ||||||||||
| Title: | Microsatellite instability in colorectal cancer. | ||||||||||
| Author: | Soreide, K|Janssen, E A M|Soiland, H|Korner, H|Baak, J P A | ||||||||||
| PMID: | 16555243 | ||||||||||
| 51. | |||||||||||
| Journal: | Cancer Genet Cytogenet. 2006 Jun;167(2):138-44. | ||||||||||
| Title: | RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. | ||||||||||
| Author: | Iglesias, Daniel|Fernandez-Peralta, Antonia M|Nejda, Nargisse|Daimiel, Lidia|Azcoita, Mariano Moreno|Oliart, Soledad|Gonzalez-Aguilera, Juan J | ||||||||||
| PMID: | 16737913 | ||||||||||
| 52. | |||||||||||
| Journal: | Cancer Res. 2006 Oct 15;66(20):9837-44. | ||||||||||
| Title: | Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. | ||||||||||
| Author: | Munoz, Nina M|Upton, Melissa|Rojas, Andres|Washington, M Kay|Lin, Li|Chytil, Anna|Sozmen, Elif G|Madison, Blair B|Pozzi, Ambra|Moon, Randall T|Moses, Harold L|Grady, William M | ||||||||||
| PMID: | 17047044 | ||||||||||
| 53. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2006 Sep;25(3):433-42. | ||||||||||
| Title: | Expression and mutation of SMAD4 in poorly differentiated carcinoma and signet-ring cell carcinoma of the colorectum. | ||||||||||
| Author: | Seshimo, I|Yamamoto, H|Mishima, H|Kurata, A|Suzuki, R|Ezumi, K|Takemasa, I|Ikeda, M|Fukushima, T|Tsujinaka, T|Sekimoto, M|Kikkawa, N|Takenoshita, S|Monden, M | ||||||||||
| PMID: | 17167985 | ||||||||||
| 54. | |||||||||||
| Journal: | Gastroenterology. 2007 Feb;132(2):527-30. Epub 2006 Nov 29. | ||||||||||
| Title: | Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. | ||||||||||
| Author: | Will, Olivia|Carvajal-Carmona, Luis G|Gorman, Patricia|Howarth, Kimberley M|Jones, Angela M|Polanco-Echeverry, Guadalupe M|Chinaleong, Jo-Anne|Gunther, Thomas|Silver, Andrew|Clark, Susan K|Tomlinson, Ian | ||||||||||
| PMID: | 17258725 | ||||||||||
| 55. | |||||||||||
| Journal: | Hum Pathol. 2007 Apr;38(4):614-20. Epub 2007 Jan 31. | ||||||||||
| Title: | TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S | ||||||||||
| PMID: | 17270239 | ||||||||||
| 56. | |||||||||||
| Journal: | Exp Mol Pathol. 2007 Jun;82(3):284-91. Epub 2006 Dec 15. | ||||||||||
| Title: | Expression of TGF-beta1, TbetaRII and Smad4 in colorectal carcinoma. | ||||||||||
| Author: | Xu, Wei-Qing|Jiang, Xu-Cheng|Zheng, Lin|Yu, Yin-Yan|Tang, Jian-Min | ||||||||||
| PMID: | 17289018 | ||||||||||
| 57. | |||||||||||
| Journal: | J Cancer Res Clin Oncol. 2007 Oct;133(10):749-59. Epub 2007 May 25. | ||||||||||
| Title: | Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. | ||||||||||
| Author: | Alldinger, I|Schaefer, K L|Goedde, D|Ottaviano, L|Dirksen, U|Ranft, A|Juergens, H|Gabbert, H E|Knoefel, W T|Poremba, C | ||||||||||
| PMID: | 17530287 | ||||||||||
| 58. | |||||||||||
| Journal: | J Pathol. 2007 Nov;213(3):257-65. | ||||||||||
| Title: | Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta. | ||||||||||
| Author: | Baker, K|Raut, P|Jass, J R | ||||||||||
| PMID: | 17893910 | ||||||||||
| 59. | |||||||||||
| Journal: | Neoplasia. 2007 Dec;9(12):1091-8. | ||||||||||
| Title: | IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. | ||||||||||
| Author: | Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 18084616 | ||||||||||
| 60. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2008 Feb;47(2):95-106. | ||||||||||
| Title: | Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. | ||||||||||
| Author: | Biswas, Swati|Trobridge, Patricia|Romero-Gallo, Judith|Billheimer, Dean|Myeroff, Lois L|Willson, James K V|Markowitz, Sanford D|Grady, William M | ||||||||||
| PMID: | 17985359 | ||||||||||
| 61. | |||||||||||
| Journal: | Dis Colon Rectum. 2008 Sep;51(9):1387-94. | ||||||||||
| Title: | Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. | ||||||||||
| Author: | Fujiwara, Ichiro|Yashiro, Masakazu|Kubo, Naoshi|Maeda, Kiyoshi|Hirakawa, Kosei | ||||||||||
| PMID: | 18546042 | ||||||||||
| 62. | |||||||||||
| Journal: | Br J Cancer. 2008 Sep 16;99(6):957-65. | ||||||||||
| Title: | Smad7 induces hepatic metastasis in colorectal cancer. | ||||||||||
| Author: | Halder, S K|Rachakonda, G|Deane, N G|Datta, P K | ||||||||||
| PMID: | 18781153 | ||||||||||
| 63. | |||||||||||
| Journal: | Oncol Rep. 2008 Dec;20(6):1449-56. | ||||||||||
| Title: | Soluble transforming growth factor beta type II receptor attenuates TGF-beta1 activity in human colorectal cancer LoVo cells. | ||||||||||
| Author: | Zhou, Rui|Xiong, Bin|Song, Haibin|Liu, Shiquan|Wang, Xinbo | ||||||||||
| PMID: | 19020727 | ||||||||||
| 64. | |||||||||||
| Journal: | Int J Colorectal Dis. 2009 Feb;24(2):139-44. | ||||||||||
| Title: | Restoring TGFbeta function in microsatellite unstable (MSI-H) colorectal cancer reduces tumourigenicity but increases metastasis formation. | ||||||||||
| Author: | Warusavitarne, Janindra|McDougall, Fiona|de Silva, Keshani|Barnetson, Rebecca|Messina, Marinella|Robinson, Bruce G|Schnitzler, Margaret | ||||||||||
| PMID: | 18985362 | ||||||||||
| 65. | |||||||||||
| Journal: | Gastroenterology. 2009 May;136(5):1680-8.e7. | ||||||||||
| Title: | TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. | ||||||||||
| Author: | Trobridge, Patty|Knoblaugh, Sue|Washington, M Kay|Munoz, Nina M|Tsuchiya, Karen D|Rojas, Andres|Song, Xiaoling|Ulrich, Cornelia M|Sasazuki, Takehiko|Shirasawa, Senji|Grady, William M | ||||||||||
| PMID: | 19208363 | ||||||||||
| 66. | |||||||||||
| Journal: | Glycobiology. 2009 Jul;19(7):726-34. | ||||||||||
| Title: | Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. | ||||||||||
| Author: | Patsos, Georgios|Andre, Sabine|Roeckel, Nina|Gromes, Roland|Gebert, Johannes|Kopitz, Jurgen|Gabius, Hans-Joachim | ||||||||||
| PMID: | 19293232 | ||||||||||
| 67. | |||||||||||
| Journal: | Int J Colorectal Dis. 2009 Aug;24(8):875-84. | ||||||||||
| Title: | Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. | ||||||||||
| Author: | Fang, Y J|Lu, Z H|Wang, G Q|Pan, Z Z|Zhou, Z W|Yun, J P|Zhang, M F|Wan, D S | ||||||||||
| PMID: | 19421758 | ||||||||||
| 68. | |||||||||||
| Journal: | Mod Pathol. 2009 Sep;22(9):1186-95. | ||||||||||
| Title: | Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. | ||||||||||
| Author: | Tougeron, David|Fauquembergue, Emilie|Rouquette, Alexandre|Le Pessot, Florence|Sesboue, Richard|Laurent, Michele|Berthet, Pascaline|Mauillon, Jacques|Di Fiore, Frederic|Sabourin, Jean-Christophe|Michel, Pierre|Tosi, Mario|Frebourg, Thierry|Latouche, Jean- | ||||||||||
| PMID: | 19503063 | ||||||||||
| 69. | |||||||||||
| Journal: | Pathobiology. 2009;76(4):163-9. | ||||||||||
| Title: | RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. | ||||||||||
| Author: | Tong, Dan-Dan|Jiang, Ying|Li, Ming|Kong, Dan|Meng, Xiang-Nin|Zhao, Yu-Zhen|Jin, Yan|Bai, Jing|Fu, Song-Bin|Geng, Jing-Shu | ||||||||||
| PMID: | 19571605 | ||||||||||
| 70. | |||||||||||
| Journal: | Nucleic Acids Res. 2010 Jan;38(Database issue):D682-9. | ||||||||||
| Title: | SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology. | ||||||||||
| Author: | Woerner, Stefan M|Yuan, Yan P|Benner, Axel|Korff, Sebastian|von Knebel Doeberitz, Magnus|Bork, Peer | ||||||||||
| PMID: | 19820113 | ||||||||||
| 71. | |||||||||||
| Journal: | Fam Cancer. 2010 Jun;9(2):173-9. | ||||||||||
| Title: | Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome. | ||||||||||
| Author: | Reuschenbach, Miriam|Kloor, Matthias|Morak, Monika|Wentzensen, Nicolas|Germann, Anja|Garbe, Yvette|Tariverdian, Mirjam|Findeisen, Peter|Neumaier, Michael|Holinski-Feder, Elke|von Knebel Doeberitz, Magnus | ||||||||||
| PMID: | 19957108 | ||||||||||
| 72. | |||||||||||
| Journal: | Gastroenterology. 2010 Apr;138(4):1406-17. | ||||||||||
| Title: | Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. | ||||||||||
| Author: | Pino, Maria S|Kikuchi, Hirotoshi|Zeng, Min|Herraiz, Maria-Teresa|Sperduti, Isabella|Berger, David|Park, Do-Youn|Iafrate, A John|Zukerberg, Lawrence R|Chung, Daniel C | ||||||||||
| PMID: | 20026115 | ||||||||||
| 73. | |||||||||||
| Journal: | Cancer Treat Res. 2010;155:85-103. | ||||||||||
| Title: | Tgf-beta signaling alterations and colon cancer. | ||||||||||
| Author: | Bellam, Naresh|Pasche, Boris | ||||||||||
| PMID: | 20517689 | ||||||||||
| 74. | |||||||||||
| Journal: | BMC Cancer. 2010 Jun 18;10:303. | ||||||||||
| Title: | Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. | ||||||||||
| Author: | Yashiro, Masakazu|Hirakawa, Kosei|Boland, C Richard | ||||||||||
| PMID: | 20565851 | ||||||||||
| 75. | |||||||||||
| Journal: | Int J Oncol. 2010 Nov;37(5):1153-65. | ||||||||||
| Title: | Abnormal expression of Endoglin and its receptor complex (TGF-beta1 and TGF-beta receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosa. | ||||||||||
| Author: | Bellone, Graziella|Gramigni, Claudia|Vizio, Barbara|Mauri, Francesco A|Prati, Adriana|Solerio, Dino|Dughera, Luca|Ruffini, Enrico|Gasparri, Guido|Camandona, Michele | ||||||||||
| PMID: | 20878063 | ||||||||||
| 76. | |||||||||||
| Journal: | BMC Cancer. 2010 Oct 27;10:587. | ||||||||||
| Title: | Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin. | ||||||||||
| Author: | Pinheiro, Manuela|Ahlquist, Terje|Danielsen, Stine A|Lind, Guro E|Veiga, Isabel|Pinto, Carla|Costa, Vera|Afonso, Luis|Sousa, Olga|Fragoso, Maria|Santos, Lucio|Henrique, Rui|Lopes, Paula|Lopes, Carlos|Lothe, Ragnhild A|Teixeira, Manuel R | ||||||||||
| PMID: | 20979647 | ||||||||||
| 77. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098-103. | ||||||||||
| Title: | MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). | ||||||||||
| Author: | Valeri, Nicola|Gasparini, Pierluigi|Braconi, Chiara|Paone, Alessio|Lovat, Francesca|Fabbri, Muller|Sumani, Khlea M|Alder, Hansjuerg|Amadori, Dino|Patel, Tushar|Nuovo, Gerard J|Fishel, Richard|Croce, Carlo M | ||||||||||
| PMID: | 21078976 | ||||||||||
| 78. | |||||||||||
| Journal: | J Biol Chem. 2011 May 6;286(18):16082-90. | ||||||||||
| Title: | Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. | ||||||||||
| Author: | Liu, Xiao-Qiong|Rajput, Ashwani|Geng, Liying|Ongchin, Melanie|Chaudhuri, Anathbandhu|Wang, Jing | ||||||||||
| PMID: | 21454688 | ||||||||||
| 79. | |||||||||||
| Journal: | PLoS One. 2011;6(9):e25062. | ||||||||||
| Title: | TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. | ||||||||||
| Author: | Shima, Kaori|Morikawa, Teppei|Yamauchi, Mai|Kuchiba, Aya|Imamura, Yu|Liao, Xiaoyun|Meyerhardt, Jeffrey A|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 21949851 | ||||||||||
| 80. | |||||||||||
| Journal: | Int J Cancer. 2012 Apr 1;130(7):1558-66. | ||||||||||
| Title: | Candidate driver genes in microsatellite-unstable colorectal cancer. | ||||||||||
| Author: | Alhopuro, Pia|Sammalkorpi, Heli|Niittymaki, Iina|Bistrom, Mia|Raitila, Anniina|Saharinen, Juha|Nousiainen, Kari|Lehtonen, Heli J|Heliovaara, Elina|Puhakka, Jani|Tuupanen, Sari|Sousa, Sonia|Seruca, Raquel|Ferreira, Ana M|Hofstra, Robert M W|Mecklin, Jukka- | ||||||||||
| PMID: | 21544814 | ||||||||||
| 81. | |||||||||||
| Journal: | Carcinogenesis. 2012 Jan;33(1):68-76. | ||||||||||
| Title: | MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. | ||||||||||
| Author: | Yu, Yingjie|Kanwar, Shailender S|Patel, Bhaumik B|Oh, Phil-Sun|Nautiyal, Jyoti|Sarkar, Fazlul H|Majumdar, Adhip P N | ||||||||||
| PMID: | 22072622 | ||||||||||
| 82. | |||||||||||
| Journal: | Int J Colorectal Dis. 2012 May;27(5):647-56. | ||||||||||
| Title: | T([20]) repeat in the 3'-untranslated region of the MT1X gene: a marker with high sensitivity and specificity to detect microsatellite instability in colorectal cancer. | ||||||||||
| Author: | Morandi, Luca|de Biase, Dario|Visani, Michela|Monzoni, Adriana|Tosi, Annalisa|Brulatti, Mauro|Turchetti, Daniela|Baccarini, Paola|Tallini, Giovanni|Pession, Annalisa | ||||||||||
| PMID: | 22108904 | ||||||||||
| 83. | |||||||||||
| Journal: | Tumour Biol. 2012 Aug;33(4):1005-14. | ||||||||||
| Title: | |||||||||||