Primary Site >> Colorectal Cancer
Gene >> TGFBR2
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Ref: Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. PMID: 2887281 |
Ref: Mutations of the transforming growth factor-beta type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. PMID: 7488133 Ref: Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. PMID: 7585632 Ref: Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. PMID: 7665626 |
Ref: Mutations of E2F-4 trinucleotide repeats in colorectal cancer with microsatellite instability. PMID: 8878551 Ref: [Mutations of hMSH2 gene and hMLH1 gene in human colovectal carcinomas]. PMID: 8920666 |
Ref: Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas. PMID: 9212728 |
Ref: Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. PMID: 9500552 Ref: Genetic alterations are frequent in APC but rare in the TGF-beta type II receptor gene in cancer in adenomas of the colon. PMID: 9566701 Ref: Novel mutations in the polyadenine tract of the transforming growth factor beta type II receptor gene are found in a subpopulation of human pancreatic adenocarcinomas. PMID: 9598801 Ref: Microsatellite instability and frameshift mutations in BAX and transforming growth factor-beta RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines. PMID: 9639521 Ref: A novel missense mutation and frameshift mutations in the type II receptor of transforming growth factor-beta gene in sporadic colon cancer with microsatellite instability. PMID: 9691992 Ref: [Damage to the transforming growth factor TGF-beta type II receptor gene and microsatellite instability in carcinoma cells of the gastrointestinal tract]. PMID: 10087960 |
Ref: Frequent aberration of the transforming growth factor-beta receptor II gene in cell lines but no apparent mutation in pre-invasive and invasive carcinomas of the uterine cervix. PMID: 9935148 Ref: Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression. PMID: 10077641 Ref: Evidence for control of nitric oxide synthesis by intracellular transforming growth factor-beta1 in tumor cells. Implications for tumor development. PMID: 10362813 Ref: The mannose 6-phosphate/insulin-like growth factor-II receptor is a substrate of type V transforming growth factor-beta receptor. PMID: 10391950 Ref: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. PMID: 10559252 |
Ref: Mechanical deformation induces proliferation of human colorectal carcinoma cells. PMID: 10675497 Ref: A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. PMID: 10789724 Ref: Genetic analysis of multiple sporadic colon carcinomas from a single patient. PMID: 10855548 Ref: Expression of transforming growth factor beta1 and its type II receptor in mouse colon tumors induced by azoxymethane. PMID: 10938397 Ref: [Mechanism of resistance to growth inhibition by transforming growth factor-beta 1 (TGF-beta 1) in primary lung cancer and new molecular targets in therapy]. PMID: 10945024 |
Ref: Germline mutation analysis of the transforming growth factor beta receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer. PMID: 11158177 Ref: Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects. PMID: 11159190 Ref: Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer. PMID: 11212236 Ref: Growth inhibition due to complementation of transforming growth factor-beta receptor type II-defect by human chromosome 3 transfer in human colorectal carcinoma cells. PMID: 11319759 Ref: Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability. PMID: 11507051 Ref: Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. PMID: 11536370 Ref: A TGF betaRII frameshift-mutation-derived CTL epitope recognised by HLA-A2-restricted CD8+ T cells. PMID: 11761441 |
Ref: Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. PMID: 11966532 Ref: Genetic and epigenetic alterations in colon cancer. PMID: 12142355 |
Ref: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells. PMID: 12651806 Ref: Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. PMID: 12661003 Ref: Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. PMID: 12866583 Ref: Prognostic significance and correlation with survival of bcl-2 and TGF-beta RII in colon cancer. PMID: 14714614 |
Ref: Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. PMID: 14988818 Ref: [Transforming growth factor beta receptor II mutations in RER positive colorectal cancers]. PMID: 14989920 Ref: Genomic instability and colon cancer. PMID: 15000146 Ref: Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. PMID: 15256431 Ref: Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. PMID: 15350299 Ref: Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes. PMID: 15520171 |
Ref: IL-6 signaling promotes tumor growth in colorectal cancer. PMID: 15655344 Ref: Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability. PMID: 15676142 Ref: Microsatellite instability of selective target genes in HNPCC-associated colon adenomas. PMID: 15735733 Ref: A genetic screen for candidate tumor suppressors identifies REST. PMID: 15960972 |
Ref: Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. PMID: 16108056 Ref: Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers. PMID: 16177881 Ref: Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. PMID: 16380996 Ref: Microsatellite instability in colorectal cancer. PMID: 16555243 Ref: RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. PMID: 16737913 Ref: Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. PMID: 17047044 Ref: Expression and mutation of SMAD4 in poorly differentiated carcinoma and signet-ring cell carcinoma of the colorectum. PMID: 17167985 |
Ref: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. PMID: 17258725 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Expression of TGF-beta1, TbetaRII and Smad4 in colorectal carcinoma. PMID: 17289018 Ref: Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. PMID: 17530287 Ref: Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta. PMID: 17893910 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 |
Ref: Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. PMID: 17985359 Ref: Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. PMID: 18546042 Ref: Smad7 induces hepatic metastasis in colorectal cancer. PMID: 18781153 Ref: Soluble transforming growth factor beta type II receptor attenuates TGF-beta1 activity in human colorectal cancer LoVo cells. PMID: 19020727 |
Ref: Restoring TGFbeta function in microsatellite unstable (MSI-H) colorectal cancer reduces tumourigenicity but increases metastasis formation. PMID: 18985362 Ref: TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. PMID: 19208363 Ref: Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. PMID: 19293232 Ref: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. PMID: 19421758 Ref: Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. PMID: 19503063 Ref: RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. PMID: 19571605 |
Ref: SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology. PMID: 19820113 Ref: Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome. PMID: 19957108 Ref: Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. PMID: 20026115 Ref: Tgf-beta signaling alterations and colon cancer. PMID: 20517689 Ref: Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. PMID: 20565851 Ref: Abnormal expression of Endoglin and its receptor complex (TGF-beta1 and TGF-beta receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosa. PMID: 20878063 Ref: Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin. PMID: 20979647 Ref: MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). PMID: 21078976 |
Ref: Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. PMID: 21454688 Ref: TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PMID: 21949851 |
Ref: Candidate driver genes in microsatellite-unstable colorectal cancer. PMID: 21544814 Ref: MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. PMID: 22072622 Ref: T([20]) repeat in the 3'-untranslated region of the MT1X gene: a marker with high sensitivity and specificity to detect microsatellite instability in colorectal cancer. PMID: 22108904 Ref: Prognostic significance of transforming growth factor beta (TGF-beta) signaling axis molecules and E-cadherin in colorectal cancer. PMID: 22278155 Ref: Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters. PMID: 22452939 Ref: Transforming growth factor-beta suppresses metastasis in a subset of human colon carcinoma cells. PMID: 22672900 Ref: Effects of activin and TGFbeta on p21 in colon cancer. PMID: 22761777 Ref: Colorectal cancer migration and invasion initiated by microRNA-106a. PMID: 22912877 |
Ref: SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. PMID: 23139211 Ref: Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116. PMID: 23468914 Ref: TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PMID: 23536895 Ref: Induction of the expression of genes encoding TGF-beta isoforms and their receptors by inositol hexaphosphate in human colon cancer cells. PMID: 23614294 Ref: Myeloid TGF-beta signaling contributes to colitis-associated tumorigenesis in mice. PMID: 23695722 Ref: Clinical applications of gene expression in colorectal cancer. PMID: 23730510 Ref: [Pathogenesis of microsatellite-unstable colorectal cancer. Evaluation of new diagnostic and therapeutic options]. PMID: 24196629 |
Ref: Inactivation of TGF-beta signaling and loss of PTEN cooperate to induce colon cancer in vivo. PMID: 23604118 Ref: MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1. PMID: 24151081 Ref: MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer. PMID: 25551793 |
Ref: Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors. PMID: 24917558 Ref: Suppressing TGFbeta signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer. PMID: 25687406 Ref: Microsatellite instability: an update. PMID: 25701956 Ref: Transforming Growth Factor beta Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2. PMID: 25736321 Ref: Polymerase Slippage Restoration of Frameshifted TGFBR2 in Colorectal Cancer: A Novel Paradigm. PMID: 25921376 Ref: miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer. PMID: 26061281 Ref: Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells. PMID: 26114631 Ref: A new method for detection of tumor driver-dependent changes of protein sialylation in a colon cancer cell line reveals nectin-3 as TGFBR2 target. PMID: 26177744 Ref: Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer. PMID: 26205949 Ref: Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation. PMID: 26247575 Ref: Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma. PMID: 26336987 Ref: Correction: miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer. PMID: 26677848 |
Ref: Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies. PMID: 26650777 Ref: MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis. PMID: 27080303 Ref: Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1. PMID: 27156840 Ref: Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). PMID: 27234654 Ref: Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor beta Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation. PMID: 27835699 |
Ref: Loss of TGFbeta signaling promotes colon cancer progression and tumor-associated inflammation. PMID: 27270652 Ref: Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms. PMID: 27790711 Ref: TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. PMID: 28376875 Ref: The screening of the functional microRNA binding site SNPs in sporadic colorectal cancer genes. PMID: 28494187 |
Ref: Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer. PMID: 29282223 Ref: The miR-371 approximately 373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis. PMID: 29748374 Ref: Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort. PMID: 29986644 Ref: The TGFbeta-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. PMID: 29986714 Ref: EGFR, SMAD7, and TGFBR2 Polymorphisms Are Associated with Colorectal Cancer in Patients with Lynch Syndrome. PMID: 30275229 |