Primary Site >> Colorectal Cancer

Gene >> TGFBR1

Journal: Cancer Res. 1999 Nov 15;59(22):5678-82.
Title: TbetaR-I(6A) is a candidate tumor susceptibility allele.
Author: Pasche, B|Kolachana, P|Nafa, K|Satagopan, J|Chen, Y G|Lo, R S|Brener, D|Yang, D|Kirstein, L|Oddoux, C|Ostrer, H|Vineis, P|Varesco, L|Jhanwar, S|Luzzatto, L|Massague, J|Offit, K
PMID: 10582683
Journal: J Biol Chem. 1999 Jul 9;274(28):20002-10.
Title: The mannose 6-phosphate/insulin-like growth factor-II receptor is a substrate of type V transforming growth factor-beta receptor.
Author: Liu, Q|Grubb, J H|Huang, S S|Sly, W S|Huang, J S
PMID: 10391950
Journal: Oncogene. 2000 Sep 21;19(40):4660-7.
Title: Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency.
Author: Periyasamy, S|Ammanamanchi, S|Tillekeratne, M P|Brattain, M G
PMID: 11030155
Journal: Gan To Kagaku Ryoho. 2000 Jul;27(8):1253-9.
Title: [Mechanism of resistance to growth inhibition by transforming growth factor-beta 1 (TGF-beta 1) in primary lung cancer and new molecular targets in therapy].
Author: Gemma, A|Uematsu, K|Hagiwara, K|Takenoshita, S|Kudoh, S
PMID: 10945024
Journal: Mol Carcinog. 2001 Aug;31(4):204-13.
Title: Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.
Author: Guda, K|Giardina, C|Nambiar, P|Cui, H|Rosenberg, D W
PMID: 11536370
Journal: J Clin Oncol. 2003 Sep 1;21(17):3236-43.
Title: TGFBR1*6A and cancer risk: a meta-analysis of seven case-control studies.
Author: Kaklamani, Virginia G|Hou, Nanjiang|Bian, Yiansong|Reich, Jennifer|Offit, Kenneth|Michel, Loren S|Rubinstein, W S|Rademaker, Alfred|Pasche, Boris
PMID: 12947057
Journal: Cancer Sci. 2004 Jan;95(1):12-7.
Title: Transforming growth factor-beta signaling is differentially inhibited by Smad2D450E and Smad3D407E.
Author: Kondo, Miki|Suzuki, Hiroyuki|Takehara, Kazuhiko|Miyazono, Kohei|Kato, Mitsuyasu
PMID: 14720321
Journal: J Clin Oncol. 2005 May 1;23(13):3074-8.
Title: TGFBR1*6A may contribute to hereditary colorectal cancer.
Author: Bian, Yansong|Caldes, Trinidad|Wijnen, Juul|Franken, Patrick|Vasen, Hans|Kaklamani, Virginia|Nafa, Khedoudja|Peterlongo, Paolo|Ellis, Nathan|Baron, John A|Burn, John|Moeslein, Gabriela|Morrison, Patrick J|Chen, Yu|Ahsan, Habibul|Watson, Patrice|Lynch, Hen
PMID: 15860866
Journal: JAMA. 2005 Oct 5;294(13):1634-46.
Title: Somatic acquisition and signaling of TGFBR1*6A in cancer.
Author: Pasche, Boris|Knobloch, Thomas J|Bian, Yansong|Liu, Junjian|Phukan, Sharbani|Rosman, Diana|Kaklamani, Virginia|Baddi, Lisa|Siddiqui, Farida S|Frankel, Wendy|Prior, Thomas W|Schuller, David E|Agrawal, Amit|Lang, Jas|Dolan, M Eileen|Vokes, Everett E|Lane, W
PMID: 16204663
Journal: Cancer Res. 2006 Oct 15;66(20):9837-44.
Title: Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.
Author: Munoz, Nina M|Upton, Melissa|Rojas, Andres|Washington, M Kay|Lin, Li|Chytil, Anna|Sozmen, Elif G|Madison, Blair B|Pozzi, Ambra|Moon, Randall T|Moses, Harold L|Grady, William M
PMID: 17047044
Journal: Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
Title: TGF-beta signaling alterations and susceptibility to colorectal cancer.
Author: Xu, Yanfei|Pasche, Boris
PMID: 17613544
Journal: Hum Mol Genet. 2007 Dec 15;16(24):3128-35. Epub 2007 Sep 21.
Title: Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development.
Author: Bian, Yansong|Knobloch, Thomas J|Sadim, Maureen|Kaklamani, Virginia|Raji, Adekunle|Yang, Guang-Yu|Weghorst, Christopher M|Pasche, Boris
PMID: 17890272
Journal: Clin Cancer Res. 2007 Jun 15;13(12):3748-52.
Title: Lack of an association between the TGFBR1*6A variant and colorectal cancer risk.
Author: Skoglund, Johanna|Song, Bo|Dalen, Johan|Dedorson, Stefan|Edler, David|Hjern, Fredrik|Holm, Jorn|Lenander, Claes|Lindforss, Ulrik|Lundqvist, Nils|Olivecrona, Hans|Olsson, Louise|Pahlman, Lars|Rutegard, Jorgen|Smedh, Kennet|Tornqvist, Anders|Houlston, Richa
PMID: 17575241
Journal: Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):892-4.
Title: Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?
Author: Daley, Denise|Morgan, Wendi|Lewis, Susan|Willis, Joseph|Elston, Robert C|Markowitz, Sanford D|Wiesner, Georgia L
PMID: 17507611
Journal: J Chir (Paris). 2007 Jan-Feb;144(1):13-8.
Title: [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer].
Author: Karoui, M|Tresallet, C|Brouquet, A|Radvanyi, H|Penna, C
PMID: 17369756
Journal: Science. 2008 Sep 5;321(5894):1361-5.
Title: Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer.
Author: Valle, Laura|Serena-Acedo, Tarsicio|Liyanarachchi, Sandya|Hampel, Heather|Comeras, Ilene|Li, Zhongyuan|Zeng, Qinghua|Zhang, Hong-Tao|Pennison, Michael J|Sadim, Maureen|Pasche, Boris|Tanner, Stephan M|de la Chapelle, Albert
PMID: 18703712
Journal: Mutat Res. 2008 Oct 14;645(1-2):27-32.
Title: Colorectal cancers in patients with the (9A/6A) polymorphism of TGFBR1 exhibit lesser inter-(simple sequence repeat) PCR genomic instability and present clinically at greater age.
Author: Dutt, Smitha S|Chen, Neng|Darbary, Huferesh K|Swede, Helen|Petrelli, Nicholas J|Stoler, Daniel L|Anderson, Garth R
PMID: 18778720
Journal: Cancer Res. 2009 Jan 15;69(2):678-86.
Title: Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Author: Zeng, Qinghua|Phukan, Sharbani|Xu, Yanfei|Sadim, Maureen|Rosman, Diana S|Pennison, Michael|Liao, Jie|Yang, Guang-Yu|Huang, Chiang-Ching|Valle, Laura|Di Cristofano, Antonio|de la Chapelle, Albert|Pasche, Boris
PMID: 19147584
Journal: Br J Cancer. 2009 May 19;100(10):1674-9.
Title: TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk.
Author: Skoglund Lundin, J|Vandrovcova, J|Song, B|Zhou, X|Zelada-Hedman, M|Werelius, B|Houlston, R S|Lindblom, A
PMID: 19401691
Journal: Cancer Res. 2009 Jun 15;69(12):4959-61.
Title: Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.
Author: Guda, Kishore|Natale, Leanna|Lutterbaugh, James|Wiesner, Georgia L|Lewis, Susan|Tanner, Stephan M|Tomsic, Jerneja|Valle, Laura|de la Chapelle, Albert|Elston, Robert C|Willis, Joseph|Markowitz, Sanford D
PMID: 19509225
Journal: BMC Cancer. 2009 Jun 18;9:193.
Title: The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study.
Author: Castillejo, Adela|Mata-Balaguer, Trinidad|Montenegro, Paola|Ochoa, Enrique|Lazaro, Rafael|Martinez-Canto, Ana|Castillejo, Maria-Isabel|Guarinos, Carla|Barbera, Victor-Manuel|Guillen-Ponce, Carmen|Carrato, Alfredo|Soto, Jose-Luis
PMID: 19538729
Journal: BMC Cancer. 2009 Nov 20;9:406.
Title: The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study.
Author: Castillejo, Adela|Mata-Balaguer, Trinidad|Guarinos, Carla|Castillejo, Maria-Isabel|Martinez-Canto, Ana|Barbera, Victor-Manuel|Montenegro, Paola|Ochoa, Enrique|Lazaro, Rafael|Guillen-Ponce, Carmen|Carrato, Alfredo|Soto, Jose-Luis
PMID: 19930569
Journal: Carcinogenesis. 2010 Oct;31(10):1800-4.
Title: Allele-specific expression of TGFBR1 in colon cancer patients.
Author: Tomsic, Jerneja|Guda, Kishore|Liyanarachchi, Sandya|Hampel, Heather|Natale, Leanna|Markowitz, Sanford D|Tanner, Stephan M|de la Chapelle, Albert
PMID: 20705955
Journal: Cancer Treat Res. 2010;155:85-103.
Title: Tgf-beta signaling alterations and colon cancer.
Author: Bellam, Naresh|Pasche, Boris
PMID: 20517689
Journal: Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7858-62.
Title: Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.
Author: Carvajal-Carmona, Luis G|Churchman, Mike|Bonilla, Carolina|Walther, Axel|Lefevre, Jeremie H|Kerr, David|Dunlop, Malcolm|Houlston, Richard|Bodmer, Walter F|Tomlinson, Ian
PMID: 20368424
Journal: Genes Chromosomes Cancer. 2010 Mar;49(3):270-81.
Title: Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.
Author: Forsti, Asta|Li, Xuchen|Wagner, Kerstin|Tavelin, Bjorn|Enquist, Kerstin|Palmqvist, Richard|Altieri, Andrea|Hallmans, Goran|Hemminki, Kari|Lenner, Per
PMID: 19998449
Journal: Mol Biol Rep. 2010 Oct;37(7):3227-32.
Title: TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls.
Author: Liao, Ru-Yan|Mao, Chen|Qiu, Li-Xin|Ding, Hong|Chen, Qing|Pan, Hai-Feng
PMID: 19882361
Journal: J Exp Clin Cancer Res. 2010 May 25;29:57.
Title: Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs.
Author: Pasche, Boris|Wisinski, Kari B|Sadim, Maureen|Kaklamani, Virginia|Pennison, Michael J|Zeng, Qinghua|Bellam, Naresh|Zimmerman, Jacquelyn|Yi, Nengjun|Zhang, Kui|Baron, John|Stram, Daniel O|Hayes, M Geoffrey
PMID: 20500843
Journal: Br J Cancer. 2011 Feb 15;104(4):735-40.
Title: No association between germline allele-specific expression of TGFBR1 and colorectal cancer risk in Caucasian and Ashkenazi populations.
Author: Segui, N|Stevens, K N|Guino, E|Rozek, L S|Moreno, V R|Capella, G|Gruber, S B|Valle, L
PMID: 21224855
Journal: Br J Cancer. 2011 Sep 6;105(6):870-5.
Title: A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22.
Author: Abuli, A|Fernandez-Rozadilla, C|Giraldez, M D|Munoz, J|Gonzalo, V|Bessa, X|Bujanda, L|Rene, J M|Lanas, A|Garcia, A M|Salo, J|Arguello, L|Vilella, A|Carreno, R|Jover, R|Xicola, R M|Llor, X|Carvajal-Carmona, L|Tomlinson, I P M|Kerr, D J|Houlston, R S|Pique,
PMID: 21811255
Journal: Mol Biol Rep. 2012 Mar;39(3):2567-74.
Title: The association of polymorphisms on TGFBR1 and colorectal cancer risk: a meta-analysis.
Author: Zhang, Xueli|Wu, Liang|Sheng, Youhua|Zhou, Wenhua|Huang, Zhongming|Qu, Jun|Gao, Ganglong|Cai, Duan|Zhang, Ming
PMID: 21858550
Journal: PLoS One. 2012;7(1):e30812.
Title: TGFBR1 intralocus epistatic interaction as a risk factor for colorectal cancer.
Author: Martinez-Canto, Ana|Castillejo, Adela|Mata-Balaguer, Trinidad|Castillejo, Maria-Isabel|Hernandez-Illan, Eva|Irles, Esperanza|Barbera, Victor Manuel|Egoavil, Cecilia|Guarinos, Carla|Alenda, Cristina|Ochoa, Enrique|Lazaro, Rafael|Fajardo, Silvia|Lacueva, Ja
PMID: 22292045
Journal: World J Gastrointest Oncol. 2012 Jan 15;4(1):1-8.
Title: Debate about TGFBR1 and the susceptibility to colorectal cancer.
Author: Valle, Laura
PMID: 22347533
Journal: PLoS One. 2012;7(8):e42899.
Title: Association between TGFBR1 polymorphisms and cancer risk: a meta-analysis of 35 case-control studies.
Author: Wang, Yong-qiang|Qi, Xiao-wei|Wang, Fan|Jiang, Jun|Guo, Qiao-nan
PMID: 22905183
Journal: Cancer Cell. 2012 Nov 13;22(5):571-84.
Title: Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation.
Author: Calon, Alexandre|Espinet, Elisa|Palomo-Ponce, Sergio|Tauriello, Daniele V F|Iglesias, Mar|Cespedes, Maria Virtudes|Sevillano, Marta|Nadal, Cristina|Jung, Peter|Zhang, Xiang H-F|Byrom, Daniel|Riera, Antoni|Rossell, David|Mangues, Ramon|Massague, Joan|Sanch
PMID: 23153532
Journal: Carcinogenesis. 2013 Apr;34(4):936-42.
Title: Genetic variations in the TGFbeta signaling pathway, smoking and risk of colorectal cancer in a Chinese population.
Author: Zhong, Rong|Liu, Li|Zou, Li|Sheng, Wei|Zhu, Beibei|Xiang, Hao|Chen, Wei|Chen, Jigui|Rui, Rui|Zheng, Xiawen|Yin, Jieyun|Duan, Shengyu|Yang, Beifang|Sun, Jingwen|Lou, Jiao|Liu, Li|Xie, Duoshuang|Xu, Yihua|Nie, Shaofa|Miao, Xiaoping
PMID: 23275154
Journal: J Gastrointest Oncol. 2013 Jun;4(2):144-57.
Title: Clinical applications of gene expression in colorectal cancer.
Author: Kheirelseid, Elrasheid A H|Miller, Nicola|Chang, Kah Hoong|Nugent, Mary|Kerin, Michael J
PMID: 23730510
Journal: J Gastrointest Cancer. 2014 Dec;45(4):441-7.
Title: TGFBR1*6A polymorphism in sporadic and familial colorectal Carcinoma: a case-control study and systematic literature review.
Author: Ibrahim, Tony|Yazbeck, Charbel|Maalouly, Georges|Baz, Maria|Haddad, Fady|Sabbagh, Chadi|Chahine, Georges
PMID: 24880985
Journal: Trans Am Clin Climatol Assoc. 2014;125:300-12.
Title: TGFBR1 and cancer susceptibility.
Author: Pasche, Boris|Pennison, Michael J|Jimenez, Hugo|Wang, Minghui
PMID: 25125747
Journal: BMC Cancer. 2014 Jul 1;14:475.
Title: Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain.
Author: Ross, Jason P|Lockett, Linda J|Tabor, Bruce|Saunders, Ian W|Young, Graeme P|Macrae, Finlay|Blanco, Ignacio|Capella, Gabriel|Brown, Glenn S|Lockett, Trevor J|Hannan, Garry N
PMID: 24981199
Journal: PLoS One. 2016 Apr 21;11(4):e0153933.
Title: Mutational Profiles Reveal an Aberrant TGF-beta-CEA Regulated Pathway in Colon Adenomas.
Author: Chen, Jian|Raju, Gottumukkala S|Jogunoori, Wilma|Menon, Vipin|Majumdar, Avijit|Chen, Jiun-Sheng|Gi, Young Jin|Jeong, Yun Seong|Phan, Liem|Belkin, Mitchell|Gu, Shoujun|Kundra, Suchin|Mistry, Nipun A|Zhang, Jianping|Su, Xiaoping|Li, Shulin|Lin, Sue-Hwa|Javl
PMID: 27100181
Journal: Carcinogenesis. 2016 Aug;37(8):751-8.
Title: Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC).
Author: Xicola, Rosa M|Bontu, Sneha|Doyle, Brian J|Rawson, Jamie|Garre, Pilar|Lee, Esther|de la Hoya, Miguel|Bessa, Xavier|Clofent, Joan|Bujanda, Luis|Balaguer, Francesc|Castellvi-Bel, Sergi|Alenda, Cristina|Jover, Rodrigo|Ruiz-Ponte, Clara|Syngal, Sapna|Andreu,
PMID: 27234654
Journal: Oncotarget. 2016 Aug 2;7(31):49834-49847.
Title: High expression of WISP1 in colon cancer is associated with apoptosis, invasion and poor prognosis.
Author: Wu, Jianghong|Long, Ziwen|Cai, Hong|Du, Chunyan|Liu, Xiaowen|Yu, Shengjia|Wang, Yanong
PMID: 27409174
Journal: Oncotarget. 2017 Mar 7;8(10):16765-16783.
Title: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.
Author: Slattery, Martha L|Trivellas, Andromahi|Pellatt, Andrew J|Mullany, Lila E|Stevens, John R|Wolff, Roger K|Herrick, Jennifer S
PMID: 28061442
Journal: Oncogene. 2017 Jul 27;36(30):4336-4348.
Title: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.
Author: Principe, D R|Diaz, A M|Torres, C|Mangan, R J|DeCant, B|McKinney, R|Tsao, M-S|Lowy, A|Munshi, H G|Jung, B|Grippo, P J
PMID: 28368414
Journal: Oncol Lett. 2018 Mar;15(3):3971-3976.
Title: TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells.
Author: Zhou, Rui|Huang, Ying|Cheng, Boran|Wang, Yulei|Xiong, Bin
PMID: 29467907
Journal: Cancer Inform. 2018 Mar 26;17:1176935118766522.
Title: The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs.
Author: Slattery, Martha L|Mullany, Lila E|Sakoda, Lori C|Wolff, Roger K|Samowitz, Wade S|Herrick, Jennifer S
PMID: 29636593
Journal: J Gastroenterol. 2018 Jul 3. pii: 10.1007/s00535-018-1490-y.
Title: A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk.
Author: Gu, Dongying|Li, Shuwei|Du, Mulong|Tang, Cuiju|Chu, Haiyan|Tong, Na|Zhang, Zhengdong|Wang, Meilin|Chen, Jinfei
PMID: 29971498
Journal: J Transl Med. 2018 Jul 9;16(1):191.
Title: The TGFbeta-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs.
Author: Pellatt, Andrew J|Mullany, Lila E|Herrick, Jennifer S|Sakoda, Lori C|Wolff, Roger K|Samowitz, Wade S|Slattery, Martha L
PMID: 29986714