Primary Site >> Colorectal Cancer

Gene >> TGFA

Journal: Int J Cancer. 1987 Nov 15;40(5):646-52.
Title: Simultaneous production of IGF-I and EGF competing growth factors by HT-29 human colon cancer line.
Author: Culouscou, J M|Remacle-Bonnet, M|Garrouste, F|Marvaldi, J|Pommier, G
PMID: 3500134
Journal: Cancer Res. 1987 Sep 1;47(17):4590-4.
Title: Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model.
Author: Coffey, R J Jr|Goustin, A S|Soderquist, A M|Shipley, G D|Wolfshohl, J|Carpenter, G|Moses, H L
PMID: 2887281
Journal: Anticancer Res. 1988 Jan-Feb;8(1):1-7.
Title: Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines.
Author: Untawale, S|Blick, M
PMID: 3282475
Journal: Cancer Res. 1989 Jun 1;49(11):2898-904.
Title: Growth factor production by human colon carcinoma cell lines.
Author: Anzano, M A|Rieman, D|Prichett, W|Bowen-Pope, D F|Greig, R
PMID: 2541895
Journal: Int J Cancer. 1989 Jul 15;44(1):110-5.
Title: Expression of TGF-alpha/EGF and TGF-beta receptors in human colon carcinoma cell lines.
Author: Murthy, U|Anzano, M A|Greig, R G
PMID: 2545633
Journal: Cancer Res. 1990 Dec 1;50(23):7581-6.
Title: Inhibitory effects of transforming growth factor beta 1 on mitogenic response, transforming growth factor alpha, and c-myc in quiescent, well-differentiated colon carcinoma cells.
Author: Mulder, K M|Zhong, Q|Choi, H G|Humphrey, L E|Brattain, M G
PMID: 1701348
Journal: Br J Cancer. 1990 Oct;62(4):627-30.
Title: Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects.
Author: Klijn, J G|Hoff, A M|Planting, A S|Verweij, J|Kok, T|Lamberts, S W|Portengen, H|Foekens, J A
PMID: 1977468
Journal: J Clin Invest. 1990 Jul;86(1):356-62.
Title: Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.
Author: Markowitz, S D|Molkentin, K|Gerbic, C|Jackson, J|Stellato, T|Willson, J K
PMID: 2365825
Journal: Cancer Biochem Biophys. 1991 Aug;12(2):137-51.
Title: Proteins secreted by Caco-2 cells support growth of other tumor cells in Chee's Essential Medium without supplements.
Author: Zirvi, K A|Grimmond, H E
PMID: 1769010
Journal: J Cell Biochem Suppl. 1992;16G:111-8.
Title: Transforming growth factors and related peptides in gastrointestinal neoplasia.
Author: Coffey, R J|McCutchen, C M|Graves-Deal, R|Polk, W H Jr
PMID: 1335097
Journal: Cancer Metastasis Rev. 1993 Sep;12(3-4):275-86.
Title: The role of growth regulatory aberrations in progression of human colon carcinoma.
Author: Howell, G M|Sun, L|Ziober, B L|Wu, S P|Brattain, M G
PMID: 8281613
Journal: Int J Cancer. 1993 Jul 30;54(6):952-8.
Title: Infection with a transforming growth factor alpha anti-sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line.
Author: Ciardiello, F|Bianco, C|Normanno, N|Baldassarre, G|Pepe, S|Tortora, G|Bianco, A R|Salomon, D S
PMID: 8335403
Journal: J Biol Chem. 1993 Jan 5;268(1):691-8.
Title: Autocrine transforming growth factor-alpha is associated with progression of transformed properties in human colon cancer cells.
Author: Ziober, B L|Willson, J K|Hymphrey, L E|Childress-Fields, K|Brattain, M G
PMID: 8416972
Journal: Exp Cell Res. 1995 Jul;219(1):8-14.
Title: Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate.
Author: Huang, F|Sauma, S|Yan, Z|Friedman, E
PMID: 7628553
Journal: Int J Oncol. 1995 May;6(5):1027-31.
Title: Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Author: Uckert, W|Walther, W|Hummel, O
PMID: 21556635
Journal: Anticancer Res. 1995 Nov-Dec;15(6B):2889-94.
Title: Expression of growth factors and their receptors in human early colorectal carcinomas: immunohistochemical study.
Author: Shirai, H|Ueno, E|Osaki, M|Tatebe, S|Ito, H|Kaibara, N
PMID: 8669884
Journal: Ann Surg. 1995 Jun;221(6):767-76; discussion 776-7.
Title: Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors.
Author: MacKay, S L|Yaswen, L R|Tarnuzzer, R W|Moldawer, L L|Bland, K I|Copeland, E M 3rd|Schultz, G S
PMID: 7794080
Journal: Int J Cancer. 1995 Jun 9;61(6):848-53.
Title: Colon goblet cells lose proliferative response to TGF alpha as they differentiate.
Author: Sauma, S|Huang, F|Winawer, S|Friedman, E
PMID: 7790121
Journal: J Cell Physiol. 1995 Nov;165(2):239-45.
Title: Platelet-derived growth factor-B increases colon cancer cell growth in vivo by a paracrine effect.
Author: Hsu, S|Huang, F|Friedman, E
PMID: 7593201
Journal: Hepatogastroenterology. 1997 Mar-Apr;44(14):435-40.
Title: Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer.
Author: Malecka-Panas, E|Kordek, R|Biernat, W|Tureaud, J|Liberski, P P|Majumdar, A P
PMID: 9164515
Journal: Oncogene. 1997 Nov 27;15(22):2705-16.
Title: ErbB kinases and NDF signaling in human prostate cancer cells.
Author: Grasso, A W|Wen, D|Miller, C M|Rhim, J S|Pretlow, T G|Kung, H J
PMID: 9400997
Journal: Acta Oncol. 1998;37(3):285-9.
Title: EGF, TGF-alpha, and EGF-R in human colorectal adenocarcinoma.
Author: Messa, C|Russo, F|Caruso, M G|Di Leo, A
PMID: 9677101
Journal: Int J Cancer. 1999 Jan 5;80(1):72-7.
Title: Increased transforming growth factor-alpha levels in human colon carcinoma cell lines over-expressing protein kinase C.
Author: Maruvada, P|Levine, A E
PMID: 9935234
Journal: Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 1):311-5.
Title: Effect of aspirin on prostaglandin E2 formation and transforming growth factor alpha expression in human rectal mucosa from individuals with a history of adenomatous polyps of the colon.
Author: Barnes, C J|Hamby-Mason, R L|Hardman, W E|Cameron, I L|Speeg, K V|Lee, M
PMID: 10207634
Journal: Oncogene. 1999 Oct 21;18(43):5923-35.
Title: The EGF/TGFalpha response element within the TGFalpha promoter consists of a multi-complex regulatory element.
Author: Awwad, R|Humphrey, L E|Periyasamy, B|Scovell, W Jr|Li, W|Coleman, K|Lynch, M|Carboni, J|Brattain, M G|Howell, G M
PMID: 10557079
Journal: Dig Dis Sci. 2001 Jun;46(6):1157-62.
Title: Transforming growth factor-alpha precursors in human colon carcinoma cells.
Author: Asbert, M|Montaner, B|Perez-Tomas, R
PMID: 11414287
Journal: Cancer. 2002 Feb 1;94(3):647-57.
Title: Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel.
Author: Barozzi, Chiara|Ravaioli, Matteo|D'Errico, Antonia|Grazi, Gian Luca|Poggioli, Gilberto|Cavrini, Giulia|Mazziotti, Alighieri|Grigioni, Walter Franco
PMID: 11857296
Journal: Oncogene. 2002 Apr 25;21(18):2785-96.
Title: Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells.
Author: Wang, Degeng|Patil, Sandip|Li, Wenhui|Humphrey, Lisa E|Brattain, Michael G|Howell, Gillian M
PMID: 11973637
Journal: Histochem Cell Biol. 2002 Mar;117(3):235-41.
Title: Tissue localization of TGFalpha and apoptosis are inversely related in colorectal tumors.
Author: Habel, O|Bertario, L|Andreola, S|Sirizzotti, G|Marian, B
PMID: 11914921
Journal: Recent Results Cancer Res. 2003;162:115-32.
Title: Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options.
Author: Kopp, Reinhard|Rothbauer, Elisabeth|Ruge, Maximilian|Arnholdt, Hans|Spranger, Joachim|Muders, M|Pfeiffer, Doris G|Schildberg, Friedrich Wilhelm|Pfeiffer, Andreas
PMID: 12790326
Journal: Cancer Chemother Pharmacol. 2005 Apr;55(4):369-78. Epub 2004 Nov 5.
Title: Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells.
Author: Gali-Muhtasib, Hala U|Diab-Assaf, Mona|Haddadin, Makhluf J
PMID: 15538569
Journal: Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G70-8. Epub 2005 Mar 3.
Title: Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling.
Author: Nkabyo, Yvonne S|Go, Young-Mi|Ziegler, Thomas R|Jones, Dean P
PMID: 15746213
Journal: Int J Mol Med. 2006 Jun;17(6):1163-6.
Title: Canonical WNT signaling pathway and human AREG.
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 16685431
Journal: Hum Pathol. 2008 Oct;39(10):1483-94.
Title: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas.
Author: Furlan, Daniela|Sahnane, Nora|Carnevali, Ileana|Cerutti, Roberta|Bertoni, Francesco|Kwee, Ivo|Uccella, Silvia|Bertolini, Valentina|Chiaravalli, Anna Maria|Capella, Carlo
PMID: 18619649
Journal: Arch Oral Biol. 2009 Jan;54(1):45-9.
Title: Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis.
Author: Callahan, N|Modesto, A|Meira, R|Seymen, F|Patir, A|Vieira, A R
PMID: 18790474
Journal: Clin Cancer Res. 2009 Apr 1;15(7):2397-405.
Title: Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent.
Author: Mutsaers, Anthony J|Francia, Giulio|Man, Shan|Lee, Christina R|Ebos, John M L|Wu, Yan|Witte, Larry|Berry, Scott|Moore, Malcolm|Kerbel, Robert S
PMID: 19276250
Journal: Cancer Lett. 2009 Aug 28;281(2):213-9.
Title: Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway.
Author: Ouyang, Gaoliang|Liu, Min|Ruan, Kai|Song, Gang|Mao, Yubin|Bao, Shideng
PMID: 19328625
Journal: BMC Res Notes. 2011 May 10;4:140.
Title: Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models.
Author: Matsuo, Teppei|Nishizuka, Satoshi S|Ishida, Kazushige|Iwaya, Takeshi|Ikeda, Miyuki|Wakabayashi, Go
PMID: 21554739
Journal: Curr Biol. 2011 May 10;21(9):779-86.
Title: Amphiregulin exosomes increase cancer cell invasion.
Author: Higginbotham, James N|Demory Beckler, Michelle|Gephart, Jonathan D|Franklin, Jeffrey L|Bogatcheva, Galina|Kremers, Gert-Jan|Piston, David W|Ayers, Gregory D|McConnell, Russell E|Tyska, Matthew J|Coffey, Robert J
PMID: 21514161
Journal: Am J Clin Oncol. 2011 Dec;34(6):581-6.
Title: Dual blockade of the EGFR and COX-2 pathways: a phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer.
Author: Chan, Emily|Lafleur, Bonnie|Rothenberg, Mace L|Merchant, Nipun|Lockhart, Albert Craig|Trivedi, Bakula|Chung, Christine H|Coffey, Robert J|Berlin, Jordan D
PMID: 21217396
Journal: Cancer Res. 2011 Feb 1;71(3):1071-80.
Title: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.
Author: Van Schaeybroeck, Sandra|Kyula, Joan N|Fenton, Audrey|Fenning, Catherine S|Sasazuki, Takehiko|Shirasawa, Senji|Longley, Daniel B|Johnston, Patrick G
PMID: 21148749
Journal: Carcinogenesis. 2012 Oct;33(10):1930-9.
Title: Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.
Author: Mustafi, Reba|Dougherty, Urszula|Shah, Hardik|Dehghan, Hooman|Gliksberg, Ariel|Wu, Jiang|Zhu, Hongyan|Joseph, Loren|Hart, John|Dive, Caroline|Fichera, Alessandro|Threadgill, David|Bissonnette, Marc
PMID: 22791816
Journal: BMC Cancer. 2013 Feb 2;13:49.
Title: Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes.
Author: Pentheroudakis, George|Kotoula, Vassiliki|De Roock, Wendy|Kouvatseas, George|Papakostas, Pavlos|Makatsoris, Thomas|Papamichael, Demetris|Xanthakis, Ioannis|Sgouros, Joseph|Televantou, Despina|Kafiri, Georgia|Tsamandas, Athanassios C|Razis, Evangelia|Galan
PMID: 23374602
Journal: PLoS One. 2013;8(3):e59918.
Title: TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis.
Author: Geng, Liying|Chaudhuri, Anathbandhu|Talmon, Geoffrey|Wisecarver, James L|Wang, Jing
PMID: 23536895
Journal: Biomed Res Int. 2013;2013:546318.
Title: The role of epidermal growth factor receptor in cancer metastasis and microenvironment.
Author: Sasaki, Takamitsu|Hiroki, Kuniyasu|Yamashita, Yuichi
PMID: 23986907
Journal: Clin Cancer Res. 2013 Dec 15;19(24):6751-65.
Title: Increased TGF-alpha as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells.
Author: Troiani, Teresa|Martinelli, Erika|Napolitano, Stefania|Vitagliano, Donata|Ciuffreda, Loreta Pia|Costantino, Sara|Morgillo, Floriana|Capasso, Anna|Sforza, Vincenzo|Nappi, Anna|De Palma, Raffaele|D'Aiuto, Elena|Berrino, Liberato|Bianco, Roberto|Ciardiello,
PMID: 24122793
Journal: BMC Cancer. 2013 Nov 2;13:518.
Title: Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer.
Author: Khong, Tak L|Thairu, Ngayu|Larsen, Helene|Dawson, Peter M|Kiriakidis, Serafim|Paleolog, Ewa M
PMID: 24180698
Journal: Cancer Res. 2014 Apr 1;74(7):2062-72.
Title: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids.
Author: Nagathihalli, Nagaraj S|Beesetty, Yugandhar|Lee, Wooin|Washington, M Kay|Chen, Xi|Lockhart, A Craig|Merchant, Nipun B
PMID: 24520077
Journal: Clin Cancer Res. 2014 Dec 15;20(24):6227-9.
Title: Paracrine network: another step in the complexity of resistance to EGFR blockade?
Author: Salazar, Ramon|Capella, Gabriel|Tabernero, Josep
PMID: 25139340
Journal: Nat Commun. 2015 Aug 24;6:8022.
Title: Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.
Author: Song, Wei|Liu, Wenjie|Zhao, Hong|Li, Shangze|Guan, Xin|Ying, Jianming|Zhang, Yefan|Miao, Fei|Zhang, Mengmeng|Ren, Xiaoxia|Li, Xiaolu|Wu, Fan|Zhao, Yuechao|Tian, Yuanyuan|Wu, Wenming|Fu, Jun|Liang, Junbo|Wu, Wei|Liu, Changzheng|Yu, Jia|Zong, Shudong|Miao,
PMID: 26300397
Journal: Anticancer Res. 2016 Apr;36(4):1901-7.
Title: Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application.
Author: Fichtl, Jakub|Treska, Vladislav|Lysak, Daniel|Mirka, Hynek|Duras, Petr|Karlikova, Marie|Skalicky, Tomas|Vodicka, Josef|Topolcan, Ondrej
PMID: 27069178
Journal: J Cancer Res Ther. 2018 Apr-Jun;14(3):527-531.
Title: Tooth agenesis: A susceptible indicator for colorectal cancer?
Author: Paranjyothi, M V|Kumaraswamy, K L|Begum, Lubna Firdose|Manjunath, K|Basheer, Shaini
PMID: 29893310