Primary Site >> Colorectal Cancer
Gene >> TGFA
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Ref: Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. PMID: 2887281 Ref: Simultaneous production of IGF-I and EGF competing growth factors by HT-29 human colon cancer line. PMID: 3500134 |
Ref: Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines. PMID: 3282475 |
Ref: Growth factor production by human colon carcinoma cell lines. PMID: 2541895 Ref: Expression of TGF-alpha/EGF and TGF-beta receptors in human colon carcinoma cell lines. PMID: 2545633 |
Ref: Inhibitory effects of transforming growth factor beta 1 on mitogenic response, transforming growth factor alpha, and c-myc in quiescent, well-differentiated colon carcinoma cells. PMID: 1701348 Ref: Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects. PMID: 1977468 Ref: Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium. PMID: 2365825 |
Ref: Proteins secreted by Caco-2 cells support growth of other tumor cells in Chee's Essential Medium without supplements. PMID: 1769010 |
Ref: Transforming growth factors and related peptides in gastrointestinal neoplasia. PMID: 1335097 |
Ref: The role of growth regulatory aberrations in progression of human colon carcinoma. PMID: 8281613 Ref: Infection with a transforming growth factor alpha anti-sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line. PMID: 8335403 Ref: Autocrine transforming growth factor-alpha is associated with progression of transformed properties in human colon cancer cells. PMID: 8416972 |
Ref: Platelet-derived growth factor-B increases colon cancer cell growth in vivo by a paracrine effect. PMID: 7593201 Ref: Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate. PMID: 7628553 Ref: Colon goblet cells lose proliferative response to TGF alpha as they differentiate. PMID: 7790121 Ref: Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors. PMID: 7794080 Ref: Expression of growth factors and their receptors in human early colorectal carcinomas: immunohistochemical study. PMID: 8669884 Ref: Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. PMID: 21556635 |
Ref: Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer. PMID: 9164515 Ref: ErbB kinases and NDF signaling in human prostate cancer cells. PMID: 9400997 |
Ref: EGF, TGF-alpha, and EGF-R in human colorectal adenocarcinoma. PMID: 9677101 |
Ref: Increased transforming growth factor-alpha levels in human colon carcinoma cell lines over-expressing protein kinase C. PMID: 9935234 Ref: Effect of aspirin on prostaglandin E2 formation and transforming growth factor alpha expression in human rectal mucosa from individuals with a history of adenomatous polyps of the colon. PMID: 10207634 Ref: The EGF/TGFalpha response element within the TGFalpha promoter consists of a multi-complex regulatory element. PMID: 10557079 |
Ref: Transforming growth factor-alpha precursors in human colon carcinoma cells. PMID: 11414287 |
Ref: Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. PMID: 11857296 Ref: Tissue localization of TGFalpha and apoptosis are inversely related in colorectal tumors. PMID: 11914921 Ref: Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. PMID: 11973637 |
Ref: Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options. PMID: 12790326 |
Ref: Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells. PMID: 15538569 Ref: Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling. PMID: 15746213 |
Ref: Canonical WNT signaling pathway and human AREG. PMID: 16685431 |
Ref: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. PMID: 18619649 |
Ref: Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. PMID: 18790474 Ref: Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent. PMID: 19276250 Ref: Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. PMID: 19328625 |
Ref: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17. PMID: 21148749 Ref: Dual blockade of the EGFR and COX-2 pathways: a phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer. PMID: 21217396 Ref: Amphiregulin exosomes increase cancer cell invasion. PMID: 21514161 Ref: Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models. PMID: 21554739 |
Ref: Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. PMID: 22791816 |
Ref: Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. PMID: 23374602 Ref: TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PMID: 23536895 Ref: The role of epidermal growth factor receptor in cancer metastasis and microenvironment. PMID: 23986907 Ref: Increased TGF-alpha as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells. PMID: 24122793 Ref: Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer. PMID: 24180698 |
Ref: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids. PMID: 24520077 Ref: Paracrine network: another step in the complexity of resistance to EGFR blockade? PMID: 25139340 |
Ref: Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway. PMID: 26300397 |
Ref: Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application. PMID: 27069178 |
Ref: Tooth agenesis: A susceptible indicator for colorectal cancer? PMID: 29893310 |