Primary Site >> Colorectal Cancer

Gene >> TFF3

Journal: J Biol Chem. 1995 Apr 21;270(16):9353-61.
Title: Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter.
Author: Sands, B E|Ogata, H|Lynch-Devaney, K|deBeaumont, M|Ezzell, R M|Podolsky, D K
PMID: 7721858
Journal: Lab Invest. 1996 Jul;75(1):25-32.
Title: Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence.
Author: Taupin, D|Ooi, K|Yeomans, N|Giraud, A
PMID: 8683937
Journal: Am J Physiol. 1997 Aug;273(2 Pt 1):G348-54.
Title: Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine.
Author: Ogata, H|Podolsky, D K
PMID: 9277413
Journal: Oncol Rep. 1997 Nov-Dec;4(6):1367-71.
Title: Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas.
Author: Labouvie, C|Machado, J|Carneiro, F|Seitz, G|Blin, N
PMID: 21590255
Journal: J Biol Chem. 1998 Jan 30;273(5):3060-7.
Title: Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein.
Author: Ogata, H|Inoue, N|Podolsky, D K
PMID: 9446622
Journal: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3122-7.
Title: Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells.
Author: Efstathiou, J A|Noda, M|Rowan, A|Dixon, C|Chinery, R|Jawhari, A|Hattori, T|Wright, N A|Bodmer, W F|Pignatelli, M
PMID: 9501226
Journal: Am J Physiol. 1998 Jul;275(1 Pt 1):G85-94.
Title: Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells.
Author: Tran, C P|Familari, M|Parker, L M|Whitehead, R H|Giraud, A S
PMID: 9655688
Journal: FEBS Lett. 1998 Nov 13;439(1-2):180-4.
Title: Osmotic changes and ethanol modify TFF gene expression in gastrointestinal cell lines.
Author: Ludeking, A|Fegert, P|Blin, N|Gott, P
PMID: 9849902
Journal: Gastroenterology. 1999 May;116(5):1072-80.
Title: Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation.
Author: Taupin, D|Podolsky, D K
PMID: 10220499
Journal: Hum Cell. 1999 Dec;12(4):181-8.
Title: Roles of intestinal trefoil factor (ITF) in human colorectal cancer: ITF suppresses the growth of colorectal carcinoma cells.
Author: Uchino, H|Kataoka, H|Itoh, H|Sekiya, R|Onitsuka, T|Koono, M
PMID: 10834104
Journal: Gastroenterology. 2000 Jan;118(1):60-9.
Title: Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo.
Author: Uchino, H|Kataoka, H|Itoh, H|Hamasuna, R|Koono, M
PMID: 10611154
Journal: Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):799-804.
Title: Intestinal trefoil factor confers colonic epithelial resistance to apoptosis.
Author: Taupin, D R|Kinoshita, K|Podolsky, D K
PMID: 10639160
Journal: FASEB J. 2001 Jul;15(9):1517-28.
Title: Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways.
Author: Rodrigues, S|Nguyen, Q D|Faivre, S|Bruyneel, E|Thim, L|Westley, B|May, F|Flatau, G|Mareel, M|Gespach, C|Emami, S
PMID: 11427483
Journal: Aliment Pharmacol Ther. 2002 Apr;16 Suppl 2:115-27.
Title: Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice.
Author: Hahm, K-B|Lee, K M|Kim, Y B|Hong, W S|Lee, W H|Han, S U|Kim, M W|Ahn, B O|Oh, T Y|Lee, M H|Green, J|Kim, S J
PMID: 11966532
Journal: Int J Mol Med. 2003 Jul;12(1):3-9.
Title: Trefoil factors and human gastric cancer (review).
Author: Katoh, Masaru
PMID: 12792801
Journal: Oncogene. 2003 Jul 17;22(29):4488-97.
Title: Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells.
Author: Rodrigues, Sylvie|Attoub, Samir|Nguyen, Quang-De|Bruyneel, Erik|Rodrigue, Christelle M|Westley, Bruce R|May, Felicity E B|Thim, Lars|Mareel, Marc|Emami, Shahin|Gespach, Christian
PMID: 12881705
Journal: Int J Oncol. 2004 Oct;25(4):1049-56.
Title: Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR.
Author: Solmi, Rossella|De Sanctis, Paola|Zucchini, Cinzia|Ugolini, Giampaolo|Rosati, Giancarlo|Del Governatore, Marco|Coppola, Domenico|Yeatman, Thymothy J|Lenzi, Luca|Caira, Antonello|Zanotti, Simone|Taffurelli, Mario|Carinci, Paolo|Valvassori, Luisa|Strippoli,
PMID: 15375555
Journal: Mol Cancer Res. 2004 Sep;2(9):504-13.
Title: Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon.
Author: Gum, James R Jr|Hicks, James W|Crawley, Suzanne C|Yang, Stacey C|Borowsky, Alexander D|Dahl, Christine M|Kakar, Sanjay|Kim, Dong Hoon|Cardiff, Robert D|Kim, Young S
PMID: 15383629
Journal: Cancer Res. 2005 Jan 1;65(1):195-202.
Title: Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth.
Author: Rivat, Christine|Rodrigues, Sylvie|Bruyneel, Erik|Pietu, Genevieve|Robert, Amelie|Redeuilh, Gerard|Bracke, Marc|Gespach, Christian|Attoub, Samir
PMID: 15665295
Journal: Clin Exp Metastasis. 2005;22(2):157-65.
Title: Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells.
Author: Yio, Xianyang|Zhang, Jie-yu|Babyatsky, Mark|Chen, Anli|Lin, Jing|Fan, Qui-Xiang|Werther, J Lawrence|Itzkowitz, Steven
PMID: 16086236
Journal: Int J Oncol. 2005 Oct;27(4):957-64.
Title: Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum.
Author: Kim, Dong Hoon|Kim, Jong Woo|Cho, Joong Hyeon|Baek, Sun Heum|Kakar, Sanjay|Kim, Grace E|Sleisenger, Marvin H|Kim, Young S
PMID: 16142311
Journal: J Biol Chem. 2006 Mar 10;281(10):6434-41.
Title: Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium.
Author: Kalabis, Jiri|Rosenberg, Ian|Podolsky, Daniel K
PMID: 16410243
Journal: Histol Histopathol. 2007 Jul;22(7):743-51.
Title: Expression of TFF3 during multistep colon carcinogenesis.
Author: John, R|El-Rouby, N M|Tomasetto, C|Rio, M-C|Karam, S M
PMID: 17455148
Journal: J Pathol. 2007 Jul;212(3):278-86.
Title: Signet ring cell differentiation in mucinous colorectal carcinoma.
Author: Borger, M E|Gosens, M J E M|Jeuken, J W M|van Kempen, L C L T|van de Velde, C J H|van Krieken, J H J M|Nagtegaal, I D
PMID: 17471475
Journal: Carcinogenesis. 2008 Jul;29(7):1435-40.
Title: Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation.
Author: Bi, Xiuli|Tong, Chang|Dockendorff, Ashley|Bancroft, Laura|Gallagher, Lindsay|Guzman, Grace|Iozzo, Renato V|Augenlicht, Leonard H|Yang, Wancai
PMID: 18550571
Journal: Clin Exp Metastasis. 2009;26(2):143-51.
Title: Trefoil factor-3 expression in human colon cancer liver metastasis.
Author: Babyatsky, Mark|Lin, Jing|Yio, Xianyang|Chen, Anli|Zhang, Jie-yu|Zheng, Yan|Twyman, Christina|Bao, Xiuliang|Schwartz, Myron|Thung, Swan|Lawrence Werther, J|Itzkowitz, Steven
PMID: 18979216
Journal: Biochem Biophys Res Commun. 2009 Oct 2;387(4):736-40.
Title: The transcription factor ITF-2A induces cell cycle arrest via p21(Cip1).
Author: Herbst, Andreas|Helferich, Simone|Behrens, Andrea|Goke, Burkhard|Kolligs, Frank T
PMID: 19635457
Journal: Hum Pathol. 2009 Mar;40(3):398-404.
Title: Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation.
Author: Winn, Brody|Tavares, Rosemarie|Fanion, Jacqueline|Noble, Lelia|Gao, John|Sabo, Edmond|Resnick, Murray B
PMID: 18992917
Journal: Gastroenterology. 2009 Aug;137(2):639-48, 648.e1-9.
Title: ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
Author: Herbst, Andreas|Bommer, Guido T|Kriegl, Lydia|Jung, Andreas|Behrens, Andrea|Csanadi, Endy|Gerhard, Markus|Bolz, Christian|Riesenberg, Rainer|Zimmermann, Wolfgang|Dietmaier, Wolfgang|Wolf, Isabella|Brabletz, Thomas|Goke, Burkhard|Kolligs, Frank T
PMID: 19394332
Journal: J Proteome Res. 2010 Jan;9(1):545-55.
Title: Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach.
Author: Xue, Hua|Lu, Bingjian|Zhang, Jun|Wu, Minliang|Huang, Qiong|Wu, Qiang|Sheng, Hongqiang|Wu, Dongdong|Hu, Jianwen|Lai, Maode
PMID: 19924834
Journal: J Nutr. 2011 Jul;141(7):1239-46.
Title: Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-alpha in colon of dextran sodium sulfate-treated C57BL/6 mice.
Author: Jiang, Huanyi|Przybyszewski, Joseph|Mitra, Debjani|Becker, Chad|Brehm-Stecher, Byron|Tentinger, Amy|MacDonald, Ruth S
PMID: 21593350
Journal: Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):1151-8.
Title: Upregulation of trefoil factor 3 (TFF3) after rectal cancer chemoradiotherapy is an adverse prognostic factor and a potential therapeutic target.
Author: Casado, Enrique|Garcia, Victor Moreno|Sanchez, Jose Javier|Gomez Del Pulgar, Maria Teresa|Feliu, Jaime|Maurel, Joan|Castelo, Beatriz|Moreno Rubio, Juan|Lopez, Rocio A B|Garcia-Cabezas, Miguel Angel|Burgos, Emilio|de Castro, Javier|Belda-Iniesta, Cristobal
PMID: 22516806
Journal: PLoS One. 2013 Apr 24;8(4):e62429.
Title: Recombinant adenovirus-mediated intestinal trefoil factor gene therapy for burn-induced intestinal mucosal injury.
Author: Sun, Yong|Zhu, Yun|Wang, Liangxi|Mao, Xuefei|Peng, Xi|Peng, Yizhi
PMID: 23638081
Journal: J Cancer Res Ther. 2013 Jul-Sep;9(3):376-80.
Title: Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis.
Author: Huang, You-Guang|Li, Yun-Feng|Wang, Li-Ping|Zhang, Yun
PMID: 24125969
Journal: Probiotics Antimicrob Proteins. 2013 Mar;5(1):51-8.
Title: In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei.
Author: Karthikeyan, Thirugnanam|Pravin, Mariappan|Muthusamy, Velusamy Shanmuganathan|Bharathi Raja, Rajaganapathy|Lakshmi, Baddireddi Subhadra
PMID: 26782605
Journal: Arch Pathol Lab Med. 2014 Aug;138(8):1015-26.
Title: Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine.
Author: Lin, Fan|Shi, Jianhui|Zhu, Shaobo|Chen, Zongming|Li, Aihua|Chen, Taiying|Wang, Hanlin L|Liu, Haiyan
PMID: 24437456
Journal: BMC Genomics. 2014 Jan 28;15:74.
Title: Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling.
Author: Herbst, Andreas|Jurinovic, Vindi|Krebs, Stefan|Thieme, Susanne E|Blum, Helmut|Goke, Burkhard|Kolligs, Frank T
PMID: 24467841
Journal: BMC Clin Pathol. 2014 Jun 14;14:26.
Title: Serum TFF3 may be a pharamcodynamic marker of responses to chemotherapy in gastrointestinal cancers.
Author: Xiao, Li|Liu, Yun-Peng|Xiao, Chuan-Xing|Ren, Jian-Lin|Guleng, Bayasi
PMID: 25031551
Journal: Neoplasma. 2015;62(3):470-7.
Title: Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer.
Author: Vocka, M|Langer, D|Petrtyl, J|Vockova, P|Hanus, T|Kalousova, M|Zima, T|Petruzelka, L
PMID: 25866228
Journal: Am J Cancer Res. 2015 Jun 15;5(7):2241-8. eCollection 2015.
Title: ITF-2B protein levels are correlated with favorable prognosis in patients with colorectal carcinomas.
Author: Brandl, Lydia|Horst, David|de Toni, Enrico|Kirchner, Thomas|Herbst, Andreas|Kolligs, Frank T
PMID: 26328254
Journal: Oncotarget. 2015 Oct 13;6(31):30993-1006.
Title: Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation.
Author: Shang, Yangyang|Pan, Qiong|Chen, Lei|Ye, Jun|Zhong, Xiaoli|Li, Xiaohuan|Meng, Linkuan|Guo, Jin|Tian, Yin|He, Yonghong|Chen, Wensheng|Peng, Zhihong|Wang, Rongquan
PMID: 26307678
Journal: Biochem Biophys Res Commun. 2015 May 29;461(2):249-53.
Title: Inactivation of Itf2 promotes intestinal tumorigenesis in Apc(Min/+) mice.
Author: Grill, Jessica I|Herbst, Andreas|Brandl, Lydia|Kong, Lixia|Schneider, Marlon R|Kirchner, Thomas|Wolf, Eckhard|Kolligs, Frank T
PMID: 25869068
Journal: Int J Oncol. 2015 Feb;46(2):563-8.
Title: The value of trefoil factor 3 expression in predicting the longterm outcome and early recurrence of colorectal cancer.
Author: Morito, Kiyoto|Nakamura, Jun|Kitajima, Yoshihiko|Kai, Keita|Tanaka, Tomokazu|Kubo, Hiroshi|Miyake, Shuusuke|Noshiro, Hirokazu
PMID: 25405728
Journal: Technol Cancer Res Treat. 2017 Aug;16(4):440-445.
Title: Serum Trefoil Factor 3 as a Protein Biomarker for the Diagnosis of Colorectal Cancer.
Author: Li, Qiang|Wang, Keke|Su, Chang|Fang, Jieyu
PMID: 27760866
Journal: World J Gastroenterol. 2017 Jan 7;23(1):110-120.
Title: Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis.
Author: Yusup, Akram|Huji, Bailikezi|Fang, Cheng|Wang, Fei|Dadihan, Tuerxunjiang|Wang, Hai-Jiang|Upur, Halmurat
PMID: 28104986
Journal: Cell Death Discov. 2017 Jan 30;3:16106.
Title: TFF3-dependent resistance of human colorectal adenocarcinoma cells HT-29/B6 to apoptosis is mediated by miR-491-5p regulation of lncRNA PRINS.
Author: Hanisch, Carlos|Sharbati, Jutta|Kutz-Lohroff, Barbara|Huber, Otmar|Einspanier, Ralf|Sharbati, Soroush
PMID: 28149533
Journal: Cell Death Dis. 2017 Mar 9;8(3):e2660.
Title: Trefoil factor 3 mediates resistance to apoptosis in colon carcinoma cells by a regulatory RNA axis.
Author: Hanisch, Carlos|Sharbati, Jutta|Kutz-Lohroff, Barbara|Huber, Otmar|Einspanier, Ralf|Sharbati, Soroush
PMID: 28277538
Journal: World J Gastroenterol. 2017 Mar 28;23(12):2159-2167.
Title: Diagnostic value evaluation of trefoil factors family 3 for the early detection of colorectal cancer.
Author: Xie, Hui|Guo, Jian-Hai|An, Wei-Min|Tian, Sheng-Tao|Yu, Hai-Peng|Yang, Xue-Ling|Wang, Hua-Ming|Guo, Zhi
PMID: 28405143
Journal: Arab J Gastroenterol. 2017 Dec;18(4):191-200.
Title: Simple classifiers for molecular subtypes of colorectal cancer.
Author: Kim, Woo Gyeong|Kim, Joo Yeon|Park, Do Youn
PMID: 29241727
Journal: Br J Nutr. 2018 Jul;120(2):121-130.
Title: Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Author: Liu, Cuiping|Chen, Chen|Yang, Fuguo|Li, Xin|Cheng, Lixue|Song, Yang
PMID: 29947321
Journal: Oncol Lett. 2018 Sep;16(3):3658-3664.
Title: Downregulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer.
Author: Kondo, Satoru|Araki, Toshimitsu|Toiyama, Yuji|Tanaka, Koji|Kawamura, Mikio|Okugawa, Yoshinaga|Okita, Yoshiki|Saigusa, Susumu|Inoue, Yasuhiro|Uchida, Keiichi|Mohri, Yasuhiko|Kusunoki, Masato
PMID: 30127975