Primary Site >> Colorectal Cancer
Gene >> TFF3
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Ref: Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter. PMID: 7721858 |
Ref: Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence. PMID: 8683937 |
Ref: Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine. PMID: 9277413 Ref: Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas. PMID: 21590255 |
Ref: Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein. PMID: 9446622 Ref: Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. PMID: 9501226 Ref: Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells. PMID: 9655688 Ref: Osmotic changes and ethanol modify TFF gene expression in gastrointestinal cell lines. PMID: 9849902 |
Ref: Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. PMID: 10220499 Ref: Roles of intestinal trefoil factor (ITF) in human colorectal cancer: ITF suppresses the growth of colorectal carcinoma cells. PMID: 10834104 |
Ref: Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo. PMID: 10611154 Ref: Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. PMID: 10639160 |
Ref: Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways. PMID: 11427483 |
Ref: Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. PMID: 11966532 |
Ref: Trefoil factors and human gastric cancer (review). PMID: 12792801 Ref: Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells. PMID: 12881705 |
Ref: Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. PMID: 15375555 Ref: Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon. PMID: 15383629 |
Ref: Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth. PMID: 15665295 Ref: Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells. PMID: 16086236 Ref: Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. PMID: 16142311 |
Ref: Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium. PMID: 16410243 |
Ref: Expression of TFF3 during multistep colon carcinogenesis. PMID: 17455148 Ref: Signet ring cell differentiation in mucinous colorectal carcinoma. PMID: 17471475 |
Ref: Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. PMID: 18550571 |
Ref: Trefoil factor-3 expression in human colon cancer liver metastasis. PMID: 18979216 Ref: Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation. PMID: 18992917 Ref: ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition. PMID: 19394332 Ref: The transcription factor ITF-2A induces cell cycle arrest via p21(Cip1). PMID: 19635457 |
Ref: Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach. PMID: 19924834 |
Ref: Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-alpha in colon of dextran sodium sulfate-treated C57BL/6 mice. PMID: 21593350 |
Ref: Upregulation of trefoil factor 3 (TFF3) after rectal cancer chemoradiotherapy is an adverse prognostic factor and a potential therapeutic target. PMID: 22516806 |
Ref: Recombinant adenovirus-mediated intestinal trefoil factor gene therapy for burn-induced intestinal mucosal injury. PMID: 23638081 Ref: Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis. PMID: 24125969 Ref: In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei. PMID: 26782605 |
Ref: Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. PMID: 24437456 Ref: Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling. PMID: 24467841 Ref: Serum TFF3 may be a pharamcodynamic marker of responses to chemotherapy in gastrointestinal cancers. PMID: 25031551 |
Ref: The value of trefoil factor 3 expression in predicting the longterm outcome and early recurrence of colorectal cancer. PMID: 25405728 Ref: Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer. PMID: 25866228 Ref: Inactivation of Itf2 promotes intestinal tumorigenesis in Apc(Min/+) mice. PMID: 25869068 Ref: Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation. PMID: 26307678 Ref: ITF-2B protein levels are correlated with favorable prognosis in patients with colorectal carcinomas. PMID: 26328254 |
Ref: Serum Trefoil Factor 3 as a Protein Biomarker for the Diagnosis of Colorectal Cancer. PMID: 27760866 Ref: Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis. PMID: 28104986 Ref: TFF3-dependent resistance of human colorectal adenocarcinoma cells HT-29/B6 to apoptosis is mediated by miR-491-5p regulation of lncRNA PRINS. PMID: 28149533 Ref: Trefoil factor 3 mediates resistance to apoptosis in colon carcinoma cells by a regulatory RNA axis. PMID: 28277538 Ref: Diagnostic value evaluation of trefoil factors family 3 for the early detection of colorectal cancer. PMID: 28405143 Ref: Simple classifiers for molecular subtypes of colorectal cancer. PMID: 29241727 |
Ref: Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. PMID: 29947321 Ref: Downregulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer. PMID: 30127975 |